Clathrin coat assembly protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

clathrin coat assembly protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HPG9_LEIBR

TriTrypDb:

LbrM.35.3250 , LBRM2903_350041200

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030119	AP-type membrane coat adaptor complex	3	11
GO:0030131	clathrin adaptor complex	4	11
GO:0032991	protein-containing complex	1	11
GO:0098796	membrane protein complex	2	11
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HPG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPG9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016192	vesicle-mediated transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0006897	endocytosis	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.617
CLV_NRD_NRD_1	130	132	PF00675	0.398
CLV_PCSK_KEX2_1	52	54	PF00082	0.323
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.323
CLV_PCSK_SKI1_1	100	104	PF00082	0.426
CLV_PCSK_SKI1_1	132	136	PF00082	0.532
CLV_PCSK_SKI1_1	264	268	PF00082	0.470
CLV_PCSK_SKI1_1	367	371	PF00082	0.385
CLV_PCSK_SKI1_1	393	397	PF00082	0.459
DEG_APCC_KENBOX_2	102	106	PF00400	0.426
DEG_Nend_Nbox_1	1	3	PF02207	0.331
DOC_CKS1_1	419	424	PF01111	0.206
DOC_MAPK_FxFP_2	119	122	PF00069	0.315
DOC_MAPK_gen_1	100	109	PF00069	0.426
DOC_MAPK_gen_1	302	309	PF00069	0.315
DOC_MAPK_gen_1	319	328	PF00069	0.315
DOC_MAPK_gen_1	52	59	PF00069	0.425
DOC_MAPK_MEF2A_6	171	179	PF00069	0.357
DOC_MAPK_MEF2A_6	319	328	PF00069	0.363
DOC_MAPK_MEF2A_6	389	396	PF00069	0.327
DOC_MAPK_MEF2A_6	52	61	PF00069	0.364
DOC_PP1_RVXF_1	262	269	PF00149	0.363
DOC_PP1_RVXF_1	365	371	PF00149	0.206
DOC_PP1_RVXF_1	391	397	PF00149	0.357
DOC_PP1_RVXF_1	50	57	PF00149	0.394
DOC_PP4_FxxP_1	119	122	PF00568	0.315
DOC_PP4_FxxP_1	268	271	PF00568	0.386
DOC_USP7_MATH_1	108	112	PF00917	0.364
DOC_USP7_MATH_1	193	197	PF00917	0.206
DOC_USP7_UBL2_3	363	367	PF12436	0.206
DOC_WW_Pin1_4	158	163	PF00397	0.566
DOC_WW_Pin1_4	223	228	PF00397	0.206
DOC_WW_Pin1_4	375	380	PF00397	0.447
DOC_WW_Pin1_4	418	423	PF00397	0.268
LIG_14-3-3_CanoR_1	131	139	PF00244	0.340
LIG_14-3-3_CanoR_1	21	27	PF00244	0.450
LIG_14-3-3_CanoR_1	264	269	PF00244	0.359
LIG_14-3-3_CanoR_1	281	287	PF00244	0.327
LIG_14-3-3_CanoR_1	427	431	PF00244	0.330
LIG_Actin_WH2_2	241	259	PF00022	0.459
LIG_Actin_WH2_2	44	62	PF00022	0.426
LIG_AP2alpha_1	176	180	PF02296	0.426
LIG_APCC_ABBA_1	177	182	PF00400	0.459
LIG_APCC_ABBA_1	309	314	PF00400	0.206
LIG_BIR_III_4	314	318	PF00653	0.206
LIG_BRCT_BRCA1_1	115	119	PF00533	0.387
LIG_BRCT_BRCA1_1	16	20	PF00533	0.315
LIG_CaM_IQ_9	77	93	PF13499	0.459
LIG_deltaCOP1_diTrp_1	160	170	PF00928	0.427
LIG_FHA_1	134	140	PF00498	0.458
LIG_FHA_1	237	243	PF00498	0.407
LIG_FHA_1	33	39	PF00498	0.321
LIG_FHA_1	381	387	PF00498	0.394
LIG_FHA_2	123	129	PF00498	0.387
LIG_FHA_2	301	307	PF00498	0.304
LIG_Integrin_RGD_1	11	13	PF01839	0.334
LIG_LIR_Apic_2	116	122	PF02991	0.311
LIG_LIR_Apic_2	267	271	PF02991	0.387
LIG_LIR_Apic_2	384	390	PF02991	0.315
LIG_LIR_Gen_1	104	113	PF02991	0.344
LIG_LIR_Gen_1	174	183	PF02991	0.304
LIG_LIR_Gen_1	272	280	PF02991	0.315
LIG_LIR_Gen_1	347	356	PF02991	0.338
LIG_LIR_Gen_1	62	69	PF02991	0.357
