Putative pre-mRNA splicing factor ATP-dependent RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-mRNA splicing factor ATP-dependent RNA helicase, putative

Species:

Leishmania braziliensis

UniProt:

A4HPE9_LEIBR

TriTrypDb:

LbrM.35.3050 , LBRM2903_350039000

Length:

1080

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HPE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPE9

Function

Biological processes
Term	Name	Level	Count
GO:0000390	spliceosomal complex disassembly	7	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022411	cellular component disassembly	4	1
GO:0032984	protein-containing complex disassembly	5	1
GO:0032988	ribonucleoprotein complex disassembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016787	hydrolase activity	2	11
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	46	50	PF00656	0.498
CLV_C14_Caspase3-7	77	81	PF00656	0.696
CLV_C14_Caspase3-7	882	886	PF00656	0.410
CLV_C14_Caspase3-7	96	100	PF00656	0.313
CLV_NRD_NRD_1	183	185	PF00675	0.560
CLV_NRD_NRD_1	251	253	PF00675	0.592
CLV_NRD_NRD_1	308	310	PF00675	0.510
CLV_NRD_NRD_1	312	314	PF00675	0.503
CLV_NRD_NRD_1	395	397	PF00675	0.635
CLV_NRD_NRD_1	470	472	PF00675	0.210
CLV_NRD_NRD_1	556	558	PF00675	0.280
CLV_NRD_NRD_1	652	654	PF00675	0.331
CLV_NRD_NRD_1	687	689	PF00675	0.210
CLV_NRD_NRD_1	888	890	PF00675	0.312
CLV_NRD_NRD_1	944	946	PF00675	0.517
CLV_NRD_NRD_1	960	962	PF00675	0.212
CLV_NRD_NRD_1	974	976	PF00675	0.302
CLV_NRD_NRD_1	989	991	PF00675	0.165
CLV_PCSK_KEX2_1	1017	1019	PF00082	0.312
CLV_PCSK_KEX2_1	150	152	PF00082	0.496
CLV_PCSK_KEX2_1	251	253	PF00082	0.592
CLV_PCSK_KEX2_1	308	310	PF00082	0.551
CLV_PCSK_KEX2_1	470	472	PF00082	0.227
CLV_PCSK_KEX2_1	652	654	PF00082	0.264
CLV_PCSK_KEX2_1	870	872	PF00082	0.221
CLV_PCSK_KEX2_1	888	890	PF00082	0.210
CLV_PCSK_KEX2_1	944	946	PF00082	0.446
CLV_PCSK_KEX2_1	974	976	PF00082	0.277
CLV_PCSK_KEX2_1	989	991	PF00082	0.210
CLV_PCSK_PC1ET2_1	1017	1019	PF00082	0.312
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.595
CLV_PCSK_PC1ET2_1	870	872	PF00082	0.221
CLV_PCSK_SKI1_1	1006	1010	PF00082	0.221
CLV_PCSK_SKI1_1	28	32	PF00082	0.501
CLV_PCSK_SKI1_1	337	341	PF00082	0.604
CLV_PCSK_SKI1_1	422	426	PF00082	0.477
CLV_PCSK_SKI1_1	500	504	PF00082	0.215
CLV_PCSK_SKI1_1	510	514	PF00082	0.201
