Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPF6_LEIBR

TriTrypDb:

LbrM.35.3120 , LBRM2903_350039600

Length:

855

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HPF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPF6

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0032392	DNA geometric change	7	2
GO:0032508	DNA duplex unwinding	8	2
GO:0051276	chromosome organization	5	2
GO:0071103	DNA conformation change	6	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.392
CLV_NRD_NRD_1	207	209	PF00675	0.531
CLV_NRD_NRD_1	308	310	PF00675	0.473
CLV_NRD_NRD_1	404	406	PF00675	0.596
CLV_NRD_NRD_1	577	579	PF00675	0.527
CLV_NRD_NRD_1	847	849	PF00675	0.524
CLV_PCSK_KEX2_1	207	209	PF00082	0.531
CLV_PCSK_KEX2_1	308	310	PF00082	0.473
CLV_PCSK_KEX2_1	404	406	PF00082	0.666
CLV_PCSK_KEX2_1	577	579	PF00082	0.527
CLV_PCSK_KEX2_1	784	786	PF00082	0.465
CLV_PCSK_KEX2_1	847	849	PF00082	0.524
CLV_PCSK_PC1ET2_1	784	786	PF00082	0.499
CLV_PCSK_SKI1_1	137	141	PF00082	0.546
CLV_PCSK_SKI1_1	157	161	PF00082	0.410
CLV_PCSK_SKI1_1	272	276	PF00082	0.508
CLV_PCSK_SKI1_1	286	290	PF00082	0.341
CLV_PCSK_SKI1_1	321	325	PF00082	0.343
CLV_PCSK_SKI1_1	360	364	PF00082	0.372
CLV_PCSK_SKI1_1	663	667	PF00082	0.493
CLV_PCSK_SKI1_1	787	791	PF00082	0.509
DEG_APCC_DBOX_1	344	352	PF00400	0.418
DEG_APCC_DBOX_1	662	670	PF00400	0.387
DEG_APCC_DBOX_1	784	792	PF00400	0.517
DEG_Nend_UBRbox_4	1	3	PF02207	0.499
DEG_SCF_FBW7_1	45	52	PF00400	0.341
DEG_SCF_FBW7_1	496	501	PF00400	0.354
DEG_SCF_FBW7_1	551	558	PF00400	0.550
DEG_SPOP_SBC_1	467	471	PF00917	0.348
DOC_CDC14_PxL_1	172	180	PF14671	0.477
DOC_CKS1_1	552	557	PF01111	0.554
DOC_CYCLIN_RxL_1	131	142	PF00134	0.551
DOC_MAPK_gen_1	404	410	PF00069	0.347
DOC_MAPK_gen_1	783	791	PF00069	0.424
DOC_MAPK_MEF2A_6	124	132	PF00069	0.481
DOC_MAPK_MEF2A_6	321	328	PF00069	0.331
DOC_MAPK_MEF2A_6	345	352	PF00069	0.415
DOC_MAPK_NFAT4_5	321	329	PF00069	0.329
DOC_PP1_RVXF_1	117	123	PF00149	0.464
DOC_PP1_RVXF_1	319	326	PF00149	0.264
DOC_PP1_RVXF_1	785	791	PF00149	0.512
DOC_PP2B_LxvP_1	620	623	PF13499	0.733
DOC_PP4_FxxP_1	828	831	PF00568	0.466
DOC_PP4_FxxP_1	91	94	PF00568	0.499
DOC_USP7_MATH_1	110	114	PF00917	0.721
DOC_USP7_MATH_1	392	396	PF00917	0.642
DOC_USP7_MATH_1	450	454	PF00917	0.529
DOC_USP7_MATH_1	467	471	PF00917	0.305
DOC_USP7_MATH_1	498	502	PF00917	0.568
DOC_USP7_MATH_1	518	522	PF00917	0.382
DOC_USP7_MATH_1	541	545	PF00917	0.704
DOC_USP7_MATH_1	612	616	PF00917	0.699
DOC_USP7_MATH_1	743	747	PF00917	0.665
DOC_USP7_MATH_1	765	769	PF00917	0.743
DOC_USP7_MATH_1	79	83	PF00917	0.497
DOC_USP7_UBL2_3	779	783	PF12436	0.473