LIG_LIR_LC3C_4	410	413	PF02991	0.459
LIG_LIR_Nem_3	104	109	PF02991	0.314
LIG_LIR_Nem_3	118	124	PF02991	0.315
LIG_LIR_Nem_3	174	179	PF02991	0.317
LIG_LIR_Nem_3	347	351	PF02991	0.338
LIG_LYPXL_yS_3	121	124	PF13949	0.387
LIG_Pex14_2	176	180	PF04695	0.426
LIG_SH2_CRK	348	352	PF00017	0.426
LIG_SH2_NCK_1	348	352	PF00017	0.426
LIG_SH2_STAP1	428	432	PF00017	0.368
LIG_SH2_STAP1	82	86	PF00017	0.329
LIG_SH2_STAT5	420	423	PF00017	0.334
LIG_SH2_STAT5	428	431	PF00017	0.292
LIG_SH2_STAT5	65	68	PF00017	0.341
LIG_SH2_STAT5	89	92	PF00017	0.215
LIG_SH3_3	283	289	PF00018	0.426
LIG_SH3_3	325	331	PF00018	0.340
LIG_SH3_3	410	416	PF00018	0.357
LIG_SUMO_SIM_par_1	65	72	PF11976	0.387
LIG_UBA3_1	86	92	PF00899	0.206
MOD_CDK_SPxK_1	158	164	PF00069	0.555
MOD_CDK_SPxK_1	418	424	PF00069	0.268
MOD_CDK_SPxxK_3	375	382	PF00069	0.206
MOD_CK1_1	196	202	PF00069	0.299
MOD_CK1_1	246	252	PF00069	0.381
MOD_CK1_1	282	288	PF00069	0.333
MOD_CK2_1	122	128	PF00069	0.387
MOD_CK2_1	223	229	PF00069	0.206
MOD_CK2_1	25	31	PF00069	0.370
MOD_CK2_1	256	262	PF00069	0.459
MOD_CK2_1	300	306	PF00069	0.304
MOD_CK2_1	375	381	PF00069	0.409
MOD_GlcNHglycan	198	201	PF01048	0.320
MOD_GlcNHglycan	208	211	PF01048	0.309
MOD_GlcNHglycan	258	261	PF01048	0.459
MOD_GlcNHglycan	293	296	PF01048	0.407
MOD_GlcNHglycan	363	366	PF01048	0.392
MOD_GSK3_1	223	230	PF00069	0.241
MOD_GSK3_1	25	32	PF00069	0.426
MOD_GSK3_1	276	283	PF00069	0.363
MOD_GSK3_1	298	305	PF00069	0.355
MOD_GSK3_1	397	404	PF00069	0.318
MOD_GSK3_1	414	421	PF00069	0.341
MOD_N-GLC_1	223	228	PF02516	0.206
MOD_N-GLC_1	246	251	PF02516	0.206
MOD_NEK2_1	16	21	PF00069	0.316
MOD_NEK2_1	185	190	PF00069	0.379
MOD_NEK2_1	194	199	PF00069	0.298
MOD_NEK2_1	256	261	PF00069	0.206
MOD_NEK2_1	29	34	PF00069	0.301
MOD_NEK2_1	399	404	PF00069	0.365
MOD_NEK2_1	7	12	PF00069	0.326
MOD_NEK2_2	22	27	PF00069	0.459
MOD_PIKK_1	185	191	PF00454	0.303
MOD_PKA_2	147	153	PF00069	0.514
MOD_PKA_2	155	161	PF00069	0.447
MOD_PKA_2	280	286	PF00069	0.314
MOD_PKA_2	426	432	PF00069	0.381
MOD_Plk_1	113	119	PF00069	0.364
MOD_Plk_1	246	252	PF00069	0.236
MOD_Plk_1	307	313	PF00069	0.426
MOD_Plk_1	331	337	PF00069	0.309
MOD_Plk_4	108	114	PF00069	0.466
MOD_Plk_4	264	270	PF00069	0.387
MOD_Plk_4	382	388	PF00069	0.268
MOD_Plk_4	414	420	PF00069	0.428
MOD_Plk_4	426	432	PF00069	0.432
MOD_ProDKin_1	158	164	PF00069	0.555
MOD_ProDKin_1	223	229	PF00069	0.206
MOD_ProDKin_1	375	381	PF00069	0.447
MOD_ProDKin_1	418	424	PF00069	0.268
MOD_SUMO_rev_2	332	341	PF00179	0.415
TRG_DiLeu_BaEn_1	181	186	PF01217	0.336
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.426
TRG_ENDOCYTIC_2	121	124	PF00928	0.387
TRG_ENDOCYTIC_2	348	351	PF00928	0.426
TRG_ENDOCYTIC_2	428	431	PF00928	0.461
TRG_ENDOCYTIC_2	65	68	PF00928	0.341
TRG_ENDOCYTIC_2	94	97	PF00928	0.459
TRG_NES_CRM1_1	166	181	PF08389	0.394
TRG_NES_CRM1_1	397	410	PF08389	0.206
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.334
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.206
TRG_PTS1	436	439	PF00515	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6F2	Leptomonas seymouri	26%	93%
A0A0N1I7F0	Leptomonas seymouri	27%	100%
A0A0N1ILY9	Leptomonas seymouri	72%	100%
A0A0N1PAY6	Leptomonas seymouri	22%	97%
