| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0000176 | nuclear exosome (RNase complex) | 3 | 1 |
| GO:0000177 | cytoplasmic exosome (RNase complex) | 5 | 1 |
| GO:0000178 | exosome (RNase complex) | 4 | 1 |
| GO:0005730 | nucleolus | 5 | 1 |
| GO:0032991 | protein-containing complex | 1 | 1 |
| GO:0043226 | organelle | 2 | 1 |
| GO:0043228 | non-membrane-bounded organelle | 3 | 1 |
| GO:0043229 | intracellular organelle | 3 | 1 |
| GO:0043232 | intracellular non-membrane-bounded organelle | 4 | 1 |
| GO:0110165 | cellular anatomical entity | 1 | 1 |
| GO:0140513 | nuclear protein-containing complex | 2 | 1 |
| GO:1902494 | catalytic complex | 2 | 1 |
| GO:1905354 | exoribonuclease complex | 3 | 1 |
Related structures:
AlphaFold database: A4HPG8
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic | 8 | 1 |
| GO:0000956 | nuclear-transcribed mRNA catabolic process | 7 | 1 |
| GO:0006139 | nucleobase-containing compound metabolic process | 3 | 1 |
| GO:0006364 | rRNA processing | 8 | 1 |
| GO:0006396 | RNA processing | 6 | 1 |
| GO:0006401 | RNA catabolic process | 5 | 1 |
| GO:0006402 | mRNA catabolic process | 6 | 1 |
| GO:0006725 | cellular aromatic compound metabolic process | 3 | 1 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 1 |
| GO:0008152 | metabolic process | 1 | 1 |
| GO:0009056 | catabolic process | 2 | 1 |
| GO:0009057 | macromolecule catabolic process | 4 | 1 |
| GO:0009892 | negative regulation of metabolic process | 4 | 1 |
| GO:0009987 | cellular process | 1 | 1 |
| GO:0010468 | regulation of gene expression | 5 | 1 |
| GO:0010605 | negative regulation of macromolecule metabolic process | 5 | 1 |
| GO:0010629 | negative regulation of gene expression | 6 | 1 |
| GO:0016070 | RNA metabolic process | 5 | 1 |
| GO:0016071 | mRNA metabolic process | 6 | 1 |
| GO:0016072 | rRNA metabolic process | 7 | 1 |
| GO:0016073 | snRNA metabolic process | 7 | 1 |
| GO:0016074 | sno(s)RNA metabolic process | 7 | 1 |
| GO:0016075 | rRNA catabolic process | 7 | 1 |
| GO:0016180 | snRNA processing | 8 | 1 |
| GO:0019222 | regulation of metabolic process | 3 | 1 |
| GO:0019439 | aromatic compound catabolic process | 4 | 1 |
| GO:0031123 | RNA 3'-end processing | 7 | 1 |
| GO:0031126 | sno(s)RNA 3'-end processing | 9 | 1 |
| GO:0034427 | nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' | 9 | 1 |
| GO:0034470 | ncRNA processing | 7 | 1 |
| GO:0034472 | snRNA 3'-end processing | 8 | 1 |
| GO:0034475 | U4 snRNA 3'-end processing | 9 | 1 |
| GO:0034641 | cellular nitrogen compound metabolic process | 3 | 1 |
| GO:0034655 | nucleobase-containing compound catabolic process | 4 | 1 |
| GO:0034660 | ncRNA metabolic process | 6 | 1 |
| GO:0034661 | ncRNA catabolic process | 6 | 1 |
| GO:0043144 | sno(s)RNA processing | 8 | 1 |
| GO:0043170 | macromolecule metabolic process | 3 | 1 |
| GO:0043628 | regulatory ncRNA 3'-end processing | 8 | 1 |
| GO:0044237 | cellular metabolic process | 2 | 1 |
| GO:0044238 | primary metabolic process | 2 | 1 |
| GO:0044248 | cellular catabolic process | 3 | 1 |
| GO:0044260 | obsolete cellular macromolecule metabolic process | 3 | 1 |
