Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPE6_LEIBR

TriTrypDb:

LbrM.35.3020 , LBRM2903_350038600 , LBRM2903_350038700

Length:

874

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPE6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.601
CLV_C14_Caspase3-7	177	181	PF00656	0.660
CLV_C14_Caspase3-7	352	356	PF00656	0.660
CLV_NRD_NRD_1	116	118	PF00675	0.555
CLV_NRD_NRD_1	127	129	PF00675	0.600
CLV_NRD_NRD_1	17	19	PF00675	0.615
CLV_NRD_NRD_1	288	290	PF00675	0.648
CLV_NRD_NRD_1	64	66	PF00675	0.720
CLV_NRD_NRD_1	641	643	PF00675	0.433
CLV_NRD_NRD_1	708	710	PF00675	0.423
CLV_NRD_NRD_1	73	75	PF00675	0.488
CLV_PCSK_KEX2_1	116	118	PF00082	0.555
CLV_PCSK_KEX2_1	127	129	PF00082	0.600
CLV_PCSK_KEX2_1	17	19	PF00082	0.615
CLV_PCSK_KEX2_1	288	290	PF00082	0.648
CLV_PCSK_KEX2_1	294	296	PF00082	0.640
CLV_PCSK_KEX2_1	64	66	PF00082	0.618
CLV_PCSK_KEX2_1	641	643	PF00082	0.468
CLV_PCSK_KEX2_1	708	710	PF00082	0.423
CLV_PCSK_KEX2_1	73	75	PF00082	0.564
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.634
CLV_PCSK_SKI1_1	17	21	PF00082	0.589
CLV_PCSK_SKI1_1	384	388	PF00082	0.573
CLV_PCSK_SKI1_1	642	646	PF00082	0.411
CLV_PCSK_SKI1_1	696	700	PF00082	0.366
CLV_PCSK_SKI1_1	74	78	PF00082	0.529
CLV_PCSK_SKI1_1	801	805	PF00082	0.390
DEG_Nend_Nbox_1	1	3	PF02207	0.557
DEG_SPOP_SBC_1	54	58	PF00917	0.568
DOC_CKS1_1	343	348	PF01111	0.638
DOC_CKS1_1	59	64	PF01111	0.605
DOC_CYCLIN_RxL_1	381	391	PF00134	0.576
DOC_CYCLIN_RxL_1	845	856	PF00134	0.366
DOC_CYCLIN_yClb5_NLxxxL_5	845	854	PF00134	0.380
DOC_CYCLIN_yCln2_LP_2	338	341	PF00134	0.559
DOC_CYCLIN_yCln2_LP_2	670	676	PF00134	0.454
DOC_CYCLIN_yCln2_LP_2	723	729	PF00134	0.394
DOC_CYCLIN_yCln2_LP_2	811	817	PF00134	0.582
DOC_MAPK_DCC_7	342	351	PF00069	0.612
DOC_MAPK_gen_1	124	133	PF00069	0.583
DOC_MAPK_gen_1	236	243	PF00069	0.661
DOC_MAPK_gen_1	641	649	PF00069	0.409
DOC_MAPK_gen_1	95	104	PF00069	0.585
DOC_MAPK_MEF2A_6	342	351	PF00069	0.608
DOC_MAPK_MEF2A_6	641	649	PF00069	0.407
DOC_MAPK_MEF2A_6	95	104	PF00069	0.585
DOC_MAPK_NFAT4_5	642	650	PF00069	0.409
DOC_PP1_RVXF_1	307	313	PF00149	0.637
DOC_PP1_RVXF_1	474	481	PF00149	0.415
DOC_PP1_RVXF_1	766	773	PF00149	0.481
DOC_PP2B_LxvP_1	338	341	PF13499	0.714
DOC_PP2B_LxvP_1	670	673	PF13499	0.437
DOC_PP2B_LxvP_1	852	855	PF13499	0.381
DOC_USP7_MATH_1	138	142	PF00917	0.594
DOC_USP7_MATH_1	196	200	PF00917	0.779
DOC_USP7_MATH_1	210	214	PF00917	0.693
DOC_USP7_MATH_1	227	231	PF00917	0.520
DOC_USP7_MATH_1	242	246	PF00917	0.794
DOC_USP7_MATH_1	275	279	PF00917	0.643
