Glutathione peroxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutathione peroxidase, putative

Species:

Leishmania braziliensis

UniProt:

A4HPG7_LEIBR

TriTrypDb:

LbrM.35.3230 , LBRM2903_350040900

Length:

152

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPG7

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	10
GO:0006979	response to oxidative stress	3	10
GO:0050896	response to stimulus	1	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004601	peroxidase activity	2	10
GO:0004602	glutathione peroxidase activity	3	10
GO:0016209	antioxidant activity	1	10
GO:0016491	oxidoreductase activity	2	10
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.456
CLV_NRD_NRD_1	55	57	PF00675	0.372
CLV_PCSK_KEX2_1	132	134	PF00082	0.398
CLV_PCSK_KEX2_1	55	57	PF00082	0.316
CLV_PCSK_SKI1_1	55	59	PF00082	0.252
DOC_MAPK_gen_1	55	62	PF00069	0.368
DOC_MAPK_MEF2A_6	20	29	PF00069	0.169
DOC_SPAK_OSR1_1	56	60	PF12202	0.316
DOC_USP7_MATH_1	137	141	PF00917	0.381
DOC_USP7_MATH_1	51	55	PF00917	0.300
LIG_14-3-3_CanoR_1	34	44	PF00244	0.368
LIG_BIR_II_1	1	5	PF00653	0.382
LIG_BRCT_BRCA1_1	53	57	PF00533	0.368
LIG_FHA_1	119	125	PF00498	0.277
LIG_FHA_1	13	19	PF00498	0.307
LIG_FHA_1	24	30	PF00498	0.345
LIG_FHA_2	38	44	PF00498	0.294
LIG_LIR_Gen_1	22	32	PF02991	0.368
LIG_LIR_Gen_1	54	65	PF02991	0.368
LIG_LIR_Nem_3	22	27	PF02991	0.368
LIG_LIR_Nem_3	54	60	PF02991	0.368
LIG_LIR_Nem_3	6	10	PF02991	0.373
LIG_PDZ_Class_1	147	152	PF00595	0.230
LIG_SH2_CRK	7	11	PF00017	0.311
LIG_SH2_NCK_1	7	11	PF00017	0.316
LIG_SH2_PTP2	24	27	PF00017	0.247
LIG_SH2_STAP1	120	124	PF00017	0.301
LIG_SH2_STAT5	120	123	PF00017	0.301
LIG_SH2_STAT5	24	27	PF00017	0.196
LIG_SH3_3	94	100	PF00018	0.200
LIG_TRAF2_1	68	71	PF00917	0.275
MOD_CK1_1	3	9	PF00069	0.366
MOD_CK1_1	33	39	PF00069	0.252
MOD_CK2_1	37	43	PF00069	0.294
MOD_CK2_1	71	77	PF00069	0.200
MOD_GlcNHglycan	100	103	PF01048	0.323
MOD_GlcNHglycan	126	130	PF01048	0.429
MOD_GlcNHglycan	21	24	PF01048	0.400
MOD_GlcNHglycan	7	10	PF01048	0.429
MOD_GSK3_1	19	26	PF00069	0.333
MOD_GSK3_1	33	40	PF00069	0.359
MOD_GSK3_1	51	58	PF00069	0.275
MOD_N-GLC_1	118	123	PF02516	0.287
MOD_NEK2_1	37	42	PF00069	0.401
MOD_NEK2_1	5	10	PF00069	0.354
MOD_PKA_1	55	61	PF00069	0.368
MOD_PKA_2	144	150	PF00069	0.378
MOD_PKA_2	19	25	PF00069	0.174
MOD_PKA_2	33	39	PF00069	0.398
MOD_PKA_2	55	61	PF00069	0.316
MOD_Plk_4	23	29	PF00069	0.252
TRG_DiLeu_BaEn_1	83	88	PF01217	0.251
TRG_ENDOCYTIC_2	24	27	PF00928	0.368
TRG_ENDOCYTIC_2	7	10	PF00928	0.357
TRG_ER_diArg_1	131	133	PF00400	0.385
TRG_ER_diArg_1	55	57	PF00400	0.316
TRG_Pf-PMV_PEXEL_1	107	112	PF00026	0.174

