DNA topoisomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA topoisomerase

Gene product:

DNA topoisomerase III, putative

Species:

Leishmania braziliensis

UniProt:

A4HPI6_LEIBR

TriTrypDb:

LbrM.35.3420 , LBRM2903_350043100

Length:

951

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0005694	chromosome	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HPI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPI6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006265	DNA topological change	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006996	organelle organization	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0051276	chromosome organization	5	12
GO:0071103	DNA conformation change	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0003916	DNA topoisomerase activity	3	12
GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	4	12
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	11
GO:0016853	isomerase activity	2	12
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0097159	organic cyclic compound binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.351
CLV_C14_Caspase3-7	328	332	PF00656	0.266
CLV_C14_Caspase3-7	492	496	PF00656	0.356
CLV_NRD_NRD_1	216	218	PF00675	0.345
CLV_NRD_NRD_1	284	286	PF00675	0.297
CLV_NRD_NRD_1	519	521	PF00675	0.186
CLV_NRD_NRD_1	883	885	PF00675	0.641
CLV_NRD_NRD_1	926	928	PF00675	0.289
CLV_NRD_NRD_1	941	943	PF00675	0.216
CLV_PCSK_FUR_1	932	936	PF00082	0.395
CLV_PCSK_KEX2_1	131	133	PF00082	0.269
CLV_PCSK_KEX2_1	138	140	PF00082	0.230
CLV_PCSK_KEX2_1	162	164	PF00082	0.333
CLV_PCSK_KEX2_1	216	218	PF00082	0.345
CLV_PCSK_KEX2_1	283	285	PF00082	0.275
CLV_PCSK_KEX2_1	519	521	PF00082	0.266
CLV_PCSK_KEX2_1	599	601	PF00082	0.503
CLV_PCSK_KEX2_1	883	885	PF00082	0.639
CLV_PCSK_KEX2_1	934	936	PF00082	0.277
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.275
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.225
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.356
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.503
CLV_PCSK_PC1ET2_1	934	936	PF00082	0.330
CLV_PCSK_PC7_1	280	286	PF00082	0.288
CLV_PCSK_PC7_1	515	521	PF00082	0.266
CLV_PCSK_SKI1_1	148	152	PF00082	0.345
CLV_PCSK_SKI1_1	191	195	PF00082	0.421
CLV_PCSK_SKI1_1	309	313	PF00082	0.358
CLV_PCSK_SKI1_1	406	410	PF00082	0.300
CLV_PCSK_SKI1_1	46	50	PF00082	0.297
CLV_PCSK_SKI1_1	510	514	PF00082	0.286
CLV_PCSK_SKI1_1	846	850	PF00082	0.352
CLV_PCSK_SKI1_1	934	938	PF00082	0.265
CLV_PCSK_SKI1_1	943	947	PF00082	0.280
DEG_APCC_DBOX_1	147	155	PF00400	0.384
DEG_APCC_DBOX_1	396	404	PF00400	0.264
DEG_APCC_DBOX_1	405	413	PF00400	0.204
DEG_APCC_DBOX_1	86	94	PF00400	0.482
DOC_ANK_TNKS_1	818	825	PF00023	0.464
DOC_CYCLIN_RxL_1	188	196	PF00134	0.261
DOC_CYCLIN_RxL_1	597	608	PF00134	0.514
DOC_MAPK_DCC_7	819	827	PF00069	0.456
DOC_MAPK_gen_1	131	137	PF00069	0.509
DOC_MAPK_gen_1	280	290	PF00069	0.303
DOC_MAPK_gen_1	838	845	PF00069	0.442
