Cullin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Cullin-like protein

Gene product:

cullin-like protein

Species:

Leishmania braziliensis

UniProt:

A4HPH2_LEIBR

TriTrypDb:

LbrM.35.3280 , LBRM2903_350041500

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPH2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006511	ubiquitin-dependent protein catabolic process	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0019941	modification-dependent protein catabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043632	modification-dependent macromolecule catabolic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0051603	proteolysis involved in protein catabolic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901575	organic substance catabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0019899	enzyme binding	3	11
GO:0031625	ubiquitin protein ligase binding	5	11
GO:0044389	ubiquitin-like protein ligase binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	95	99	PF00656	0.512
CLV_NRD_NRD_1	513	515	PF00675	0.253
CLV_NRD_NRD_1	517	519	PF00675	0.232
CLV_NRD_NRD_1	601	603	PF00675	0.297
CLV_NRD_NRD_1	7	9	PF00675	0.570
CLV_PCSK_KEX2_1	286	288	PF00082	0.321
CLV_PCSK_KEX2_1	512	514	PF00082	0.303
CLV_PCSK_KEX2_1	601	603	PF00082	0.297
CLV_PCSK_KEX2_1	9	11	PF00082	0.566
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.293
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.566
CLV_PCSK_SKI1_1	202	206	PF00082	0.372
CLV_PCSK_SKI1_1	353	357	PF00082	0.304
CLV_PCSK_SKI1_1	452	456	PF00082	0.276
CLV_PCSK_SKI1_1	504	508	PF00082	0.308
CLV_PCSK_SKI1_1	519	523	PF00082	0.231
CLV_PCSK_SKI1_1	648	652	PF00082	0.321
CLV_PCSK_SKI1_1	690	694	PF00082	0.227
DEG_MDM2_SWIB_1	17	24	PF02201	0.436
DEG_SCF_FBW7_2	393	400	PF00400	0.473
DOC_CKS1_1	182	187	PF01111	0.493
DOC_CKS1_1	394	399	PF01111	0.473
DOC_CYCLIN_RxL_1	319	328	PF00134	0.484
DOC_CYCLIN_RxL_1	687	697	PF00134	0.438
DOC_MAPK_FxFP_2	315	318	PF00069	0.493
DOC_MAPK_gen_1	286	294	PF00069	0.438
DOC_MAPK_gen_1	466	476	PF00069	0.490
DOC_MAPK_gen_1	518	526	PF00069	0.521
DOC_MAPK_MEF2A_6	407	414	PF00069	0.493
DOC_MAPK_MEF2A_6	468	476	PF00069	0.518
DOC_MAPK_MEF2A_6	677	684	PF00069	0.499
DOC_MAPK_NFAT4_5	677	685	PF00069	0.387
DOC_PP1_RVXF_1	516	523	PF00149	0.428
DOC_PP2B_LxvP_1	494	497	PF13499	0.521
DOC_PP4_FxxP_1	315	318	PF00568	0.493
DOC_USP7_MATH_1	139	143	PF00917	0.521
DOC_USP7_MATH_1	157	161	PF00917	0.521
DOC_USP7_MATH_1	172	176	PF00917	0.370
DOC_USP7_MATH_1	405	409	PF00917	0.508
DOC_USP7_MATH_1	554	558	PF00917	0.530
DOC_USP7_MATH_1	571	575	PF00917	0.452
DOC_USP7_MATH_1	664	668	PF00917	0.538