CLV_PCSK_SKI1_1	519	523	PF00082	0.163
CLV_PCSK_SKI1_1	553	557	PF00082	0.221
CLV_PCSK_SKI1_1	609	613	PF00082	0.458
CLV_PCSK_SKI1_1	689	693	PF00082	0.210
CLV_PCSK_SKI1_1	761	765	PF00082	0.405
CLV_PCSK_SKI1_1	845	849	PF00082	0.210
CLV_PCSK_SKI1_1	871	875	PF00082	0.210
CLV_PCSK_SKI1_1	939	943	PF00082	0.488
CLV_PCSK_SKI1_1	962	966	PF00082	0.211
CLV_Separin_Metazoa	649	653	PF03568	0.512
DEG_APCC_DBOX_1	608	616	PF00400	0.451
DEG_APCC_DBOX_1	776	784	PF00400	0.329
DEG_APCC_DBOX_1	934	942	PF00400	0.357
DEG_Nend_UBRbox_3	1	3	PF02207	0.716
DEG_SCF_FBW7_1	826	832	PF00400	0.512
DOC_CKS1_1	655	660	PF01111	0.512
DOC_CKS1_1	826	831	PF01111	0.421
DOC_CYCLIN_RxL_1	842	852	PF00134	0.410
DOC_MAPK_gen_1	184	190	PF00069	0.538
DOC_MAPK_gen_1	421	428	PF00069	0.441
DOC_PP4_FxxP_1	400	403	PF00568	0.665
DOC_PP4_FxxP_1	874	877	PF00568	0.410
DOC_PP4_FxxP_1	891	894	PF00568	0.318
DOC_USP7_MATH_1	114	118	PF00917	0.493
DOC_USP7_MATH_1	139	143	PF00917	0.582
DOC_USP7_MATH_1	149	153	PF00917	0.596
DOC_USP7_MATH_1	258	262	PF00917	0.575
DOC_USP7_MATH_1	697	701	PF00917	0.410
DOC_USP7_MATH_1	807	811	PF00917	0.443
DOC_USP7_MATH_1	829	833	PF00917	0.461
DOC_USP7_MATH_1	841	845	PF00917	0.378
DOC_USP7_MATH_2	672	678	PF00917	0.435
DOC_USP7_UBL2_3	185	189	PF12436	0.679
DOC_WW_Pin1_4	1055	1060	PF00397	0.585
DOC_WW_Pin1_4	188	193	PF00397	0.641
DOC_WW_Pin1_4	266	271	PF00397	0.488
DOC_WW_Pin1_4	654	659	PF00397	0.512
DOC_WW_Pin1_4	680	685	PF00397	0.410
DOC_WW_Pin1_4	825	830	PF00397	0.421
LIG_14-3-3_CanoR_1	413	417	PF00244	0.370
LIG_14-3-3_CanoR_1	529	533	PF00244	0.410
LIG_14-3-3_CanoR_1	541	551	PF00244	0.410
LIG_14-3-3_CanoR_1	652	658	PF00244	0.466
LIG_14-3-3_CanoR_1	756	763	PF00244	0.354
LIG_14-3-3_CanoR_1	777	781	PF00244	0.458
LIG_14-3-3_CanoR_1	961	970	PF00244	0.410
LIG_14-3-3_CanoR_1	981	987	PF00244	0.440
LIG_Actin_WH2_2	505	521	PF00022	0.410
LIG_APCC_ABBAyCdc20_2	1006	1012	PF00400	0.410
LIG_BRCT_BRCA1_1	582	586	PF00533	0.478
LIG_BRCT_BRCA1_1	676	680	PF00533	0.421
LIG_Clathr_ClatBox_1	1024	1028	PF01394	0.435
LIG_Clathr_ClatBox_1	794	798	PF01394	0.342
LIG_deltaCOP1_diTrp_1	915	922	PF00928	0.346
LIG_EH1_1	431	439	PF00400	0.262
LIG_FHA_1	1020	1026	PF00498	0.512
LIG_FHA_1	1056	1062	PF00498	0.577
LIG_FHA_1	286	292	PF00498	0.426
LIG_FHA_1	433	439	PF00498	0.431
