G protein-coupled receptor

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPE8_LEIBR

TriTrypDb:

LbrM.35.3040 , LBRM2903_350038900

Length:

598

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HPE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.648
CLV_C14_Caspase3-7	322	326	PF00656	0.696
CLV_NRD_NRD_1	12	14	PF00675	0.374
CLV_NRD_NRD_1	481	483	PF00675	0.518
CLV_NRD_NRD_1	485	487	PF00675	0.523
CLV_NRD_NRD_1	573	575	PF00675	0.438
CLV_PCSK_FUR_1	482	486	PF00082	0.565
CLV_PCSK_KEX2_1	12	14	PF00082	0.414
CLV_PCSK_KEX2_1	320	322	PF00082	0.559
CLV_PCSK_KEX2_1	480	482	PF00082	0.519
CLV_PCSK_KEX2_1	484	486	PF00082	0.526
CLV_PCSK_KEX2_1	573	575	PF00082	0.438
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.466
CLV_PCSK_PC7_1	480	486	PF00082	0.522
CLV_PCSK_SKI1_1	167	171	PF00082	0.550
CLV_PCSK_SKI1_1	247	251	PF00082	0.417
CLV_PCSK_SKI1_1	255	259	PF00082	0.365
CLV_PCSK_SKI1_1	309	313	PF00082	0.435
DEG_APCC_DBOX_1	11	19	PF00400	0.610
DEG_Nend_Nbox_1	1	3	PF02207	0.624
DOC_CKS1_1	5	10	PF01111	0.623
DOC_CYCLIN_RxL_1	10	21	PF00134	0.599
DOC_CYCLIN_RxL_1	252	262	PF00134	0.634
DOC_CYCLIN_yClb5_NLxxxL_5	114	123	PF00134	0.210
DOC_MAPK_FxFP_2	3	6	PF00069	0.581
DOC_MAPK_gen_1	130	139	PF00069	0.603
DOC_MAPK_gen_1	277	284	PF00069	0.542
DOC_MAPK_MEF2A_6	133	141	PF00069	0.607
DOC_PIKK_1	586	593	PF02985	0.749
DOC_PP1_RVXF_1	11	18	PF00149	0.601
DOC_PP4_FxxP_1	3	6	PF00568	0.607
DOC_PP4_FxxP_1	370	373	PF00568	0.715
DOC_USP7_MATH_1	243	247	PF00917	0.651
DOC_USP7_MATH_1	436	440	PF00917	0.617
DOC_USP7_MATH_1	464	468	PF00917	0.624
DOC_USP7_UBL2_3	255	259	PF12436	0.635
DOC_USP7_UBL2_3	277	281	PF12436	0.653
DOC_WW_Pin1_4	4	9	PF00397	0.587
DOC_WW_Pin1_4	444	449	PF00397	0.750
DOC_WW_Pin1_4	499	504	PF00397	0.636
DOC_WW_Pin1_4	524	529	PF00397	0.718
LIG_14-3-3_CanoR_1	12	16	PF00244	0.520
LIG_14-3-3_CanoR_1	283	289	PF00244	0.683
LIG_14-3-3_CanoR_1	44	50	PF00244	0.315
LIG_AP2alpha_1	374	378	PF02296	0.712
LIG_BRCT_BRCA1_1	38	42	PF00533	0.254
LIG_BRCT_BRCA1_1	593	597	PF00533	0.663
LIG_CaM_NSCaTE_8	337	344	PF13499	0.578
LIG_Clathr_ClatBox_1	65	69	PF01394	0.346
LIG_CSL_BTD_1	445	448	PF09270	0.749
LIG_EH1_1	141	149	PF00400	0.521
LIG_eIF4E_1	53	59	PF01652	0.409
LIG_eIF4E_1	73	79	PF01652	0.223
LIG_FHA_1	143	149	PF00498	0.320
LIG_FHA_1	83	89	PF00498	0.371
LIG_FHA_2	182	188	PF00498	0.466
LIG_FHA_2	289	295	PF00498	0.591
LIG_FHA_2	320	326	PF00498	0.679
LIG_FHA_2	377	383	PF00498	0.629
LIG_GBD_Chelix_1	115	123	PF00786	0.210
LIG_LIR_Apic_2	367	373	PF02991	0.721
LIG_LIR_Apic_2	523	528	PF02991	0.673
LIG_LIR_Gen_1	111	120	PF02991	0.381