| GO:0044265 | obsolete cellular macromolecule catabolic process | 4 | 1 |
| GO:0044270 | cellular nitrogen compound catabolic process | 4 | 1 |
| GO:0046483 | heterocycle metabolic process | 3 | 1 |
| GO:0046700 | heterocycle catabolic process | 4 | 1 |
| GO:0048519 | negative regulation of biological process | 3 | 1 |
| GO:0050789 | regulation of biological process | 2 | 1 |
| GO:0060255 | regulation of macromolecule metabolic process | 4 | 1 |
| GO:0065007 | biological regulation | 1 | 1 |
| GO:0071025 | RNA surveillance | 6 | 1 |
| GO:0071027 | nuclear RNA surveillance | 7 | 1 |
| GO:0071028 | nuclear mRNA surveillance | 8 | 1 |
| GO:0071051 | polyadenylation-dependent snoRNA 3'-end processing | 10 | 1 |
| GO:0071704 | organic substance metabolic process | 2 | 1 |
| GO:0090304 | nucleic acid metabolic process | 4 | 1 |
| GO:1901360 | organic cyclic compound metabolic process | 3 | 1 |
| GO:1901361 | organic cyclic compound catabolic process | 4 | 1 |
| GO:1901575 | organic substance catabolic process | 3 | 1 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 10 |
| GO:0004518 | nuclease activity | 4 | 10 |
| GO:0004527 | exonuclease activity | 5 | 10 |
| GO:0016787 | hydrolase activity | 2 | 10 |
| GO:0016788 | hydrolase activity, acting on ester bonds | 3 | 10 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 97 | 101 | PF00656 | 0.354 |
| CLV_NRD_NRD_1 | 18 | 20 | PF00675 | 0.482 |
| CLV_NRD_NRD_1 | 230 | 232 | PF00675 | 0.638 |
| CLV_NRD_NRD_1 | 24 | 26 | PF00675 | 0.209 |
| CLV_NRD_NRD_1 | 86 | 88 | PF00675 | 0.209 |
| CLV_NRD_NRD_1 | 91 | 93 | PF00675 | 0.209 |
| CLV_PCSK_KEX2_1 | 18 | 20 | PF00082 | 0.470 |
| CLV_PCSK_KEX2_1 | 24 | 26 | PF00082 | 0.209 |
| CLV_PCSK_KEX2_1 | 86 | 88 | PF00082 | 0.211 |
| CLV_PCSK_KEX2_1 | 91 | 93 | PF00082 | 0.212 |
| CLV_PCSK_PC7_1 | 14 | 20 | PF00082 | 0.472 |
| CLV_PCSK_PC7_1 | 87 | 93 | PF00082 | 0.251 |
| CLV_PCSK_SKI1_1 | 213 | 217 | PF00082 | 0.234 |
| CLV_PCSK_SKI1_1 | 239 | 243 | PF00082 | 0.527 |
| DOC_MAPK_gen_1 | 239 | 246 | PF00069 | 0.398 |
| DOC_MAPK_gen_1 | 24 | 30 | PF00069 | 0.417 |
| DOC_MAPK_MEF2A_6 | 239 | 246 | PF00069 | 0.398 |
| DOC_MAPK_RevD_3 | 11 | 25 | PF00069 | 0.612 |
| DOC_USP7_MATH_1 | 56 | 60 | PF00917 | 0.513 |
| DOC_USP7_MATH_1 | 82 | 86 | PF00917 | 0.429 |
| DOC_USP7_UBL2_3 | 62 | 66 | PF12436 | 0.513 |
| DOC_WW_Pin1_4 | 6 | 11 | PF00397 | 0.558 |
| LIG_14-3-3_CanoR_1 | 231 | 235 | PF00244 | 0.653 |
| LIG_APCC_ABBA_1 | 121 | 126 | PF00400 | 0.513 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.548 |
| LIG_FHA_1 | 192 | 198 | PF00498 | 0.461 |
| LIG_FHA_1 | 201 | 207 | PF00498 | 0.493 |
| LIG_FHA_1 | 71 | 77 | PF00498 | 0.457 |
| LIG_FHA_2 | 188 | 194 | PF00498 | 0.461 |
| LIG_GBD_Chelix_1 | 156 | 164 | PF00786 | 0.154 |
| LIG_LIR_Apic_2 | 6 | 10 | PF02991 | 0.480 |
| LIG_LIR_Nem_3 | 27 | 33 | PF02991 | 0.411 |
| LIG_PDZ_Class_2 | 241 | 246 | PF00595 | 0.404 |
| LIG_Rb_LxCxE_1 | 210 | 229 | PF01857 | 0.455 |
| LIG_SH2_PTP2 | 124 | 127 | PF00017 | 0.513 |
| LIG_SH2_PTP2 | 7 | 10 | PF00017 | 0.475 |
| LIG_SH2_SRC | 124 | 127 | PF00017 | 0.513 |
| LIG_SH2_STAT5 | 124 | 127 | PF00017 | 0.513 |
| LIG_SH2_STAT5 | 7 | 10 | PF00017 | 0.460 |
