RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted zinc finger protein

Species:

Leishmania braziliensis

UniProt:

A4HPF9_LEIBR

TriTrypDb:

LbrM.35.3150 , LBRM2903_350040000

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HPF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPF9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	427	429	PF00675	0.583
CLV_NRD_NRD_1	442	444	PF00675	0.444
CLV_NRD_NRD_1	513	515	PF00675	0.534
CLV_NRD_NRD_1	549	551	PF00675	0.601
CLV_PCSK_FUR_1	513	517	PF00082	0.519
CLV_PCSK_KEX2_1	427	429	PF00082	0.583
CLV_PCSK_KEX2_1	441	443	PF00082	0.461
CLV_PCSK_KEX2_1	512	514	PF00082	0.531
CLV_PCSK_KEX2_1	515	517	PF00082	0.529
CLV_PCSK_KEX2_1	548	550	PF00082	0.521
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.537
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.531
CLV_PCSK_PC7_1	437	443	PF00082	0.530
CLV_PCSK_SKI1_1	114	118	PF00082	0.415
CLV_PCSK_SKI1_1	287	291	PF00082	0.461
CLV_PCSK_SKI1_1	33	37	PF00082	0.331
CLV_PCSK_SKI1_1	413	417	PF00082	0.416
CLV_PCSK_SKI1_1	46	50	PF00082	0.250
CLV_PCSK_SKI1_1	526	530	PF00082	0.415
DEG_APCC_DBOX_1	113	121	PF00400	0.538
DEG_APCC_DBOX_1	271	279	PF00400	0.493
DOC_MAPK_gen_1	363	372	PF00069	0.709
DOC_MAPK_gen_1	441	447	PF00069	0.725
DOC_MAPK_MEF2A_6	363	372	PF00069	0.709
DOC_MAPK_RevD_3	535	549	PF00069	0.620
DOC_PP4_FxxP_1	71	74	PF00568	0.530
DOC_USP7_MATH_1	137	141	PF00917	0.513
DOC_USP7_MATH_1	277	281	PF00917	0.581
DOC_USP7_MATH_1	368	372	PF00917	0.790
DOC_USP7_MATH_1	401	405	PF00917	0.784
DOC_USP7_MATH_1	462	466	PF00917	0.657
DOC_USP7_MATH_1	497	501	PF00917	0.773
DOC_USP7_MATH_1	504	508	PF00917	0.787
DOC_USP7_MATH_2	497	503	PF00917	0.644
DOC_USP7_MATH_2	520	526	PF00917	0.632
DOC_WW_Pin1_4	416	421	PF00397	0.793
LIG_14-3-3_CanoR_1	208	214	PF00244	0.624
LIG_14-3-3_CanoR_1	33	42	PF00244	0.490
LIG_14-3-3_CanoR_1	369	373	PF00244	0.735
LIG_14-3-3_CanoR_1	393	399	PF00244	0.697
LIG_14-3-3_CanoR_1	402	409	PF00244	0.741
LIG_14-3-3_CanoR_1	442	446	PF00244	0.703
LIG_14-3-3_CanoR_1	526	535	PF00244	0.737
LIG_14-3-3_CanoR_1	60	65	PF00244	0.486
LIG_14-3-3_CanoR_1	67	72	PF00244	0.542
LIG_14-3-3_CanoR_1	82	90	PF00244	0.326
LIG_Actin_WH2_2	179	194	PF00022	0.480
LIG_APCC_ABBA_1	230	235	PF00400	0.631
LIG_BRCT_BRCA1_1	102	106	PF00533	0.227
LIG_BRCT_BRCA1_1	13	17	PF00533	0.227
LIG_BRCT_BRCA1_1	62	66	PF00533	0.381
LIG_CaM_NSCaTE_8	254	261	PF13499	0.494
LIG_Clathr_ClatBox_1	495	499	PF01394	0.609
LIG_CtBP_PxDLS_1	423	427	PF00389	0.788
LIG_EH_1	230	234	PF12763	0.654
LIG_EH1_1	16	24	PF00400	0.227
LIG_EH1_1	58	66	PF00400	0.435
LIG_eIF4E_1	24	30	PF01652	0.447
LIG_eIF4E_1	59	65	PF01652	0.323
LIG_FHA_1	106	112	PF00498	0.480
LIG_FHA_1	171	177	PF00498	0.396
LIG_FHA_1	179	185	PF00498	0.291
LIG_FHA_1	2	8	PF00498	0.459
LIG_FHA_1	25	31	PF00498	0.454
LIG_FHA_1	34	40	PF00498	0.365
LIG_FHA_1	382	388	PF00498	0.737
LIG_FHA_1	395	401	PF00498	0.657
LIG_FHA_1	540	546	PF00498	0.797
LIG_FHA_2	87	93	PF00498	0.314
LIG_GBD_Chelix_1	39	47	PF00786	0.227
LIG_HP1_1	368	372	PF01393	0.762
LIG_LIR_Apic_2	70	74	PF02991	0.531
LIG_LIR_Gen_1	138	149	PF02991	0.444
LIG_LIR_Gen_1	350	361	PF02991	0.552
LIG_LIR_Nem_3	138	144	PF02991	0.430
LIG_LIR_Nem_3	238	243	PF02991	0.637
LIG_LIR_Nem_3	252	258	PF02991	0.560
LIG_LIR_Nem_3	291	296	PF02991	0.598
LIG_LIR_Nem_3	350	356	PF02991	0.545
LIG_LIR_Nem_3	56	62	PF02991	0.613
LIG_LIR_Nem_3	85	90	PF02991	0.503
LIG_NRBOX	209	215	PF00104	0.467
LIG_Pex14_1	264	268	PF04695	0.659
LIG_Pex14_2	51	55	PF04695	0.480
LIG_Pex14_2	68	72	PF04695	0.335
LIG_REV1ctd_RIR_1	78	86	PF16727	0.333
LIG_SH2_CRK	160	164	PF00017	0.442
LIG_SH2_CRK	180	184	PF00017	0.150
LIG_SH2_CRK	207	211	PF00017	0.609
LIG_SH2_CRK	59	63	PF00017	0.320
LIG_SH2_GRB2like	24	27	PF00017	0.378
LIG_SH2_NCK_1	13	17	PF00017	0.341
LIG_SH2_NCK_1	88	92	PF00017	0.490
LIG_SH2_SRC	243	246	PF00017	0.623
LIG_SH2_SRC	274	277	PF00017	0.672
LIG_SH2_STAP1	13	17	PF00017	0.447
LIG_SH2_STAP1	180	184	PF00017	0.335
LIG_SH2_STAT5	160	163	PF00017	0.388
LIG_SH2_STAT5	180	183	PF00017	0.150
LIG_SH2_STAT5	185	188	PF00017	0.335
LIG_SH2_STAT5	243	246	PF00017	0.586
LIG_SH2_STAT5	256	259	PF00017	0.509
LIG_SH2_STAT5	274	277	PF00017	0.511
LIG_SH2_STAT5	88	91	PF00017	0.379
LIG_SH3_3	355	361	PF00018	0.561
LIG_SH3_3	386	392	PF00018	0.740
LIG_SH3_3	417	423	PF00018	0.770
LIG_SUMO_SIM_anti_2	95	100	PF11976	0.447
LIG_SUMO_SIM_par_1	274	280	PF11976	0.493
LIG_TRAF2_1	164	167	PF00917	0.449
LIG_TRAF2_1	464	467	PF00917	0.717
LIG_TRFH_1	160	164	PF08558	0.419
LIG_UBA3_1	275	282	PF00899	0.495
LIG_UBA3_1	42	46	PF00899	0.480
LIG_WRC_WIRS_1	68	73	PF05994	0.533
MOD_CK1_1	259	265	PF00069	0.668
MOD_CK1_1	316	322	PF00069	0.518
MOD_CK1_1	507	513	PF00069	0.635
MOD_CK1_1	527	533	PF00069	0.742
MOD_CK2_1	132	138	PF00069	0.581
MOD_GlcNHglycan	134	137	PF01048	0.348
MOD_GlcNHglycan	192	195	PF01048	0.434
MOD_GlcNHglycan	226	230	PF01048	0.453
MOD_GlcNHglycan	279	282	PF01048	0.456
MOD_GlcNHglycan	410	413	PF01048	0.541
MOD_GlcNHglycan	480	484	PF01048	0.559
MOD_GlcNHglycan	499	502	PF01048	0.429
MOD_GSK3_1	166	173	PF00069	0.414
MOD_GSK3_1	25	32	PF00069	0.424
MOD_GSK3_1	254	261	PF00069	0.628