DOC_USP7_MATH_1	410	414	PF00917	0.462
DOC_USP7_MATH_1	499	503	PF00917	0.611
DOC_USP7_MATH_1	54	58	PF00917	0.632
DOC_USP7_MATH_1	583	587	PF00917	0.548
DOC_USP7_MATH_1	617	621	PF00917	0.607
DOC_USP7_MATH_1	76	80	PF00917	0.536
DOC_WW_Pin1_4	342	347	PF00397	0.641
DOC_WW_Pin1_4	36	41	PF00397	0.581
DOC_WW_Pin1_4	401	406	PF00397	0.624
DOC_WW_Pin1_4	456	461	PF00397	0.525
DOC_WW_Pin1_4	58	63	PF00397	0.692
DOC_WW_Pin1_4	601	606	PF00397	0.546
DOC_WW_Pin1_4	731	736	PF00397	0.501
LIG_14-3-3_CanoR_1	132	139	PF00244	0.590
LIG_14-3-3_CanoR_1	148	153	PF00244	0.635
LIG_14-3-3_CanoR_1	17	22	PF00244	0.535
LIG_14-3-3_CanoR_1	238	242	PF00244	0.656
LIG_14-3-3_CanoR_1	265	270	PF00244	0.624
LIG_14-3-3_CanoR_1	400	405	PF00244	0.627
LIG_14-3-3_CanoR_1	629	634	PF00244	0.546
LIG_14-3-3_CanoR_1	64	70	PF00244	0.749
LIG_14-3-3_CanoR_1	689	695	PF00244	0.352
LIG_14-3-3_CanoR_1	708	712	PF00244	0.433
LIG_14-3-3_CanoR_1	74	84	PF00244	0.490
LIG_Actin_WH2_2	681	698	PF00022	0.280
LIG_APCC_ABBA_1	215	220	PF00400	0.615
LIG_APCC_ABBA_1	772	777	PF00400	0.433
LIG_APCC_ABBA_1	807	812	PF00400	0.383
LIG_Clathr_ClatBox_1	184	188	PF01394	0.656
LIG_CtBP_PxDLS_1	685	689	PF00389	0.398
LIG_deltaCOP1_diTrp_1	767	775	PF00928	0.417
LIG_FHA_1	11	17	PF00498	0.513
LIG_FHA_1	381	387	PF00498	0.565
LIG_FHA_1	388	394	PF00498	0.603
LIG_FHA_1	457	463	PF00498	0.477
LIG_FHA_1	538	544	PF00498	0.530
LIG_FHA_1	54	60	PF00498	0.548
LIG_FHA_1	649	655	PF00498	0.357
LIG_FHA_1	690	696	PF00498	0.249
LIG_FHA_1	856	862	PF00498	0.396
LIG_FHA_2	163	169	PF00498	0.681
LIG_FHA_2	18	24	PF00498	0.518
LIG_FHA_2	181	187	PF00498	0.628
LIG_FHA_2	355	361	PF00498	0.633
LIG_FHA_2	389	395	PF00498	0.517
LIG_FHA_2	428	434	PF00498	0.352
LIG_FHA_2	452	458	PF00498	0.569
LIG_FHA_2	514	520	PF00498	0.637
LIG_FHA_2	606	612	PF00498	0.670
LIG_FHA_2	831	837	PF00498	0.327
LIG_FHA_2	854	860	PF00498	0.474
LIG_LIR_Apic_2	404	410	PF02991	0.516
LIG_LIR_Gen_1	213	220	PF02991	0.655
LIG_LIR_Gen_1	3	9	PF02991	0.577
LIG_LIR_Gen_1	485	495	PF02991	0.412
LIG_LIR_Gen_1	690	699	PF02991	0.344
LIG_LIR_Gen_1	758	764	PF02991	0.335
LIG_LIR_Gen_1	767	776	PF02991	0.461
LIG_LIR_Gen_1	821	832	PF02991	0.391
LIG_LIR_Nem_3	192	198	PF02991	0.658
LIG_LIR_Nem_3	213	218	PF02991	0.656
LIG_LIR_Nem_3	3	8	PF02991	0.580
LIG_LIR_Nem_3	472	478	PF02991	0.395
LIG_LIR_Nem_3	485	490	PF02991	0.371
LIG_LIR_Nem_3	620	626	PF02991	0.544
LIG_LIR_Nem_3	690	694	PF02991	0.336
LIG_LIR_Nem_3	758	763	PF02991	0.399
LIG_LIR_Nem_3	767	772	PF02991	0.387