DOC_MAPK_MEF2A_6	103	111	PF00069	0.428
DOC_MAPK_MEF2A_6	171	178	PF00069	0.266
DOC_MAPK_MEF2A_6	283	290	PF00069	0.209
DOC_MAPK_MEF2A_6	552	559	PF00069	0.251
DOC_MAPK_MEF2A_6	819	827	PF00069	0.456
DOC_MAPK_NFAT4_5	171	179	PF00069	0.266
DOC_MAPK_NFAT4_5	552	560	PF00069	0.251
DOC_PP2B_LxvP_1	157	160	PF13499	0.349
DOC_PP4_FxxP_1	704	707	PF00568	0.353
DOC_PP4_FxxP_1	78	81	PF00568	0.518
DOC_USP7_MATH_1	533	537	PF00917	0.252
DOC_USP7_MATH_1	792	796	PF00917	0.539
DOC_USP7_MATH_1	798	802	PF00917	0.526
DOC_USP7_MATH_1	853	857	PF00917	0.619
DOC_USP7_MATH_1	882	886	PF00917	0.705
DOC_USP7_MATH_1	904	908	PF00917	0.655
DOC_USP7_UBL2_3	158	162	PF12436	0.488
DOC_WW_Pin1_4	410	415	PF00397	0.270
DOC_WW_Pin1_4	703	708	PF00397	0.380
DOC_WW_Pin1_4	796	801	PF00397	0.485
LIG_14-3-3_CanoR_1	177	183	PF00244	0.326
LIG_14-3-3_CanoR_1	184	189	PF00244	0.308
LIG_14-3-3_CanoR_1	27	37	PF00244	0.369
LIG_14-3-3_CanoR_1	304	313	PF00244	0.247
LIG_14-3-3_CanoR_1	478	482	PF00244	0.218
LIG_14-3-3_CanoR_1	489	494	PF00244	0.242
LIG_14-3-3_CanoR_1	586	595	PF00244	0.282
LIG_14-3-3_CanoR_1	665	670	PF00244	0.562
LIG_Actin_WH2_2	161	179	PF00022	0.266
LIG_Actin_WH2_2	291	306	PF00022	0.216
LIG_Actin_WH2_2	357	375	PF00022	0.311
LIG_APCC_ABBA_1	577	582	PF00400	0.330
LIG_BRCT_BRCA1_1	331	335	PF00533	0.266
LIG_BRCT_BRCA1_1	423	427	PF00533	0.395
LIG_Clathr_ClatBox_1	811	815	PF01394	0.446
LIG_eIF4E_1	72	78	PF01652	0.457
LIG_FHA_1	229	235	PF00498	0.286
LIG_FHA_1	356	362	PF00498	0.363
LIG_FHA_1	418	424	PF00498	0.297
LIG_FHA_1	435	441	PF00498	0.402
LIG_FHA_1	45	51	PF00498	0.467
LIG_FHA_1	468	474	PF00498	0.406
LIG_FHA_1	527	533	PF00498	0.327
LIG_FHA_1	608	614	PF00498	0.498
LIG_FHA_1	675	681	PF00498	0.493
LIG_FHA_1	753	759	PF00498	0.405
LIG_FHA_1	828	834	PF00498	0.425
LIG_FHA_1	870	876	PF00498	0.670
LIG_FHA_1	906	912	PF00498	0.558
LIG_FHA_2	100	106	PF00498	0.335
LIG_FHA_2	144	150	PF00498	0.330
LIG_FHA_2	310	316	PF00498	0.229
LIG_FHA_2	326	332	PF00498	0.321
LIG_FHA_2	391	397	PF00498	0.345
LIG_FHA_2	509	515	PF00498	0.266
LIG_FHA_2	687	693	PF00498	0.382
LIG_FHA_2	86	92	PF00498	0.359
LIG_GBD_Chelix_1	290	298	PF00786	0.162
LIG_GBD_Chelix_1	505	513	PF00786	0.286
LIG_Integrin_isoDGR_2	663	665	PF01839	0.431
LIG_LIR_Apic_2	870	876	PF02991	0.619
LIG_LIR_Gen_1	183	193	PF02991	0.288
LIG_LIR_Gen_1	247	257	PF02991	0.302
LIG_LIR_Gen_1	3	11	PF02991	0.316
LIG_LIR_Gen_1	399	409	PF02991	0.189
LIG_LIR_Gen_1	536	546	PF02991	0.286
LIG_LIR_Gen_1	581	589	PF02991	0.353
LIG_LIR_Gen_1	841	849	PF02991	0.406
LIG_LIR_Nem_3	181	185	PF02991	0.293
LIG_LIR_Nem_3	187	193	PF02991	0.288
LIG_LIR_Nem_3	227	232	PF02991	0.307
LIG_LIR_Nem_3	247	252	PF02991	0.302
LIG_LIR_Nem_3	3	7	PF02991	0.316
LIG_LIR_Nem_3	33	38	PF02991	0.426
LIG_LIR_Nem_3	399	404	PF02991	0.189
LIG_LIR_Nem_3	536	541	PF02991	0.286
LIG_LIR_Nem_3	581	587	PF02991	0.356
LIG_LIR_Nem_3	66	72	PF02991	0.443
LIG_LIR_Nem_3	733	737	PF02991	0.402
LIG_LIR_Nem_3	841	845	PF02991	0.375
LIG_NRBOX	542	548	PF00104	0.266
