Putative ADP-ribosylation factor GTPase activating protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylation factor GTPase activating protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HPI1_LEIBR

TriTrypDb:

LbrM.35.3370 , LBRM2903_350042500

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPI1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	8
GO:0008047	enzyme activator activity	3	8
GO:0030234	enzyme regulator activity	2	8
GO:0030695	GTPase regulator activity	4	8
GO:0060589	nucleoside-triphosphatase regulator activity	3	8
GO:0098772	molecular function regulator activity	1	8
GO:0140677	molecular function activator activity	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.595
CLV_NRD_NRD_1	15	17	PF00675	0.341
CLV_NRD_NRD_1	5	7	PF00675	0.541
CLV_PCSK_KEX2_1	117	119	PF00082	0.595
CLV_PCSK_SKI1_1	111	115	PF00082	0.467
CLV_PCSK_SKI1_1	12	16	PF00082	0.482
CLV_PCSK_SKI1_1	62	66	PF00082	0.430
DEG_APCC_DBOX_1	32	40	PF00400	0.421
DEG_Nend_UBRbox_3	1	3	PF02207	0.610
DEG_SCF_FBW7_1	352	357	PF00400	0.565
DEG_SPOP_SBC_1	185	189	PF00917	0.547
DEG_SPOP_SBC_1	328	332	PF00917	0.543
DOC_CKS1_1	304	309	PF01111	0.601
DOC_PP4_FxxP_1	207	210	PF00568	0.670
DOC_PP4_MxPP_1	305	308	PF00568	0.674
DOC_SPAK_OSR1_1	76	80	PF12202	0.501
DOC_USP7_MATH_1	186	190	PF00917	0.564
DOC_USP7_MATH_1	191	195	PF00917	0.556
DOC_USP7_MATH_1	309	313	PF00917	0.739
DOC_USP7_MATH_1	341	345	PF00917	0.664
DOC_USP7_MATH_1	360	364	PF00917	0.572
DOC_USP7_MATH_1	374	378	PF00917	0.557
DOC_USP7_MATH_1	394	398	PF00917	0.423
DOC_WW_Pin1_4	210	215	PF00397	0.756
DOC_WW_Pin1_4	226	231	PF00397	0.573
DOC_WW_Pin1_4	303	308	PF00397	0.601
DOC_WW_Pin1_4	350	355	PF00397	0.583
DOC_WW_Pin1_4	370	375	PF00397	0.700
DOC_WW_Pin1_4	392	397	PF00397	0.520
LIG_14-3-3_CanoR_1	293	301	PF00244	0.556
LIG_BRCT_BRCA1_1	283	287	PF00533	0.571
LIG_CtBP_PxDLS_1	145	149	PF00389	0.629
LIG_deltaCOP1_diTrp_1	384	391	PF00928	0.572
LIG_FHA_1	247	253	PF00498	0.784
LIG_FHA_2	63	69	PF00498	0.405
LIG_FHA_2	90	96	PF00498	0.397
LIG_LIR_Apic_2	204	210	PF02991	0.665
LIG_LIR_Apic_2	384	389	PF02991	0.639
LIG_LIR_Gen_1	124	131	PF02991	0.435
LIG_LIR_Gen_1	200	211	PF02991	0.650
LIG_LIR_Nem_3	124	128	PF02991	0.393
LIG_LIR_Nem_3	200	206	PF02991	0.608
LIG_LIR_Nem_3	254	259	PF02991	0.702
LIG_LIR_Nem_3	40	45	PF02991	0.433
LIG_Pex14_1	89	93	PF04695	0.376
LIG_Pex14_2	203	207	PF04695	0.702
LIG_SH2_CRK	270	274	PF00017	0.802
LIG_SH2_CRK	338	342	PF00017	0.759
LIG_SH2_NCK_1	338	342	PF00017	0.759
LIG_SH2_SRC	370	373	PF00017	0.696
LIG_SH2_STAP1	270	274	PF00017	0.558
LIG_SH2_STAT3	317	320	PF00017	0.716
LIG_SH2_STAT5	37	40	PF00017	0.376
LIG_SH3_2	237	242	PF14604	0.540
LIG_SH3_3	132	138	PF00018	0.479
LIG_SH3_3	139	145	PF00018	0.648
LIG_SH3_3	173	179	PF00018	0.681