LIG_FHA_1	444	450	PF00498	0.421
LIG_FHA_1	501	507	PF00498	0.413
LIG_FHA_1	543	549	PF00498	0.410
LIG_FHA_1	590	596	PF00498	0.380
LIG_FHA_1	603	609	PF00498	0.344
LIG_FHA_1	763	769	PF00498	0.439
LIG_FHA_1	782	788	PF00498	0.435
LIG_FHA_2	1	7	PF00498	0.455
LIG_FHA_2	1014	1020	PF00498	0.410
LIG_FHA_2	316	322	PF00498	0.430
LIG_FHA_2	368	374	PF00498	0.585
LIG_FHA_2	406	412	PF00498	0.501
LIG_FHA_2	42	48	PF00498	0.597
LIG_FHA_2	630	636	PF00498	0.410
LIG_FHA_2	769	775	PF00498	0.357
LIG_FHA_2	847	853	PF00498	0.410
LIG_FHA_2	953	959	PF00498	0.591
LIG_FHA_2	983	989	PF00498	0.415
LIG_HCF-1_HBM_1	455	458	PF13415	0.421
LIG_LIR_Apic_2	991	996	PF02991	0.421
LIG_LIR_Gen_1	29	39	PF02991	0.488
LIG_LIR_Gen_1	546	556	PF02991	0.421
LIG_LIR_Gen_1	980	988	PF02991	0.415
LIG_LIR_Nem_3	1055	1060	PF02991	0.585
LIG_LIR_Nem_3	29	35	PF02991	0.390
LIG_LIR_Nem_3	496	502	PF02991	0.421
LIG_LIR_Nem_3	524	530	PF02991	0.432
LIG_LIR_Nem_3	546	552	PF02991	0.410
LIG_LIR_Nem_3	573	579	PF02991	0.332
LIG_LIR_Nem_3	704	710	PF02991	0.426
LIG_LIR_Nem_3	980	986	PF02991	0.415
LIG_NRP_CendR_1	1077	1080	PF00754	0.553
LIG_PCNA_PIPBox_1	115	124	PF02747	0.443
LIG_Pex14_2	576	580	PF04695	0.310
LIG_PTB_Apo_2	239	246	PF02174	0.586
LIG_PTB_Apo_2	702	709	PF02174	0.410
LIG_PTB_Phospho_1	702	708	PF10480	0.435
LIG_Rb_LxCxE_1	56	77	PF01857	0.503
LIG_Rb_LxCxE_1	849	864	PF01857	0.512
LIG_SH2_CRK	1040	1044	PF00017	0.381
LIG_SH2_CRK	122	126	PF00017	0.475
LIG_SH2_CRK	255	259	PF00017	0.497
LIG_SH2_CRK	530	534	PF00017	0.410
LIG_SH2_PTP2	983	986	PF00017	0.435
LIG_SH2_PTP2	993	996	PF00017	0.383
LIG_SH2_SRC	817	820	PF00017	0.410
LIG_SH2_SRC	993	996	PF00017	0.421
LIG_SH2_STAP1	495	499	PF00017	0.410
LIG_SH2_STAP1	530	534	PF00017	0.410
LIG_SH2_STAP1	905	909	PF00017	0.328
LIG_SH2_STAT3	161	164	PF00017	0.581
LIG_SH2_STAT3	357	360	PF00017	0.572
LIG_SH2_STAT5	1007	1010	PF00017	0.418
LIG_SH2_STAT5	26	29	PF00017	0.424
LIG_SH2_STAT5	452	455	PF00017	0.428
LIG_SH2_STAT5	495	498	PF00017	0.417
LIG_SH2_STAT5	51	54	PF00017	0.513
LIG_SH2_STAT5	579	582	PF00017	0.321
LIG_SH2_STAT5	599	602	PF00017	0.221
LIG_SH2_STAT5	607	610	PF00017	0.300
LIG_SH2_STAT5	62	65	PF00017	0.473
LIG_SH2_STAT5	708	711	PF00017	0.419
LIG_SH2_STAT5	758	761	PF00017	0.340
LIG_SH2_STAT5	817	820	PF00017	0.410
LIG_SH2_STAT5	968	971	PF00017	0.444
