Acetyltransferase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acetyltransferase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HPE1_LEIBR

TriTrypDb:

LbrM.35.2970 , LBRM2903_350037900

Length:

158

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPE1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016407	acetyltransferase activity	5	6
GO:0016740	transferase activity	2	6
GO:0016746	acyltransferase activity	3	6
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	6
GO:0008080	N-acetyltransferase activity	6	1
GO:0016410	N-acyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.534
CLV_NRD_NRD_1	9	11	PF00675	0.531
CLV_PCSK_KEX2_1	141	143	PF00082	0.251
CLV_PCSK_KEX2_1	9	11	PF00082	0.531
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.251
CLV_PCSK_SKI1_1	107	111	PF00082	0.321
DOC_CKS1_1	132	137	PF01111	0.251
DOC_CYCLIN_RxL_1	101	111	PF00134	0.321
DOC_CYCLIN_RxL_1	84	93	PF00134	0.321
DOC_PP2B_PxIxI_1	3	9	PF00149	0.488
DOC_WW_Pin1_4	131	136	PF00397	0.260
LIG_14-3-3_CanoR_1	51	61	PF00244	0.310
LIG_14-3-3_CanoR_1	80	85	PF00244	0.321
LIG_BIR_II_1	1	5	PF00653	0.535
LIG_deltaCOP1_diTrp_1	148	158	PF00928	0.686
LIG_FHA_1	132	138	PF00498	0.315
LIG_LIR_Gen_1	17	28	PF02991	0.470
LIG_LIR_Nem_3	17	23	PF02991	0.469
LIG_PDZ_Class_2	153	158	PF00595	0.546
LIG_SH2_CRK	20	24	PF00017	0.543
LIG_SH2_NCK_1	29	33	PF00017	0.563
LIG_SH2_STAP1	143	147	PF00017	0.551
LIG_SH2_STAP1	20	24	PF00017	0.595
LIG_SH2_STAT5	90	93	PF00017	0.321
LIG_TRAF2_1	117	120	PF00917	0.321
MOD_CK2_1	36	42	PF00069	0.518
MOD_GlcNHglycan	1	4	PF01048	0.627
MOD_GlcNHglycan	54	57	PF01048	0.541
MOD_N-GLC_1	152	157	PF02516	0.476
MOD_NEK2_2	4	9	PF00069	0.618
MOD_PKA_1	13	19	PF00069	0.455
MOD_PKA_2	79	85	PF00069	0.321
MOD_Plk_1	152	158	PF00069	0.545
MOD_ProDKin_1	131	137	PF00069	0.260
MOD_SUMO_for_1	117	120	PF00179	0.321
TRG_ENDOCYTIC_2	20	23	PF00928	0.542
TRG_ER_diArg_1	8	10	PF00400	0.547
TRG_ER_diArg_1	84	87	PF00400	0.321
TRG_NES_CRM1_1	17	30	PF08389	0.539
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.336
TRG_Pf-PMV_PEXEL_1	87	92	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE86	Leptomonas seymouri	79%	100%
A0A3Q8IJ73	Leishmania donovani	89%	100%
A4ICI2	Leishmania infantum	89%	100%
O17731	Caenorhabditis elegans	31%	99%
P21673	Homo sapiens	37%	92%
P48026	Mus musculus	36%	92%
P49431	Mus saxicola	36%	92%
P79081	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	94%
Q01612	Mesocricetus auratus	36%	92%
Q28999	Sus scrofa	37%	92%
Q3T0Q0	Bos taurus	37%	92%
Q53HX3	Leishmania major	88%	100%
Q6P8J2	Mus musculus	35%	93%
Q7PCJ8	Bos taurus	38%	93%
Q7PCJ9	Sus scrofa	36%	93%
Q8AXL1	Gallus gallus	37%	92%
Q96F10	Homo sapiens	36%	93%
Q9JHW6	Cricetulus griseus	36%	92%
Q9ZV05	Arabidopsis thaliana	25%	69%
Q9ZV06	Arabidopsis thaliana	26%	67%