DOC_USP7_MATH_1	70	74	PF00917	0.493
DOC_USP7_UBL2_3	607	611	PF12436	0.514
DOC_WW_Pin1_4	181	186	PF00397	0.493
DOC_WW_Pin1_4	343	348	PF00397	0.441
DOC_WW_Pin1_4	393	398	PF00397	0.473
DOC_WW_Pin1_4	468	473	PF00397	0.533
DOC_WW_Pin1_4	671	676	PF00397	0.462
LIG_14-3-3_CanoR_1	129	139	PF00244	0.499
LIG_14-3-3_CanoR_1	38	42	PF00244	0.562
LIG_14-3-3_CanoR_1	43	49	PF00244	0.547
LIG_14-3-3_CanoR_1	452	461	PF00244	0.484
LIG_14-3-3_CanoR_1	601	610	PF00244	0.546
LIG_14-3-3_CanoR_1	638	643	PF00244	0.514
LIG_APCC_ABBA_1	366	371	PF00400	0.521
LIG_BIR_II_1	1	5	PF00653	0.590
LIG_BRCT_BRCA1_1	174	178	PF00533	0.493
LIG_BRCT_BRCA1_1	527	531	PF00533	0.521
LIG_EH1_1	546	554	PF00400	0.521
LIG_EVH1_2	472	476	PF00568	0.493
LIG_FHA_1	182	188	PF00498	0.572
LIG_FHA_1	236	242	PF00498	0.462
LIG_FHA_1	259	265	PF00498	0.464
LIG_FHA_1	363	369	PF00498	0.525
LIG_FHA_1	394	400	PF00498	0.502
LIG_FHA_1	465	471	PF00498	0.510
LIG_FHA_1	480	486	PF00498	0.364
LIG_FHA_1	537	543	PF00498	0.452
LIG_FHA_1	544	550	PF00498	0.432
LIG_FHA_1	637	643	PF00498	0.399
LIG_FHA_2	14	20	PF00498	0.486
LIG_FHA_2	674	680	PF00498	0.521
LIG_Integrin_isoDGR_2	516	518	PF01839	0.242
LIG_LIR_Apic_2	312	318	PF02991	0.492
LIG_LIR_Gen_1	13	19	PF02991	0.483
LIG_LIR_Gen_1	228	237	PF02991	0.521
LIG_LIR_Gen_1	346	356	PF02991	0.493
LIG_LIR_Gen_1	40	49	PF02991	0.442
LIG_LIR_Gen_1	475	481	PF02991	0.460
LIG_LIR_Gen_1	579	589	PF02991	0.493
LIG_LIR_Gen_1	655	665	PF02991	0.528
LIG_LIR_Gen_1	66	76	PF02991	0.538
LIG_LIR_Nem_3	13	17	PF02991	0.487
LIG_LIR_Nem_3	18	24	PF02991	0.239
LIG_LIR_Nem_3	227	233	PF02991	0.521
LIG_LIR_Nem_3	346	351	PF02991	0.493
LIG_LIR_Nem_3	40	44	PF02991	0.442
LIG_LIR_Nem_3	430	436	PF02991	0.538
LIG_LIR_Nem_3	475	479	PF02991	0.448
LIG_LIR_Nem_3	483	489	PF02991	0.432
LIG_LIR_Nem_3	579	584	PF02991	0.493
LIG_LIR_Nem_3	655	661	PF02991	0.490
LIG_LIR_Nem_3	66	72	PF02991	0.538
LIG_LIR_Nem_3	92	96	PF02991	0.444
LIG_MLH1_MIPbox_1	174	178	PF16413	0.493
LIG_Pex14_2	17	21	PF04695	0.448
LIG_Pex14_2	402	406	PF04695	0.428
LIG_Pex14_2	599	603	PF04695	0.366
LIG_Pex14_2	89	93	PF04695	0.530
LIG_PTB_Apo_2	108	115	PF02174	0.460
LIG_PTB_Apo_2	236	243	PF02174	0.438
LIG_PTB_Phospho_1	108	114	PF10480	0.460
LIG_PTB_Phospho_1	236	242	PF10480	0.438
LIG_SH2_CRK	242	246	PF00017	0.521
LIG_SH2_CRK	416	420	PF00017	0.493
LIG_SH2_CRK	489	493	PF00017	0.484
LIG_SH2_CRK	658	662	PF00017	0.528
LIG_SH2_CRK	69	73	PF00017	0.411
LIG_SH2_GRB2like	109	112	PF00017	0.446
LIG_SH2_GRB2like	370	373	PF00017	0.493
LIG_SH2_GRB2like	489	492	PF00017	0.484
LIG_SH2_NCK_1	489	493	PF00017	0.484
LIG_SH2_NCK_1	69	73	PF00017	0.368
LIG_SH2_PTP2	231	234	PF00017	0.521