LIG_LIR_Nem_3	821	827	PF02991	0.388
LIG_LIR_Nem_3	88	93	PF02991	0.541
LIG_LYPXL_yS_3	195	198	PF13949	0.578
LIG_Pex14_2	624	628	PF04695	0.412
LIG_Pex14_2	760	764	PF04695	0.352
LIG_REV1ctd_RIR_1	84	90	PF16727	0.604
LIG_SH2_CRK	407	411	PF00017	0.642
LIG_SH2_CRK	475	479	PF00017	0.384
LIG_SH2_CRK	5	9	PF00017	0.573
LIG_SH2_CRK	676	680	PF00017	0.436
LIG_SH2_CRK	691	695	PF00017	0.335
LIG_SH2_CRK	93	97	PF00017	0.495
LIG_SH2_NCK_1	5	9	PF00017	0.573
LIG_SH2_PTP2	487	490	PF00017	0.451
LIG_SH2_PTP2	824	827	PF00017	0.384
LIG_SH2_SRC	280	283	PF00017	0.549
LIG_SH2_SRC	446	449	PF00017	0.354
LIG_SH2_SRC	661	664	PF00017	0.429
LIG_SH2_STAP1	5	9	PF00017	0.580
LIG_SH2_STAP1	650	654	PF00017	0.327
LIG_SH2_STAP1	691	695	PF00017	0.335
LIG_SH2_STAT3	650	653	PF00017	0.340
LIG_SH2_STAT3	843	846	PF00017	0.457
LIG_SH2_STAT5	15	18	PF00017	0.562
LIG_SH2_STAT5	24	27	PF00017	0.527
LIG_SH2_STAT5	446	449	PF00017	0.352
LIG_SH2_STAT5	487	490	PF00017	0.451
LIG_SH2_STAT5	623	626	PF00017	0.429
LIG_SH2_STAT5	650	653	PF00017	0.353
LIG_SH2_STAT5	691	694	PF00017	0.370
LIG_SH2_STAT5	824	827	PF00017	0.384
LIG_SH2_STAT5	843	846	PF00017	0.457
LIG_SH3_3	326	332	PF00018	0.655
LIG_SH3_3	334	340	PF00018	0.664
LIG_SH3_3	341	347	PF00018	0.675
LIG_SH3_3	35	41	PF00018	0.608
LIG_SH3_3	557	563	PF00018	0.678
LIG_SH3_3	723	729	PF00018	0.369
LIG_SUMO_SIM_par_1	182	188	PF11976	0.630
LIG_SUMO_SIM_par_1	684	690	PF11976	0.385
LIG_SUMO_SIM_par_1	850	859	PF11976	0.371
LIG_TRAF2_1	20	23	PF00917	0.524
LIG_TRAF2_1	449	452	PF00917	0.467
LIG_TRAF2_1	587	590	PF00917	0.556
LIG_TYR_ITIM	674	679	PF00017	0.482
LIG_UBA3_1	844	848	PF00899	0.387
LIG_WW_3	339	343	PF00397	0.648
MOD_CDC14_SPxK_1	734	737	PF00782	0.515
MOD_CDK_SPxK_1	58	64	PF00069	0.633
MOD_CDK_SPxK_1	731	737	PF00069	0.504
MOD_CDK_SPxxK_3	36	43	PF00069	0.558
MOD_CDK_SPxxK_3	401	408	PF00069	0.614
MOD_CDK_SPxxK_3	58	65	PF00069	0.632
MOD_CK1_1	126	132	PF00069	0.587
MOD_CK1_1	141	147	PF00069	0.628
MOD_CK1_1	155	161	PF00069	0.630
MOD_CK1_1	190	196	PF00069	0.604
MOD_CK1_1	213	219	PF00069	0.807
MOD_CK1_1	221	227	PF00069	0.650
MOD_CK1_1	298	304	PF00069	0.648
MOD_CK1_1	374	380	PF00069	0.609
MOD_CK1_1	396	402	PF00069	0.678
MOD_CK1_1	455	461	PF00069	0.543
MOD_CK1_1	502	508	PF00069	0.654
MOD_CK1_1	57	63	PF00069	0.547
MOD_CK1_1	603	609	PF00069	0.577
MOD_CK1_1	648	654	PF00069	0.361
MOD_CK1_1	687	693	PF00069	0.393
MOD_CK1_1	795	801	PF00069	0.606
MOD_CK1_1	853	859	PF00069	0.474
MOD_CK2_1	162	168	PF00069	0.743
MOD_CK2_1	17	23	PF00069	0.528
