Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPE7_LEIBR

TriTrypDb:

LbrM.35.3030 , LBRM2903_350038800

Length:

644

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0020016	ciliary pocket	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPE7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.560
CLV_NRD_NRD_1	307	309	PF00675	0.451
CLV_NRD_NRD_1	563	565	PF00675	0.666
CLV_PCSK_FUR_1	561	565	PF00082	0.553
CLV_PCSK_KEX2_1	255	257	PF00082	0.435
CLV_PCSK_KEX2_1	307	309	PF00082	0.451
CLV_PCSK_KEX2_1	563	565	PF00082	0.666
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.435
CLV_PCSK_SKI1_1	222	226	PF00082	0.400
CLV_PCSK_SKI1_1	285	289	PF00082	0.440
CLV_PCSK_SKI1_1	311	315	PF00082	0.408
CLV_PCSK_SKI1_1	359	363	PF00082	0.553
CLV_PCSK_SKI1_1	594	598	PF00082	0.691
CLV_Separin_Metazoa	219	223	PF03568	0.414
CLV_Separin_Metazoa	328	332	PF03568	0.596
DEG_APCC_DBOX_1	284	292	PF00400	0.438
DEG_Kelch_Keap1_1	545	550	PF01344	0.531
DEG_SCF_FBW7_1	74	79	PF00400	0.517
DEG_SPOP_SBC_1	137	141	PF00917	0.520
DEG_SPOP_SBC_1	247	251	PF00917	0.603
DEG_SPOP_SBC_1	460	464	PF00917	0.450
DEG_SPOP_SBC_1	98	102	PF00917	0.543
DOC_CYCLIN_RxL_1	219	229	PF00134	0.487
DOC_CYCLIN_yCln2_LP_2	217	223	PF00134	0.417
DOC_MAPK_DCC_7	195	204	PF00069	0.439
DOC_MAPK_gen_1	195	204	PF00069	0.446
DOC_MAPK_gen_1	255	261	PF00069	0.435
DOC_MAPK_gen_1	282	291	PF00069	0.434
DOC_MAPK_gen_1	307	315	PF00069	0.506
DOC_MAPK_MEF2A_6	160	167	PF00069	0.441
DOC_MAPK_MEF2A_6	195	204	PF00069	0.435
DOC_MAPK_MEF2A_6	282	291	PF00069	0.434
DOC_MAPK_RevD_3	295	308	PF00069	0.400
DOC_PP1_RVXF_1	201	208	PF00149	0.410
DOC_PP1_RVXF_1	487	493	PF00149	0.497
DOC_PP1_RVXF_1	66	73	PF00149	0.565
DOC_PP2B_LxvP_1	322	325	PF13499	0.448
DOC_PP4_FxxP_1	9	12	PF00568	0.544
DOC_USP7_MATH_1	136	140	PF00917	0.574
DOC_USP7_MATH_1	171	175	PF00917	0.410
DOC_USP7_MATH_1	176	180	PF00917	0.389
DOC_USP7_MATH_1	206	210	PF00917	0.430
DOC_USP7_MATH_1	235	239	PF00917	0.611
DOC_USP7_MATH_1	33	37	PF00917	0.421
DOC_USP7_MATH_1	384	388	PF00917	0.566
DOC_USP7_MATH_1	389	393	PF00917	0.546
DOC_USP7_MATH_1	420	424	PF00917	0.421
DOC_USP7_MATH_1	580	584	PF00917	0.620
DOC_USP7_MATH_1	99	103	PF00917	0.626
DOC_USP7_MATH_2	454	460	PF00917	0.459
DOC_WW_Pin1_4	118	123	PF00397	0.590
DOC_WW_Pin1_4	297	302	PF00397	0.505
