cobW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CobW/HypB/UreG, nucleotide-binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HPI3_LEIBR

TriTrypDb:

LbrM.35.3390 , LBRM2903_350042700

Length:

344

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPI3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.414
CLV_NRD_NRD_1	190	192	PF00675	0.148
CLV_NRD_NRD_1	98	100	PF00675	0.200
CLV_PCSK_SKI1_1	162	166	PF00082	0.209
CLV_PCSK_SKI1_1	169	173	PF00082	0.193
CLV_PCSK_SKI1_1	184	188	PF00082	0.203
CLV_PCSK_SKI1_1	211	215	PF00082	0.361
CLV_PCSK_SKI1_1	220	224	PF00082	0.457
CLV_PCSK_SKI1_1	333	337	PF00082	0.325
CLV_PCSK_SKI1_1	338	342	PF00082	0.345
CLV_PCSK_SKI1_1	59	63	PF00082	0.233
CLV_Separin_Metazoa	275	279	PF03568	0.283
DOC_CYCLIN_RxL_1	55	67	PF00134	0.414
DOC_CYCLIN_yClb5_NLxxxL_5	206	214	PF00134	0.320
DOC_MAPK_gen_1	99	107	PF00069	0.392
DOC_PP1_RVXF_1	209	216	PF00149	0.355
DOC_USP7_MATH_1	251	255	PF00917	0.443
DOC_USP7_MATH_1	92	96	PF00917	0.453
DOC_USP7_UBL2_3	64	68	PF12436	0.415
DOC_WW_Pin1_4	303	308	PF00397	0.345
LIG_14-3-3_CanoR_1	220	228	PF00244	0.628
LIG_Actin_WH2_2	320	335	PF00022	0.314
LIG_Actin_WH2_2	50	66	PF00022	0.414
LIG_APCC_ABBAyCdc20_2	211	217	PF00400	0.477
LIG_BIR_II_1	1	5	PF00653	0.547
LIG_BRCT_BRCA1_1	239	243	PF00533	0.322
LIG_BRCT_BRCA1_1	311	315	PF00533	0.511
LIG_Clathr_ClatBox_1	105	109	PF01394	0.403
LIG_FHA_1	100	106	PF00498	0.393
LIG_FHA_1	108	114	PF00498	0.407
LIG_FHA_1	19	25	PF00498	0.434
LIG_FHA_1	221	227	PF00498	0.546
LIG_FHA_1	261	267	PF00498	0.357
LIG_FHA_1	27	33	PF00498	0.430
LIG_FHA_1	304	310	PF00498	0.476
LIG_FHA_1	316	322	PF00498	0.315
LIG_FHA_1	39	45	PF00498	0.348
LIG_FHA_1	85	91	PF00498	0.469
LIG_FHA_2	138	144	PF00498	0.414
LIG_LIR_Gen_1	102	108	PF02991	0.403
LIG_LIR_Gen_1	271	282	PF02991	0.300
LIG_LIR_Gen_1	70	81	PF02991	0.414
LIG_LIR_Nem_3	102	106	PF02991	0.425
LIG_LIR_Nem_3	271	277	PF02991	0.292
LIG_LIR_Nem_3	290	294	PF02991	0.402
LIG_LIR_Nem_3	70	76	PF02991	0.414
LIG_PTB_Apo_2	285	292	PF02174	0.245
LIG_PTB_Phospho_1	285	291	PF10480	0.247
LIG_Rb_pABgroove_1	297	305	PF01858	0.304
LIG_SH2_CRK	291	295	PF00017	0.351
LIG_SH2_GRB2like	286	289	PF00017	0.258
LIG_SH2_SRC	286	289	PF00017	0.364
LIG_SH2_STAT5	132	135	PF00017	0.485
LIG_SH2_STAT5	150	153	PF00017	0.352
LIG_SH2_STAT5	34	37	PF00017	0.414
LIG_SUMO_SIM_anti_2	104	111	PF11976	0.403
LIG_SUMO_SIM_par_1	104	111	PF11976	0.403
LIG_SUMO_SIM_par_1	136	144	PF11976	0.403