LIG_SH2_STAT5	983	986	PF00017	0.401
LIG_SH2_STAT5	993	996	PF00017	0.426
LIG_SH3_3	108	114	PF00018	0.638
LIG_SH3_3	652	658	PF00018	0.480
LIG_SH3_5	603	607	PF00018	0.353
LIG_SUMO_SIM_anti_2	531	537	PF11976	0.423
LIG_SUMO_SIM_anti_2	661	666	PF11976	0.477
LIG_SUMO_SIM_anti_2	897	903	PF11976	0.410
LIG_SUMO_SIM_par_1	1022	1028	PF11976	0.423
LIG_SUMO_SIM_par_1	434	441	PF11976	0.438
LIG_SUMO_SIM_par_1	531	537	PF11976	0.410
LIG_SUMO_SIM_par_1	856	864	PF11976	0.431
LIG_TRAF2_1	107	110	PF00917	0.715
LIG_TRAF2_1	152	155	PF00917	0.608
LIG_TRAF2_1	191	194	PF00917	0.626
LIG_TRAF2_1	318	321	PF00917	0.410
LIG_TRAF2_1	408	411	PF00917	0.553
LIG_TRAF2_1	43	46	PF00917	0.628
LIG_TRAF2_1	632	635	PF00917	0.410
LIG_TYR_ITIM	1008	1013	PF00017	0.262
LIG_UBA3_1	1024	1030	PF00899	0.445
LIG_WW_1	1004	1007	PF00397	0.281
MOD_CDK_SPxxK_3	1055	1062	PF00069	0.576
MOD_CDK_SPxxK_3	266	273	PF00069	0.484
MOD_CK1_1	1063	1069	PF00069	0.433
MOD_CK1_1	176	182	PF00069	0.571
MOD_CK1_1	443	449	PF00069	0.278
MOD_CK1_1	504	510	PF00069	0.247
MOD_CK1_1	542	548	PF00069	0.247
MOD_CK1_1	982	988	PF00069	0.390
MOD_CK2_1	1013	1019	PF00069	0.260
MOD_CK2_1	149	155	PF00069	0.606
MOD_CK2_1	177	183	PF00069	0.674
MOD_CK2_1	188	194	PF00069	0.637
MOD_CK2_1	315	321	PF00069	0.587
MOD_CK2_1	340	346	PF00069	0.453
MOD_CK2_1	367	373	PF00069	0.604
MOD_CK2_1	405	411	PF00069	0.509
MOD_CK2_1	41	47	PF00069	0.580
MOD_CK2_1	61	67	PF00069	0.260
MOD_CK2_1	629	635	PF00069	0.247
MOD_CK2_1	807	813	PF00069	0.447
MOD_Cter_Amidation	394	397	PF01082	0.624
MOD_GlcNHglycan	151	154	PF01048	0.534
MOD_GlcNHglycan	169	172	PF01048	0.596
MOD_GlcNHglycan	203	206	PF01048	0.524
MOD_GlcNHglycan	442	445	PF01048	0.247
MOD_GlcNHglycan	567	570	PF01048	0.247
MOD_GlcNHglycan	711	714	PF01048	0.277
MOD_GlcNHglycan	742	745	PF01048	0.341
MOD_GlcNHglycan	809	812	PF01048	0.380
MOD_GSK3_1	1066	1073	PF00069	0.434
MOD_GSK3_1	167	174	PF00069	0.724
MOD_GSK3_1	286	293	PF00069	0.622
MOD_GSK3_1	315	322	PF00069	0.497
MOD_GSK3_1	351	358	PF00069	0.711
MOD_GSK3_1	359	366	PF00069	0.672
MOD_GSK3_1	41	48	PF00069	0.596
MOD_GSK3_1	440	447	PF00069	0.294
MOD_GSK3_1	500	507	PF00069	0.252
MOD_GSK3_1	594	601	PF00069	0.495
MOD_GSK3_1	607	614	PF00069	0.348
MOD_GSK3_1	697	704	PF00069	0.245
MOD_GSK3_1	825	832	PF00069	0.322
MOD_GSK3_1	835	842	PF00069	0.216