DOC_WW_Pin1_4	354	359	PF00397	0.607
DOC_WW_Pin1_4	370	375	PF00397	0.641
DOC_WW_Pin1_4	427	432	PF00397	0.554
DOC_WW_Pin1_4	567	572	PF00397	0.623
DOC_WW_Pin1_4	576	581	PF00397	0.703
DOC_WW_Pin1_4	616	621	PF00397	0.567
DOC_WW_Pin1_4	72	77	PF00397	0.541
LIG_14-3-3_CanoR_1	222	228	PF00244	0.425
LIG_14-3-3_CanoR_1	347	354	PF00244	0.581
LIG_14-3-3_CanoR_1	537	542	PF00244	0.523
LIG_14-3-3_CanoR_1	563	571	PF00244	0.668
LIG_14-3-3_CanoR_1	594	600	PF00244	0.639
LIG_14-3-3_CanoR_1	632	636	PF00244	0.555
LIG_Actin_WH2_2	277	294	PF00022	0.359
LIG_BRCT_BRCA1_1	470	474	PF00533	0.481
LIG_Clathr_ClatBox_1	184	188	PF01394	0.504
LIG_deltaCOP1_diTrp_1	601	605	PF00928	0.630
LIG_eIF4E_1	283	289	PF01652	0.429
LIG_EVH1_1	149	153	PF00568	0.543
LIG_FHA_1	194	200	PF00498	0.461
LIG_FHA_1	242	248	PF00498	0.504
LIG_FHA_1	271	277	PF00498	0.433
LIG_FHA_1	301	307	PF00498	0.441
LIG_FHA_1	347	353	PF00498	0.481
LIG_FHA_1	42	48	PF00498	0.512
LIG_FHA_1	55	61	PF00498	0.663
LIG_FHA_1	617	623	PF00498	0.565
LIG_FHA_2	111	117	PF00498	0.668
LIG_FHA_2	261	267	PF00498	0.551
LIG_FHA_2	360	366	PF00498	0.712
LIG_FHA_2	371	377	PF00498	0.588
LIG_FHA_2	417	423	PF00498	0.488
LIG_FHA_2	471	477	PF00498	0.479
LIG_FHA_2	580	586	PF00498	0.532
LIG_FHA_2	76	82	PF00498	0.452
LIG_LIR_Gen_1	344	353	PF02991	0.495
LIG_LIR_Gen_1	422	431	PF02991	0.473
LIG_LIR_Gen_1	585	596	PF02991	0.682
LIG_LIR_Nem_3	344	348	PF02991	0.558
LIG_LIR_Nem_3	422	427	PF02991	0.480
LIG_LIR_Nem_3	476	481	PF02991	0.468
LIG_LIR_Nem_3	582	587	PF02991	0.662
LIG_LIR_Nem_3	623	627	PF02991	0.559
LIG_NRBOX	180	186	PF00104	0.471
LIG_NRBOX	283	289	PF00104	0.429
LIG_PCNA_yPIPBox_3	178	191	PF02747	0.486
LIG_Pex14_2	9	13	PF04695	0.550
LIG_PTB_Apo_2	251	258	PF02174	0.445
LIG_SH2_CRK	213	217	PF00017	0.496
LIG_SH2_CRK	32	36	PF00017	0.460
LIG_SH2_CRK	345	349	PF00017	0.543
LIG_SH2_CRK	478	482	PF00017	0.520
LIG_SH2_CRK	487	491	PF00017	0.585
LIG_SH2_NCK_1	32	36	PF00017	0.460
LIG_SH2_NCK_1	345	349	PF00017	0.603
LIG_SH2_STAP1	213	217	PF00017	0.496
LIG_SH2_STAP1	584	588	PF00017	0.516
LIG_SH2_STAT5	230	233	PF00017	0.490
LIG_SH2_STAT5	283	286	PF00017	0.434
LIG_SH2_STAT5	345	348	PF00017	0.496
LIG_SH2_STAT5	587	590	PF00017	0.625
LIG_SH2_STAT5	69	72	PF00017	0.484
LIG_SH3_3	116	122	PF00018	0.514
LIG_SH3_3	147	153	PF00018	0.582
LIG_SH3_3	194	200	PF00018	0.472