LIG_LIR_Gen_1	183	194	PF02991	0.410
LIG_LIR_Gen_1	195	205	PF02991	0.268
LIG_LIR_Gen_1	293	303	PF02991	0.597
LIG_LIR_Gen_1	313	323	PF02991	0.628
LIG_LIR_Gen_1	39	50	PF02991	0.378
LIG_LIR_Nem_3	111	115	PF02991	0.381
LIG_LIR_Nem_3	16	22	PF02991	0.552
LIG_LIR_Nem_3	183	189	PF02991	0.397
LIG_LIR_Nem_3	192	197	PF02991	0.305
LIG_LIR_Nem_3	198	203	PF02991	0.250
LIG_LIR_Nem_3	293	299	PF02991	0.665
LIG_LIR_Nem_3	313	319	PF02991	0.616
LIG_LIR_Nem_3	367	372	PF02991	0.703
LIG_LIR_Nem_3	39	45	PF02991	0.350
LIG_MLH1_MIPbox_1	38	42	PF16413	0.254
LIG_NRBOX	109	115	PF00104	0.398
LIG_Pex14_1	427	431	PF04695	0.612
LIG_Pex14_2	108	112	PF04695	0.385
LIG_Pex14_2	37	41	PF04695	0.340
LIG_Pex14_2	370	374	PF04695	0.715
LIG_PTB_Apo_2	188	195	PF02174	0.263
LIG_PTB_Apo_2	425	432	PF02174	0.612
LIG_PTB_Apo_2	67	74	PF02174	0.318
LIG_PTB_Phospho_1	67	73	PF10480	0.314
LIG_REV1ctd_RIR_1	39	48	PF16727	0.253
LIG_SH2_GRB2like	426	429	PF00017	0.612
LIG_SH2_GRB2like	531	534	PF00017	0.623
LIG_SH2_NCK_1	23	27	PF00017	0.313
LIG_SH2_PTP2	525	528	PF00017	0.624
LIG_SH2_SRC	462	465	PF00017	0.740
LIG_SH2_STAP1	152	156	PF00017	0.377
LIG_SH2_STAP1	186	190	PF00017	0.466
LIG_SH2_STAT5	103	106	PF00017	0.385
LIG_SH2_STAT5	125	128	PF00017	0.623
LIG_SH2_STAT5	176	179	PF00017	0.282
LIG_SH2_STAT5	205	208	PF00017	0.404
LIG_SH2_STAT5	218	221	PF00017	0.352
LIG_SH2_STAT5	227	230	PF00017	0.651
LIG_SH2_STAT5	23	26	PF00017	0.264
LIG_SH2_STAT5	377	380	PF00017	0.711
LIG_SH2_STAT5	453	456	PF00017	0.630
LIG_SH2_STAT5	525	528	PF00017	0.736
LIG_SH3_1	5	11	PF00018	0.626
LIG_SH3_2	8	13	PF14604	0.622
LIG_SH3_3	134	140	PF00018	0.611
LIG_SH3_3	201	207	PF00018	0.366
LIG_SH3_3	5	11	PF00018	0.559
LIG_SH3_3	500	506	PF00018	0.762
LIG_SH3_4	255	262	PF00018	0.629
LIG_SH3_5	373	377	PF00018	0.711
LIG_Sin3_3	296	303	PF02671	0.654
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.385
LIG_SUMO_SIM_anti_2	220	226	PF11976	0.282
LIG_SUMO_SIM_anti_2	229	239	PF11976	0.490
LIG_SUMO_SIM_anti_2	61	69	PF11976	0.361
LIG_SUMO_SIM_par_1	144	149	PF11976	0.292
LIG_SUMO_SIM_par_1	229	239	PF11976	0.556
LIG_SUMO_SIM_par_1	406	414	PF11976	0.739
LIG_SUMO_SIM_par_1	61	69	PF11976	0.348
LIG_SUMO_SIM_par_1	84	90	PF11976	0.366
LIG_TRAF2_1	291	294	PF00917	0.544
LIG_TRAF2_1	447	450	PF00917	0.694
LIG_TRFH_1	431	435	PF08558	0.705
MOD_CDK_SPK_2	499	504	PF00069	0.636
MOD_CK1_1	21	27	PF00069	0.210
MOD_CK1_1	48	54	PF00069	0.364
MOD_CK1_1	558	564	PF00069	0.637
MOD_CK2_1	181	187	PF00069	0.460
MOD_CK2_1	226	232	PF00069	0.532
MOD_CK2_1	288	294	PF00069	0.661
MOD_CK2_1	356	362	PF00069	0.622
MOD_CK2_1	376	382	PF00069	0.555
MOD_CK2_1	408	414	PF00069	0.777