LIG_PCNA_yPIPBox_3	397	409	PF02747	0.266
LIG_Pex14_1	444	448	PF04695	0.251
LIG_Pex14_2	190	194	PF04695	0.266
LIG_Pex14_2	35	39	PF04695	0.354
LIG_Pex14_2	74	78	PF04695	0.520
LIG_PTB_Apo_2	33	40	PF02174	0.426
LIG_SH2_CRK	185	189	PF00017	0.421
LIG_SH2_CRK	249	253	PF00017	0.345
LIG_SH2_CRK	401	405	PF00017	0.309
LIG_SH2_CRK	873	877	PF00017	0.540
LIG_SH2_NCK_1	249	253	PF00017	0.317
LIG_SH2_NCK_1	580	584	PF00017	0.354
LIG_SH2_NCK_1	873	877	PF00017	0.555
LIG_SH2_PTP2	842	845	PF00017	0.385
LIG_SH2_SRC	318	321	PF00017	0.266
LIG_SH2_SRC	461	464	PF00017	0.395
LIG_SH2_SRC	580	583	PF00017	0.446
LIG_SH2_STAP1	249	253	PF00017	0.317
LIG_SH2_STAP1	258	262	PF00017	0.322
LIG_SH2_STAP1	356	360	PF00017	0.363
LIG_SH2_STAP1	580	584	PF00017	0.354
LIG_SH2_STAT3	218	221	PF00017	0.395
LIG_SH2_STAT3	333	336	PF00017	0.395
LIG_SH2_STAT3	72	75	PF00017	0.467
LIG_SH2_STAT5	333	336	PF00017	0.349
LIG_SH2_STAT5	517	520	PF00017	0.251
LIG_SH2_STAT5	842	845	PF00017	0.366
LIG_SH2_STAT5	85	88	PF00017	0.531
LIG_SH2_STAT5	873	876	PF00017	0.577
LIG_SH3_1	283	289	PF00018	0.172
LIG_SH3_2	383	388	PF14604	0.293
LIG_SH3_3	283	289	PF00018	0.263
LIG_SH3_3	365	371	PF00018	0.372
LIG_SH3_3	380	386	PF00018	0.239
LIG_SH3_3	668	674	PF00018	0.517
LIG_SH3_3	785	791	PF00018	0.391
LIG_SUMO_SIM_anti_2	337	345	PF11976	0.353
LIG_SUMO_SIM_par_1	486	496	PF11976	0.272
LIG_TRAF2_1	170	173	PF00917	0.286
LIG_TRAF2_1	334	337	PF00917	0.401
LIG_TYR_ITSM	181	188	PF00017	0.395
LIG_WRC_WIRS_1	200	205	PF05994	0.266
LIG_WRC_WIRS_1	811	816	PF05994	0.374
LIG_WW_3	706	710	PF00397	0.305
MOD_CDC14_SPxK_1	706	709	PF00782	0.460
MOD_CDK_SPxK_1	703	709	PF00069	0.434
MOD_CDK_SPxxK_3	796	803	PF00069	0.487
MOD_CK1_1	143	149	PF00069	0.486
MOD_CK1_1	244	250	PF00069	0.374
MOD_CK1_1	431	437	PF00069	0.263
MOD_CK1_1	861	867	PF00069	0.638
MOD_CK1_1	877	883	PF00069	0.568
MOD_CK2_1	309	315	PF00069	0.223
MOD_CK2_1	331	337	PF00069	0.275
MOD_CK2_1	390	396	PF00069	0.324
MOD_CK2_1	533	539	PF00069	0.266
MOD_CK2_1	686	692	PF00069	0.393
MOD_CK2_1	85	91	PF00069	0.398
MOD_CK2_1	923	929	PF00069	0.279
MOD_Cter_Amidation	932	935	PF01082	0.266
MOD_GlcNHglycan	142	145	PF01048	0.240
MOD_GlcNHglycan	21	24	PF01048	0.282
MOD_GlcNHglycan	423	426	PF01048	0.351
MOD_GlcNHglycan	479	482	PF01048	0.380
MOD_GlcNHglycan	535	538	PF01048	0.257
MOD_GlcNHglycan	78	81	PF01048	0.289
MOD_GlcNHglycan	815	819	PF01048	0.516
MOD_GlcNHglycan	855	858	PF01048	0.599
MOD_GlcNHglycan	860	863	PF01048	0.610
MOD_GlcNHglycan	880	883	PF01048	0.645
MOD_GlcNHglycan	884	887	PF01048	0.658
MOD_GlcNHglycan	895	898	PF01048	0.623
MOD_GSK3_1	180	187	PF00069	0.277
MOD_GSK3_1	236	243	PF00069	0.324
MOD_GSK3_1	309	316	PF00069	0.241
MOD_GSK3_1	321	328	PF00069	0.290
MOD_GSK3_1	331	338	PF00069	0.251
MOD_GSK3_1	417	424	PF00069	0.276
MOD_GSK3_1	430	437	PF00069	0.203
MOD_GSK3_1	44	51	PF00069	0.490
MOD_GSK3_1	463	470	PF00069	0.402
MOD_GSK3_1	485	492	PF00069	0.442
MOD_GSK3_1	521	528	PF00069	0.329
