Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPH1_LEIBR

TriTrypDb:

LbrM.35.3270 , LBRM2903_350041400

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HPH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPH1

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	11
GO:0007031	peroxisome organization	5	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	39	41	PF00675	0.361
CLV_NRD_NRD_1	52	54	PF00675	0.459
CLV_NRD_NRD_1	6	8	PF00675	0.556
CLV_NRD_NRD_1	78	80	PF00675	0.313
CLV_PCSK_KEX2_1	176	178	PF00082	0.415
CLV_PCSK_KEX2_1	39	41	PF00082	0.360
CLV_PCSK_KEX2_1	52	54	PF00082	0.461
CLV_PCSK_KEX2_1	6	8	PF00082	0.649
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.410
CLV_PCSK_SKI1_1	126	130	PF00082	0.346
CLV_PCSK_SKI1_1	142	146	PF00082	0.303
CLV_PCSK_SKI1_1	7	11	PF00082	0.554
DEG_APCC_DBOX_1	6	14	PF00400	0.397
DEG_SPOP_SBC_1	18	22	PF00917	0.325
DOC_CYCLIN_RxL_1	139	149	PF00134	0.561
DOC_MAPK_gen_1	125	131	PF00069	0.557
DOC_MAPK_gen_1	176	184	PF00069	0.581
DOC_MAPK_MEF2A_6	157	165	PF00069	0.491
DOC_MAPK_RevD_3	25	40	PF00069	0.313
DOC_PP1_RVXF_1	140	146	PF00149	0.520
DOC_PP2B_LxvP_1	55	58	PF13499	0.604
DOC_USP7_MATH_1	108	112	PF00917	0.555
DOC_USP7_UBL2_3	95	99	PF12436	0.591
LIG_14-3-3_CanoR_1	16	25	PF00244	0.294
LIG_14-3-3_CanoR_1	177	183	PF00244	0.591
LIG_14-3-3_CanoR_1	46	55	PF00244	0.716
LIG_14-3-3_CanoR_1	6	10	PF00244	0.405
LIG_FHA_1	154	160	PF00498	0.579
LIG_FHA_1	179	185	PF00498	0.549
LIG_FHA_1	19	25	PF00498	0.270
LIG_LIR_Gen_1	149	159	PF02991	0.570
LIG_LIR_Nem_3	149	155	PF02991	0.570
LIG_LIR_Nem_3	33	38	PF02991	0.269
LIG_Pex14_1	85	89	PF04695	0.474
LIG_SH2_STAT5	114	117	PF00017	0.476
LIG_SH2_STAT5	35	38	PF00017	0.237
LIG_SUMO_SIM_anti_2	181	186	PF11976	0.529
LIG_SUMO_SIM_anti_2	20	30	PF11976	0.247
LIG_UBA3_1	128	133	PF00899	0.598
MOD_CK1_1	20	26	PF00069	0.346
MOD_CK1_1	30	36	PF00069	0.359
MOD_CK2_1	5	11	PF00069	0.354
MOD_Cter_Amidation	77	80	PF01082	0.377
MOD_GlcNHglycan	29	32	PF01048	0.404
MOD_GlcNHglycan	49	52	PF01048	0.573
MOD_GSK3_1	159	166	PF00069	0.523
MOD_NEK2_1	163	168	PF00069	0.603
MOD_PKA_2	5	11	PF00069	0.405
MOD_Plk_4	159	165	PF00069	0.530
MOD_Plk_4	178	184	PF00069	0.396
MOD_Plk_4	20	26	PF00069	0.300
MOD_Plk_4	30	36	PF00069	0.213
MOD_SUMO_rev_2	121	128	PF00179	0.552
TRG_ENDOCYTIC_2	152	155	PF00928	0.494
TRG_ER_diArg_1	140	143	PF00400	0.558
TRG_ER_diArg_1	38	40	PF00400	0.606
TRG_ER_diArg_1	5	7	PF00400	0.450
TRG_ER_diArg_1	52	54	PF00400	0.669

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N3	Leptomonas seymouri	67%	100%
A0A0S4JN26	Bodo saltans	30%	100%
A0A1X0NKF5	Trypanosomatidae	41%	100%
A0A3S7XB48	Leishmania donovani	92%	100%
A0A422NM43	Trypanosoma rangeli	39%	100%
A4ID93	Leishmania infantum	92%	100%
D0A3I1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AT83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q1B4	Leishmania major	92%	100%
V5BKE1	Trypanosoma cruzi	37%	100%