Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HPE0_LEIBR

TriTrypDb:

LbrM.35.2960 , LBRM2903_350037700

Length:

1020

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPE0

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009308	amine metabolic process	4	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	6
GO:0005507	copper ion binding	6	6
GO:0008131	primary amine oxidase activity	5	6
GO:0016491	oxidoreductase activity	2	6
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	3	6
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	4	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	6
GO:0048038	quinone binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	842	846	PF00656	0.582
CLV_NRD_NRD_1	1015	1017	PF00675	0.548
CLV_NRD_NRD_1	1018	1020	PF00675	0.614
CLV_NRD_NRD_1	313	315	PF00675	0.546
CLV_NRD_NRD_1	999	1001	PF00675	0.534
CLV_PCSK_FUR_1	1013	1017	PF00082	0.613
CLV_PCSK_KEX2_1	1015	1017	PF00082	0.548
CLV_PCSK_KEX2_1	1018	1020	PF00082	0.614
CLV_PCSK_KEX2_1	235	237	PF00082	0.337
CLV_PCSK_KEX2_1	313	315	PF00082	0.544
CLV_PCSK_KEX2_1	964	966	PF00082	0.588
CLV_PCSK_KEX2_1	999	1001	PF00082	0.534
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.337
CLV_PCSK_PC1ET2_1	964	966	PF00082	0.588
CLV_PCSK_SKI1_1	121	125	PF00082	0.350
CLV_PCSK_SKI1_1	167	171	PF00082	0.310
CLV_PCSK_SKI1_1	26	30	PF00082	0.517
CLV_PCSK_SKI1_1	289	293	PF00082	0.414
CLV_PCSK_SKI1_1	298	302	PF00082	0.450
CLV_PCSK_SKI1_1	373	377	PF00082	0.403
CLV_PCSK_SKI1_1	408	412	PF00082	0.339
CLV_PCSK_SKI1_1	663	667	PF00082	0.471
CLV_PCSK_SKI1_1	767	771	PF00082	0.456
CLV_PCSK_SKI1_1	901	905	PF00082	0.492
CLV_PCSK_SKI1_1	928	932	PF00082	0.515
CLV_PCSK_SKI1_1	965	969	PF00082	0.534
CLV_Separin_Metazoa	422	426	PF03568	0.658
CLV_Separin_Metazoa	943	947	PF03568	0.746
DEG_APCC_DBOX_1	166	174	PF00400	0.507
DEG_APCC_DBOX_1	25	33	PF00400	0.616
DEG_APCC_DBOX_1	662	670	PF00400	0.681
DEG_SPOP_SBC_1	21	25	PF00917	0.704
DEG_SPOP_SBC_1	691	695	PF00917	0.716
DOC_CKS1_1	67	72	PF01111	0.694
DOC_CKS1_1	84	89	PF01111	0.530
DOC_CYCLIN_RxL_1	144	154	PF00134	0.619
DOC_CYCLIN_yCln2_LP_2	560	566	PF00134	0.507
DOC_MAPK_gen_1	296	303	PF00069	0.732
DOC_MAPK_gen_1	916	926	PF00069	0.696
DOC_MAPK_MEF2A_6	663	670	PF00069	0.755
DOC_MAPK_MEF2A_6	916	924	PF00069	0.698
DOC_MAPK_MEF2A_6	92	100	PF00069	0.654
DOC_MAPK_NFAT4_5	663	671	PF00069	0.755
DOC_PP1_RVXF_1	233	240	PF00149	0.640
DOC_PP1_RVXF_1	287	293	PF00149	0.615