MOD_GSK3_1	911	918	PF00069	0.494
MOD_GSK3_1	975	982	PF00069	0.390
MOD_LATS_1	539	545	PF00433	0.323
MOD_N-GLC_1	14	19	PF02516	0.580
MOD_N-GLC_1	952	957	PF02516	0.499
MOD_NEK2_1	1013	1018	PF00069	0.296
MOD_NEK2_1	177	182	PF00069	0.676
MOD_NEK2_1	243	248	PF00069	0.584
MOD_NEK2_1	340	345	PF00069	0.440
MOD_NEK2_1	390	395	PF00069	0.469
MOD_NEK2_1	523	528	PF00069	0.273
MOD_NEK2_1	565	570	PF00069	0.390
MOD_NEK2_1	667	672	PF00069	0.266
MOD_NEK2_1	776	781	PF00069	0.481
MOD_NEK2_2	329	334	PF00069	0.442
MOD_PIKK_1	258	264	PF00454	0.617
MOD_PIKK_1	315	321	PF00454	0.695
MOD_PIKK_1	356	362	PF00454	0.497
MOD_PIKK_1	41	47	PF00454	0.614
MOD_PIKK_1	444	450	PF00454	0.247
MOD_PIKK_1	464	470	PF00454	0.118
MOD_PIKK_1	732	738	PF00454	0.247
MOD_PIKK_1	839	845	PF00454	0.262
MOD_PKA_2	1013	1019	PF00069	0.390
MOD_PKA_2	1046	1052	PF00069	0.566
MOD_PKA_2	1070	1076	PF00069	0.448
MOD_PKA_2	412	418	PF00069	0.348
MOD_PKA_2	528	534	PF00069	0.247
MOD_PKA_2	776	782	PF00069	0.464
MOD_PKA_2	931	937	PF00069	0.345
MOD_PKA_2	960	966	PF00069	0.323
MOD_PKB_1	498	506	PF00069	0.262
MOD_Plk_1	14	20	PF00069	0.454
MOD_Plk_1	154	160	PF00069	0.516
MOD_Plk_1	335	341	PF00069	0.606
MOD_Plk_1	523	529	PF00069	0.247
MOD_Plk_1	539	545	PF00069	0.247
MOD_Plk_1	697	703	PF00069	0.247
MOD_Plk_2-3	127	133	PF00069	0.332
MOD_Plk_2-3	335	341	PF00069	0.606
MOD_Plk_2-3	367	373	PF00069	0.644
MOD_Plk_4	139	145	PF00069	0.614
MOD_Plk_4	14	20	PF00069	0.536
MOD_Plk_4	244	250	PF00069	0.609
MOD_Plk_4	359	365	PF00069	0.624
MOD_Plk_4	432	438	PF00069	0.271
MOD_Plk_4	528	534	PF00069	0.247
MOD_Plk_4	594	600	PF00069	0.467
MOD_Plk_4	611	617	PF00069	0.247
MOD_Plk_4	776	782	PF00069	0.464
MOD_Plk_4	843	849	PF00069	0.247
MOD_Plk_4	858	864	PF00069	0.247
MOD_Plk_4	897	903	PF00069	0.343
MOD_Plk_4	995	1001	PF00069	0.390
MOD_ProDKin_1	1055	1061	PF00069	0.580
MOD_ProDKin_1	188	194	PF00069	0.637
MOD_ProDKin_1	266	272	PF00069	0.487
MOD_ProDKin_1	654	660	PF00069	0.390
MOD_ProDKin_1	680	686	PF00069	0.247
MOD_ProDKin_1	825	831	PF00069	0.262
MOD_SUMO_for_1	420	423	PF00179	0.432
MOD_SUMO_rev_2	1023	1032	PF00179	0.390
MOD_SUMO_rev_2	142	152	PF00179	0.597
MOD_SUMO_rev_2	180	187	PF00179	0.627
TRG_DiLeu_BaEn_1	1028	1033	PF01217	0.262
TRG_DiLeu_BaEn_2	234	240	PF01217	0.518
TRG_DiLeu_BaEn_4	154	160	PF01217	0.625
TRG_DiLeu_BaEn_4	193	199	PF01217	0.476
TRG_DiLeu_BaEn_4	235	241	PF01217	0.476
TRG_ENDOCYTIC_2	1010	1013	PF00928	0.249
TRG_ENDOCYTIC_2	122	125	PF00928	0.432
TRG_ENDOCYTIC_2	32	35	PF00928	0.394
TRG_ENDOCYTIC_2	530	533	PF00928	0.247
TRG_ENDOCYTIC_2	707	710	PF00928	0.281
TRG_ENDOCYTIC_2	983	986	PF00928	0.247
TRG_ER_diArg_1	251	253	PF00400	0.562
TRG_ER_diArg_1	308	310	PF00400	0.517
TRG_ER_diArg_1	469	471	PF00400	0.247
TRG_ER_diArg_1	651	653	PF00400	0.323
TRG_ER_diArg_1	875	878	PF00400	0.247
TRG_ER_diArg_1	974	976	PF00400	0.307
TRG_ER_diLys_1	1076	1080	PF00400	0.595
TRG_NES_CRM1_1	119	135	PF08389	0.313
TRG_NES_CRM1_1	774	786	PF08389	0.453
TRG_NLS_MonoCore_2	395	400	PF00514	0.611
TRG_NLS_MonoExtC_3	1075	1080	PF00514	0.588
TRG_NLS_MonoExtN_4	1074	1080	PF00514	0.583
TRG_Pf-PMV_PEXEL_1	1030	1034	PF00026	0.341
TRG_Pf-PMV_PEXEL_1	350	355	PF00026	0.695
TRG_Pf-PMV_PEXEL_1	926	930	PF00026	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Y1	Leptomonas seymouri	34%	100%
A0A0N1I0Z0	Leptomonas seymouri	83%	99%
A0A0N1PEU4	Leptomonas seymouri	35%	100%
A0A0S4JCY8	Bodo saltans	55%	100%
A0A1X0NKY7	Trypanosomatidae	60%	100%
A0A3Q8II71	Leishmania donovani	34%	100%
A0A3Q8IJ24	Leishmania donovani	35%	100%
A0A3S7XB01	Leishmania donovani	95%	99%
A0A422MXB1	Trypanosoma rangeli	61%	100%
A4HAT8	Leishmania braziliensis	34%	100%
A4HNU7	Leishmania braziliensis	35%	100%
A4IA06	Leishmania infantum	33%	100%
A4ICJ0	Leishmania infantum	95%	99%
A4ICP7	Leishmania infantum	35%	100%
B4JT42	Drosophila grimshawi	28%	75%
D0A3F8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9ASK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AT60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	99%
E9B512	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
O60114	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	76%
Q09530	Caenorhabditis elegans	42%	90%
Q296Q5	Drosophila pseudoobscura pseudoobscura	28%	75%
Q38953	Arabidopsis thaliana	47%	92%
Q4Q1D7	Leishmania major	94%	100%
Q4Q1Y9	Leishmania major	34%	100%
Q4Q2X4	Leishmania major	34%	100%
Q54F05	Dictyostelium discoideum	43%	93%
Q9HDY4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	91%
Q9VF26	Drosophila melanogaster	27%	75%
V5BPV3	Trypanosoma cruzi	62%	100%
V5BV22	Trypanosoma cruzi	37%	100%