LIG_SH3_3	192	198	PF00018	0.703
LIG_SH3_3	208	214	PF00018	0.610
LIG_SH3_3	234	240	PF00018	0.614
LIG_SH3_3	256	262	PF00018	0.654
LIG_SH3_3	272	278	PF00018	0.619
LIG_SH3_4	277	284	PF00018	0.559
LIG_SUMO_SIM_par_1	102	108	PF11976	0.229
LIG_SUMO_SIM_par_1	402	407	PF11976	0.685
LIG_TRAF2_1	381	384	PF00917	0.786
LIG_TRFH_1	154	158	PF08558	0.538
LIG_WRC_WIRS_1	90	95	PF05994	0.501
MOD_CK1_1	171	177	PF00069	0.765
MOD_CK1_1	229	235	PF00069	0.551
MOD_CK1_1	373	379	PF00069	0.586
MOD_CK1_1	387	393	PF00069	0.614
MOD_CK1_1	395	401	PF00069	0.531
MOD_CK1_1	416	422	PF00069	0.544
MOD_CK1_1	48	54	PF00069	0.436
MOD_CK1_1	67	73	PF00069	0.501
MOD_CK2_1	109	115	PF00069	0.406
MOD_CK2_1	210	216	PF00069	0.636
MOD_CK2_1	62	68	PF00069	0.376
MOD_GlcNHglycan	124	128	PF01048	0.524
MOD_GlcNHglycan	170	173	PF01048	0.765
MOD_GlcNHglycan	180	183	PF01048	0.595
MOD_GlcNHglycan	188	191	PF01048	0.674
MOD_GlcNHglycan	270	273	PF01048	0.725
MOD_GlcNHglycan	331	334	PF01048	0.804
MOD_GlcNHglycan	338	341	PF01048	0.745
MOD_GlcNHglycan	360	363	PF01048	0.734
MOD_GlcNHglycan	386	389	PF01048	0.573
MOD_GlcNHglycan	392	395	PF01048	0.511
MOD_GlcNHglycan	47	50	PF01048	0.396
MOD_GlcNHglycan	79	82	PF01048	0.385
MOD_GSK3_1	105	112	PF00069	0.412
MOD_GSK3_1	299	306	PF00069	0.692
MOD_GSK3_1	348	355	PF00069	0.802
MOD_GSK3_1	370	377	PF00069	0.724
MOD_GSK3_1	390	397	PF00069	0.455
MOD_N-GLC_1	23	28	PF02516	0.365
MOD_N-GLC_1	294	299	PF02516	0.763
MOD_NEK2_1	146	151	PF00069	0.786
MOD_NEK2_1	231	236	PF00069	0.689
MOD_NEK2_1	310	315	PF00069	0.822
MOD_NEK2_1	329	334	PF00069	0.744
MOD_NEK2_1	406	411	PF00069	0.697
MOD_NEK2_1	45	50	PF00069	0.376
MOD_NEK2_1	77	82	PF00069	0.494
MOD_NEK2_2	23	28	PF00069	0.365
MOD_NEK2_2	354	359	PF00069	0.544
MOD_NEK2_2	89	94	PF00069	0.462
MOD_PIKK_1	137	143	PF00454	0.692
MOD_PIKK_1	16	22	PF00454	0.430
MOD_PIKK_1	294	300	PF00454	0.772
MOD_PIKK_1	310	316	PF00454	0.639
MOD_PIKK_1	413	419	PF00454	0.523
MOD_PKA_1	16	22	PF00069	0.376
MOD_PKA_2	149	155	PF00069	0.527
MOD_PKA_2	5	11	PF00069	0.610
MOD_Plk_1	123	129	PF00069	0.598
MOD_Plk_1	23	29	PF00069	0.365
MOD_Plk_4	247	253	PF00069	0.784
MOD_Plk_4	354	360	PF00069	0.679
MOD_ProDKin_1	210	216	PF00069	0.758
MOD_ProDKin_1	226	232	PF00069	0.574
MOD_ProDKin_1	303	309	PF00069	0.603
MOD_ProDKin_1	350	356	PF00069	0.584
MOD_ProDKin_1	370	376	PF00069	0.701
MOD_ProDKin_1	392	398	PF00069	0.515
TRG_ENDOCYTIC_2	270	273	PF00928	0.596
TRG_ER_diArg_1	3	6	PF00400	0.666
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P3S6	Trypanosomatidae	35%	94%
A0A3S7XB38	Leishmania donovani	70%	90%
A4IDA3	Leishmania infantum	70%	90%
D0A8E3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AT93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4Q1A4	Leishmania major	64%	95%