Meiosis recombination protein SPO11

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPE4_LEIBR

TriTrypDb:

LbrM.35.3000 , LBRM2903_350038400

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005694	chromosome	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0000228	nuclear chromosome	6	1

Expansion

Sequence features

A4HPE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPE4

Function

Biological processes
Term	Name	Level	Count
GO:0000706	meiotic DNA double-strand break processing	3	1
GO:0000729	DNA double-strand break processing	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006259	DNA metabolic process	4	6
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0007131	reciprocal meiotic recombination	3	1
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0035825	homologous recombination	6	1
GO:0042138	meiotic DNA double-strand break formation	4	1
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0061982	meiosis I cell cycle process	3	1
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0140527	reciprocal homologous recombination	7	1
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1903046	meiotic cell cycle process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0003916	DNA topoisomerase activity	3	11
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	3	11
GO:0005488	binding	1	11
GO:0008094	ATP-dependent activity, acting on DNA	2	11
GO:0016853	isomerase activity	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140097	catalytic activity, acting on DNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901363	heterocyclic compound binding	2	11
GO:0000166	nucleotide binding	3	5
GO:0005524	ATP binding	5	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0097367	carbohydrate derivative binding	2	5
GO:1901265	nucleoside phosphate binding	3	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	459	463	PF00656	0.552
CLV_NRD_NRD_1	105	107	PF00675	0.505
CLV_NRD_NRD_1	185	187	PF00675	0.613
CLV_NRD_NRD_1	324	326	PF00675	0.398
CLV_NRD_NRD_1	468	470	PF00675	0.495
CLV_PCSK_KEX2_1	105	107	PF00082	0.505
CLV_PCSK_KEX2_1	153	155	PF00082	0.536
CLV_PCSK_KEX2_1	185	187	PF00082	0.607
CLV_PCSK_KEX2_1	324	326	PF00082	0.398
CLV_PCSK_KEX2_1	444	446	PF00082	0.404
CLV_PCSK_KEX2_1	468	470	PF00082	0.484
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.392
CLV_PCSK_PC1ET2_1	444	446	PF00082	0.496
CLV_PCSK_PC7_1	320	326	PF00082	0.445
CLV_PCSK_SKI1_1	185	189	PF00082	0.608
CLV_PCSK_SKI1_1	217	221	PF00082	0.333
CLV_PCSK_SKI1_1	278	282	PF00082	0.508
CLV_PCSK_SKI1_1	393	397	PF00082	0.429
CLV_PCSK_SKI1_1	481	485	PF00082	0.438
DEG_APCC_DBOX_1	184	192	PF00400	0.366
DEG_APCC_DBOX_1	475	483	PF00400	0.345
DOC_CKS1_1	108	113	PF01111	0.605
DOC_CKS1_1	458	463	PF01111	0.429
DOC_CYCLIN_yCln2_LP_2	12	18	PF00134	0.433
DOC_CYCLIN_yCln2_LP_2	228	234	PF00134	0.447
DOC_MAPK_DCC_7	391	400	PF00069	0.421
DOC_MAPK_gen_1	153	161	PF00069	0.382
DOC_MAPK_gen_1	391	400	PF00069	0.421
DOC_MAPK_gen_1	491	500	PF00069	0.438
DOC_MAPK_JIP1_4	275	281	PF00069	0.394
DOC_MAPK_MEF2A_6	391	400	PF00069	0.421
DOC_MAPK_MEF2A_6	55	64	PF00069	0.256
DOC_MAPK_NFAT4_5	393	401	PF00069	0.405
DOC_PP1_RVXF_1	482	489	PF00149	0.245
DOC_PP2B_LxvP_1	139	142	PF13499	0.458
DOC_PP4_FxxP_1	181	184	PF00568	0.504