MOD_GSK3_1	533	540	PF00069	0.313
MOD_GSK3_1	63	70	PF00069	0.494
MOD_GSK3_1	711	718	PF00069	0.533
MOD_GSK3_1	76	83	PF00069	0.425
MOD_GSK3_1	780	787	PF00069	0.358
MOD_GSK3_1	792	799	PF00069	0.473
MOD_GSK3_1	810	817	PF00069	0.511
MOD_GSK3_1	847	854	PF00069	0.555
MOD_GSK3_1	857	864	PF00069	0.585
MOD_GSK3_1	865	872	PF00069	0.654
MOD_GSK3_1	874	881	PF00069	0.671
MOD_LATS_1	302	308	PF00433	0.311
MOD_N-GLC_1	390	395	PF02516	0.326
MOD_N-GLC_1	67	72	PF02516	0.318
MOD_N-GLC_1	711	716	PF02516	0.374
MOD_N-GLC_1	904	909	PF02516	0.656
MOD_N-GLC_2	119	121	PF02516	0.228
MOD_NEK2_1	17	22	PF00069	0.488
MOD_NEK2_1	241	246	PF00069	0.393
MOD_NEK2_1	298	303	PF00069	0.288
MOD_NEK2_1	313	318	PF00069	0.286
MOD_NEK2_1	408	413	PF00069	0.353
MOD_NEK2_1	48	53	PF00069	0.444
MOD_NEK2_1	485	490	PF00069	0.320
MOD_NEK2_1	493	498	PF00069	0.339
MOD_NEK2_1	587	592	PF00069	0.464
MOD_NEK2_1	686	691	PF00069	0.254
MOD_NEK2_1	774	779	PF00069	0.417
MOD_NEK2_1	786	791	PF00069	0.386
MOD_NEK2_1	814	819	PF00069	0.525
MOD_NEK2_1	827	832	PF00069	0.288
MOD_NEK2_2	792	797	PF00069	0.505
MOD_OFUCOSY	778	784	PF10250	0.455
MOD_PIKK_1	28	34	PF00454	0.522
MOD_PIKK_1	798	804	PF00454	0.512
MOD_PKA_1	162	168	PF00069	0.395
MOD_PKA_2	162	168	PF00069	0.395
MOD_PKA_2	244	250	PF00069	0.355
MOD_PKA_2	272	278	PF00069	0.305
MOD_PKA_2	279	285	PF00069	0.268
MOD_PKA_2	303	309	PF00069	0.216
MOD_PKA_2	396	402	PF00069	0.261
MOD_PKA_2	421	427	PF00069	0.261
MOD_PKA_2	477	483	PF00069	0.321
MOD_PKA_2	686	692	PF00069	0.255
MOD_PKA_2	882	888	PF00069	0.658
MOD_Plk_1	453	459	PF00069	0.368
MOD_Plk_1	501	507	PF00069	0.251
MOD_Plk_1	67	73	PF00069	0.467
MOD_Plk_2-3	331	337	PF00069	0.266
MOD_Plk_4	244	250	PF00069	0.331
MOD_Plk_4	252	258	PF00069	0.371
MOD_Plk_4	289	295	PF00069	0.345
MOD_Plk_4	313	319	PF00069	0.251
MOD_Plk_4	396	402	PF00069	0.162
MOD_Plk_4	435	441	PF00069	0.302
MOD_Plk_4	44	50	PF00069	0.507
MOD_Plk_4	508	514	PF00069	0.270
MOD_Plk_4	521	527	PF00069	0.336
MOD_Plk_4	542	548	PF00069	0.269
MOD_Plk_4	613	619	PF00069	0.535
MOD_ProDKin_1	410	416	PF00069	0.270
MOD_ProDKin_1	703	709	PF00069	0.396
MOD_ProDKin_1	796	802	PF00069	0.488
MOD_SUMO_rev_2	40	48	PF00179	0.459
TRG_DiLeu_BaEn_1	339	344	PF01217	0.395
TRG_DiLeu_BaEn_1	521	526	PF01217	0.266
TRG_DiLeu_BaLyEn_6	486	491	PF01217	0.162
TRG_ENDOCYTIC_2	185	188	PF00928	0.421
TRG_ENDOCYTIC_2	249	252	PF00928	0.317
TRG_ENDOCYTIC_2	258	261	PF00928	0.322
TRG_ENDOCYTIC_2	401	404	PF00928	0.251
TRG_ENDOCYTIC_2	538	541	PF00928	0.286
TRG_ENDOCYTIC_2	580	583	PF00928	0.317
TRG_ENDOCYTIC_2	595	598	PF00928	0.328
TRG_ENDOCYTIC_2	842	845	PF00928	0.366
TRG_ER_diArg_1	215	217	PF00400	0.345
TRG_ER_diArg_1	283	285	PF00400	0.289
TRG_ER_diArg_1	367	370	PF00400	0.244
TRG_ER_diArg_1	518	520	PF00400	0.186
TRG_ER_diArg_1	650	653	PF00400	0.275
TRG_ER_diArg_1	765	768	PF00400	0.352
TRG_NES_CRM1_1	149	161	PF08389	0.399
TRG_NES_CRM1_1	339	352	PF08389	0.299
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.261