MOD_CK2_1	444	450	PF00069	0.834
MOD_CK2_1	563	569	PF00069	0.752
MOD_GlcNHglycan	200	203	PF01048	0.514
MOD_GlcNHglycan	219	222	PF01048	0.414
MOD_GlcNHglycan	347	352	PF01048	0.582
MOD_GlcNHglycan	358	361	PF01048	0.480
MOD_GlcNHglycan	437	441	PF01048	0.555
MOD_GlcNHglycan	513	516	PF01048	0.460
MOD_GlcNHglycan	569	572	PF01048	0.431
MOD_GlcNHglycan	89	92	PF01048	0.489
MOD_GSK3_1	142	149	PF00069	0.534
MOD_GSK3_1	284	291	PF00069	0.621
MOD_GSK3_1	464	471	PF00069	0.761
MOD_GSK3_1	563	570	PF00069	0.751
MOD_GSK3_1	69	76	PF00069	0.414
MOD_GSK3_1	82	89	PF00069	0.436
MOD_N-GLC_1	123	128	PF02516	0.365
MOD_N-GLC_1	195	200	PF02516	0.525
MOD_N-GLC_1	251	256	PF02516	0.421
MOD_N-GLC_1	325	330	PF02516	0.471
MOD_N-GLC_1	69	74	PF02516	0.537
MOD_NEK2_1	123	128	PF00069	0.565
MOD_NEK2_1	181	186	PF00069	0.435
MOD_NEK2_1	208	213	PF00069	0.401
MOD_NEK2_1	250	255	PF00069	0.648
MOD_NEK2_1	319	324	PF00069	0.751
MOD_NEK2_1	45	50	PF00069	0.367
MOD_NEK2_1	556	561	PF00069	0.666
MOD_PIKK_1	146	152	PF00454	0.385
MOD_PIKK_1	325	331	PF00454	0.687
MOD_PIKK_1	462	468	PF00454	0.698
MOD_PKA_2	11	17	PF00069	0.527
MOD_PKA_2	181	187	PF00069	0.382
MOD_PKA_2	43	49	PF00069	0.316
MOD_PKA_2	511	517	PF00069	0.633
MOD_PKA_2	567	573	PF00069	0.747
MOD_PKA_2	82	88	PF00069	0.336
MOD_Plk_1	195	201	PF00069	0.278
MOD_Plk_1	325	331	PF00069	0.673
MOD_Plk_1	451	457	PF00069	0.719
MOD_Plk_1	69	75	PF00069	0.410
MOD_Plk_2-3	376	382	PF00069	0.628
MOD_Plk_2-3	408	414	PF00069	0.730
MOD_Plk_2-3	591	597	PF00069	0.738
MOD_Plk_4	18	24	PF00069	0.521
MOD_Plk_4	30	36	PF00069	0.351
MOD_Plk_4	48	54	PF00069	0.315
MOD_Plk_4	521	527	PF00069	0.703
MOD_Plk_4	60	66	PF00069	0.374
MOD_Plk_4	73	79	PF00069	0.319
MOD_ProDKin_1	4	10	PF00069	0.590
MOD_ProDKin_1	444	450	PF00069	0.750
MOD_ProDKin_1	499	505	PF00069	0.637
MOD_ProDKin_1	524	530	PF00069	0.718
TRG_DiLeu_BaEn_1	232	237	PF01217	0.571
TRG_DiLeu_BaEn_1	245	250	PF01217	0.654
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.635
TRG_ENDOCYTIC_2	186	189	PF00928	0.409
TRG_ENDOCYTIC_2	205	208	PF00928	0.237
TRG_ENDOCYTIC_2	95	98	PF00928	0.362
TRG_ER_diArg_1	11	13	PF00400	0.579
TRG_ER_diArg_1	388	391	PF00400	0.624
TRG_ER_diArg_1	480	482	PF00400	0.721
TRG_ER_diArg_1	484	486	PF00400	0.721
TRG_ER_diArg_1	53	56	PF00400	0.279
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7M6	Leptomonas seymouri	57%	99%
A0A3Q8IW35	Leishmania donovani	74%	100%
A4ICI9	Leishmania infantum	74%	100%
D0A3F7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AT59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q1D8	Leishmania major	74%	98%
V5BFT0	Trypanosoma cruzi	37%	100%