40S ribosomal protein S24

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

40S ribosomal protein S24e

Species:

Leishmania braziliensis

UniProt:

A4HPF3_LEIBR

TriTrypDb:

LbrM.35.3090 , LBRM2903_350039300

Length:

137

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 21

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HPF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPF3

PDB structure(s): 6az1_Z

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.281
CLV_NRD_NRD_1	117	119	PF00675	0.415
CLV_NRD_NRD_1	24	26	PF00675	0.341
CLV_NRD_NRD_1	46	48	PF00675	0.314
CLV_NRD_NRD_1	96	98	PF00675	0.235
CLV_PCSK_KEX2_1	117	119	PF00082	0.460
CLV_PCSK_KEX2_1	90	92	PF00082	0.235
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.235
CLV_PCSK_SKI1_1	112	116	PF00082	0.400
CLV_PCSK_SKI1_1	49	53	PF00082	0.325
DEG_APCC_DBOX_1	46	54	PF00400	0.235
DOC_MAPK_gen_1	25	32	PF00069	0.320
DOC_MAPK_gen_1	5	12	PF00069	0.393
DOC_MAPK_gen_1	97	103	PF00069	0.366
DOC_PP4_FxxP_1	103	106	PF00568	0.145
DOC_USP7_MATH_1	110	114	PF00917	0.409
DOC_USP7_MATH_1	8	12	PF00917	0.365
DOC_USP7_UBL2_3	123	127	PF12436	0.430
DOC_USP7_UBL2_3	131	135	PF12436	0.476
LIG_14-3-3_CanoR_1	111	115	PF00244	0.405
LIG_14-3-3_CanoR_1	13	19	PF00244	0.360
LIG_ActinCP_TwfCPI_2	103	112	PF01115	0.323
LIG_EH1_1	16	24	PF00400	0.335
LIG_FHA_1	41	47	PF00498	0.314
LIG_LIR_Apic_2	52	57	PF02991	0.357
LIG_LIR_Gen_1	84	94	PF02991	0.145
LIG_LIR_Nem_3	76	82	PF02991	0.235
LIG_LIR_Nem_3	84	89	PF02991	0.241
LIG_PCNA_yPIPBox_3	13	23	PF02747	0.337
LIG_Pex14_2	67	71	PF04695	0.235
LIG_SH2_STAP1	83	87	PF00017	0.235
LIG_SH3_2	106	111	PF14604	0.332
LIG_SH3_3	103	109	PF00018	0.323
LIG_SH3_3	29	35	PF00018	0.235
MOD_CK1_1	11	17	PF00069	0.315
MOD_CK2_1	110	116	PF00069	0.404
MOD_GSK3_1	8	15	PF00069	0.316
MOD_NEK2_2	110	115	PF00069	0.407
MOD_NEK2_2	8	13	PF00069	0.255
MOD_PIKK_1	12	18	PF00454	0.337
MOD_PIKK_1	40	46	PF00454	0.381
MOD_PKA_2	110	116	PF00069	0.271
MOD_PKA_2	12	18	PF00069	0.355
MOD_PKA_2	96	102	PF00069	0.366
MOD_Plk_1	8	14	PF00069	0.253
MOD_Plk_4	49	55	PF00069	0.229
MOD_Plk_4	60	66	PF00069	0.246
TRG_ENDOCYTIC_2	83	86	PF00928	0.235
TRG_ER_diArg_1	117	120	PF00400	0.413
TRG_NLS_Bipartite_1	111	126	PF00514	0.412
TRG_NLS_MonoExtN_4	120	126	PF00514	0.421
TRG_NLS_MonoExtN_4	94	101	PF00514	0.235

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P792	Leptomonas seymouri	94%	100%
A0A0S4IT08	Bodo saltans	79%	100%
A0A1X0NL68	Trypanosomatidae	82%	100%
A0A3Q8IKW0	Leishmania donovani	93%	100%
A0A3R7MID6	Trypanosoma rangeli	82%	100%
A4ID74	Leishmania infantum	93%	100%
D0A3G5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	100%
E9AT64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O13784	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
O42387	Takifugu rubripes	50%	100%
O59865	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	100%
P02377	Xenopus laevis	50%	100%
P0CU28	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	48%	100%
P0CX31	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	100%
P0CX32	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	100%
P14249	Mucor circinelloides f. lusitanicus	48%	93%
P62847	Homo sapiens	51%	100%
P62848	Mesocricetus auratus	51%	100%
P62849	Mus musculus	51%	100%
P62850	Rattus norvegicus	51%	100%
Q4Q1D2	Leishmania major	93%	100%
Q4R5H5	Macaca fascicularis	51%	100%
Q56JU9	Bos taurus	51%	100%
Q5A7K0	Candida albicans (strain SC5314 / ATCC MYA-2876)	47%	100%
Q5RAQ8	Pongo abelii	51%	100%
Q75K27	Dictyostelium discoideum	51%	100%
Q8LC83	Arabidopsis thaliana	48%	100%
Q90YQ0	Ictalurus punctatus	50%	100%
Q962Q6	Spodoptera frugiperda	52%	100%
Q9SS17	Arabidopsis thaliana	49%	100%
Q9W6X9	Oryzias latipes	49%	100%