Conserved plasma membrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPG3_LEIBR

TriTrypDb:

LbrM.35.3190 , LBRM2903_350040500

Length:

171


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

A4HPG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPG3


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	154	156	PF00675	0.401
CLV_PCSK_FUR_1	155	159	PF00082	0.442
CLV_PCSK_KEX2_1	157	159	PF00082	0.414
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.414
DEG_Nend_Nbox_1	1	3	PF02207	0.755
DOC_MAPK_MEF2A_6	52	61	PF00069	0.398
DOC_PP4_FxxP_1	20	23	PF00568	0.357
LIG_Actin_RPEL_3	62	81	PF02755	0.357
LIG_eIF4E_1	112	118	PF01652	0.396
LIG_FHA_1	108	114	PF00498	0.366
LIG_FHA_2	135	141	PF00498	0.669
LIG_Integrin_RGD_1	30	32	PF01839	0.576
LIG_LIR_Gen_1	53	63	PF02991	0.262
LIG_LIR_Nem_3	53	59	PF02991	0.277
LIG_LIR_Nem_3	7	13	PF02991	0.533
LIG_SH2_GRB2like	48	51	PF00017	0.398
LIG_SH2_PTP2	56	59	PF00017	0.438
LIG_SH2_STAT5	112	115	PF00017	0.372
LIG_SH2_STAT5	13	16	PF00017	0.422
LIG_SH2_STAT5	48	51	PF00017	0.451
LIG_SH2_STAT5	56	59	PF00017	0.357
LIG_SH2_STAT5	84	87	PF00017	0.422
LIG_SH2_STAT5	96	99	PF00017	0.317
LIG_SUMO_SIM_anti_2	116	121	PF11976	0.498
LIG_SUMO_SIM_anti_2	149	155	PF11976	0.624
LIG_SUMO_SIM_anti_2	24	30	PF11976	0.326
LIG_SUMO_SIM_par_1	84	90	PF11976	0.490
LIG_TYR_ITIM	54	59	PF00017	0.401
LIG_WRC_WIRS_1	88	93	PF05994	0.492
MOD_CK2_1	134	140	PF00069	0.603
MOD_GSK3_1	46	53	PF00069	0.372
MOD_N-GLC_1	107	112	PF02516	0.609
MOD_N-GLC_1	50	55	PF02516	0.495
MOD_N-GLC_2	121	123	PF02516	0.240
MOD_NEK2_1	4	9	PF00069	0.667
MOD_NEK2_1	65	70	PF00069	0.393
MOD_NEK2_2	107	112	PF00069	0.404
MOD_NEK2_2	84	89	PF00069	0.423
MOD_Plk_1	107	113	PF00069	0.321
MOD_Plk_1	50	56	PF00069	0.217
MOD_Plk_4	113	119	PF00069	0.328
MOD_Plk_4	21	27	PF00069	0.314
MOD_Plk_4	50	56	PF00069	0.306
TRG_ENDOCYTIC_2	56	59	PF00928	0.346
TRG_ER_diLys_1	168	171	PF00400	0.737
TRG_NLS_MonoCore_2	154	159	PF00514	0.677
TRG_NLS_MonoExtC_3	154	160	PF00514	0.677


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P795	Leptomonas seymouri	50%	100%
A0A1X0NL06	Trypanosomatidae	25%	100%
A0A3Q8IJG9	Leishmania donovani	78%	100%
A0A422NLV7	Trypanosoma rangeli	30%	100%
A4ID85	Leishmania infantum	78%	100%
E9AT75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q1C2	Leishmania major	81%	100%