Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPI0_LEIBR

TriTrypDb:

LbrM.35.3360 , LBRM2903_350042400

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPI0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.490
CLV_NRD_NRD_1	119	121	PF00675	0.659
CLV_NRD_NRD_1	59	61	PF00675	0.603
CLV_PCSK_KEX2_1	119	121	PF00082	0.659
CLV_PCSK_KEX2_1	73	75	PF00082	0.632
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.669
CLV_PCSK_SKI1_1	11	15	PF00082	0.658
CLV_PCSK_SKI1_1	206	210	PF00082	0.622
DEG_SPOP_SBC_1	132	136	PF00917	0.531
DEG_SPOP_SBC_1	38	42	PF00917	0.681
DOC_CYCLIN_RxL_1	8	17	PF00134	0.475
DOC_MAPK_DCC_7	140	150	PF00069	0.519
DOC_MAPK_DCC_7	239	248	PF00069	0.427
DOC_PP1_RVXF_1	86	92	PF00149	0.571
DOC_PP2B_LxvP_1	35	38	PF13499	0.669
DOC_PP4_FxxP_1	29	32	PF00568	0.503
DOC_PP4_MxPP_1	124	127	PF00568	0.495
DOC_USP7_MATH_1	132	136	PF00917	0.722
DOC_USP7_MATH_1	39	43	PF00917	0.593
DOC_USP7_MATH_1	9	13	PF00917	0.649
DOC_USP7_MATH_1	96	100	PF00917	0.574
DOC_WW_Pin1_4	133	138	PF00397	0.642
DOC_WW_Pin1_4	161	166	PF00397	0.723
DOC_WW_Pin1_4	28	33	PF00397	0.718
DOC_WW_Pin1_4	97	102	PF00397	0.684
LIG_14-3-3_CanoR_1	111	117	PF00244	0.630
LIG_14-3-3_CanoR_1	133	137	PF00244	0.630
LIG_14-3-3_CanoR_1	179	188	PF00244	0.655
LIG_14-3-3_CanoR_1	22	29	PF00244	0.535
LIG_14-3-3_CanoR_1	60	68	PF00244	0.680
LIG_14-3-3_CanoR_1	88	92	PF00244	0.579
LIG_Actin_WH2_2	6	24	PF00022	0.632
LIG_BIR_II_1	1	5	PF00653	0.733
LIG_BIR_III_2	162	166	PF00653	0.697
LIG_BRCT_BRCA1_1	135	139	PF00533	0.781
LIG_BRCT_BRCA1_1	163	167	PF00533	0.721
LIG_BRCT_BRCA1_1	39	43	PF00533	0.763
LIG_deltaCOP1_diTrp_1	201	205	PF00928	0.569
LIG_deltaCOP1_diTrp_1	211	217	PF00928	0.572
LIG_FHA_1	108	114	PF00498	0.673
LIG_FHA_1	150	156	PF00498	0.641
LIG_FHA_2	171	177	PF00498	0.623
LIG_LIR_Apic_2	27	32	PF02991	0.502
LIG_LIR_Gen_1	211	222	PF02991	0.569
LIG_LIR_Nem_3	136	142	PF02991	0.787
LIG_LIR_Nem_3	164	170	PF02991	0.640
LIG_LIR_Nem_3	203	208	PF02991	0.589
LIG_LIR_Nem_3	211	217	PF02991	0.536
LIG_LIR_Nem_3	90	94	PF02991	0.511
LIG_PDZ_Class_3	244	249	PF00595	0.700
LIG_SH2_STAP1	170	174	PF00017	0.578
LIG_SH2_STAT5	116	119	PF00017	0.600
LIG_SH2_STAT5	199	202	PF00017	0.718
LIG_SH3_3	139	145	PF00018	0.681
LIG_SH3_3	162	168	PF00018	0.632
LIG_SUMO_SIM_anti_2	66	72	PF11976	0.613
LIG_SUMO_SIM_par_1	146	152	PF11976	0.672
MOD_CDK_SPxxK_3	133	140	PF00069	0.574
MOD_CK1_1	107	113	PF00069	0.703
MOD_CK1_1	24	30	PF00069	0.688
MOD_CK1_1	3	9	PF00069	0.718
MOD_CK1_1	42	48	PF00069	0.690
MOD_CK2_1	170	176	PF00069	0.627
MOD_CK2_1	232	238	PF00069	0.571
MOD_CMANNOS	202	205	PF00535	0.567
MOD_DYRK1A_RPxSP_1	133	137	PF00069	0.567
MOD_GlcNHglycan	217	220	PF01048	0.637
MOD_GlcNHglycan	23	26	PF01048	0.503
MOD_GlcNHglycan	44	47	PF01048	0.761
MOD_GlcNHglycan	75	78	PF01048	0.744
MOD_GSK3_1	127	134	PF00069	0.752
MOD_GSK3_1	24	31	PF00069	0.699
MOD_GSK3_1	38	45	PF00069	0.728
MOD_GSK3_1	59	66	PF00069	0.742
MOD_NEK2_1	112	117	PF00069	0.605
MOD_NEK2_1	14	19	PF00069	0.503
MOD_NEK2_1	149	154	PF00069	0.701
MOD_NEK2_1	21	26	PF00069	0.506
MOD_NEK2_1	59	64	PF00069	0.526
MOD_NEK2_2	79	84	PF00069	0.716
MOD_PIKK_1	3	9	PF00454	0.718
MOD_PKA_1	73	79	PF00069	0.733
MOD_PKA_2	107	113	PF00069	0.398
MOD_PKA_2	132	138	PF00069	0.569
MOD_PKA_2	180	186	PF00069	0.610
MOD_PKA_2	21	27	PF00069	0.613
MOD_PKA_2	59	65	PF00069	0.706
MOD_PKA_2	73	79	PF00069	0.486
MOD_PKA_2	87	93	PF00069	0.529
MOD_Plk_4	112	118	PF00069	0.630
MOD_Plk_4	9	15	PF00069	0.654
MOD_ProDKin_1	133	139	PF00069	0.643
MOD_ProDKin_1	161	167	PF00069	0.724
MOD_ProDKin_1	28	34	PF00069	0.719
MOD_ProDKin_1	97	103	PF00069	0.685
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.658
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.768
TRG_DiLeu_BaLyEn_6	223	228	PF01217	0.675
TRG_NLS_MonoExtN_4	105	112	PF00514	0.661
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.703

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1D7	Leptomonas seymouri	48%	100%
A0A3Q8IW55	Leishmania donovani	81%	100%
A0A3R7NG27	Trypanosoma rangeli	32%	100%
A4IDA2	Leishmania infantum	81%	100%
E9AT92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q1A5	Leishmania major	82%	100%