Bromo domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

bromodomain factor 2 protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HPG4_LEIBR

TriTrypDb:

LbrM.35.3200 , LBRM2903_350040600

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPG4

PDB structure(s): 5c4q_A , 5c4q_B

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.522
CLV_NRD_NRD_1	169	171	PF00675	0.613
CLV_NRD_NRD_1	57	59	PF00675	0.364
CLV_PCSK_KEX2_1	102	104	PF00082	0.447
CLV_PCSK_KEX2_1	169	171	PF00082	0.589
CLV_PCSK_KEX2_1	5	7	PF00082	0.539
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.498
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.539
CLV_PCSK_SKI1_1	169	173	PF00082	0.444
CLV_PCSK_SKI1_1	8	12	PF00082	0.332
CLV_PCSK_SKI1_1	98	102	PF00082	0.402
DEG_Nend_UBRbox_2	1	3	PF02207	0.677
DEG_SPOP_SBC_1	35	39	PF00917	0.189
DOC_CYCLIN_RxL_1	98	111	PF00134	0.357
DOC_MAPK_gen_1	98	107	PF00069	0.465
DOC_PP4_FxxP_1	32	35	PF00568	0.293
DOC_USP7_MATH_1	108	112	PF00917	0.440
DOC_USP7_MATH_1	202	206	PF00917	0.476
DOC_USP7_MATH_1	35	39	PF00917	0.189
DOC_USP7_UBL2_3	136	140	PF12436	0.599
DOC_USP7_UBL2_3	98	102	PF12436	0.451
LIG_14-3-3_CanoR_1	65	72	PF00244	0.189
LIG_BIR_III_4	201	205	PF00653	0.479
LIG_CtBP_PxDLS_1	51	55	PF00389	0.266
LIG_FHA_1	122	128	PF00498	0.547
LIG_FHA_2	170	176	PF00498	0.461
LIG_FHA_2	213	219	PF00498	0.579
LIG_FHA_2	66	72	PF00498	0.319
LIG_GBD_Chelix_1	76	84	PF00786	0.281
LIG_LIR_Gen_1	91	100	PF02991	0.348
LIG_LIR_Nem_3	91	96	PF02991	0.324
LIG_SH2_NCK_1	45	49	PF00017	0.411
LIG_SH2_STAP1	167	171	PF00017	0.418
LIG_SH2_STAT5	104	107	PF00017	0.369
LIG_SH3_3	117	123	PF00018	0.389
LIG_SH3_3	45	51	PF00018	0.331
LIG_SUMO_SIM_anti_2	146	153	PF11976	0.510
LIG_SUMO_SIM_anti_2	75	81	PF11976	0.439
LIG_SUMO_SIM_par_1	146	153	PF11976	0.390
LIG_TRAF2_1	215	218	PF00917	0.559
MOD_CK1_1	111	117	PF00069	0.492
MOD_CK1_1	189	195	PF00069	0.584
MOD_CK1_1	203	209	PF00069	0.566
MOD_CK1_1	211	217	PF00069	0.671
MOD_CK1_1	222	228	PF00069	0.600
MOD_CK2_1	169	175	PF00069	0.675
MOD_CK2_1	194	200	PF00069	0.608
MOD_CK2_1	211	217	PF00069	0.582
MOD_CK2_1	34	40	PF00069	0.281
MOD_CK2_1	65	71	PF00069	0.364
MOD_GlcNHglycan	110	113	PF01048	0.377
MOD_GlcNHglycan	182	187	PF01048	0.571
MOD_GlcNHglycan	199	205	PF01048	0.665
MOD_GlcNHglycan	226	229	PF01048	0.767
MOD_GSK3_1	178	185	PF00069	0.648
MOD_GSK3_1	189	196	PF00069	0.601
MOD_GSK3_1	200	207	PF00069	0.642
MOD_GSK3_1	208	215	PF00069	0.596
MOD_GSK3_1	222	229	PF00069	0.688
MOD_NEK2_1	1	6	PF00069	0.660
MOD_NEK2_1	52	57	PF00069	0.360
MOD_NEK2_1	78	83	PF00069	0.360
MOD_PKA_1	169	175	PF00069	0.598
MOD_PKA_2	169	175	PF00069	0.594
MOD_Plk_1	129	135	PF00069	0.512
MOD_Plk_1	193	199	PF00069	0.675
MOD_Plk_1	219	225	PF00069	0.700
MOD_Plk_1	52	58	PF00069	0.268
MOD_Plk_2-3	194	200	PF00069	0.575
MOD_Plk_4	15	21	PF00069	0.411
TRG_DiLeu_BaEn_4	218	224	PF01217	0.498
TRG_ENDOCYTIC_2	104	107	PF00928	0.350
TRG_ENDOCYTIC_2	44	47	PF00928	0.266
TRG_NLS_MonoExtN_4	98	105	PF00514	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7A0	Leptomonas seymouri	72%	100%
A0A0S4KPA6	Bodo saltans	41%	93%
A0A1X0NM37	Trypanosomatidae	53%	100%
A0A3Q8IW45	Leishmania donovani	79%	100%
A0A422NLU0	Trypanosoma rangeli	53%	100%
A4ID86	Leishmania infantum	79%	100%
D0A3H5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AT76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q1C1	Leishmania major	77%	99%
V5BPW0	Trypanosoma cruzi	49%	100%