A0A0S4INT9	Bodo saltans	25%	96%
A0A0S4JHW9	Bodo saltans	42%	96%
A0A0S4JX54	Bodo saltans	23%	91%
A0A1X0NJW3	Trypanosomatidae	26%	97%
A0A1X0NL86	Trypanosomatidae	46%	100%
A0A1X0NTD3	Trypanosomatidae	29%	100%
A0A1X0P9U6	Trypanosomatidae	26%	100%
A0A3Q8IB94	Leishmania donovani	28%	100%
A0A3Q8IKF7	Leishmania donovani	84%	100%
A0A3R7NKK1	Trypanosoma rangeli	27%	97%
A0A3S7X806	Leishmania donovani	24%	94%
A0A422NHS3	Trypanosoma rangeli	28%	100%
A0A422NLU9	Trypanosoma rangeli	46%	90%
A4HAX6	Leishmania braziliensis	23%	100%
A4HCF3	Leishmania braziliensis	27%	98%
A4HZY5	Leishmania infantum	29%	100%
A4IA35	Leishmania infantum	24%	94%
A4ID91	Leishmania infantum	84%	100%
C9ZM64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
C9ZSM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZWJ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	97%
D3ZRP6	Rattus norvegicus	29%	100%
E2RED8	Canis lupus familiaris	22%	97%
E9AT81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9AVU6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B550	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	94%
F4I562	Arabidopsis thaliana	23%	100%
O00189	Homo sapiens	22%	97%
O22715	Arabidopsis thaliana	31%	100%
O23140	Arabidopsis thaliana	34%	100%
P35585	Mus musculus	30%	100%
P35602	Caenorhabditis elegans	27%	100%
P35603	Caenorhabditis elegans	32%	100%
P38700	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	73%
P47795	Diplobatis ommata	23%	100%
P53676	Rattus norvegicus	24%	100%
P53677	Homo sapiens	24%	100%
P53678	Rattus norvegicus	24%	100%
P54672	Dictyostelium discoideum	33%	100%
P84091	Mus musculus	32%	100%
P84092	Rattus norvegicus	32%	100%
Q00776	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	92%
Q09718	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	98%
Q24K11	Bos taurus	23%	100%
Q29RY8	Bos taurus	22%	97%
Q2KJ81	Bos taurus	30%	100%
Q2PWT8	Rattus norvegicus	21%	97%
Q32Q06	Rattus norvegicus	30%	100%
Q3SYW1	Bos taurus	29%	100%
Q3ZC13	Bos taurus	32%	100%
Q4Q1B6	Leishmania major	84%	100%
Q4Q2T6	Leishmania major	24%	94%
Q4QBN3	Leishmania major	28%	98%
Q4R706	Macaca fascicularis	32%	100%
Q54HS9	Dictyostelium discoideum	31%	100%
Q5NVF7	Pongo abelii	32%	100%
Q5R478	Pongo abelii	24%	100%
Q5ZMP6	Gallus gallus	32%	100%
Q5ZMP7	Gallus gallus	24%	100%
Q6NWK2	Danio rerio	32%	100%
Q6P856	Xenopus tropicalis	32%	100%
Q750L8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	25%	97%
Q7ZW98	Danio rerio	33%	100%
Q801Q8	Xenopus laevis	32%	100%
Q8R2R9	Mus musculus	24%	100%
Q96CW1	Homo sapiens	32%	100%
Q99186	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	89%
Q9BXS5	Homo sapiens	30%	100%
Q9GPF0	Dictyostelium discoideum	24%	83%
Q9GPF1	Dictyostelium discoideum	25%	100%
Q9HFE5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q9JKC7	Mus musculus	22%	98%
Q9JKC8	Mus musculus	24%	100%
Q9SAC9	Arabidopsis thaliana	31%	100%
Q9SB50	Arabidopsis thaliana	25%	97%
Q9WVP1	Mus musculus	29%	100%
Q9Y2T2	Homo sapiens	24%	100%
Q9Y6Q5	Homo sapiens	29%	100%
V5BKQ8	Trypanosoma cruzi	22%	100%
V5BLL2	Trypanosoma cruzi	28%	100%
V5D569	Trypanosoma cruzi	24%	88%
V5DGM7	Trypanosoma cruzi	46%	100%