DOC_PP4_FxxP_1	376	379	PF00568	0.503
DOC_USP7_MATH_1	148	152	PF00917	0.537
DOC_USP7_MATH_1	176	180	PF00917	0.513
DOC_USP7_MATH_1	215	219	PF00917	0.436
DOC_USP7_MATH_1	239	243	PF00917	0.574
DOC_USP7_MATH_1	364	368	PF00917	0.641
DOC_USP7_MATH_1	370	374	PF00917	0.769
DOC_USP7_MATH_1	75	79	PF00917	0.588
DOC_WW_Pin1_4	1	6	PF00397	0.552
DOC_WW_Pin1_4	107	112	PF00397	0.621
DOC_WW_Pin1_4	11	16	PF00397	0.440
DOC_WW_Pin1_4	180	185	PF00397	0.455
DOC_WW_Pin1_4	199	204	PF00397	0.641
DOC_WW_Pin1_4	20	25	PF00397	0.410
DOC_WW_Pin1_4	297	302	PF00397	0.594
DOC_WW_Pin1_4	360	365	PF00397	0.674
DOC_WW_Pin1_4	374	379	PF00397	0.743
DOC_WW_Pin1_4	457	462	PF00397	0.482
DOC_WW_Pin1_4	71	76	PF00397	0.603
LIG_14-3-3_CanoR_1	196	205	PF00244	0.461
LIG_14-3-3_CanoR_1	268	274	PF00244	0.610
LIG_14-3-3_CanoR_1	27	31	PF00244	0.480
LIG_14-3-3_CanoR_1	476	480	PF00244	0.383
LIG_14-3-3_CanoR_1	81	88	PF00244	0.478
LIG_Actin_WH2_2	439	457	PF00022	0.353
LIG_BIR_II_1	1	5	PF00653	0.451
LIG_BRCT_BRCA1_1	372	376	PF00533	0.672
LIG_BRCT_BRCA1_1	409	413	PF00533	0.550
LIG_CaM_IQ_9	437	453	PF13499	0.430
LIG_Clathr_ClatBox_1	279	283	PF01394	0.348
LIG_EH1_1	91	99	PF00400	0.405
LIG_eIF4E_1	134	140	PF01652	0.377
LIG_FHA_1	119	125	PF00498	0.575
LIG_FHA_1	193	199	PF00498	0.474
LIG_FHA_1	246	252	PF00498	0.412
LIG_FHA_1	435	441	PF00498	0.534
LIG_FHA_1	89	95	PF00498	0.399
LIG_FHA_2	102	108	PF00498	0.394
LIG_FHA_2	115	121	PF00498	0.579
LIG_FHA_2	27	33	PF00498	0.465
LIG_FHA_2	434	440	PF00498	0.371
LIG_GBD_Chelix_1	220	228	PF00786	0.448
LIG_LIR_Apic_2	131	137	PF02991	0.478
LIG_LIR_Apic_2	179	184	PF02991	0.443
LIG_LIR_Apic_2	373	379	PF02991	0.537
LIG_LIR_Gen_1	157	166	PF02991	0.273
LIG_LIR_Gen_1	303	314	PF02991	0.553
LIG_LIR_Nem_3	109	115	PF02991	0.640
LIG_LIR_Nem_3	157	161	PF02991	0.358
LIG_LIR_Nem_3	303	309	PF02991	0.563
LIG_LIR_Nem_3	311	317	PF02991	0.463
LIG_LIR_Nem_3	91	95	PF02991	0.456
LIG_LYPXL_yS_3	112	115	PF13949	0.505
LIG_LYPXL_yS_3	314	317	PF13949	0.464
LIG_PCNA_yPIPBox_3	50	61	PF02747	0.270
LIG_Pex14_1	409	413	PF04695	0.455
LIG_Pex14_2	64	68	PF04695	0.444
LIG_SH2_CRK	134	138	PF00017	0.495
LIG_SH2_NCK_1	100	104	PF00017	0.393
LIG_SH2_PTP2	306	309	PF00017	0.230
LIG_SH2_PTP2	336	339	PF00017	0.370
LIG_SH2_STAT3	49	52	PF00017	0.471
LIG_SH2_STAT3	93	96	PF00017	0.480
LIG_SH2_STAT5	205	208	PF00017	0.376
LIG_SH2_STAT5	306	309	PF00017	0.334
LIG_SH2_STAT5	336	339	PF00017	0.370
LIG_SH2_STAT5	93	96	PF00017	0.406
LIG_SH3_1	455	461	PF00018	0.388
LIG_SH3_3	455	461	PF00018	0.388
LIG_SH3_3	501	507	PF00018	0.423
LIG_SH3_3	7	13	PF00018	0.581
LIG_SUMO_SIM_anti_2	157	163	PF11976	0.253
LIG_SUMO_SIM_anti_2	230	236	PF11976	0.433
LIG_SUMO_SIM_anti_2	58	64	PF11976	0.416
LIG_SUMO_SIM_par_1	17	23	PF11976	0.429
LIG_SUMO_SIM_par_1	224	230	PF11976	0.401
LIG_SUMO_SIM_par_1	233	238	PF11976	0.342
LIG_SUMO_SIM_par_1	278	283	PF11976	0.311
LIG_TRFH_1	6	10	PF08558	0.462
MOD_CDC14_SPxK_1	183	186	PF00782	0.321
MOD_CDC14_SPxK_1	74	77	PF00782	0.571
MOD_CDK_SPK_2	180	185	PF00069	0.455
MOD_CDK_SPxK_1	180	186	PF00069	0.306
MOD_CDK_SPxK_1	71	77	PF00069	0.548
MOD_CDK_SPxxK_3	20	27	PF00069	0.429
MOD_CK1_1	101	107	PF00069	0.470
MOD_CK1_1	11	17	PF00069	0.470
MOD_CK1_1	243	249	PF00069	0.487
MOD_CK1_1	374	380	PF00069	0.650
MOD_CK1_1	463	469	PF00069	0.548
MOD_CK2_1	101	107	PF00069	0.428