DOC_WW_Pin1_4	114	119	PF00397	0.618
DOC_WW_Pin1_4	45	50	PF00397	0.491
DOC_WW_Pin1_4	494	499	PF00397	0.323
DOC_WW_Pin1_4	537	542	PF00397	0.678
DOC_WW_Pin1_4	551	556	PF00397	0.612
DOC_WW_Pin1_4	642	647	PF00397	0.487
DOC_WW_Pin1_4	741	746	PF00397	0.496
DOC_WW_Pin1_4	85	90	PF00397	0.523
LIG_14-3-3_CanoR_1	168	176	PF00244	0.431
LIG_14-3-3_CanoR_1	404	410	PF00244	0.509
LIG_14-3-3_CanoR_1	528	536	PF00244	0.654
LIG_14-3-3_CanoR_1	542	548	PF00244	0.555
LIG_14-3-3_CanoR_1	6	12	PF00244	0.350
LIG_BRCT_BRCA1_1	87	91	PF00533	0.456
LIG_Clathr_ClatBox_1	788	792	PF01394	0.514
LIG_deltaCOP1_diTrp_1	56	63	PF00928	0.515
LIG_FHA_1	134	140	PF00498	0.483
LIG_FHA_1	188	194	PF00498	0.411
LIG_FHA_1	196	202	PF00498	0.371
LIG_FHA_1	33	39	PF00498	0.543
LIG_FHA_1	417	423	PF00498	0.485
LIG_FHA_1	433	439	PF00498	0.568
LIG_FHA_1	497	503	PF00498	0.502
LIG_FHA_2	140	146	PF00498	0.476
LIG_FHA_2	268	274	PF00498	0.495
LIG_FHA_2	51	57	PF00498	0.464
LIG_FHA_2	566	572	PF00498	0.530
LIG_FHA_2	595	601	PF00498	0.345
LIG_FHA_2	646	652	PF00498	0.644
LIG_LIR_Apic_2	826	831	PF02991	0.465
LIG_LIR_Apic_2	88	94	PF02991	0.485
LIG_LIR_Gen_1	196	205	PF02991	0.438
LIG_LIR_Gen_1	224	232	PF02991	0.379
LIG_LIR_Gen_1	273	282	PF02991	0.347
LIG_LIR_Gen_1	592	603	PF02991	0.355
LIG_LIR_Gen_1	816	827	PF02991	0.348
LIG_LIR_Nem_3	196	200	PF02991	0.448
LIG_LIR_Nem_3	224	228	PF02991	0.391
LIG_LIR_Nem_3	273	278	PF02991	0.430
LIG_LIR_Nem_3	570	576	PF02991	0.372
LIG_LIR_Nem_3	592	598	PF02991	0.362
LIG_LIR_Nem_3	67	73	PF02991	0.461
LIG_LIR_Nem_3	684	689	PF02991	0.428
LIG_LIR_Nem_3	816	822	PF02991	0.494
LIG_NRBOX	817	823	PF00104	0.429
LIG_PTAP_UEV_1	547	552	PF05743	0.550
LIG_RPA_C_Fungi	203	215	PF08784	0.418
LIG_SH2_GRB2like	21	24	PF00017	0.281
LIG_SH2_GRB2like	334	337	PF00017	0.322
LIG_SH2_NCK_1	21	25	PF00017	0.413
LIG_SH2_SRC	21	24	PF00017	0.281
LIG_SH2_SRC	334	337	PF00017	0.322
LIG_SH2_STAP1	373	377	PF00017	0.351
LIG_SH2_STAT5	202	205	PF00017	0.407
LIG_SH2_STAT5	225	228	PF00017	0.344
LIG_SH2_STAT5	237	240	PF00017	0.469
LIG_SH2_STAT5	489	492	PF00017	0.450
LIG_SH2_STAT5	574	577	PF00017	0.517
LIG_SH2_STAT5	73	76	PF00017	0.327
LIG_SH3_2	548	553	PF14604	0.552
LIG_SH3_3	189	195	PF00018	0.475
LIG_SH3_3	407	413	PF00018	0.300
LIG_SH3_3	545	551	PF00018	0.575
LIG_SUMO_SIM_anti_2	170	176	PF11976	0.390
LIG_SUMO_SIM_anti_2	39	46	PF11976	0.479
LIG_SUMO_SIM_anti_2	830	837	PF11976	0.548
LIG_SUMO_SIM_par_1	418	423	PF11976	0.483
LIG_SUMO_SIM_par_1	437	443	PF11976	0.533
LIG_SUMO_SIM_par_1	645	651	PF11976	0.581
LIG_TRAF2_1	476	479	PF00917	0.527
LIG_TRAF2_1	648	651	PF00917	0.370
