LeishMANIAdb
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DUF2203 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF2203 family protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HPF1_LEIBR
TriTrypDb:
LbrM.35.3070
Length:
92

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPF1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPF1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 53 59 PF00089 0.394
CLV_PCSK_KEX2_1 55 57 PF00082 0.486
CLV_PCSK_PC1ET2_1 55 57 PF00082 0.640
DOC_USP7_UBL2_3 55 59 PF12436 0.686
LIG_BIR_II_1 1 5 PF00653 0.534
LIG_FHA_1 41 47 PF00498 0.495
LIG_FHA_1 71 77 PF00498 0.634
LIG_FHA_2 1 7 PF00498 0.524
MOD_GSK3_1 60 67 PF00069 0.597
MOD_PKA_2 60 66 PF00069 0.735
MOD_Plk_2-3 42 48 PF00069 0.352

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I666 Leptomonas seymouri 48% 98%
A0A3Q8IG76 Leishmania donovani 87% 100%
A4ICJ2 Leishmania infantum 87% 100%
D0A3G0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 97%
E9AT62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%
Q4Q1D5 Leishmania major 83% 100%
V5BFS6 Trypanosoma cruzi 38% 99%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS