PHF5-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

PHF5-like protein

Gene product:

PHF5-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HPF8_LEIBR

TriTrypDb:

LbrM.35.3140 , LBRM2903_350039900

Length:

113

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0005686	U2 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0071011	precatalytic spliceosome	4	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HPF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPF8

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.233
CLV_NRD_NRD_1	70	72	PF00675	0.366
CLV_PCSK_KEX2_1	70	72	PF00082	0.366
CLV_PCSK_SKI1_1	70	74	PF00082	0.366
DEG_Nend_Nbox_1	1	3	PF02207	0.252
DOC_USP7_MATH_1	109	113	PF00917	0.576
LIG_14-3-3_CanoR_1	12	19	PF00244	0.380
LIG_14-3-3_CanoR_1	70	78	PF00244	0.390
LIG_14-3-3_CterR_2	108	113	PF00244	0.547
LIG_FHA_2	41	47	PF00498	0.336
LIG_FHA_2	56	62	PF00498	0.247
LIG_LIR_Gen_1	34	44	PF02991	0.287
LIG_LIR_Nem_3	34	40	PF02991	0.312
LIG_SH2_STAT5	21	24	PF00017	0.299
LIG_SH2_STAT5	78	81	PF00017	0.272
MOD_CK2_1	40	46	PF00069	0.277
MOD_CK2_1	55	61	PF00069	0.247
MOD_GSK3_1	51	58	PF00069	0.298
MOD_GSK3_1	66	73	PF00069	0.426
MOD_N-GLC_1	96	101	PF02516	0.301
MOD_NEK2_1	66	71	PF00069	0.366
MOD_NEK2_1	96	101	PF00069	0.252
MOD_PKA_1	70	76	PF00069	0.366
MOD_PKA_2	11	17	PF00069	0.380
MOD_PKA_2	2	8	PF00069	0.291
MOD_PKA_2	70	76	PF00069	0.366
MOD_Plk_1	51	57	PF00069	0.366
MOD_Plk_4	51	57	PF00069	0.366
TRG_ER_diArg_1	70	72	PF00400	0.366
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.252

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILY6	Leptomonas seymouri	91%	100%
A0A0S4J3R7	Bodo saltans	46%	100%
A0A1X0NM48	Trypanosomatidae	65%	100%
A0A3Q8IR48	Leishmania donovani	96%	100%
A0A422NLV5	Trypanosoma rangeli	65%	100%
A4ID80	Leishmania infantum	96%	100%
D0A3H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AT70	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P0DI19	Arabidopsis thaliana	41%	100%
P83870	Mus musculus	42%	100%
P83871	Rattus norvegicus	42%	100%
Q06835	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
Q0WMV8	Arabidopsis thaliana	41%	100%
Q4Q1C7	Leishmania major	95%	100%
Q7RTV0	Homo sapiens	42%	100%
Q9UTB8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	97%
Q9VMC8	Drosophila melanogaster	41%	100%