| LIG_SUMO_SIM_anti_2 | 109 | 114 | PF11976 | 0.421 |
| LIG_SUMO_SIM_par_1 | 109 | 114 | PF11976 | 0.451 |
| LIG_TRAF2_1 | 233 | 236 | PF00917 | 0.483 |
| MOD_CK1_1 | 93 | 99 | PF00069 | 0.285 |
| MOD_CK2_1 | 230 | 236 | PF00069 | 0.571 |
| MOD_Cter_Amidation | 16 | 19 | PF01082 | 0.474 |
| MOD_GlcNHglycan | 33 | 36 | PF01048 | 0.280 |
| MOD_GSK3_1 | 187 | 194 | PF00069 | 0.308 |
| MOD_GSK3_1 | 226 | 233 | PF00069 | 0.678 |
| MOD_GSK3_1 | 36 | 43 | PF00069 | 0.315 |
| MOD_NEK2_1 | 200 | 205 | PF00069 | 0.307 |
| MOD_NEK2_1 | 225 | 230 | PF00069 | 0.580 |
| MOD_NEK2_2 | 56 | 61 | PF00069 | 0.389 |
| MOD_PIKK_1 | 111 | 117 | PF00454 | 0.250 |
| MOD_PIKK_1 | 177 | 183 | PF00454 | 0.253 |
| MOD_PIKK_1 | 191 | 197 | PF00454 | 0.166 |
| MOD_PKA_2 | 230 | 236 | PF00069 | 0.529 |
| MOD_PKA_2 | 56 | 62 | PF00069 | 0.389 |
| MOD_PKA_2 | 90 | 96 | PF00069 | 0.267 |
| MOD_Plk_1 | 226 | 232 | PF00069 | 0.542 |
| MOD_Plk_1 | 40 | 46 | PF00069 | 0.442 |
| MOD_Plk_4 | 49 | 55 | PF00069 | 0.229 |
| MOD_ProDKin_1 | 6 | 12 | PF00069 | 0.555 |
| TRG_DiLeu_BaLyEn_6 | 210 | 215 | PF01217 | 0.389 |
| TRG_ENDOCYTIC_2 | 124 | 127 | PF00928 | 0.389 |
| TRG_ER_diArg_1 | 18 | 20 | PF00400 | 0.474 |
| TRG_ER_diArg_1 | 24 | 26 | PF00400 | 0.238 |
| TRG_Pf-PMV_PEXEL_1 | 232 | 236 | PF00026 | 0.591 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1ILN0 | Leptomonas seymouri | 83% | 100% |
| A0A0S4JHC4 | Bodo saltans | 30% | 89% |
| A0A0S4KJT7 | Bodo saltans | 45% | 92% |
| A0A1X0NKC4 | Trypanosomatidae | 58% | 98% |
| A0A1X0P328 | Trypanosomatidae | 23% | 100% |
| A0A3R7MIE4 | Trypanosoma rangeli | 59% | 98% |
| A0A3S7XB24 | Leishmania donovani | 89% | 100% |
| A0A3S7XBS2 | Leishmania donovani | 23% | 100% |
| A0A422NC95 | Trypanosoma rangeli | 26% | 100% |
| A0RXU1 | Cenarchaeum symbiosum (strain A) | 30% | 100% |
| A1S2C5 | Shewanella amazonensis (strain ATCC BAA-1098 / SB2B) | 23% | 100% |
| A1TD14 | Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 / PYR-1) | 26% | 95% |
| A2BKC0 | Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5) | 32% | 96% |
| A2RVK7 | Arabidopsis thaliana | 29% | 96% |
| A4HQ06 | Leishmania braziliensis | 25% | 100% |
| A4ID90 | Leishmania infantum | 89% | 100% |
| A4IDR7 | Leishmania infantum | 23% | 100% |
| A5N2V9 | Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) | 25% | 99% |
| A8GW25 | Rickettsia bellii (strain OSU 85-389) | 23% | 100% |
| A8WQQ5 | Caenorhabditis briggsae | 31% | 100% |
| A9A5C9 | Nitrosopumilus maritimus (strain SCM1) | 28% | 100% |
| B0K3T4 | Thermoanaerobacter sp. (strain X514) | 26% | 94% |
| B0KBM5 | Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) | 26% | 94% |
| B0UP55 | Methylobacterium sp. (strain 4-46) | 26% | 100% |
| B1VVV6 | Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350) | 28% | 100% |
| B5YEU4 | Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12) | 23% | 100% |
| B6YSI2 | Thermococcus onnurineus (strain NA1) | 31% | 99% |
| B8E0G7 | Dictyoglomus turgidum (strain DSM 6724 / Z-1310) | 23% | 100% |
| B8IFR7 | Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060) | 25% | 100% |
| B8ZR59 | Mycobacterium leprae (strain Br4923) | 27% | 95% |
