BSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPH7_LEIBR

TriTrypDb:

LbrM.35.3330 , LBRM2903_350042100

Length:

379

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HPH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPH7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	45	49	PF00656	0.510
CLV_NRD_NRD_1	183	185	PF00675	0.501
CLV_NRD_NRD_1	345	347	PF00675	0.502
CLV_NRD_NRD_1	45	47	PF00675	0.530
CLV_PCSK_KEX2_1	345	347	PF00082	0.538
CLV_PCSK_SKI1_1	191	195	PF00082	0.543
CLV_PCSK_SKI1_1	315	319	PF00082	0.701
CLV_PCSK_SKI1_1	328	332	PF00082	0.448
CLV_PCSK_SKI1_1	346	350	PF00082	0.343
CLV_PCSK_SKI1_1	53	57	PF00082	0.479
CLV_Separin_Metazoa	264	268	PF03568	0.481
DEG_SPOP_SBC_1	222	226	PF00917	0.760
DEG_SPOP_SBC_1	281	285	PF00917	0.490
DOC_CDC14_PxL_1	155	163	PF14671	0.348
DOC_USP7_MATH_1	222	226	PF00917	0.760
DOC_USP7_MATH_1	281	285	PF00917	0.664
DOC_USP7_UBL2_3	110	114	PF12436	0.438
DOC_USP7_UBL2_3	172	176	PF12436	0.645
DOC_WW_Pin1_4	202	207	PF00397	0.635
DOC_WW_Pin1_4	302	307	PF00397	0.776
LIG_14-3-3_CanoR_1	267	271	PF00244	0.681
LIG_Actin_WH2_2	100	116	PF00022	0.590
LIG_Actin_WH2_2	143	158	PF00022	0.592
LIG_Actin_WH2_2	252	269	PF00022	0.662
LIG_BIR_III_2	262	266	PF00653	0.612
LIG_BRCT_BRCA1_1	189	193	PF00533	0.526
LIG_Clathr_ClatBox_1	256	260	PF01394	0.722
LIG_EH1_1	36	44	PF00400	0.348
LIG_FHA_1	138	144	PF00498	0.526
LIG_FHA_1	222	228	PF00498	0.733
LIG_FHA_1	283	289	PF00498	0.620
LIG_FHA_1	38	44	PF00498	0.524
LIG_FHA_1	49	55	PF00498	0.478
LIG_FHA_2	132	138	PF00498	0.603
LIG_FHA_2	190	196	PF00498	0.529
LIG_FHA_2	373	379	PF00498	0.377
LIG_FHA_2	95	101	PF00498	0.411
LIG_LIR_Gen_1	126	136	PF02991	0.608
LIG_LIR_Gen_1	139	146	PF02991	0.620
LIG_LIR_Gen_1	177	187	PF02991	0.603
LIG_LIR_Gen_1	21	32	PF02991	0.546
LIG_LIR_Nem_3	126	132	PF02991	0.623
LIG_LIR_Nem_3	139	144	PF02991	0.484
LIG_LIR_Nem_3	177	182	PF02991	0.608
LIG_LIR_Nem_3	21	27	PF02991	0.531
LIG_PCNA_TLS_4	267	274	PF02747	0.500
LIG_Pex14_2	189	193	PF04695	0.526
LIG_PROFILIN_1	212	218	PF00235	0.533
LIG_SH2_CRK	24	28	PF00017	0.569
LIG_SH2_STAP1	24	28	PF00017	0.569
LIG_SH2_STAT5	186	189	PF00017	0.494
LIG_SH2_STAT5	352	355	PF00017	0.642
LIG_SH2_STAT5	61	64	PF00017	0.533
LIG_SH3_3	207	213	PF00018	0.755
LIG_SH3_3	25	31	PF00018	0.480
LIG_SH3_3	290	296	PF00018	0.572
LIG_SUMO_SIM_anti_2	224	231	PF11976	0.741
LIG_TRFH_1	141	145	PF08558	0.567
LIG_WRC_WIRS_1	19	24	PF05994	0.544
MOD_CDK_SPxxK_3	302	309	PF00069	0.701
MOD_CK1_1	221	227	PF00069	0.746
MOD_CK2_1	189	195	PF00069	0.453
MOD_CK2_1	86	92	PF00069	0.656
MOD_GlcNHglycan	218	221	PF01048	0.755
MOD_GlcNHglycan	290	293	PF01048	0.753
MOD_GlcNHglycan	339	342	PF01048	0.565
MOD_GSK3_1	202	209	PF00069	0.612
MOD_GSK3_1	218	225	PF00069	0.788
MOD_GSK3_1	298	305	PF00069	0.746
MOD_GSK3_1	372	379	PF00069	0.369
MOD_GSK3_1	5	12	PF00069	0.310
MOD_GSK3_1	53	60	PF00069	0.453
MOD_N-GLC_1	230	235	PF02516	0.693
MOD_N-GLC_1	37	42	PF02516	0.533
MOD_NEK2_1	187	192	PF00069	0.512
MOD_NEK2_1	218	223	PF00069	0.772
MOD_NEK2_1	23	28	PF00069	0.544
MOD_NEK2_1	337	342	PF00069	0.522
MOD_NEK2_1	42	47	PF00069	0.484
MOD_NEK2_1	74	79	PF00069	0.508
MOD_NEK2_2	330	335	PF00069	0.593
MOD_PIKK_1	37	43	PF00454	0.482
MOD_PKA_2	137	143	PF00069	0.633
MOD_PKA_2	266	272	PF00069	0.680
MOD_PKA_2	344	350	PF00069	0.542
MOD_PKA_2	359	365	PF00069	0.596
MOD_Plk_1	230	236	PF00069	0.677
MOD_Plk_1	37	43	PF00069	0.482
MOD_Plk_1	372	378	PF00069	0.356
MOD_Plk_1	9	15	PF00069	0.546
MOD_Plk_4	131	137	PF00069	0.486
MOD_Plk_4	174	180	PF00069	0.584
MOD_Plk_4	225	231	PF00069	0.729
MOD_Plk_4	23	29	PF00069	0.499
MOD_Plk_4	359	365	PF00069	0.492
MOD_Plk_4	57	63	PF00069	0.494
MOD_Plk_4	74	80	PF00069	0.391
MOD_ProDKin_1	202	208	PF00069	0.640
MOD_ProDKin_1	302	308	PF00069	0.779
MOD_SUMO_for_1	63	66	PF00179	0.562
MOD_SUMO_rev_2	109	116	PF00179	0.438
TRG_DiLeu_BaEn_1	139	144	PF01217	0.637
TRG_DiLeu_BaEn_3	111	117	PF01217	0.648
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.350
TRG_ENDOCYTIC_2	186	189	PF00928	0.494
TRG_ENDOCYTIC_2	24	27	PF00928	0.552
TRG_ER_diArg_1	309	312	PF00400	0.747
TRG_ER_diArg_1	43	46	PF00400	0.493
TRG_NLS_Bipartite_1	345	361	PF00514	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2M7	Leptomonas seymouri	60%	100%
A0A1X0P3J0	Trypanosomatidae	33%	98%
A0A3S5IRD4	Trypanosoma rangeli	36%	100%
A0A3S7XB77	Leishmania donovani	84%	100%
A4ID99	Leishmania infantum	84%	100%
D0A8D9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AT89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q1A8	Leishmania major	81%	99%
V5B9K7	Trypanosoma cruzi	36%	88%