MOD_CK2_1	453	459	PF00069	0.476
MOD_GlcNHglycan	100	103	PF01048	0.597
MOD_GlcNHglycan	199	202	PF01048	0.554
MOD_GlcNHglycan	236	240	PF01048	0.482
MOD_GlcNHglycan	242	245	PF01048	0.370
MOD_GlcNHglycan	260	264	PF01048	0.356
MOD_GlcNHglycan	385	388	PF01048	0.572
MOD_GlcNHglycan	419	422	PF01048	0.591
MOD_GlcNHglycan	455	458	PF01048	0.643
MOD_GlcNHglycan	462	465	PF01048	0.637
MOD_GlcNHglycan	77	80	PF01048	0.551
MOD_GSK3_1	114	121	PF00069	0.614
MOD_GSK3_1	176	183	PF00069	0.593
MOD_GSK3_1	199	206	PF00069	0.651
MOD_GSK3_1	235	242	PF00069	0.480
MOD_GSK3_1	26	33	PF00069	0.549
MOD_GSK3_1	291	298	PF00069	0.433
MOD_GSK3_1	34	41	PF00069	0.447
MOD_GSK3_1	360	367	PF00069	0.616
MOD_GSK3_1	370	377	PF00069	0.555
MOD_GSK3_1	4	11	PF00069	0.528
MOD_GSK3_1	403	410	PF00069	0.462
MOD_GSK3_1	453	460	PF00069	0.566
MOD_GSK3_1	71	78	PF00069	0.606
MOD_NEK2_1	114	119	PF00069	0.573
MOD_NEK2_1	210	215	PF00069	0.512
MOD_NEK2_1	308	313	PF00069	0.302
MOD_NEK2_1	355	360	PF00069	0.570
MOD_NEK2_1	407	412	PF00069	0.599
MOD_NEK2_1	427	432	PF00069	0.505
MOD_NEK2_2	148	153	PF00069	0.399
MOD_NEK2_2	176	181	PF00069	0.536
MOD_OFUCOSY	404	411	PF10250	0.407
MOD_PIKK_1	186	192	PF00454	0.392
MOD_PIKK_1	365	371	PF00454	0.648
MOD_PIKK_1	427	433	PF00454	0.584
MOD_PKA_2	192	198	PF00069	0.685
MOD_PKA_2	206	212	PF00069	0.459
MOD_PKA_2	239	245	PF00069	0.474
MOD_PKA_2	26	32	PF00069	0.527
MOD_PKA_2	475	481	PF00069	0.333
MOD_PKA_2	80	86	PF00069	0.476
MOD_Plk_1	119	125	PF00069	0.721
MOD_Plk_1	128	134	PF00069	0.348
MOD_Plk_1	31	37	PF00069	0.435
MOD_Plk_4	176	182	PF00069	0.596
MOD_Plk_4	215	221	PF00069	0.356
MOD_Plk_4	26	32	PF00069	0.436
MOD_Plk_4	291	297	PF00069	0.559
MOD_Plk_4	302	308	PF00069	0.376
MOD_Plk_4	348	354	PF00069	0.332
MOD_Plk_4	403	409	PF00069	0.503
MOD_Plk_4	506	512	PF00069	0.420
MOD_Plk_4	56	62	PF00069	0.313
MOD_Plk_4	88	94	PF00069	0.464
MOD_ProDKin_1	1	7	PF00069	0.553
MOD_ProDKin_1	107	113	PF00069	0.623
MOD_ProDKin_1	11	17	PF00069	0.439
MOD_ProDKin_1	180	186	PF00069	0.463
MOD_ProDKin_1	199	205	PF00069	0.622
MOD_ProDKin_1	20	26	PF00069	0.411
MOD_ProDKin_1	297	303	PF00069	0.595
MOD_ProDKin_1	360	366	PF00069	0.677
MOD_ProDKin_1	374	380	PF00069	0.744
MOD_ProDKin_1	457	463	PF00069	0.487
MOD_ProDKin_1	71	77	PF00069	0.609
MOD_SUMO_for_1	494	497	PF00179	0.461
TRG_DiLeu_BaEn_1	58	63	PF01217	0.448
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.501
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.313
TRG_ENDOCYTIC_2	112	115	PF00928	0.650
TRG_ENDOCYTIC_2	306	309	PF00928	0.525
TRG_ENDOCYTIC_2	314	317	PF00928	0.415
TRG_ENDOCYTIC_2	336	339	PF00928	0.421
TRG_ER_diArg_1	184	186	PF00400	0.606
TRG_ER_diArg_1	323	325	PF00400	0.398
TRG_ER_diArg_1	467	469	PF00400	0.500
TRG_ER_diArg_1	491	494	PF00400	0.536
TRG_NES_CRM1_1	51	67	PF08389	0.427
TRG_Pf-PMV_PEXEL_1	185	190	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	481	485	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7M4	Leptomonas seymouri	40%	100%
A0A1X0NL58	Trypanosomatidae	30%	100%
A0A3R7LIJ3	Trypanosoma rangeli	30%	100%
A0A3S7XAZ9	Leishmania donovani	79%	100%
A4ICI5	Leishmania infantum	79%	99%
D0A3F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AT55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q1E2	Leishmania major	77%	100%
V5BPV6	Trypanosoma cruzi	30%	100%