LeishMANIAdb
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Nodulin-like domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nodulin-like domain-containing protein
Gene product:
Nodulin-like, putative
Species:
Leishmania braziliensis
UniProt:
A4HPE2_LEIBR
TriTrypDb:
LbrM.35.2980 , LBRM2903_350038000
Length:
614

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 36
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 123
NetGPI no yes: 0, no: 123
Cellular components
Term Name Level Count
GO:0016020 membrane 2 116
GO:0110165 cellular anatomical entity 1 116
GO:0005737 cytoplasm 2 3

Expansion

Sequence features

A4HPE2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPE2

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 55
GO:0022857 transmembrane transporter activity 2 55

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 248 250 PF00675 0.258
CLV_NRD_NRD_1 331 333 PF00675 0.551
CLV_NRD_NRD_1 464 466 PF00675 0.369
CLV_PCSK_KEX2_1 248 250 PF00082 0.270
CLV_PCSK_KEX2_1 30 32 PF00082 0.286
CLV_PCSK_PC1ET2_1 30 32 PF00082 0.323
CLV_PCSK_SKI1_1 166 170 PF00082 0.358
CLV_PCSK_SKI1_1 181 185 PF00082 0.465
CLV_PCSK_SKI1_1 465 469 PF00082 0.302
CLV_PCSK_SKI1_1 545 549 PF00082 0.317
CLV_PCSK_SKI1_1 600 604 PF00082 0.360
DEG_APCC_DBOX_1 464 472 PF00400 0.565
DEG_APCC_DBOX_1 605 613 PF00400 0.451
DEG_Nend_Nbox_1 1 3 PF02207 0.706
DOC_ANK_TNKS_1 157 164 PF00023 0.549
DOC_CKS1_1 573 578 PF01111 0.382
DOC_CKS1_1 605 610 PF01111 0.439
DOC_CYCLIN_yCln2_LP_2 495 501 PF00134 0.245
DOC_MAPK_gen_1 156 164 PF00069 0.513
DOC_MAPK_gen_1 465 473 PF00069 0.463
DOC_MAPK_MEF2A_6 156 164 PF00069 0.469
DOC_MAPK_MEF2A_6 391 398 PF00069 0.530
DOC_MAPK_MEF2A_6 465 473 PF00069 0.470
DOC_MAPK_RevD_3 234 249 PF00069 0.462
DOC_PP1_RVXF_1 511 518 PF00149 0.394
DOC_PP2B_LxvP_1 488 491 PF13499 0.403
DOC_PP2B_PxIxI_1 497 503 PF00149 0.377
DOC_PP2B_PxIxI_1 575 581 PF00149 0.384
DOC_PP4_FxxP_1 82 85 PF00568 0.311
DOC_USP7_MATH_1 232 236 PF00917 0.487
DOC_USP7_MATH_2 311 317 PF00917 0.735
DOC_USP7_UBL2_3 554 558 PF12436 0.402
DOC_WW_Pin1_4 350 355 PF00397 0.756
DOC_WW_Pin1_4 458 463 PF00397 0.516
DOC_WW_Pin1_4 572 577 PF00397 0.405
DOC_WW_Pin1_4 604 609 PF00397 0.614
LIG_14-3-3_CanoR_1 425 434 PF00244 0.378
LIG_14-3-3_CanoR_1 447 451 PF00244 0.301
LIG_14-3-3_CanoR_1 600 609 PF00244 0.587
LIG_14-3-3_CanoR_1 61 69 PF00244 0.337
LIG_AP2alpha_1 54 58 PF02296 0.265
LIG_APCC_ABBA_1 500 505 PF00400 0.369
LIG_APCC_ABBA_1 51 56 PF00400 0.359
LIG_BIR_III_4 321 325 PF00653 0.715
LIG_BRCT_BRCA1_1 138 142 PF00533 0.387
LIG_BRCT_BRCA1_1 315 319 PF00533 0.701
LIG_BRCT_BRCA1_1 45 49 PF00533 0.338
LIG_BRCT_BRCA1_1 54 58 PF00533 0.266
LIG_Clathr_ClatBox_1 366 370 PF01394 0.793
LIG_Clathr_ClatBox_1 501 505 PF01394 0.376