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0P1	Leptomonas seymouri	32%	100%
A0A0N1PAL1	Leptomonas seymouri	75%	99%
A0A0S4J933	Bodo saltans	32%	100%
A0A0S4JI21	Bodo saltans	48%	97%
A0A1X0NSK9	Trypanosomatidae	31%	100%
A0A1X0P3I0	Trypanosomatidae	58%	100%
A0A3R7KDV1	Trypanosoma rangeli	58%	100%
A0A3S7WW83	Leishmania donovani	23%	100%
A0A3S7X1K1	Leishmania donovani	32%	100%
A0A3S7XB89	Leishmania donovani	88%	100%
A0A422NYW0	Trypanosoma rangeli	31%	100%
A0R979	Bacillus thuringiensis (strain Al Hakam)	23%	100%
A4HGN1	Leishmania braziliensis	32%	98%
A4HZ99	Leishmania infantum	22%	100%
A4I3Q5	Leishmania infantum	32%	100%
A4IDA8	Leishmania infantum	89%	100%
D0A8A5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A8E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AT98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AUX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9AZZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
F4ISQ7	Arabidopsis thaliana	32%	100%
O27661	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	25%	100%
O28469	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	27%	100%
O58356	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	28%	100%
O70157	Mus musculus	38%	95%
O95985	Homo sapiens	32%	100%
O96651	Drosophila melanogaster	33%	100%
P13099	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P43704	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	26%	100%
P47368	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	23%	100%
P78032	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	24%	100%
P96583	Bacillus subtilis (strain 168)	24%	100%
Q08582	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	22%	76%
Q0J0S6	Oryza sativa subsp. japonica	33%	100%
Q13472	Homo sapiens	37%	95%
Q49ZH2	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	22%	100%
Q4L8B8	Staphylococcus haemolyticus (strain JCSC1435)	21%	100%
Q4Q199	Leishmania major	87%	100%
Q4Q888	Leishmania major	32%	98%
Q4QCK3	Leishmania major	22%	100%
Q59046	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	24%	100%
Q5HLZ4	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	22%	100%
Q5WAX6	Alkalihalobacillus clausii (strain KSM-K16)	26%	100%
Q63GK5	Bacillus cereus (strain ZK / E33L)	23%	100%
Q65N90	Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46)	23%	100%
Q6HP19	Bacillus thuringiensis subsp. konkukian (strain 97-27)	23%	100%
Q73E74	Bacillus cereus (strain ATCC 10987 / NRS 248)	23%	100%
Q81IH1	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	23%	100%
Q81Z97	Bacillus anthracis	23%	100%
Q8CRF7	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	22%	100%
Q8T2T7	Dictyostelium discoideum	38%	100%
Q9CN30	Pasteurella multocida (strain Pm70)	23%	100%
Q9CP53	Pasteurella multocida (strain Pm70)	25%	100%
Q9HM08	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	26%	100%
Q9YB01	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	28%	100%
Q9Z321	Mus musculus	32%	100%
Q9ZMV7	Helicobacter pylori (strain J99 / ATCC 700824)	22%	100%
V5AV88	Trypanosoma cruzi	31%	100%
V5BE78	Trypanosoma cruzi	56%	100%