Putative ATP synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP synthase, putative

Species:

Leishmania braziliensis

UniProt:

A4HPH6_LEIBR

TriTrypDb:

LbrM.35.3320 , LBRM2903_350041900

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	11
GO:0098796	membrane protein complex	2	11
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPH6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0005215	transporter activity	1	11
GO:0008324	monoatomic cation transmembrane transporter activity	4	11
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0015078	proton transmembrane transporter activity	5	11
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	11
GO:0015399	primary active transmembrane transporter activity	4	11
GO:0016787	hydrolase activity	2	7
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	11
GO:0022804	active transmembrane transporter activity	3	11
GO:0022853	active monoatomic ion transmembrane transporter activity	4	11
GO:0022857	transmembrane transporter activity	2	11
GO:0022890	inorganic cation transmembrane transporter activity	4	11
GO:0042625	ATPase-coupled ion transmembrane transporter activity	3	11
GO:0042626	ATPase-coupled transmembrane transporter activity	2	11
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	4	11
GO:0046961	proton-transporting ATPase activity, rotational mechanism	4	11
GO:0140657	ATP-dependent activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.349
CLV_NRD_NRD_1	63	65	PF00675	0.312
CLV_PCSK_KEX2_1	63	65	PF00082	0.312
CLV_PCSK_SKI1_1	54	58	PF00082	0.471
CLV_PCSK_SKI1_1	77	81	PF00082	0.420
DEG_APCC_DBOX_1	115	123	PF00400	0.313
DOC_MAPK_gen_1	150	159	PF00069	0.387
DOC_MAPK_gen_1	54	61	PF00069	0.326
DOC_MAPK_gen_1	77	85	PF00069	0.463
DOC_MAPK_MEF2A_6	152	161	PF00069	0.293
DOC_USP7_MATH_1	212	216	PF00917	0.407
LIG_14-3-3_CanoR_1	116	120	PF00244	0.402
LIG_14-3-3_CanoR_1	5	11	PF00244	0.438
LIG_Actin_WH2_2	44	59	PF00022	0.381
LIG_BIR_II_1	1	5	PF00653	0.481
LIG_FHA_1	122	128	PF00498	0.324
LIG_FHA_1	154	160	PF00498	0.521
LIG_FHA_2	82	88	PF00498	0.224
LIG_GBD_Chelix_1	111	119	PF00786	0.384
LIG_GBD_Chelix_1	85	93	PF00786	0.224
LIG_LIR_Nem_3	170	175	PF02991	0.333
LIG_LIR_Nem_3	204	210	PF02991	0.324
LIG_MAD2	96	104	PF02301	0.381
LIG_PCNA_yPIPBox_3	102	115	PF02747	0.328
LIG_PTB_Apo_2	184	191	PF02174	0.224
LIG_SH2_CRK	70	74	PF00017	0.309
LIG_SH2_STAT5	165	168	PF00017	0.384
LIG_SH2_STAT5	208	211	PF00017	0.223
LIG_SH3_3	98	104	PF00018	0.357
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.224
LIG_TRAF2_1	28	31	PF00917	0.305
MOD_CK1_1	118	124	PF00069	0.391
MOD_CK2_1	164	170	PF00069	0.244
MOD_CK2_1	81	87	PF00069	0.224
MOD_N-GLC_1	186	191	PF02516	0.305
MOD_N-GLC_1	68	73	PF02516	0.324
MOD_N-GLC_2	162	164	PF02516	0.224
MOD_NEK2_1	110	115	PF00069	0.266
MOD_PIKK_1	102	108	PF00454	0.397
MOD_PKA_2	115	121	PF00069	0.354
MOD_PKA_2	81	87	PF00069	0.447
MOD_Plk_1	186	192	PF00069	0.305
MOD_Plk_2-3	81	87	PF00069	0.224
MOD_Plk_4	110	116	PF00069	0.364
MOD_Plk_4	6	12	PF00069	0.451
MOD_Plk_4	81	87	PF00069	0.224
TRG_DiLeu_BaEn_1	36	41	PF01217	0.305
TRG_ENDOCYTIC_2	107	110	PF00928	0.305
TRG_ENDOCYTIC_2	207	210	PF00928	0.228
TRG_ENDOCYTIC_2	70	73	PF00928	0.405
TRG_ER_diArg_1	63	65	PF00400	0.305
TRG_ER_diArg_1	75	78	PF00400	0.317
TRG_ER_diArg_1	93	96	PF00400	0.456
TRG_NES_CRM1_1	74	87	PF08389	0.224
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I680	Leptomonas seymouri	73%	100%
A0A0S4J7J5	Bodo saltans	58%	100%
A0A1X0P3P2	Trypanosomatidae	58%	100%
A0A3S7XB56	Leishmania donovani	82%	100%
A0A422NKP5	Trypanosoma rangeli	57%	100%
A4ID98	Leishmania infantum	82%	100%
D0A8D7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AT88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
O00780	Dictyostelium discoideum	27%	93%
O13687	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	95%
O23948	Gossypium hirsutum	33%	91%
O94072	Candida albicans	25%	96%
P0CAN7	Arabidopsis thaliana	34%	91%
P11019	Bos taurus	32%	96%
P22203	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	93%
P31402	Manduca sexta	33%	96%
P36543	Homo sapiens	32%	96%
P50518	Mus musculus	32%	96%
P54611	Drosophila melanogaster	33%	96%
Q01278	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	94%
Q32LB7	Bos taurus	32%	96%
Q39258	Arabidopsis thaliana	34%	94%
Q40272	Mesembryanthemum crystallinum	34%	96%
Q41396	Spinacia oleracea	34%	94%
Q4Q1A9	Leishmania major	82%	100%
Q4R761	Macaca fascicularis	32%	96%
Q5JDS0	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	28%	100%
Q6PCU2	Rattus norvegicus	33%	96%
Q95X44	Caenorhabditis elegans	31%	96%
Q96A05	Homo sapiens	31%	96%
Q9C9Z8	Arabidopsis thaliana	29%	92%
Q9D593	Mus musculus	30%	96%
Q9MB46	Citrus unshiu	32%	94%
Q9SWE7	Citrus limon	32%	94%
Q9U1G5	Heterodera schachtii	30%	96%