DOC_PP1_RVXF_1	661	668	PF00149	0.683
DOC_PP2B_LxvP_1	39	42	PF13499	0.602
DOC_PP2B_LxvP_1	560	563	PF13499	0.505
DOC_PP2B_LxvP_1	744	747	PF13499	0.789
DOC_PP4_FxxP_1	688	691	PF00568	0.705
DOC_PP4_FxxP_1	932	935	PF00568	0.786
DOC_USP7_MATH_1	21	25	PF00917	0.773
DOC_USP7_MATH_1	332	336	PF00917	0.786
DOC_USP7_MATH_1	580	584	PF00917	0.555
DOC_USP7_MATH_1	691	695	PF00917	0.716
DOC_USP7_MATH_1	860	864	PF00917	0.684
DOC_USP7_MATH_1	874	878	PF00917	0.620
DOC_USP7_MATH_1	915	919	PF00917	0.673
DOC_WW_Pin1_4	14	19	PF00397	0.708
DOC_WW_Pin1_4	180	185	PF00397	0.785
DOC_WW_Pin1_4	199	204	PF00397	0.459
DOC_WW_Pin1_4	351	356	PF00397	0.638
DOC_WW_Pin1_4	554	559	PF00397	0.352
DOC_WW_Pin1_4	66	71	PF00397	0.642
DOC_WW_Pin1_4	687	692	PF00397	0.651
DOC_WW_Pin1_4	787	792	PF00397	0.610
DOC_WW_Pin1_4	83	88	PF00397	0.532
DOC_WW_Pin1_4	863	868	PF00397	0.766
DOC_WW_Pin1_4	931	936	PF00397	0.726
LIG_14-3-3_CanoR_1	1002	1007	PF00244	0.737
LIG_14-3-3_CanoR_1	215	221	PF00244	0.657
LIG_14-3-3_CanoR_1	236	240	PF00244	0.731
LIG_14-3-3_CanoR_1	323	332	PF00244	0.795
LIG_14-3-3_CanoR_1	373	383	PF00244	0.600
LIG_14-3-3_CanoR_1	388	392	PF00244	0.671
LIG_14-3-3_CanoR_1	470	480	PF00244	0.550
LIG_14-3-3_CanoR_1	489	498	PF00244	0.632
LIG_14-3-3_CanoR_1	59	67	PF00244	0.783
LIG_14-3-3_CanoR_1	738	747	PF00244	0.680
LIG_14-3-3_CanoR_1	767	773	PF00244	0.682
LIG_14-3-3_CanoR_1	838	847	PF00244	0.639
LIG_14-3-3_CanoR_1	848	857	PF00244	0.660
LIG_14-3-3_CanoR_1	873	879	PF00244	0.728
LIG_Actin_WH2_2	202	217	PF00022	0.668
LIG_Actin_WH2_2	362	378	PF00022	0.699
LIG_Actin_WH2_2	394	410	PF00022	0.610
LIG_BIR_II_1	1	5	PF00653	0.609
LIG_BIR_III_4	974	978	PF00653	0.630
LIG_deltaCOP1_diTrp_1	618	623	PF00928	0.585
LIG_DLG_GKlike_1	1002	1010	PF00625	0.740
LIG_FHA_1	229	235	PF00498	0.512
LIG_FHA_1	267	273	PF00498	0.662
LIG_FHA_1	286	292	PF00498	0.613
LIG_FHA_1	352	358	PF00498	0.728
LIG_FHA_1	569	575	PF00498	0.512
LIG_FHA_1	748	754	PF00498	0.608
LIG_FHA_1	768	774	PF00498	0.748
LIG_FHA_1	822	828	PF00498	0.645
LIG_FHA_1	9	15	PF00498	0.633
LIG_FHA_2	114	120	PF00498	0.660
LIG_FHA_2	160	166	PF00498	0.708
LIG_FHA_2	303	309	PF00498	0.711
LIG_FHA_2	324	330	PF00498	0.646
LIG_FHA_2	354	360	PF00498	0.627
LIG_FHA_2	394	400	PF00498	0.685
LIG_FHA_2	471	477	PF00498	0.536
LIG_FHA_2	510	516	PF00498	0.589
LIG_FHA_2	548	554	PF00498	0.437
LIG_FHA_2	788	794	PF00498	0.616
LIG_FHA_2	84	90	PF00498	0.639
LIG_FHA_2	885	891	PF00498	0.599
