EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPH8_LEIBR

TriTrypDb:

LbrM.35.3340 , LBRM2903_350042200

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0016020	membrane	2	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1

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Expansion

Sequence features

A4HPH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPH8

Function

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Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0005509	calcium ion binding	5	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	382	386	PF00656	0.475
CLV_C14_Caspase3-7	442	446	PF00656	0.446
CLV_NRD_NRD_1	349	351	PF00675	0.497
CLV_NRD_NRD_1	358	360	PF00675	0.436
CLV_NRD_NRD_1	548	550	PF00675	0.469
CLV_PCSK_FUR_1	347	351	PF00082	0.472
CLV_PCSK_KEX2_1	349	351	PF00082	0.463
CLV_PCSK_KEX2_1	358	360	PF00082	0.411
CLV_PCSK_KEX2_1	378	380	PF00082	0.284
CLV_PCSK_KEX2_1	548	550	PF00082	0.494

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW03	Leptomonas seymouri	62%	99%
A0A0S4JII0	Bodo saltans	27%	97%
A0A1X0P3R1	Trypanosomatidae	43%	100%
A0A3Q8IJI1	Leishmania donovani	84%	100%
A0A422NKK1	Trypanosoma rangeli	44%	100%
A4IDA0	Leishmania infantum	84%	100%
D0A8E0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	86%
E9AT90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q1A7	Leishmania major	85%	100%
V5AU55	Trypanosoma cruzi	41%	100%

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