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZD2	Leptomonas seymouri	70%	100%
A0A0S4IL06	Bodo saltans	30%	84%
A0A0S4IL19	Bodo saltans	30%	83%
A0A0S4IZF2	Bodo saltans	29%	84%
A0A0S4JV67	Bodo saltans	42%	96%
A0A1X0NS99	Trypanosomatidae	55%	98%
A0A1X0NSC3	Trypanosomatidae	31%	94%
A0A1X0NSD3	Trypanosomatidae	36%	86%
A0A1X0NSE0	Trypanosomatidae	32%	81%
A0A3Q8IDK7	Leishmania donovani	32%	87%
A0A3Q8IDS3	Leishmania donovani	32%	83%
A0A3Q8IKY0	Leishmania donovani	84%	100%
A0A422NMY9	Trypanosoma rangeli	33%	92%
A0A422NMZ4	Trypanosoma rangeli	33%	92%
A0A422NNB6	Trypanosoma rangeli	34%	79%
A0A422NZP6	Trypanosoma rangeli	52%	95%
A1KV41	Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)	31%	86%
A4HET6	Leishmania braziliensis	33%	100%
A4HET7	Leishmania braziliensis	34%	100%
A4I211	Leishmania infantum	32%	83%
A4I212	Leishmania infantum	32%	87%
A4ID89	Leishmania infantum	84%	100%
A6QLY2	Bos taurus	39%	82%
C9ZRZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	92%
C9ZS00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	86%
D0AAG4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	97%
E9AT79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9AY59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	83%
E9AY60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	87%
G9JJU2	Procambarus clarkii	27%	88%
O02621	Caenorhabditis elegans	32%	93%
O04922	Arabidopsis thaliana	38%	90%
O08368	Pseudomonas wisconsinensis	34%	68%
O18994	Sus scrofa	27%	69%
O22850	Arabidopsis thaliana	40%	74%
O23814	Spinacia oleracea	36%	89%
O23968	Helianthus annuus	41%	84%
O23970	Helianthus annuus	37%	91%
O24031	Solanum lycopersicum	36%	90%
O32770	Lactococcus lactis subsp. cremoris (strain MG1363)	36%	97%
O46607	Canis lupus familiaris	26%	69%
O49069	Gossypium hirsutum	34%	89%
O59858	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	96%
O62327	Caenorhabditis elegans	32%	93%
O70325	Mus musculus	34%	77%
O75715	Homo sapiens	26%	69%
P00435	Bos taurus	29%	74%
P04041	Rattus norvegicus	30%	76%
P06610	Escherichia coli (strain K12)	33%	83%
P07203	Homo sapiens	31%	75%
P0A0T4	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	31%	86%
P0A0T5	Neisseria meningitidis serogroup B (strain MC58)	31%	86%
P0C2T0	Neisseria meningitidis serogroup C	31%	86%
P11352	Mus musculus	30%	76%
P11909	Oryctolagus cuniculus	30%	76%
P18283	Homo sapiens	28%	80%
P21765	Mus musculus	28%	69%
P22352	Homo sapiens	25%	67%
P23764	Rattus norvegicus	28%	67%
P28714	Macaca fascicularis	25%	69%
P30708	Nicotiana sylvestris	34%	90%
P30710	Rattus norvegicus	28%	69%
P35666	Wuchereria bancrofti	26%	68%
P36014	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	91%
P36968	Sus scrofa	36%	77%
P36969	Homo sapiens	34%	77%
P36970	Rattus norvegicus	35%	77%
P37141	Bos taurus	26%	67%
P38143	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	94%