LIG_SUMO_SIM_par_1	15	21	PF11976	0.252
LIG_TRAF2_1	3	6	PF00917	0.487
MOD_CK1_1	202	208	PF00069	0.356
MOD_CK1_1	234	240	PF00069	0.352
MOD_CK1_1	26	32	PF00069	0.414
MOD_CK2_1	92	98	PF00069	0.462
MOD_Cter_Amidation	323	326	PF01082	0.426
MOD_GlcNHglycan	109	113	PF01048	0.206
MOD_GlcNHglycan	11	14	PF01048	0.434
MOD_GlcNHglycan	135	138	PF01048	0.233
MOD_GlcNHglycan	178	181	PF01048	0.218
MOD_GlcNHglycan	236	239	PF01048	0.374
MOD_GlcNHglycan	25	28	PF01048	0.214
MOD_GlcNHglycan	36	39	PF01048	0.227
MOD_GSK3_1	133	140	PF00069	0.454
MOD_GSK3_1	216	223	PF00069	0.497
MOD_GSK3_1	23	30	PF00069	0.421
MOD_GSK3_1	34	41	PF00069	0.421
MOD_GSK3_1	59	66	PF00069	0.429
MOD_N-GLC_2	146	148	PF02516	0.245
MOD_N-GLC_2	173	175	PF02516	0.214
MOD_N-GLC_2	78	80	PF02516	0.214
MOD_NEK2_1	107	112	PF00069	0.406
MOD_NEK2_1	133	138	PF00069	0.412
MOD_NEK2_1	141	146	PF00069	0.412
MOD_NEK2_1	215	220	PF00069	0.386
MOD_NEK2_1	23	28	PF00069	0.414
MOD_NEK2_1	250	255	PF00069	0.363
MOD_NEK2_1	315	320	PF00069	0.318
MOD_NEK2_1	81	86	PF00069	0.495
MOD_NEK2_2	38	43	PF00069	0.348
MOD_PIKK_1	84	90	PF00454	0.403
MOD_PKA_1	99	105	PF00069	0.392
MOD_Plk_1	202	208	PF00069	0.442
MOD_Plk_1	38	44	PF00069	0.348
MOD_Plk_4	137	143	PF00069	0.450
MOD_Plk_4	15	21	PF00069	0.252
MOD_Plk_4	27	33	PF00069	0.414
MOD_Plk_4	92	98	PF00069	0.427
MOD_ProDKin_1	303	309	PF00069	0.357
MOD_SUMO_rev_2	328	332	PF00179	0.453
MOD_SUMO_rev_2	94	102	PF00179	0.351
TRG_DiLeu_BaEn_1	161	166	PF01217	0.449
TRG_DiLeu_BaEn_1	6	11	PF01217	0.560
TRG_ENDOCYTIC_2	132	135	PF00928	0.348
TRG_ENDOCYTIC_2	291	294	PF00928	0.352
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.231
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD31	Leptomonas seymouri	80%	100%
A0A0S4JEN9	Bodo saltans	45%	100%
A0A1X0P3M7	Trypanosomatidae	68%	97%
A0A3R7NQA1	Trypanosoma rangeli	68%	97%
A0A3S7XBA8	Leishmania donovani	89%	100%
A4IDA5	Leishmania infantum	90%	100%
D0A8E5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9AT95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
P24203	Escherichia coli (strain K12)	29%	100%
P53729	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	80%
P94400	Bacillus subtilis (strain 168)	30%	87%
Q4Q1A2	Leishmania major	89%	100%
Q4V339	Homo sapiens	35%	87%
Q5JTY5	Homo sapiens	35%	87%
Q5RIA9	Homo sapiens	35%	87%
Q869Q0	Dictyostelium discoideum	35%	72%
Q8IUF1	Homo sapiens	36%	87%
Q99MB4	Rattus norvegicus	34%	87%
Q9BRT8	Homo sapiens	36%	87%
V5AU61	Trypanosoma cruzi	70%	81%