| B9DWL2 | Clostridium kluyveri (strain NBRC 12016) | 25% | 99% |
| B9MQJ8 | Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) | 25% | 95% |
| C0ZAF8 | Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599) | 27% | 97% |
| C1A1V2 | Rhodococcus erythropolis (strain PR4 / NBRC 100887) | 26% | 94% |
| C4LJY5 | Corynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717) | 26% | 97% |
| C5A2B9 | Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3) | 33% | 99% |
| C5D5M7 | Geobacillus sp. (strain WCH70) | 28% | 96% |
| D0A3H8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 57% | 98% |
| E9AT80 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 89% | 100% |
| O26779 | Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) | 32% | 100% |
| O29757 | Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) | 33% | 95% |
| O42872 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 31% | 100% |
| O42894 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 25% | 100% |
| O59223 | Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) | 30% | 99% |
| O67069 | Aquifex aeolicus (strain VF5) | 25% | 96% |
| P37939 | Mycobacterium leprae (strain TN) | 27% | 95% |
| P46948 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 31% | 100% |
| P53256 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 26% | 100% |
| Q17533 | Caenorhabditis elegans | 31% | 100% |
| Q1RIX6 | Rickettsia bellii (strain RML369-C) | 23% | 100% |
| Q28F19 | Xenopus tropicalis | 31% | 91% |
| Q2RL40 | Moorella thermoacetica (strain ATCC 39073 / JCM 9320) | 26% | 98% |
| Q3AFA0 | Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901) | 23% | 97% |
| Q4JB27 | Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) | 31% | 100% |
| Q4Q0S3 | Leishmania major | 23% | 100% |
| Q4Q1B7 | Leishmania major | 89% | 100% |
| Q5JIR6 | Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) | 31% | 99% |
| Q5KWI5 | Geobacillus kaustophilus (strain HTA426) | 26% | 96% |
| Q5Z0V1 | Nocardia farcinica (strain IFM 10152) | 27% | 96% |
| Q74C79 | Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) | 28% | 100% |
| Q7YRA3 | Bos taurus | 34% | 100% |
| Q8G7I0 | Bifidobacterium longum (strain NCC 2705) | 28% | 99% |
| Q8TYC1 | Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) | 30% | 100% |
| Q8U0L9 | Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) | 32% | 98% |
| Q8XXF5 | Ralstonia solanacearum (strain GMI1000) | 27% | 100% |
| Q921I9 | Mus musculus | 36% | 100% |
| Q975G8 | Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) | 30% | 100% |
| Q97BZ5 | Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) | 34% | 99% |
| Q9HIP2 | Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) | 32% | 99% |
| Q9NPD3 | Homo sapiens | 36% | 100% |
| Q9S2H7 | Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) | 27% | 100% |
| Q9SP08 | Arabidopsis thaliana | 37% | 100% |
| Q9UXC2 | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) | 32% | 99% |
| Q9V119 | Pyrococcus abyssi (strain GE5 / Orsay) | 31% | 99% |
| Q9YC03 | Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) | 32% | 100% |
| V5AP50 | Trypanosoma cruzi | 24% | 95% |
| V5BKB5 | Trypanosoma cruzi | 58% | 98% |