Putative GTP-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTP-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HPG5_LEIBR

TriTrypDb:

LbrM.35.3210 , LBRM2903_350040700

Length:

487

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HPG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPG5

Function

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Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0022613	ribonucleoprotein complex biogenesis	4	12
GO:0042254	ribosome biogenesis	5	12
GO:0044085	cellular component biogenesis	3	12
GO:0071840	cellular component organization or biogenesis	2	12

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0000287	magnesium ion binding	5	12
GO:0003824	catalytic activity	1	12
GO:0003924	GTPase activity	7	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	474	478	PF00656	0.646
CLV_MEL_PAP_1	327	333	PF00089	0.525
CLV_NRD_NRD_1	329	331	PF00675	0.440
CLV_NRD_NRD_1	4	6	PF00675	0.661
CLV_PCSK_KEX2_1	328	330	PF00082	0.434
CLV_PCSK_KEX2_1	4	6	PF00082	0.619
CLV_PCSK_KEX2_1	94	96	PF00082	0.285
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.456
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.285
CLV_PCSK_SKI1_1	20	24	PF00082	0.305

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I673	Leptomonas seymouri	80%	100%
A0A0S4KJL2	Bodo saltans	57%	92%
A0A1X0NM56	Trypanosomatidae	66%	100%
A0A3Q8IG86	Leishmania donovani	92%	100%
A0A3R7L2U2	Trypanosoma rangeli	65%	100%
A0AIY6	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	39%	100%
A0K4B0	Burkholderia cenocepacia (strain HI2424)	37%	100%
A0M5C6	Gramella forsetii (strain KT0803)	36%	100%
A0Q1T4	Clostridium novyi (strain NT)	38%	100%
A0RJ47	Bacillus thuringiensis (strain Al Hakam)	37%	100%

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