LIG_SH2_SRC	370	373	PF00017	0.493
LIG_SH2_STAP1	225	229	PF00017	0.568
LIG_SH2_STAP1	242	246	PF00017	0.412
LIG_SH2_STAT3	194	197	PF00017	0.565
LIG_SH2_STAT3	56	59	PF00017	0.470
LIG_SH2_STAT5	109	112	PF00017	0.432
LIG_SH2_STAT5	170	173	PF00017	0.502
LIG_SH2_STAT5	177	180	PF00017	0.478
LIG_SH2_STAT5	210	213	PF00017	0.380
LIG_SH2_STAT5	231	234	PF00017	0.521
LIG_SH2_STAT5	489	492	PF00017	0.452
LIG_SH2_STAT5	702	705	PF00017	0.331
LIG_SH2_STAT5	85	88	PF00017	0.568
LIG_SH3_3	669	675	PF00018	0.521
LIG_SUMO_SIM_anti_2	290	296	PF11976	0.438
LIG_SUMO_SIM_anti_2	477	483	PF11976	0.463
LIG_SUMO_SIM_anti_2	562	567	PF11976	0.493
LIG_SUMO_SIM_par_1	477	483	PF11976	0.484
LIG_TRAF2_1	338	341	PF00917	0.518
LIG_TRAF2_1	456	459	PF00917	0.493
LIG_TYR_ITIM	656	661	PF00017	0.368
LIG_UBA3_1	145	150	PF00899	0.493
LIG_UBA3_1	323	331	PF00899	0.460
LIG_WRC_WIRS_1	14	19	PF05994	0.495
MOD_CDC14_SPxK_1	674	677	PF00782	0.493
MOD_CDK_SPxK_1	671	677	PF00069	0.493
MOD_CDK_SPxxK_3	343	350	PF00069	0.521
MOD_CK1_1	101	107	PF00069	0.506
MOD_CK1_1	15	21	PF00069	0.490
MOD_CK1_1	216	222	PF00069	0.465
MOD_CK1_1	248	254	PF00069	0.558
MOD_CK1_1	274	280	PF00069	0.504
MOD_CK1_1	3	9	PF00069	0.615
MOD_CK1_1	37	43	PF00069	0.442
MOD_CK1_1	499	505	PF00069	0.463
MOD_CK1_1	525	531	PF00069	0.452
MOD_CK1_1	543	549	PF00069	0.521
MOD_CK1_1	605	611	PF00069	0.572
MOD_CK2_1	118	124	PF00069	0.521
MOD_CK2_1	570	576	PF00069	0.549
MOD_Cter_Amidation	516	519	PF01082	0.259
MOD_GlcNHglycan	140	144	PF01048	0.253
MOD_GlcNHglycan	452	455	PF01048	0.321
MOD_GlcNHglycan	482	485	PF01048	0.284
MOD_GlcNHglycan	542	545	PF01048	0.321
MOD_GlcNHglycan	612	615	PF01048	0.476
MOD_GlcNHglycan	618	621	PF01048	0.506
MOD_GlcNHglycan	622	626	PF01048	0.471
MOD_GlcNHglycan	697	700	PF01048	0.461
MOD_GSK3_1	145	152	PF00069	0.371
MOD_GSK3_1	168	175	PF00069	0.558
MOD_GSK3_1	213	220	PF00069	0.477
MOD_GSK3_1	241	248	PF00069	0.493
MOD_GSK3_1	270	277	PF00069	0.485
MOD_GSK3_1	464	471	PF00069	0.484
MOD_GSK3_1	492	499	PF00069	0.501
MOD_GSK3_1	536	543	PF00069	0.496
MOD_GSK3_1	576	583	PF00069	0.540
MOD_GSK3_1	638	645	PF00069	0.459
MOD_GSK3_1	671	678	PF00069	0.447
MOD_N-GLC_1	592	597	PF02516	0.455
MOD_N-GLC_1	96	101	PF02516	0.333
MOD_NEK2_1	131	136	PF00069	0.465
MOD_NEK2_1	145	150	PF00069	0.434
MOD_NEK2_1	241	246	PF00069	0.490
MOD_NEK2_1	362	367	PF00069	0.473
MOD_NEK2_1	479	484	PF00069	0.459
MOD_NEK2_1	522	527	PF00069	0.504
MOD_NEK2_1	548	553	PF00069	0.428
MOD_NEK2_1	603	608	PF00069	0.517
MOD_NEK2_1	642	647	PF00069	0.479
MOD_NEK2_2	225	230	PF00069	0.521
MOD_PIKK_1	341	347	PF00454	0.466
MOD_PIKK_1	55	61	PF00454	0.427
MOD_PIKK_1	98	104	PF00454	0.481