LIG_TYR_ITIM	200	205	PF00017	0.384
LIG_WRC_WIRS_1	595	600	PF05994	0.429
LIG_WRC_WIRS_1	726	731	PF05994	0.479
MOD_CDC14_SPxK_1	744	747	PF00782	0.522
MOD_CDK_SPK_2	114	119	PF00069	0.409
MOD_CDK_SPK_2	537	542	PF00069	0.630
MOD_CDK_SPxK_1	551	557	PF00069	0.732
MOD_CDK_SPxK_1	741	747	PF00069	0.522
MOD_CK1_1	170	176	PF00069	0.650
MOD_CK1_1	231	237	PF00069	0.267
MOD_CK1_1	395	401	PF00069	0.533
MOD_CK1_1	520	526	PF00069	0.589
MOD_CK1_1	527	533	PF00069	0.609
MOD_CK1_1	537	543	PF00069	0.559
MOD_CK1_1	561	567	PF00069	0.669
MOD_CK1_1	704	710	PF00069	0.662
MOD_CK1_1	728	734	PF00069	0.576
MOD_CK1_1	746	752	PF00069	0.751
MOD_CK1_1	82	88	PF00069	0.491
MOD_CK2_1	139	145	PF00069	0.502
MOD_CK2_1	236	242	PF00069	0.390
MOD_CK2_1	61	67	PF00069	0.307
MOD_CK2_1	645	651	PF00069	0.663
MOD_CK2_1	810	816	PF00069	0.536
MOD_CK2_1	97	103	PF00069	0.549
MOD_GlcNHglycan	112	115	PF01048	0.645
MOD_GlcNHglycan	360	363	PF01048	0.363
MOD_GlcNHglycan	394	397	PF01048	0.550
MOD_GlcNHglycan	405	408	PF01048	0.579
MOD_GlcNHglycan	448	451	PF01048	0.638
MOD_GlcNHglycan	452	455	PF01048	0.602
MOD_GlcNHglycan	478	482	PF01048	0.554
MOD_GlcNHglycan	548	551	PF01048	0.683
MOD_GlcNHglycan	623	626	PF01048	0.656
MOD_GlcNHglycan	631	634	PF01048	0.658
MOD_GlcNHglycan	706	709	PF01048	0.677
MOD_GlcNHglycan	731	734	PF01048	0.515
MOD_GlcNHglycan	802	805	PF01048	0.634
MOD_GlcNHglycan	81	84	PF01048	0.526
MOD_GlcNHglycan	825	828	PF01048	0.448
MOD_GSK3_1	1	8	PF00069	0.477
MOD_GSK3_1	110	117	PF00069	0.454
MOD_GSK3_1	139	146	PF00069	0.434
MOD_GSK3_1	231	238	PF00069	0.273
MOD_GSK3_1	378	385	PF00069	0.455
MOD_GSK3_1	446	453	PF00069	0.576
MOD_GSK3_1	45	52	PF00069	0.564
MOD_GSK3_1	494	501	PF00069	0.447
MOD_GSK3_1	502	509	PF00069	0.523
MOD_GSK3_1	513	520	PF00069	0.572
MOD_GSK3_1	523	530	PF00069	0.616
MOD_GSK3_1	531	538	PF00069	0.585
MOD_GSK3_1	551	558	PF00069	0.655
MOD_GSK3_1	561	568	PF00069	0.663
MOD_GSK3_1	57	64	PF00069	0.470
MOD_GSK3_1	629	636	PF00069	0.608
MOD_GSK3_1	638	645	PF00069	0.513
MOD_GSK3_1	724	731	PF00069	0.586
MOD_GSK3_1	806	813	PF00069	0.470
MOD_GSK3_1	93	100	PF00069	0.542
MOD_LATS_1	522	528	PF00433	0.638
MOD_N-GLC_1	22	27	PF02516	0.444
MOD_NEK2_1	1	6	PF00069	0.711
MOD_NEK2_1	139	144	PF00069	0.450
MOD_NEK2_1	235	240	PF00069	0.467
MOD_NEK2_1	378	383	PF00069	0.491
MOD_NEK2_1	403	408	PF00069	0.614
MOD_NEK2_1	415	420	PF00069	0.438
MOD_NEK2_1	468	473	PF00069	0.437
MOD_NEK2_1	502	507	PF00069	0.560
MOD_NEK2_1	536	541	PF00069	0.683
MOD_NEK2_1	725	730	PF00069	0.653
MOD_NEK2_1	774	779	PF00069	0.546
MOD_NEK2_2	32	37	PF00069	0.356
MOD_PIKK_1	143	149	PF00454	0.523
