C-CAP/cofactor C-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin binding cofactor c, putative

Species:

Leishmania braziliensis

UniProt:

A4HPI2_LEIBR

TriTrypDb:

LbrM.35.3380 , LBRM2903_350042600

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HPI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPI2

PDB structure(s): 5aj8_A , 5aj8_B

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0007023	post-chaperonin tubulin folding pathway	3	12
GO:0009987	cellular process	1	12
GO:0007021	tubulin complex assembly	6	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.627
CLV_NRD_NRD_1	269	271	PF00675	0.301
CLV_PCSK_KEX2_1	16	18	PF00082	0.652
CLV_PCSK_KEX2_1	269	271	PF00082	0.301
CLV_PCSK_PC7_1	12	18	PF00082	0.649
CLV_PCSK_SKI1_1	105	109	PF00082	0.586
CLV_PCSK_SKI1_1	175	179	PF00082	0.303
CLV_PCSK_SKI1_1	302	306	PF00082	0.416
DEG_Nend_UBRbox_2	1	3	PF02207	0.593
DEG_SCF_FBW7_2	117	122	PF00400	0.476
DOC_MAPK_gen_1	19	28	PF00069	0.599
DOC_MAPK_gen_1	214	223	PF00069	0.320
DOC_MAPK_gen_1	279	287	PF00069	0.283
DOC_MAPK_MEF2A_6	214	223	PF00069	0.325
DOC_MAPK_NFAT4_5	216	224	PF00069	0.197
DOC_USP7_MATH_1	322	326	PF00917	0.609
DOC_WW_Pin1_4	115	120	PF00397	0.648
DOC_WW_Pin1_4	227	232	PF00397	0.291
DOC_WW_Pin1_4	293	298	PF00397	0.423
LIG_14-3-3_CanoR_1	310	318	PF00244	0.570
LIG_FHA_1	21	27	PF00498	0.632
LIG_FHA_1	228	234	PF00498	0.303
LIG_FHA_1	43	49	PF00498	0.481
LIG_FHA_2	144	150	PF00498	0.602
LIG_FHA_2	163	169	PF00498	0.511
LIG_FHA_2	261	267	PF00498	0.433
LIG_FHA_2	303	309	PF00498	0.533
LIG_FHA_2	75	81	PF00498	0.481
LIG_LIR_Apic_2	186	191	PF02991	0.308
LIG_LIR_Gen_1	281	290	PF02991	0.410
LIG_LIR_Nem_3	154	160	PF02991	0.632
LIG_LIR_Nem_3	2	8	PF02991	0.670
LIG_LIR_Nem_3	281	287	PF02991	0.392
LIG_LIR_Nem_3	288	293	PF02991	0.393
LIG_LIR_Nem_3	298	304	PF02991	0.325
LIG_SH2_CRK	188	192	PF00017	0.450
LIG_SH2_PTP2	284	287	PF00017	0.529
LIG_SH2_STAP1	224	228	PF00017	0.314
LIG_SH2_STAP1	33	37	PF00017	0.540
LIG_SH2_STAT5	188	191	PF00017	0.454
LIG_SH2_STAT5	207	210	PF00017	0.138
LIG_SH2_STAT5	284	287	PF00017	0.529
LIG_SH3_3	157	163	PF00018	0.528
LIG_SH3_3	312	318	PF00018	0.473
LIG_TRAF2_1	305	308	PF00917	0.494
MOD_CDK_SPxxK_3	295	302	PF00069	0.519
MOD_CK1_1	164	170	PF00069	0.465
MOD_CK1_1	199	205	PF00069	0.360
MOD_CK1_1	20	26	PF00069	0.604
MOD_CK1_1	252	258	PF00069	0.464
MOD_CK2_1	143	149	PF00069	0.714
MOD_CK2_1	250	256	PF00069	0.388
MOD_CK2_1	260	266	PF00069	0.204
MOD_CK2_1	302	308	PF00069	0.448
MOD_CK2_1	32	38	PF00069	0.491
MOD_CK2_1	74	80	PF00069	0.493
MOD_GlcNHglycan	133	136	PF01048	0.582
MOD_GlcNHglycan	198	201	PF01048	0.416
MOD_GlcNHglycan	324	327	PF01048	0.670
MOD_GSK3_1	120	127	PF00069	0.669
MOD_GSK3_1	133	140	PF00069	0.653
MOD_GSK3_1	143	150	PF00069	0.588
MOD_GSK3_1	192	199	PF00069	0.303
MOD_GSK3_1	20	27	PF00069	0.583
MOD_GSK3_1	317	324	PF00069	0.558
MOD_GSK3_1	70	77	PF00069	0.505
MOD_LATS_1	300	306	PF00433	0.302
MOD_N-GLC_1	151	156	PF02516	0.600
MOD_N-GLC_1	171	176	PF02516	0.197
MOD_N-GLC_1	183	188	PF02516	0.323
MOD_N-GLC_1	51	56	PF02516	0.551
MOD_NEK2_1	107	112	PF00069	0.584
MOD_NEK2_1	183	188	PF00069	0.448
MOD_NEK2_1	250	255	PF00069	0.354
MOD_NEK2_2	121	126	PF00069	0.494
MOD_PIKK_1	42	48	PF00454	0.507
MOD_PIKK_1	53	59	PF00454	0.504
MOD_PK_1	98	104	PF00069	0.376
MOD_PKA_2	309	315	PF00069	0.560
MOD_Plk_1	121	127	PF00069	0.493
MOD_Plk_1	183	189	PF00069	0.332
MOD_Plk_4	183	189	PF00069	0.214
MOD_Plk_4	192	198	PF00069	0.170
MOD_ProDKin_1	115	121	PF00069	0.648
MOD_ProDKin_1	227	233	PF00069	0.291
MOD_ProDKin_1	293	299	PF00069	0.422
MOD_SUMO_rev_2	252	260	PF00179	0.534
TRG_AP2beta_CARGO_1	2	12	PF09066	0.664
TRG_ENDOCYTIC_2	284	287	PF00928	0.397
TRG_ER_diArg_1	16	19	PF00400	0.649
TRG_ER_diArg_1	268	270	PF00400	0.295
TRG_NLS_MonoExtN_4	104	109	PF00514	0.656
TRG_Pf-PMV_PEXEL_1	302	307	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J8	Leptomonas seymouri	62%	100%
A0A0S4JHW0	Bodo saltans	35%	100%
A0A1X0P3G4	Trypanosomatidae	44%	100%
A0A3Q8IG96	Leishmania donovani	82%	100%
A0A3R7L226	Trypanosoma rangeli	45%	100%
A4IDA4	Leishmania infantum	82%	100%
D0A8E4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AT94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q15814	Homo sapiens	26%	97%
Q3SZE9	Bos taurus	25%	97%
Q4Q1A3	Leishmania major	81%	100%
Q5R5J7	Pongo abelii	26%	97%
Q8VCN9	Mus musculus	26%	98%
Q9SMR2	Arabidopsis thaliana	25%	97%
V5B9L2	Trypanosoma cruzi	47%	100%