LIG_deltaCOP1_diTrp_1 393 401 PF00928 0.361
LIG_FHA_1 10 16 PF00498 0.567
LIG_FHA_1 103 109 PF00498 0.280
LIG_FHA_1 123 129 PF00498 0.304
LIG_FHA_1 197 203 PF00498 0.359
LIG_FHA_1 265 271 PF00498 0.326
LIG_FHA_1 286 292 PF00498 0.368
LIG_FHA_1 415 421 PF00498 0.329
LIG_FHA_1 426 432 PF00498 0.342
LIG_FHA_1 434 440 PF00498 0.323
LIG_FHA_1 468 474 PF00498 0.464
LIG_FHA_1 533 539 PF00498 0.292
LIG_FHA_1 573 579 PF00498 0.308
LIG_FHA_1 581 587 PF00498 0.391
LIG_FHA_1 72 78 PF00498 0.332
LIG_FHA_2 147 153 PF00498 0.339
LIG_FHA_2 316 322 PF00498 0.615
LIG_FHA_2 336 342 PF00498 0.767
LIG_FHA_2 343 349 PF00498 0.759
LIG_FHA_2 382 388 PF00498 0.577
LIG_GBD_Chelix_1 204 212 PF00786 0.431
LIG_GBD_Chelix_1 482 490 PF00786 0.226
LIG_LIR_Apic_2 603 608 PF02991 0.427
LIG_LIR_Gen_1 189 198 PF02991 0.284
LIG_LIR_Gen_1 38 48 PF02991 0.332
LIG_LIR_Gen_1 384 394 PF02991 0.512
LIG_LIR_Gen_1 433 441 PF02991 0.298
LIG_LIR_Nem_3 129 134 PF02991 0.296
LIG_LIR_Nem_3 189 194 PF02991 0.257
LIG_LIR_Nem_3 38 43 PF02991 0.350
LIG_LIR_Nem_3 384 389 PF02991 0.526
LIG_LIR_Nem_3 393 398 PF02991 0.306
LIG_LIR_Nem_3 433 438 PF02991 0.330
LIG_LIR_Nem_3 506 512 PF02991 0.398
LIG_MAD2 466 474 PF02301 0.555
LIG_Pex14_2 216 220 PF04695 0.408
LIG_Pex14_2 5 9 PF04695 0.631
LIG_Pex14_2 517 521 PF04695 0.554
LIG_Pex14_2 54 58 PF04695 0.301
LIG_PTB_Apo_2 527 534 PF02174 0.529
LIG_SH2_CRK 252 256 PF00017 0.371
LIG_SH2_CRK 273 277 PF00017 0.317
LIG_SH2_CRK 605 609 PF00017 0.510
LIG_SH2_CRK 86 90 PF00017 0.309
LIG_SH2_NCK_1 273 277 PF00017 0.318
LIG_SH2_NCK_1 90 94 PF00017 0.371
LIG_SH2_PTP2 254 257 PF00017 0.330
LIG_SH2_PTP2 499 502 PF00017 0.356
LIG_SH2_SRC 90 93 PF00017 0.528
LIG_SH2_STAP1 240 244 PF00017 0.560
LIG_SH2_STAP1 435 439 PF00017 0.366
LIG_SH2_STAP1 598 602 PF00017 0.544
LIG_SH2_STAT5 14 17 PF00017 0.566
LIG_SH2_STAT5 193 196 PF00017 0.310
LIG_SH2_STAT5 215 218 PF00017 0.455
LIG_SH2_STAT5 254 257 PF00017 0.329
LIG_SH2_STAT5 273 276 PF00017 0.277
LIG_SH2_STAT5 419 422 PF00017 0.298
LIG_SH2_STAT5 435 438 PF00017 0.266
LIG_SH2_STAT5 456 459 PF00017 0.546
LIG_SH2_STAT5 499 502 PF00017 0.312
LIG_SH2_STAT5 503 506 PF00017 0.311
LIG_SH2_STAT5 7 10 PF00017 0.600
LIG_SH2_STAT5 81 84 PF00017 0.304
LIG_SH3_3 305 311 PF00018 0.581
LIG_SH3_3 373 379 PF00018 0.600
LIG_SH3_3 471 477 PF00018 0.286
LIG_SH3_3 570 576 PF00018 0.313
LIG_SUMO_SIM_anti_2 146 152 PF11976 0.355
LIG_SUMO_SIM_anti_2 575 581 PF11976 0.367
LIG_SUMO_SIM_par_1 146 152 PF11976 0.238
LIG_SUMO_SIM_par_1 198 203 PF11976 0.338
LIG_SUMO_SIM_par_1 325 330 PF11976 0.563
LIG_SUMO_SIM_par_1 365 370 PF11976 0.576
LIG_SUMO_SIM_par_1 575 581 PF11976 0.334
LIG_TYR_ITIM 250 255 PF00017 0.371
LIG_TYR_ITIM 271 276 PF00017 0.284
LIG_TYR_ITIM 79 84 PF00017 0.298
