Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPG2_LEIBR

TriTrypDb:

LbrM.35.3180 , LBRM2903_350040400

Length:

132

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HPG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPG2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	71	75	PF00082	0.495
DEG_Nend_Nbox_1	1	3	PF02207	0.610
DOC_CYCLIN_RxL_1	68	78	PF00134	0.348
DOC_PP2B_LxvP_1	57	60	PF13499	0.204
DOC_PP2B_PxIxI_1	59	65	PF00149	0.264
LIG_14-3-3_CanoR_1	118	127	PF00244	0.528
LIG_BRCT_BRCA1_1	88	92	PF00533	0.312
LIG_DCNL_PONY_1	1	4	PF03556	0.541
LIG_EH1_1	6	14	PF00400	0.456
LIG_FHA_1	101	107	PF00498	0.295
LIG_FHA_1	6	12	PF00498	0.569
LIG_FHA_2	76	82	PF00498	0.352
LIG_GBD_Chelix_1	45	53	PF00786	0.367
LIG_LIR_Gen_1	15	25	PF02991	0.567
LIG_LIR_Gen_1	48	58	PF02991	0.331
LIG_LIR_Nem_3	15	20	PF02991	0.584
LIG_LIR_Nem_3	48	53	PF02991	0.382
LIG_SH2_CRK	50	54	PF00017	0.367
LIG_SH2_CRK	7	11	PF00017	0.469
LIG_SH2_CRK	88	92	PF00017	0.359
LIG_SH2_STAP1	50	54	PF00017	0.212
LIG_SH2_STAP1	7	11	PF00017	0.513
LIG_SH2_STAP1	88	92	PF00017	0.359
LIG_SH2_STAT3	116	119	PF00017	0.421
LIG_SH2_STAT5	121	124	PF00017	0.521
LIG_SH2_STAT5	7	10	PF00017	0.560
LIG_Sin3_3	51	58	PF02671	0.234
LIG_SUMO_SIM_anti_2	8	15	PF11976	0.448
LIG_SUMO_SIM_par_1	102	107	PF11976	0.328
LIG_SUMO_SIM_par_1	72	78	PF11976	0.357
LIG_SUMO_SIM_par_1	8	15	PF11976	0.496
LIG_TYR_ITIM	86	91	PF00017	0.375
LIG_WRC_WIRS_1	105	110	PF05994	0.393
MOD_CK1_1	96	102	PF00069	0.385
MOD_CK2_1	75	81	PF00069	0.340
MOD_GlcNHglycan	95	98	PF01048	0.596
MOD_GSK3_1	86	93	PF00069	0.323
MOD_GSK3_1	96	103	PF00069	0.331
MOD_NEK2_1	110	115	PF00069	0.162
MOD_NEK2_1	45	50	PF00069	0.343
MOD_NEK2_1	75	80	PF00069	0.368
MOD_NEK2_1	90	95	PF00069	0.447
MOD_PIKK_1	90	96	PF00454	0.374
MOD_Plk_4	100	106	PF00069	0.258
MOD_Plk_4	110	116	PF00069	0.281
MOD_Plk_4	31	37	PF00069	0.581
MOD_Plk_4	45	51	PF00069	0.345
MOD_Plk_4	5	11	PF00069	0.477
MOD_Plk_4	86	92	PF00069	0.342
TRG_DiLeu_BaEn_1	81	86	PF01217	0.344
TRG_ENDOCYTIC_2	121	124	PF00928	0.553
TRG_ENDOCYTIC_2	17	20	PF00928	0.607
TRG_ENDOCYTIC_2	50	53	PF00928	0.367
TRG_ENDOCYTIC_2	7	10	PF00928	0.541
TRG_ENDOCYTIC_2	88	91	PF00928	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Z5	Leptomonas seymouri	56%	100%
A0A1X0NKL9	Trypanosomatidae	42%	99%
A0A3Q8IP15	Leishmania donovani	80%	100%
A0A3R7KH99	Trypanosoma rangeli	41%	100%
A4ID84	Leishmania infantum	80%	100%
E9AT74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q1C3	Leishmania major	83%	100%