LIG_SH3_3	425	431	PF00018	0.468
LIG_SH3_3	61	67	PF00018	0.570
LIG_SH3_5	620	624	PF00018	0.475
LIG_SUMO_SIM_anti_2	44	52	PF11976	0.543
LIG_SUMO_SIM_par_1	272	279	PF11976	0.380
LIG_SUMO_SIM_par_1	44	52	PF11976	0.543
LIG_SUMO_SIM_par_1	612	619	PF11976	0.744
LIG_TRAF2_1	325	328	PF00917	0.557
LIG_TYR_ITIM	622	627	PF00017	0.548
LIG_UBA3_1	59	68	PF00899	0.548
LIG_WRC_WIRS_1	421	426	PF05994	0.483
LIG_WW_3	151	155	PF00397	0.534
MOD_CDK_SPK_2	354	359	PF00069	0.534
MOD_CDK_SPK_2	72	77	PF00069	0.541
MOD_CK1_1	102	108	PF00069	0.619
MOD_CK1_1	118	124	PF00069	0.751
MOD_CK1_1	300	306	PF00069	0.394
MOD_CK1_1	372	378	PF00069	0.657
MOD_CK1_1	414	420	PF00069	0.601
MOD_CK1_1	459	465	PF00069	0.612
MOD_CK1_1	468	474	PF00069	0.550
MOD_CK1_1	529	535	PF00069	0.632
MOD_CK1_1	545	551	PF00069	0.675
MOD_CK1_1	567	573	PF00069	0.679
MOD_CK1_1	579	585	PF00069	0.755
MOD_CK2_1	109	115	PF00069	0.737
MOD_CK2_1	266	272	PF00069	0.457
MOD_CK2_1	359	365	PF00069	0.706
MOD_CK2_1	370	376	PF00069	0.589
MOD_CK2_1	416	422	PF00069	0.464
MOD_CK2_1	579	585	PF00069	0.565
MOD_CK2_1	595	601	PF00069	0.597
MOD_CK2_1	75	81	PF00069	0.513
MOD_Cter_Amidation	561	564	PF01082	0.557
MOD_DYRK1A_RPxSP_1	576	580	PF00069	0.542
MOD_GlcNHglycan	101	104	PF01048	0.693
MOD_GlcNHglycan	140	143	PF01048	0.659
MOD_GlcNHglycan	172	176	PF01048	0.605
MOD_GlcNHglycan	178	181	PF01048	0.406
MOD_GlcNHglycan	237	240	PF01048	0.556
MOD_GlcNHglycan	338	341	PF01048	0.484
MOD_GlcNHglycan	391	394	PF01048	0.552
MOD_GlcNHglycan	413	416	PF01048	0.694
MOD_GlcNHglycan	458	461	PF01048	0.593
MOD_GlcNHglycan	467	470	PF01048	0.558
MOD_GlcNHglycan	51	54	PF01048	0.687
MOD_GlcNHglycan	532	535	PF01048	0.601
MOD_GlcNHglycan	547	550	PF01048	0.615
MOD_GlcNHglycan	638	641	PF01048	0.592
MOD_GSK3_1	136	143	PF00069	0.529
MOD_GSK3_1	225	232	PF00069	0.456
MOD_GSK3_1	243	250	PF00069	0.528
MOD_GSK3_1	262	269	PF00069	0.513
MOD_GSK3_1	270	277	PF00069	0.414
MOD_GSK3_1	343	350	PF00069	0.608
MOD_GSK3_1	370	377	PF00069	0.650
MOD_GSK3_1	402	409	PF00069	0.695
MOD_GSK3_1	411	418	PF00069	0.576
MOD_GSK3_1	452	459	PF00069	0.576
MOD_GSK3_1	461	468	PF00069	0.565
MOD_GSK3_1	470	477	PF00069	0.482
MOD_GSK3_1	525	532	PF00069	0.650
MOD_GSK3_1	54	61	PF00069	0.606
MOD_GSK3_1	576	583	PF00069	0.565
MOD_GSK3_1	72	79	PF00069	0.482
MOD_GSK3_1	98	105	PF00069	0.621