MOD_GSK3_1	379	386	PF00069	0.633
MOD_GSK3_1	414	421	PF00069	0.739
MOD_GSK3_1	504	511	PF00069	0.781
MOD_GSK3_1	522	529	PF00069	0.755
MOD_GSK3_1	82	89	PF00069	0.479
MOD_N-GLC_1	25	30	PF02516	0.447
MOD_NEK2_1	1	6	PF00069	0.491
MOD_NEK2_1	148	153	PF00069	0.389
MOD_NEK2_1	178	183	PF00069	0.400
MOD_NEK2_1	196	201	PF00069	0.269
MOD_NEK2_1	225	230	PF00069	0.604
MOD_NEK2_1	258	263	PF00069	0.552
MOD_NEK2_1	29	34	PF00069	0.531
MOD_NEK2_1	38	43	PF00069	0.323
MOD_NEK2_1	383	388	PF00069	0.709
MOD_NEK2_1	505	510	PF00069	0.630
MOD_NEK2_1	521	526	PF00069	0.599
MOD_NEK2_1	53	58	PF00069	0.430
MOD_NEK2_1	80	85	PF00069	0.498
MOD_NEK2_2	313	318	PF00069	0.447
MOD_NEK2_2	322	327	PF00069	0.562
MOD_PIKK_1	130	136	PF00454	0.638
MOD_PIKK_1	166	172	PF00454	0.475
MOD_PIKK_1	402	408	PF00454	0.642
MOD_PIKK_1	414	420	PF00454	0.790
MOD_PIKK_1	462	468	PF00454	0.570
MOD_PIKK_1	80	86	PF00454	0.492
MOD_PKA_1	441	447	PF00069	0.725
MOD_PKA_2	362	368	PF00069	0.721
MOD_PKA_2	401	407	PF00069	0.757
MOD_PKA_2	441	447	PF00069	0.701
MOD_PKB_1	477	485	PF00069	0.621
MOD_Plk_1	124	130	PF00069	0.654
MOD_Plk_1	137	143	PF00069	0.432
MOD_Plk_1	25	31	PF00069	0.398
MOD_Plk_1	349	355	PF00069	0.664
MOD_Plk_1	491	497	PF00069	0.626
MOD_Plk_4	107	113	PF00069	0.391
MOD_Plk_4	158	164	PF00069	0.354
MOD_Plk_4	172	178	PF00069	0.217
MOD_Plk_4	179	185	PF00069	0.341
MOD_Plk_4	209	215	PF00069	0.539
MOD_Plk_4	25	31	PF00069	0.398
MOD_Plk_4	259	265	PF00069	0.550
MOD_Plk_4	38	44	PF00069	0.326
MOD_Plk_4	491	497	PF00069	0.608
MOD_Plk_4	60	66	PF00069	0.505
MOD_ProDKin_1	416	422	PF00069	0.794
TRG_ENDOCYTIC_2	159	162	PF00928	0.424
TRG_ENDOCYTIC_2	180	183	PF00928	0.358
TRG_ENDOCYTIC_2	207	210	PF00928	0.625
TRG_ENDOCYTIC_2	255	258	PF00928	0.596
TRG_ENDOCYTIC_2	286	289	PF00928	0.641
TRG_ENDOCYTIC_2	353	356	PF00928	0.560
TRG_ENDOCYTIC_2	432	435	PF00928	0.745
TRG_ENDOCYTIC_2	59	62	PF00928	0.322
TRG_ER_diArg_1	426	428	PF00400	0.783
TRG_ER_diArg_1	512	514	PF00400	0.745
TRG_ER_diArg_1	516	519	PF00400	0.739
TRG_ER_diArg_1	547	550	PF00400	0.738
TRG_NLS_Bipartite_1	427	445	PF00514	0.743
TRG_NLS_MonoExtC_3	513	518	PF00514	0.770
TRG_NLS_MonoExtN_4	512	519	PF00514	0.730
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9B9	Leptomonas seymouri	54%	100%
A0A1X0NKB6	Trypanosomatidae	25%	100%
A0A1X0NKU5	Trypanosomatidae	25%	100%
A0A3Q8IJ86	Leishmania donovani	78%	100%
A0A3R7NH33	Trypanosoma rangeli	25%	100%
A4ID81	Leishmania infantum	78%	100%
E9AT71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q1C6	Leishmania major	77%	100%
V5BKC4	Trypanosoma cruzi	22%	100%