MOD_CK2_1	242	248	PF00069	0.622
MOD_CK2_1	354	360	PF00069	0.634
MOD_CK2_1	427	433	PF00069	0.360
MOD_CK2_1	446	452	PF00069	0.420
MOD_CK2_1	455	461	PF00069	0.429
MOD_CK2_1	500	506	PF00069	0.590
MOD_CK2_1	513	519	PF00069	0.597
MOD_CK2_1	564	570	PF00069	0.601
MOD_CK2_1	583	589	PF00069	0.599
MOD_CK2_1	830	836	PF00069	0.377
MOD_CK2_1	853	859	PF00069	0.476
MOD_CMANNOS	766	769	PF00535	0.409
MOD_DYRK1A_RPxSP_1	342	346	PF00069	0.550
MOD_GlcNHglycan	128	131	PF01048	0.597
MOD_GlcNHglycan	133	136	PF01048	0.571
MOD_GlcNHglycan	144	147	PF01048	0.634
MOD_GlcNHglycan	198	201	PF01048	0.669
MOD_GlcNHglycan	208	211	PF01048	0.543
MOD_GlcNHglycan	220	224	PF01048	0.544
MOD_GlcNHglycan	300	303	PF01048	0.760
MOD_GlcNHglycan	376	379	PF01048	0.647
MOD_GlcNHglycan	418	421	PF01048	0.535
MOD_GlcNHglycan	451	457	PF01048	0.584
MOD_GlcNHglycan	471	474	PF01048	0.530
MOD_GlcNHglycan	513	516	PF01048	0.658
MOD_GlcNHglycan	585	588	PF01048	0.545
MOD_GlcNHglycan	681	684	PF01048	0.396
MOD_GlcNHglycan	715	718	PF01048	0.533
MOD_GSK3_1	138	145	PF00069	0.642
MOD_GSK3_1	148	155	PF00069	0.708
MOD_GSK3_1	164	171	PF00069	0.692
MOD_GSK3_1	190	197	PF00069	0.592
MOD_GSK3_1	202	209	PF00069	0.670
MOD_GSK3_1	271	278	PF00069	0.642
MOD_GSK3_1	297	304	PF00069	0.604
MOD_GSK3_1	370	377	PF00069	0.646
MOD_GSK3_1	388	395	PF00069	0.499
MOD_GSK3_1	396	403	PF00069	0.584
MOD_GSK3_1	423	430	PF00069	0.360
MOD_GSK3_1	451	458	PF00069	0.645
MOD_GSK3_1	495	502	PF00069	0.752
MOD_GSK3_1	505	512	PF00069	0.705
MOD_GSK3_1	53	60	PF00069	0.612
MOD_GSK3_1	577	584	PF00069	0.613
MOD_GSK3_1	601	608	PF00069	0.601
MOD_GSK3_1	645	652	PF00069	0.371
MOD_GSK3_1	700	707	PF00069	0.370
MOD_N-GLC_1	713	718	PF02516	0.490
MOD_NEK2_1	218	223	PF00069	0.610
MOD_NEK2_1	234	239	PF00069	0.615
MOD_NEK2_1	264	269	PF00069	0.533
MOD_NEK2_1	386	391	PF00069	0.601
MOD_NEK2_1	418	423	PF00069	0.645
MOD_NEK2_1	438	443	PF00069	0.312
MOD_NEK2_1	564	569	PF00069	0.618
MOD_NEK2_1	645	650	PF00069	0.430
MOD_NEK2_1	75	80	PF00069	0.732
MOD_NEK2_1	803	808	PF00069	0.490
MOD_NEK2_1	830	835	PF00069	0.403
MOD_NEK2_1	850	855	PF00069	0.377
MOD_PIKK_1	162	168	PF00454	0.690
MOD_PIKK_1	283	289	PF00454	0.711
MOD_PIKK_1	617	623	PF00454	0.532
MOD_PIKK_1	649	655	PF00454	0.326
MOD_PIKK_1	835	841	PF00454	0.505
MOD_PK_1	148	154	PF00069	0.708
MOD_PKA_1	17	23	PF00069	0.586
MOD_PKA_1	64	70	PF00069	0.591
MOD_PKA_2	123	129	PF00069	0.581
MOD_PKA_2	131	137	PF00069	0.558
MOD_PKA_2	152	158	PF00069	0.684
MOD_PKA_2	17	23	PF00069	0.528
MOD_PKA_2	210	216	PF00069	0.762