P40581	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	93%
P46412	Mus musculus	27%	67%
P52033	Dirofilaria immitis	31%	69%
P52035	Bacillus subtilis (strain 168)	39%	95%
P59796	Homo sapiens	28%	69%
P64290	Staphylococcus aureus (strain Mu50 / ATCC 700699)	39%	96%
P64291	Staphylococcus aureus (strain MW2)	39%	96%
P67877	Brugia malayi	27%	68%
P67878	Brugia pahangi	27%	68%
P73824	Synechocystis sp. (strain PCC 6803 / Kazusa)	30%	99%
P74250	Synechocystis sp. (strain PCC 6803 / Kazusa)	39%	90%
P83564	Chlamydomonas reinhardtii	28%	76%
P83645	Rattus norvegicus	27%	80%
P99097	Staphylococcus aureus (strain N315)	39%	96%
Q00277	Schistosoma mansoni	35%	90%
Q06652	Citrus sinensis	36%	91%
Q0EF98	Callithrix jacchus	28%	80%
Q0EF99	Callithrix jacchus	29%	76%
Q0EFA0	Pan troglodytes	30%	76%
Q2NL01	Bos taurus	33%	73%
Q32QL6	Callithrix jacchus	35%	77%
Q4AEG9	Sapajus apella	34%	77%
Q4AEH0	Macaca fuscata fuscata	34%	77%
Q4AEH1	Hylobates lar	35%	77%
Q4AEH2	Pongo pygmaeus	34%	77%
Q4AEH3	Sapajus apella	25%	67%
Q4AEH4	Macaca fuscata fuscata	25%	67%
Q4AEH5	Hylobates lar	25%	67%
Q4AEH7	Sapajus apella	28%	80%
Q4AEH8	Macaca fuscata fuscata	32%	80%
Q4AEH9	Hylobates lar	28%	80%
Q4AEI0	Pongo pygmaeus	26%	80%
Q4AEI1	Sapajus apella	29%	76%
Q4AEI2	Hylobates lar	30%	76%
Q4AEI3	Pongo pygmaeus	31%	76%
Q4Q1B8	Leishmania major	87%	100%
Q4Q9B2	Leishmania major	31%	100%
Q4Q9B3	Leishmania major	31%	100%
Q4Q9B4	Leishmania major	31%	100%
Q4RSM6	Tetraodon nigroviridis	34%	72%
Q59WD3	Candida albicans (strain SC5314 / ATCC MYA-2876)	32%	89%
Q5HGC7	Staphylococcus aureus (strain COL)	39%	96%
Q5HKZ3	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	32%	96%
Q5RFG3	Pongo pygmaeus	25%	67%
Q5U583	Xenopus laevis	35%	73%
Q64625	Rattus norvegicus	30%	69%
Q6G9Q8	Staphylococcus aureus (strain MSSA476)	39%	96%
Q6GHD0	Staphylococcus aureus (strain MRSA252)	39%	96%
Q6IRC8	Xenopus laevis	34%	73%
Q7ZV14	Danio rerio	33%	72%
Q865R2	Macaca fuscata fuscata	31%	76%
Q8CSR9	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	40%	96%
Q8L910	Arabidopsis thaliana	40%	89%
Q8LBU2	Arabidopsis thaliana	34%	91%
Q8MJ14	Sus scrofa	31%	74%
Q8SSH7	Encephalitozoon cuniculi (strain GB-M1)	33%	86%
Q8TED1	Homo sapiens	34%	73%
Q91WR8	Mus musculus	31%	69%
Q95003	Caenorhabditis elegans	28%	68%
Q96SL4	Homo sapiens	39%	81%
Q98234	Molluscum contagiosum virus subtype 1	32%	69%
Q99LJ6	Mus musculus	45%	82%
Q9CFV1	Lactococcus lactis subsp. lactis (strain IL1403)	34%	97%
Q9D7B7	Mus musculus	34%	73%
Q9FXS3	Nicotiana tabacum	33%	90%
Q9JHC0	Mus musculus	27%	80%
Q9LEF0	Mesembryanthemum crystallinum	37%	89%
Q9LYB4	Arabidopsis thaliana	35%	88%
Q9N2J2	Bos taurus	36%	77%
Q9Z9N7	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	41%	97%
V5B9J0	Trypanosoma cruzi	36%	85%
V5BZH0	Trypanosoma cruzi	34%	86%