LIG_TYR_ITIM 88 93 PF00017 0.317
LIG_UBA3_1 547 554 PF00899 0.449
LIG_WRC_WIRS_1 2 7 PF05994 0.485
MOD_CDK_SPxK_1 604 610 PF00069 0.437
MOD_CDK_SPxxK_3 458 465 PF00069 0.592
MOD_CDK_SPxxK_3 604 611 PF00069 0.443
MOD_CK1_1 146 152 PF00069 0.347
MOD_CK1_1 174 180 PF00069 0.359
MOD_CK1_1 235 241 PF00069 0.500
MOD_CK1_1 353 359 PF00069 0.753
MOD_CK1_1 433 439 PF00069 0.356
MOD_CK1_1 532 538 PF00069 0.344
MOD_CK1_1 70 76 PF00069 0.322
MOD_CK2_1 146 152 PF00069 0.388
MOD_CK2_1 335 341 PF00069 0.741
MOD_CK2_1 342 348 PF00069 0.751
MOD_CK2_1 381 387 PF00069 0.546
MOD_Cter_Amidation 330 333 PF01082 0.377
MOD_GlcNHglycan 138 141 PF01048 0.342
MOD_GlcNHglycan 188 191 PF01048 0.453
MOD_GlcNHglycan 442 445 PF01048 0.297
MOD_GSK3_1 1 8 PF00069 0.651
MOD_GSK3_1 122 129 PF00069 0.304
MOD_GSK3_1 166 173 PF00069 0.339
MOD_GSK3_1 182 189 PF00069 0.228
MOD_GSK3_1 196 203 PF00069 0.279
MOD_GSK3_1 35 42 PF00069 0.333
MOD_GSK3_1 381 388 PF00069 0.588
MOD_GSK3_1 409 416 PF00069 0.408
MOD_GSK3_1 585 592 PF00069 0.367
MOD_GSK3_1 600 607 PF00069 0.547
MOD_GSK3_1 67 74 PF00069 0.269
MOD_N-GLC_1 186 191 PF02516 0.460
MOD_N-GLC_1 223 228 PF02516 0.168
MOD_N-GLC_1 413 418 PF02516 0.550
MOD_N-GLC_1 529 534 PF02516 0.437
MOD_N-GLC_1 62 67 PF02516 0.504
MOD_N-GLC_2 136 138 PF02516 0.357
MOD_NEK2_1 1 6 PF00069 0.662
MOD_NEK2_1 134 139 PF00069 0.337
MOD_NEK2_1 171 176 PF00069 0.379
MOD_NEK2_1 196 201 PF00069 0.287
MOD_NEK2_1 263 268 PF00069 0.322
MOD_NEK2_1 271 276 PF00069 0.259
MOD_NEK2_1 291 296 PF00069 0.318
MOD_NEK2_1 35 40 PF00069 0.299
MOD_NEK2_1 9 14 PF00069 0.563
MOD_NEK2_2 126 131 PF00069 0.285
MOD_NEK2_2 232 237 PF00069 0.502
MOD_PIKK_1 600 606 PF00454 0.514
MOD_PIKK_1 7 13 PF00454 0.593
MOD_PKA_2 446 452 PF00069 0.330
MOD_PKB_1 221 229 PF00069 0.512
MOD_Plk_1 362 368 PF00069 0.685
MOD_Plk_1 529 535 PF00069 0.437
MOD_Plk_1 67 73 PF00069 0.259
MOD_Plk_4 143 149 PF00069 0.326
MOD_Plk_4 171 177 PF00069 0.365
MOD_Plk_4 196 202 PF00069 0.252
MOD_Plk_4 235 241 PF00069 0.490
MOD_Plk_4 291 297 PF00069 0.357
MOD_Plk_4 35 41 PF00069 0.302
MOD_Plk_4 362 368 PF00069 0.773
MOD_Plk_4 381 387 PF00069 0.558
MOD_Plk_4 406 412 PF00069 0.341
MOD_Plk_4 414 420 PF00069 0.306
MOD_Plk_4 43 49 PF00069 0.311
MOD_Plk_4 430 436 PF00069 0.252
MOD_Plk_4 585 591 PF00069 0.276
MOD_ProDKin_1 350 356 PF00069 0.755
MOD_ProDKin_1 458 464 PF00069 0.519
MOD_ProDKin_1 572 578 PF00069 0.384
MOD_ProDKin_1 604 610 PF00069 0.618
MOD_SUMO_rev_2 27 32 PF00179 0.510
TRG_ENDOCYTIC_2 132 135 PF00928 0.278
TRG_ENDOCYTIC_2 193 196 PF00928 0.311
TRG_ENDOCYTIC_2 252 255 PF00928 0.357
TRG_ENDOCYTIC_2 273 276 PF00928 0.259
TRG_ENDOCYTIC_2 435 438 PF00928 0.299
TRG_ENDOCYTIC_2 499 502 PF00928 0.355
TRG_ENDOCYTIC_2 598 601 PF00928 0.520