MOD_PKA_2	309	315	PF00069	0.473
MOD_PKA_2	37	43	PF00069	0.429
MOD_Plk_1	12	18	PF00069	0.508
MOD_Plk_1	24	30	PF00069	0.438
MOD_Plk_1	270	276	PF00069	0.463
MOD_Plk_1	559	565	PF00069	0.565
MOD_Plk_1	642	648	PF00069	0.501
MOD_Plk_1	79	85	PF00069	0.421
MOD_Plk_1	96	102	PF00069	0.465
MOD_Plk_2-3	13	19	PF00069	0.542
MOD_Plk_2-3	249	255	PF00069	0.493
MOD_Plk_2-3	652	658	PF00069	0.473
MOD_Plk_4	157	163	PF00069	0.475
MOD_Plk_4	206	212	PF00069	0.550
MOD_Plk_4	213	219	PF00069	0.497
MOD_Plk_4	225	231	PF00069	0.465
MOD_Plk_4	24	30	PF00069	0.438
MOD_Plk_4	241	247	PF00069	0.492
MOD_Plk_4	274	280	PF00069	0.473
MOD_Plk_4	364	370	PF00069	0.495
MOD_Plk_4	388	394	PF00069	0.493
MOD_Plk_4	436	442	PF00069	0.456
MOD_Plk_4	44	50	PF00069	0.435
MOD_Plk_4	548	554	PF00069	0.431
MOD_Plk_4	642	648	PF00069	0.527
MOD_Plk_4	71	77	PF00069	0.479
MOD_Plk_4	80	86	PF00069	0.474
MOD_ProDKin_1	181	187	PF00069	0.493
MOD_ProDKin_1	343	349	PF00069	0.441
MOD_ProDKin_1	393	399	PF00069	0.473
MOD_ProDKin_1	468	474	PF00069	0.533
MOD_ProDKin_1	671	677	PF00069	0.462
MOD_SUMO_for_1	285	288	PF00179	0.493
MOD_SUMO_for_1	32	35	PF00179	0.493
MOD_SUMO_rev_2	459	467	PF00179	0.558
MOD_SUMO_rev_2	674	682	PF00179	0.480
TRG_DiLeu_BaEn_1	475	480	PF01217	0.521
TRG_DiLeu_BaEn_1	689	694	PF01217	0.368
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.368
TRG_DiLeu_BaLyEn_6	410	415	PF01217	0.512
TRG_ENDOCYTIC_2	14	17	PF00928	0.577
TRG_ENDOCYTIC_2	231	234	PF00928	0.521
TRG_ENDOCYTIC_2	242	245	PF00928	0.521
TRG_ENDOCYTIC_2	489	492	PF00928	0.452
TRG_ENDOCYTIC_2	658	661	PF00928	0.528
TRG_ENDOCYTIC_2	69	72	PF00928	0.411
TRG_ER_diArg_1	511	514	PF00400	0.521
TRG_ER_diArg_1	601	603	PF00400	0.353
TRG_ER_diArg_1	8	11	PF00400	0.570
TRG_NES_CRM1_1	235	249	PF08389	0.521
TRG_NLS_MonoExtC_3	7	13	PF00514	0.560
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.284
TRG_Pf-PMV_PEXEL_1	518	523	PF00026	0.321
TRG_Pf-PMV_PEXEL_1	648	652	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9C6	Leptomonas seymouri	66%	100%
A0A1X0NKJ9	Trypanosomatidae	27%	100%
A0A1X0NXD6	Trypanosomatidae	20%	95%
A0A3R7LZU1	Trypanosoma rangeli	28%	99%
A0A3S7XB28	Leishmania donovani	89%	100%
A2A432	Mus musculus	20%	73%
A4ID94	Leishmania infantum	89%	100%
D0A3I2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AT84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O14122	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	20%	96%
Q09760	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	90%
Q4Q1B3	Leishmania major	88%	100%
Q8LGH4	Arabidopsis thaliana	21%	89%
Q9ZVH4	Arabidopsis thaliana	20%	96%
V5B0B0	Trypanosoma cruzi	28%	100%