MOD_N-GLC_1	537	542	PF02516	0.641
MOD_NEK2_1	109	114	PF00069	0.514
MOD_NEK2_1	225	230	PF00069	0.432
MOD_NEK2_1	248	253	PF00069	0.492
MOD_NEK2_1	270	275	PF00069	0.476
MOD_NEK2_1	276	281	PF00069	0.473
MOD_NEK2_1	291	296	PF00069	0.387
MOD_NEK2_1	329	334	PF00069	0.606
MOD_NEK2_1	341	346	PF00069	0.501
MOD_NEK2_1	465	470	PF00069	0.678
MOD_NEK2_1	474	479	PF00069	0.516
MOD_NEK2_1	49	54	PF00069	0.652
MOD_NEK2_1	526	531	PF00069	0.643
MOD_NEK2_1	565	570	PF00069	0.673
MOD_NEK2_1	59	64	PF00069	0.573
MOD_NEK2_1	631	636	PF00069	0.733
MOD_NEK2_1	92	97	PF00069	0.645
MOD_NEK2_2	505	510	PF00069	0.599
MOD_PIKK_1	140	146	PF00454	0.755
MOD_PK_1	537	543	PF00069	0.526
MOD_PKA_2	1	7	PF00069	0.557
MOD_PKA_2	153	159	PF00069	0.786
MOD_PKA_2	291	297	PF00069	0.478
MOD_PKA_2	346	352	PF00069	0.659
MOD_PKA_2	565	571	PF00069	0.647
MOD_PKA_2	631	637	PF00069	0.554
MOD_Plk_1	115	121	PF00069	0.598
MOD_Plk_1	526	532	PF00069	0.789
MOD_Plk_1	537	543	PF00069	0.627
MOD_Plk_2-3	266	272	PF00069	0.457
MOD_Plk_2-3	402	408	PF00069	0.571
MOD_Plk_4	1	7	PF00069	0.557
MOD_Plk_4	115	121	PF00069	0.564
MOD_Plk_4	226	232	PF00069	0.457
MOD_Plk_4	243	249	PF00069	0.549
MOD_Plk_4	266	272	PF00069	0.471
MOD_Plk_4	276	282	PF00069	0.462
MOD_Plk_4	311	317	PF00069	0.429
MOD_Plk_4	470	476	PF00069	0.546
MOD_Plk_4	526	532	PF00069	0.629
MOD_Plk_4	631	637	PF00069	0.554
MOD_ProDKin_1	118	124	PF00069	0.592
MOD_ProDKin_1	297	303	PF00069	0.508
MOD_ProDKin_1	354	360	PF00069	0.608
MOD_ProDKin_1	370	376	PF00069	0.642
MOD_ProDKin_1	427	433	PF00069	0.558
MOD_ProDKin_1	567	573	PF00069	0.623
MOD_ProDKin_1	576	582	PF00069	0.703
MOD_ProDKin_1	616	622	PF00069	0.566
MOD_ProDKin_1	72	78	PF00069	0.530
TRG_ENDOCYTIC_2	213	216	PF00928	0.505
TRG_ENDOCYTIC_2	32	35	PF00928	0.452
TRG_ENDOCYTIC_2	345	348	PF00928	0.569
TRG_ENDOCYTIC_2	478	481	PF00928	0.543
TRG_ENDOCYTIC_2	487	490	PF00928	0.580
TRG_ENDOCYTIC_2	624	627	PF00928	0.545
TRG_ENDOCYTIC_2	69	72	PF00928	0.614
TRG_ER_diArg_1	306	308	PF00400	0.469
TRG_ER_diArg_1	330	333	PF00400	0.530
TRG_ER_diArg_1	561	564	PF00400	0.677
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9B6	Leptomonas seymouri	54%	98%
A0A3Q8IJG0	Leishmania donovani	77%	100%
A4ICI8	Leishmania infantum	77%	100%
E9AT58	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q1D9	Leishmania major	77%	100%