TRG_ENDOCYTIC_2 81 84 PF00928 0.309
TRG_ENDOCYTIC_2 86 89 PF00928 0.318
TRG_ENDOCYTIC_2 90 93 PF00928 0.482
TRG_ER_diArg_1 155 158 PF00400 0.526
TRG_ER_diArg_1 220 223 PF00400 0.509
TRG_ER_diArg_1 247 249 PF00400 0.458
TRG_ER_diLys_1 610 614 PF00400 0.491

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6G0 Leptomonas seymouri 28% 97%
A0A0N1HT40 Leptomonas seymouri 30% 100%
A0A0N1HZC2 Leptomonas seymouri 72% 98%
A0A0N1IKC5 Leptomonas seymouri 32% 100%
A0A0N1PAX2 Leptomonas seymouri 39% 100%
A0A0N1PB63 Leptomonas seymouri 47% 93%
A0A0N1PD04 Leptomonas seymouri 24% 96%
A0A0N1PFR4 Leptomonas seymouri 29% 93%
A0A0S4JR45 Bodo saltans 25% 100%
A0A1X0NKK0 Trypanosomatidae 54% 100%
A0A1X0NL32 Trypanosomatidae 30% 98%
A0A1X0NM09 Trypanosomatidae 54% 100%
A0A1X0NRW5 Trypanosomatidae 26% 88%
A0A1X0NV13 Trypanosomatidae 31% 94%
A0A1X0NV19 Trypanosomatidae 32% 100%
A0A1X0NV27 Trypanosomatidae 30% 100%
A0A1X0NVH8 Trypanosomatidae 30% 93%
A0A1X0NVM7 Trypanosomatidae 30% 95%
A0A1X0NWQ1 Trypanosomatidae 29% 96%
A0A1X0NZE6 Trypanosomatidae 32% 100%
A0A1X0NZU2 Trypanosomatidae 28% 95%
A0A1X0NZU5 Trypanosomatidae 30% 100%
A0A1X0NZW1 Trypanosomatidae 29% 100%
A0A1X0P0M7 Trypanosomatidae 31% 100%
A0A381MMW5 Leishmania infantum 29% 94%
A0A3Q8I7Y9 Leishmania donovani 29% 100%
A0A3Q8IEC4 Leishmania donovani 29% 95%
A0A3Q8IF95 Leishmania donovani 45% 97%
A0A3Q8IIT5 Leishmania donovani 28% 91%
A0A3Q8ISY9 Leishmania donovani 27% 97%
A0A3R7JSQ9 Trypanosoma rangeli 27% 100%
A0A3R7KKN8 Trypanosoma rangeli 30% 100%
A0A3R7MAQ7 Trypanosoma rangeli 26% 87%
A0A3R7N3S6 Trypanosoma rangeli 24% 95%
A0A3R7N415 Trypanosoma rangeli 31% 100%
A0A3R7N921 Trypanosoma rangeli 29% 100%
A0A3R7R443 Trypanosoma rangeli 29% 100%
A0A3S7WRJ4 Leishmania donovani 31% 96%
A0A3S7WRJ5 Leishmania donovani 29% 88%
A0A3S7WRL4 Leishmania donovani 29% 99%
A0A3S7WRS3 Leishmania donovani 26% 98%
A0A3S7WSR4 Leishmania donovani 32% 100%
A0A3S7WWU1 Leishmania donovani 48% 92%
A0A3S7X2G0 Leishmania donovani 29% 94%
A0A3S7X2K5 Leishmania donovani 29% 100%
A0A3S7XB11 Leishmania donovani 87% 100%
A0A422MSE4 Trypanosoma rangeli 32% 100%
A0A422MSP6 Trypanosoma rangeli 28% 100%
A0A422MST9 Trypanosoma rangeli 30% 100%
A0A422MU68 Trypanosoma rangeli 50% 100%
A4H6J0 Leishmania braziliensis 29% 100%
A4H6J1 Leishmania braziliensis 32% 100%
A4H6J3 Leishmania braziliensis 30% 100%
A4H6Q5 Leishmania braziliensis 25% 100%
A4HC19 Leishmania braziliensis 48% 100%
A4HHG2 Leishmania braziliensis 28% 100%
A4HHG3 Leishmania braziliensis 29% 100%
A4HHG4 Leishmania braziliensis 30% 100%
A4HJW3 Leishmania braziliensis 27% 100%
A4HUX5 Leishmania infantum 31% 96%
A4HUX6 Leishmania infantum 29% 88%
A4HUX7 Leishmania infantum 29% 99%
A4HUX8 Leishmania infantum 28% 100%