MOD_PKA_2	218	224	PF00069	0.615
MOD_PKA_2	237	243	PF00069	0.614
MOD_PKA_2	264	270	PF00069	0.529
MOD_PKA_2	298	304	PF00069	0.713
MOD_PKA_2	305	311	PF00069	0.690
MOD_PKA_2	368	374	PF00069	0.625
MOD_PKA_2	380	386	PF00069	0.567
MOD_PKA_2	387	393	PF00069	0.596
MOD_PKA_2	399	405	PF00069	0.569
MOD_PKA_2	506	512	PF00069	0.656
MOD_PKA_2	628	634	PF00069	0.528
MOD_PKA_2	63	69	PF00069	0.773
MOD_PKA_2	707	713	PF00069	0.422
MOD_PKB_1	295	303	PF00069	0.644
MOD_PKB_1	627	635	PF00069	0.384
MOD_Plk_1	11	17	PF00069	0.566
MOD_Plk_1	168	174	PF00069	0.632
MOD_Plk_1	187	193	PF00069	0.493
MOD_Plk_1	213	219	PF00069	0.615
MOD_Plk_1	359	365	PF00069	0.640
MOD_Plk_1	518	524	PF00069	0.554
MOD_Plk_1	551	557	PF00069	0.668
MOD_Plk_1	713	719	PF00069	0.486
MOD_Plk_1	770	776	PF00069	0.586
MOD_Plk_2-3	180	186	PF00069	0.630
MOD_Plk_2-3	519	525	PF00069	0.541
MOD_Plk_4	11	17	PF00069	0.548
MOD_Plk_4	180	186	PF00069	0.683
MOD_Plk_4	190	196	PF00069	0.520
MOD_Plk_4	242	248	PF00069	0.604
MOD_Plk_4	411	417	PF00069	0.438
MOD_Plk_4	418	424	PF00069	0.446
MOD_Plk_4	605	611	PF00069	0.539
MOD_Plk_4	645	651	PF00069	0.342
MOD_Plk_4	690	696	PF00069	0.368
MOD_Plk_4	701	707	PF00069	0.413
MOD_Plk_4	792	798	PF00069	0.460
MOD_ProDKin_1	342	348	PF00069	0.641
MOD_ProDKin_1	36	42	PF00069	0.587
MOD_ProDKin_1	401	407	PF00069	0.614
MOD_ProDKin_1	456	462	PF00069	0.516
MOD_ProDKin_1	58	64	PF00069	0.692
MOD_ProDKin_1	601	607	PF00069	0.546
MOD_ProDKin_1	731	737	PF00069	0.504
MOD_SUMO_for_1	28	31	PF00179	0.557
TRG_DiLeu_BaEn_1	169	174	PF01217	0.509
TRG_DiLeu_BaEn_1	249	254	PF01217	0.593
TRG_DiLeu_BaEn_1	758	763	PF01217	0.282
TRG_DiLeu_BaEn_2	821	827	PF01217	0.299
TRG_ENDOCYTIC_2	195	198	PF00928	0.578
TRG_ENDOCYTIC_2	475	478	PF00928	0.378
TRG_ENDOCYTIC_2	487	490	PF00928	0.378
TRG_ENDOCYTIC_2	5	8	PF00928	0.579
TRG_ENDOCYTIC_2	676	679	PF00928	0.462
TRG_ENDOCYTIC_2	691	694	PF00928	0.368
TRG_ENDOCYTIC_2	824	827	PF00928	0.384
TRG_ENDOCYTIC_2	93	96	PF00928	0.490
TRG_ER_diArg_1	115	117	PF00400	0.552
TRG_ER_diArg_1	16	18	PF00400	0.626
TRG_ER_diArg_1	288	290	PF00400	0.551
TRG_ER_diArg_1	309	312	PF00400	0.739
TRG_ER_diArg_1	490	493	PF00400	0.342
TRG_ER_diArg_1	73	75	PF00400	0.557
TRG_NES_CRM1_1	94	108	PF08389	0.587
TRG_Pf-PMV_PEXEL_1	116	121	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P794	Leptomonas seymouri	52%	100%
A0A3Q8INY8	Leishmania donovani	80%	100%
A4ICI7	Leishmania infantum	80%	100%
E9AT57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q1E0	Leishmania major	79%	99%