B30.2/SPRY domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPF2_LEIBR

TriTrypDb:

LbrM.35.3080 , LBRM2903_350039200

Length:

261

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPF2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	7	9	PF00675	0.721
CLV_PCSK_KEX2_1	156	158	PF00082	0.451
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.451
CLV_PCSK_SKI1_1	38	42	PF00082	0.537
CLV_PCSK_SKI1_1	86	90	PF00082	0.527
DEG_Nend_Nbox_1	1	3	PF02207	0.768
DOC_CKS1_1	150	155	PF01111	0.464
DOC_CKS1_1	34	39	PF01111	0.615
DOC_MAPK_gen_1	156	164	PF00069	0.473
DOC_MAPK_gen_1	178	186	PF00069	0.464
DOC_MAPK_MEF2A_6	178	186	PF00069	0.512
DOC_MAPK_MEF2A_6	224	232	PF00069	0.283
DOC_PP1_RVXF_1	39	46	PF00149	0.507
DOC_PP1_RVXF_1	97	103	PF00149	0.520
DOC_PP2B_LxvP_1	182	185	PF13499	0.475
DOC_PP4_FxxP_1	250	253	PF00568	0.490
DOC_USP7_MATH_1	127	131	PF00917	0.617
DOC_USP7_MATH_1	139	143	PF00917	0.680
DOC_USP7_MATH_1	238	242	PF00917	0.593
DOC_USP7_MATH_1	27	31	PF00917	0.614
DOC_WW_Pin1_4	149	154	PF00397	0.470
DOC_WW_Pin1_4	33	38	PF00397	0.553
LIG_14-3-3_CanoR_1	92	100	PF00244	0.493
LIG_APCC_ABBA_1	202	207	PF00400	0.452
LIG_BRCT_BRCA1_1	166	170	PF00533	0.538
LIG_BRCT_BRCA1_1	189	193	PF00533	0.259
LIG_BRCT_BRCA1_1	41	45	PF00533	0.432
LIG_DCNL_PONY_1	1	4	PF03556	0.513
LIG_FHA_1	164	170	PF00498	0.384
LIG_FHA_1	174	180	PF00498	0.405
LIG_LIR_Gen_1	159	169	PF02991	0.494
LIG_LIR_Nem_3	155	161	PF02991	0.527
LIG_LIR_Nem_3	68	74	PF02991	0.498
LIG_LYPXL_SIV_4	70	78	PF13949	0.474
LIG_PTB_Apo_2	113	120	PF02174	0.555
LIG_REV1ctd_RIR_1	86	96	PF16727	0.496
LIG_SH2_CRK	71	75	PF00017	0.432
LIG_SH2_STAT5	210	213	PF00017	0.447
LIG_SH2_STAT5	32	35	PF00017	0.584
LIG_SH2_STAT5	54	57	PF00017	0.443
LIG_SH2_STAT5	87	90	PF00017	0.408
LIG_SH3_2	151	156	PF14604	0.611
LIG_SH3_3	135	141	PF00018	0.683
LIG_SH3_3	147	153	PF00018	0.583
LIG_SH3_3	21	27	PF00018	0.544
LIG_SH3_3	250	256	PF00018	0.343
LIG_SH3_3	31	37	PF00018	0.554
LIG_SH3_3	67	73	PF00018	0.495
LIG_TRAF2_1	109	112	PF00917	0.348
LIG_TYR_ITIM	69	74	PF00017	0.525
LIG_UBA3_1	1	9	PF00899	0.768
MOD_CDK_SPK_2	33	38	PF00069	0.376
MOD_CDK_SPxxK_3	149	156	PF00069	0.459
MOD_CK1_1	13	19	PF00069	0.525
MOD_CK1_1	241	247	PF00069	0.562
MOD_CK1_1	39	45	PF00069	0.455
MOD_CK2_1	107	113	PF00069	0.459
MOD_GlcNHglycan	128	132	PF01048	0.422
MOD_GlcNHglycan	218	221	PF01048	0.561
MOD_GlcNHglycan	232	235	PF01048	0.397
MOD_GlcNHglycan	243	246	PF01048	0.506
MOD_GlcNHglycan	29	32	PF01048	0.699
MOD_GlcNHglycan	59	62	PF01048	0.389
MOD_GSK3_1	10	17	PF00069	0.777
MOD_GSK3_1	139	146	PF00069	0.611
MOD_GSK3_1	22	29	PF00069	0.691
MOD_GSK3_1	32	39	PF00069	0.557
MOD_N-GLC_1	238	243	PF02516	0.578
MOD_NEK2_1	129	134	PF00069	0.566
MOD_NEK2_1	143	148	PF00069	0.562
MOD_NEK2_1	164	169	PF00069	0.501
MOD_NEK2_2	52	57	PF00069	0.561
MOD_PIKK_1	10	16	PF00454	0.614
MOD_Plk_1	238	244	PF00069	0.632
MOD_Plk_4	129	135	PF00069	0.692
MOD_Plk_4	139	145	PF00069	0.596
MOD_Plk_4	189	195	PF00069	0.461
MOD_ProDKin_1	149	155	PF00069	0.463
MOD_ProDKin_1	33	39	PF00069	0.546
TRG_DiLeu_BaEn_2	17	23	PF01217	0.521
TRG_ENDOCYTIC_2	161	164	PF00928	0.485
TRG_ENDOCYTIC_2	210	213	PF00928	0.424
TRG_ENDOCYTIC_2	71	74	PF00928	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCH2	Leptomonas seymouri	67%	100%
A0A0S4IV73	Bodo saltans	36%	100%
A0A1X0NKA4	Trypanosomatidae	45%	100%
A0A3S7XB21	Leishmania donovani	79%	100%
A4ICJ3	Leishmania infantum	79%	100%
D0A3G4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AT63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q1D4	Leishmania major	76%	99%