MOD_PIKK_1	167	173	PF00454	0.499
MOD_PIKK_1	179	185	PF00454	0.406
MOD_PIKK_1	506	512	PF00454	0.488
MOD_PIKK_1	531	537	PF00454	0.723
MOD_PIKK_1	541	547	PF00454	0.706
MOD_PIKK_1	57	63	PF00454	0.410
MOD_PIKK_1	6	12	PF00454	0.349
MOD_PIKK_1	774	780	PF00454	0.480
MOD_PIKK_1	82	88	PF00454	0.554
MOD_PIKK_1	834	840	PF00454	0.594
MOD_PKA_2	167	173	PF00069	0.531
MOD_PKA_2	403	409	PF00069	0.522
MOD_PKA_2	5	11	PF00069	0.364
MOD_PKA_2	518	524	PF00069	0.603
MOD_PKA_2	527	533	PF00069	0.644
MOD_PKA_2	541	547	PF00069	0.691
MOD_PKA_2	565	571	PF00069	0.636
MOD_PKA_2	746	752	PF00069	0.646
MOD_PKA_2	800	806	PF00069	0.573
MOD_PKB_1	155	163	PF00069	0.462
MOD_Plk_1	22	28	PF00069	0.463
MOD_Plk_1	32	38	PF00069	0.326
MOD_Plk_1	502	508	PF00069	0.582
MOD_Plk_1	806	812	PF00069	0.374
MOD_Plk_4	170	176	PF00069	0.474
MOD_Plk_4	231	237	PF00069	0.301
MOD_Plk_4	378	384	PF00069	0.445
MOD_Plk_4	40	46	PF00069	0.333
MOD_Plk_4	416	422	PF00069	0.481
MOD_Plk_4	468	474	PF00069	0.555
MOD_Plk_4	50	56	PF00069	0.302
MOD_Plk_4	558	564	PF00069	0.788
MOD_Plk_4	594	600	PF00069	0.476
MOD_ProDKin_1	114	120	PF00069	0.599
MOD_ProDKin_1	45	51	PF00069	0.486
MOD_ProDKin_1	494	500	PF00069	0.337
MOD_ProDKin_1	537	543	PF00069	0.678
MOD_ProDKin_1	551	557	PF00069	0.613
MOD_ProDKin_1	642	648	PF00069	0.475
MOD_ProDKin_1	741	747	PF00069	0.497
MOD_ProDKin_1	85	91	PF00069	0.518
MOD_SUMO_for_1	755	758	PF00179	0.495
TRG_DiLeu_BaEn_1	366	371	PF01217	0.499
TRG_DiLeu_BaEn_1	40	45	PF01217	0.467
TRG_DiLeu_BaEn_1	841	846	PF01217	0.491
TRG_DiLeu_BaEn_4	841	847	PF01217	0.543
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.509
TRG_DiLeu_BaLyEn_6	243	248	PF01217	0.397
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.494
TRG_ENDOCYTIC_2	202	205	PF00928	0.424
TRG_ENDOCYTIC_2	225	228	PF00928	0.308
TRG_ENDOCYTIC_2	489	492	PF00928	0.450
TRG_ENDOCYTIC_2	595	598	PF00928	0.489
TRG_ER_diArg_1	308	310	PF00400	0.473
TRG_ER_diArg_1	403	405	PF00400	0.600
TRG_ER_diArg_1	576	578	PF00400	0.445
TRG_ER_diArg_1	785	788	PF00400	0.520
TRG_ER_diArg_1	794	797	PF00400	0.514
TRG_ER_diArg_1	799	802	PF00400	0.587
TRG_ER_diArg_1	846	848	PF00400	0.498
TRG_NLS_MonoExtC_3	782	787	PF00514	0.530
TRG_NLS_MonoExtN_4	781	788	PF00514	0.542
TRG_Pf-PMV_PEXEL_1	76	81	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P797	Leptomonas seymouri	45%	100%
A0A1X0NKL2	Trypanosomatidae	26%	100%
A0A3R7LZS8	Trypanosoma rangeli	26%	100%
A0A3S5H829	Leishmania donovani	75%	95%
A4ID78	Leishmania infantum	75%	95%
E9AT68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q1C9	Leishmania major	75%	100%
V5B0C2	Trypanosoma cruzi	26%	100%