A4HV40 Leishmania infantum 26% 98%
A4HZF5 Leishmania infantum 45% 97%
A4HZJ4 Leishmania infantum 47% 92%
A4I4L2 Leishmania infantum 27% 91%
A4I7C5 Leishmania infantum 27% 97%
A4ICI3 Leishmania infantum 87% 100%
C9ZL97 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZL98 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZL99 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZLA0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZLA1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZTR5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
C9ZTR6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
C9ZTR7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZTR8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
C9ZTR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
C9ZTS1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
C9ZUT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
D0A7B1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 95%
D0A7H1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
D0AAQ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 90%
E8NHE1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 98%
E9AE01 Leishmania major 30% 100%
E9AE09 Leishmania major 27% 100%
E9AE10 Leishmania major 27% 100%
E9AE11 Leishmania major 31% 100%
E9AGK5 Leishmania infantum 32% 100%
E9AHJ0 Leishmania infantum 29% 95%
E9AHJ1 Leishmania infantum 29% 100%
E9ALS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 95%
E9ALS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 91%
E9ANL0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 96%
E9ANL1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 94%
E9ANL2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9ANS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 97%
E9APJ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AT53 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
E9AVF1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E9AVF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 93%
E9B2B8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 97%
Q4Q1E4 Leishmania major 87% 99%
Q4Q5T8 Leishmania major 28% 100%
Q4QC27 Leishmania major 48% 100%
Q4QC28 Leishmania major 44% 99%
Q4QFY5 Leishmania major 31% 100%
Q4QGU8 Leishmania major 26% 100%
Q4QH10 Leishmania major 28% 97%
Q4QH11 Leishmania major 28% 95%
Q4QH12 Leishmania major 28% 95%
Q4QH13 Leishmania major 29% 95%
Q4QH14 Leishmania major 29% 100%
Q4QH15 Leishmania major 31% 100%
V5B647 Trypanosoma cruzi 31% 97%
V5B983 Trypanosoma cruzi 30% 100%
V5BBB1 Trypanosoma cruzi 29% 100%
V5BFV8 Trypanosoma cruzi 29% 92%
V5BQY6 Trypanosoma cruzi 26% 87%
V5BVP0 Trypanosoma cruzi 29% 100%
V5DT25 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS