Nucleic acid binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleic acid binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HPI5_LEIBR

TriTrypDb:

LbrM.35.3410 , LBRM2903_350043000

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPI5

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034250	positive regulation of amide metabolic process	6	1
GO:0045727	positive regulation of translation	7	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051247	positive regulation of protein metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1
GO:2000765	regulation of cytoplasmic translation	7	1
GO:2000767	positive regulation of cytoplasmic translation	8	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003723	RNA binding	4	1
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0045182	translation regulator activity	1	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004540	RNA nuclease activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	368	372	PF00656	0.279
CLV_NRD_NRD_1	357	359	PF00675	0.518
CLV_NRD_NRD_1	422	424	PF00675	0.412
CLV_NRD_NRD_1	483	485	PF00675	0.435
CLV_NRD_NRD_1	509	511	PF00675	0.405
CLV_NRD_NRD_1	62	64	PF00675	0.431
CLV_NRD_NRD_1	80	82	PF00675	0.217
CLV_PCSK_KEX2_1	336	338	PF00082	0.474
CLV_PCSK_KEX2_1	357	359	PF00082	0.509
CLV_PCSK_KEX2_1	424	426	PF00082	0.443
CLV_PCSK_KEX2_1	449	451	PF00082	0.487
CLV_PCSK_KEX2_1	483	485	PF00082	0.435
CLV_PCSK_KEX2_1	509	511	PF00082	0.405
CLV_PCSK_KEX2_1	62	64	PF00082	0.431
CLV_PCSK_KEX2_1	74	76	PF00082	0.275
CLV_PCSK_KEX2_1	80	82	PF00082	0.223
CLV_PCSK_KEX2_1	89	91	PF00082	0.423
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.461
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.443
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.487
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.368
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.424
CLV_PCSK_PC7_1	58	64	PF00082	0.616
CLV_PCSK_SKI1_1	425	429	PF00082	0.456
CLV_PCSK_SKI1_1	546	550	PF00082	0.459
DOC_CKS1_1	39	44	PF01111	0.452
DOC_CYCLIN_RxL_1	543	553	PF00134	0.471
DOC_CYCLIN_yClb5_NLxxxL_5	69	76	PF00134	0.335
DOC_MAPK_gen_1	336	345	PF00069	0.379
DOC_MAPK_gen_1	483	491	PF00069	0.384
DOC_MAPK_MEF2A_6	336	345	PF00069	0.398
DOC_PP1_RVXF_1	557	564	PF00149	0.483
DOC_PP2B_LxvP_1	10	13	PF13499	0.478
DOC_PP2B_LxvP_1	332	335	PF13499	0.411
DOC_USP7_MATH_1	186	190	PF00917	0.637
DOC_USP7_MATH_1	272	276	PF00917	0.690
DOC_USP7_MATH_1	291	295	PF00917	0.701
DOC_USP7_MATH_1	318	322	PF00917	0.570
DOC_USP7_MATH_1	42	46	PF00917	0.495
DOC_USP7_MATH_2	283	289	PF00917	0.545
DOC_USP7_UBL2_3	532	536	PF12436	0.466
DOC_WW_Pin1_4	264	269	PF00397	0.432
DOC_WW_Pin1_4	3	8	PF00397	0.504
DOC_WW_Pin1_4	38	43	PF00397	0.592
LIG_14-3-3_CanoR_1	109	113	PF00244	0.360
LIG_14-3-3_CanoR_1	181	187	PF00244	0.392
LIG_14-3-3_CanoR_1	278	283	PF00244	0.600
LIG_14-3-3_CanoR_1	357	363	PF00244	0.611
LIG_14-3-3_CanoR_1	452	459	PF00244	0.629
LIG_14-3-3_CanoR_1	551	561	PF00244	0.561
LIG_14-3-3_CanoR_1	90	98	PF00244	0.737
LIG_14-3-3_CterR_2	570	573	PF00244	0.393
LIG_APCC_ABBA_1	477	482	PF00400	0.476
LIG_BIR_II_1	1	5	PF00653	0.498
LIG_Clathr_ClatBox_1	16	20	PF01394	0.645
LIG_FHA_1	238	244	PF00498	0.531
LIG_FHA_1	368	374	PF00498	0.429
LIG_FHA_1	396	402	PF00498	0.355
LIG_FHA_1	440	446	PF00498	0.311
LIG_FHA_1	472	478	PF00498	0.345
LIG_FHA_1	539	545	PF00498	0.597
LIG_FHA_1	563	569	PF00498	0.435
LIG_FHA_2	464	470	PF00498	0.383
LIG_GBD_Chelix_1	440	448	PF00786	0.393
LIG_LIR_Gen_1	397	408	PF02991	0.474
LIG_LIR_Nem_3	397	403	PF02991	0.438
LIG_LIR_Nem_3	497	502	PF02991	0.381
LIG_LIR_Nem_3	560	566	PF02991	0.575
LIG_LYPXL_S_1	498	502	PF13949	0.337
LIG_LYPXL_yS_3	499	502	PF13949	0.343
LIG_MYND_1	14	18	PF01753	0.642
LIG_PDZ_Class_1	568	573	PF00595	0.358
LIG_SH2_CRK	265	269	PF00017	0.695
LIG_SH2_PTP2	329	332	PF00017	0.526
LIG_SH2_SRC	366	369	PF00017	0.302
LIG_SH2_STAP1	375	379	PF00017	0.419
LIG_SH2_STAT5	329	332	PF00017	0.651
LIG_SH2_STAT5	349	352	PF00017	0.236
LIG_SH2_STAT5	375	378	PF00017	0.358
LIG_SH2_STAT5	379	382	PF00017	0.334
LIG_SH2_STAT5	454	457	PF00017	0.414
LIG_SH2_STAT5	504	507	PF00017	0.389
LIG_SH3_3	16	22	PF00018	0.483
LIG_SH3_3	321	327	PF00018	0.608
LIG_SH3_3	6	12	PF00018	0.488
LIG_SUMO_SIM_anti_2	338	346	PF11976	0.275
LIG_TRAF2_1	18	21	PF00917	0.647
LIG_TYR_ITIM	128	133	PF00017	0.485
LIG_WRC_WIRS_1	563	568	PF05994	0.320
MOD_CK1_1	2	8	PF00069	0.490
MOD_CK1_1	267	273	PF00069	0.613
MOD_CK1_1	281	287	PF00069	0.670
MOD_CK1_1	294	300	PF00069	0.539
MOD_CK1_1	38	44	PF00069	0.695
MOD_CK1_1	433	439	PF00069	0.518
MOD_CK1_1	45	51	PF00069	0.522
MOD_CK2_1	345	351	PF00069	0.467
MOD_CK2_1	550	556	PF00069	0.459
MOD_GlcNHglycan	177	180	PF01048	0.528
MOD_GlcNHglycan	278	281	PF01048	0.599
MOD_GlcNHglycan	289	292	PF01048	0.491
MOD_GlcNHglycan	432	435	PF01048	0.550
MOD_GlcNHglycan	44	47	PF01048	0.525
MOD_GlcNHglycan	92	95	PF01048	0.574
MOD_GSK3_1	144	151	PF00069	0.392
MOD_GSK3_1	155	162	PF00069	0.382
MOD_GSK3_1	175	182	PF00069	0.266
MOD_GSK3_1	272	279	PF00069	0.673
MOD_GSK3_1	281	288	PF00069	0.542
MOD_GSK3_1	291	298	PF00069	0.545
MOD_GSK3_1	31	38	PF00069	0.708
MOD_GSK3_1	504	511	PF00069	0.482
MOD_GSK3_1	524	531	PF00069	0.314
MOD_LATS_1	235	241	PF00433	0.434
MOD_N-GLC_1	294	299	PF02516	0.633
MOD_N-GLC_1	358	363	PF02516	0.517
MOD_N-GLC_2	232	234	PF02516	0.427
MOD_N-GLC_2	71	73	PF02516	0.396
MOD_NEK2_1	144	149	PF00069	0.499
MOD_NEK2_1	159	164	PF00069	0.358
MOD_NEK2_1	173	178	PF00069	0.343
MOD_NEK2_1	403	408	PF00069	0.527
MOD_NEK2_1	417	422	PF00069	0.363
MOD_NEK2_1	508	513	PF00069	0.486
MOD_NEK2_2	504	509	PF00069	0.440
MOD_PIKK_1	160	166	PF00454	0.364
MOD_PIKK_1	23	29	PF00454	0.628
MOD_PIKK_1	35	41	PF00454	0.502
MOD_PKA_1	509	515	PF00069	0.567
MOD_PKA_2	108	114	PF00069	0.582
MOD_PKA_2	180	186	PF00069	0.387
MOD_PKA_2	272	278	PF00069	0.729
MOD_PKA_2	373	379	PF00069	0.323
MOD_PKA_2	417	423	PF00069	0.355
MOD_PKA_2	508	514	PF00069	0.429
MOD_PKA_2	550	556	PF00069	0.541
MOD_PKB_1	423	431	PF00069	0.555
MOD_PKB_1	450	458	PF00069	0.599
MOD_Plk_1	294	300	PF00069	0.557
MOD_Plk_1	395	401	PF00069	0.365
MOD_Plk_4	345	351	PF00069	0.467
MOD_Plk_4	403	409	PF00069	0.514
MOD_ProDKin_1	264	270	PF00069	0.436
MOD_ProDKin_1	3	9	PF00069	0.504
MOD_ProDKin_1	38	44	PF00069	0.589
TRG_DiLeu_BaLyEn_6	543	548	PF01217	0.496
TRG_ENDOCYTIC_2	130	133	PF00928	0.484
TRG_ENDOCYTIC_2	329	332	PF00928	0.526
TRG_ENDOCYTIC_2	366	369	PF00928	0.513
TRG_ENDOCYTIC_2	499	502	PF00928	0.431
TRG_ER_diArg_1	356	358	PF00400	0.528
TRG_ER_diArg_1	422	425	PF00400	0.430
TRG_ER_diArg_1	508	510	PF00400	0.526
TRG_ER_diArg_1	61	63	PF00400	0.425
TRG_ER_diArg_1	79	81	PF00400	0.223
TRG_NLS_Bipartite_1	74	93	PF00514	0.398
TRG_Pf-PMV_PEXEL_1	425	429	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	546	550	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIN4	Leptomonas seymouri	72%	100%
A0A1X0P496	Trypanosomatidae	52%	100%
A0A3Q8IKH2	Leishmania donovani	86%	100%
A0A3R7MHM2	Trypanosoma rangeli	52%	100%
A4IDA7	Leishmania infantum	86%	100%
D0A8E8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AT97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q1A0	Leishmania major	85%	100%
V5DA56	Trypanosoma cruzi	52%	100%