LIG_GBD_Chelix_1	371	379	PF00786	0.401
LIG_GBD_Chelix_1	93	101	PF00786	0.411
LIG_Integrin_RGD_1	345	347	PF01839	0.406
LIG_LIR_Apic_2	686	691	PF02991	0.618
LIG_LIR_Apic_2	929	935	PF02991	0.786
LIG_LIR_Gen_1	238	247	PF02991	0.787
LIG_LIR_Gen_1	664	673	PF02991	0.645
LIG_LIR_Gen_1	7	18	PF02991	0.649
LIG_LIR_Gen_1	703	713	PF02991	0.776
LIG_LIR_Gen_1	802	812	PF02991	0.691
LIG_LIR_Gen_1	966	976	PF02991	0.718
LIG_LIR_Nem_3	238	242	PF02991	0.774
LIG_LIR_Nem_3	402	407	PF02991	0.621
LIG_LIR_Nem_3	411	416	PF02991	0.613
LIG_LIR_Nem_3	479	485	PF02991	0.540
LIG_LIR_Nem_3	573	579	PF02991	0.485
LIG_LIR_Nem_3	618	623	PF02991	0.765
LIG_LIR_Nem_3	664	670	PF02991	0.645
LIG_LIR_Nem_3	7	13	PF02991	0.701
LIG_LIR_Nem_3	703	708	PF02991	0.787
LIG_LIR_Nem_3	802	807	PF02991	0.684
LIG_LIR_Nem_3	876	881	PF02991	0.697
LIG_LIR_Nem_3	966	971	PF02991	0.783
LIG_MYND_1	559	563	PF01753	0.330
LIG_NRBOX	144	150	PF00104	0.609
LIG_NRBOX	289	295	PF00104	0.614
LIG_NRBOX	664	670	PF00104	0.684
LIG_NRBOX	96	102	PF00104	0.690
LIG_SH2_CRK	705	709	PF00017	0.792
LIG_SH2_CRK	823	827	PF00017	0.566
LIG_SH2_NCK_1	536	540	PF00017	0.411
LIG_SH2_STAP1	536	540	PF00017	0.411
LIG_SH2_STAP1	823	827	PF00017	0.566
LIG_SH2_STAT3	384	387	PF00017	0.657
LIG_SH2_STAT5	253	256	PF00017	0.659
LIG_SH2_STAT5	426	429	PF00017	0.567
LIG_SH2_STAT5	482	485	PF00017	0.484
LIG_SH2_STAT5	554	557	PF00017	0.410
LIG_SH2_STAT5	567	570	PF00017	0.427
LIG_SH2_STAT5	577	580	PF00017	0.378
LIG_SH2_STAT5	823	826	PF00017	0.570
LIG_SH3_3	101	107	PF00018	0.648
LIG_SH3_3	15	21	PF00018	0.763
LIG_SH3_3	44	50	PF00018	0.627
LIG_SH3_3	529	535	PF00018	0.591
LIG_SH3_3	553	559	PF00018	0.357
LIG_SH3_3	804	810	PF00018	0.739
LIG_SH3_3	876	882	PF00018	0.723
LIG_Sin3_3	540	547	PF02671	0.416
LIG_SUMO_SIM_anti_2	368	373	PF11976	0.698
LIG_SUMO_SIM_anti_2	492	500	PF11976	0.736
LIG_SUMO_SIM_anti_2	541	546	PF11976	0.290
LIG_SUMO_SIM_anti_2	715	721	PF11976	0.774
LIG_SUMO_SIM_anti_2	770	776	PF11976	0.688
LIG_SUMO_SIM_anti_2	824	829	PF11976	0.719
LIG_SUMO_SIM_par_1	667	672	PF11976	0.745
LIG_SUMO_SIM_par_1	749	754	PF11976	0.637
LIG_SUMO_SIM_par_1	823	829	PF11976	0.723
LIG_TRAF2_1	396	399	PF00917	0.611
LIG_TRAF2_1	528	531	PF00917	0.546
LIG_TRAF2_1	887	890	PF00917	0.598
LIG_TYR_ITIM	480	485	PF00017	0.323
LIG_TYR_ITIM	574	579	PF00017	0.669
LIG_TYR_ITIM	821	826	PF00017	0.423
LIG_UBA3_1	622	630	PF00899	0.626
LIG_UBA3_1	665	674	PF00899	0.602
MOD_CDK_SPK_2	787	792	PF00069	0.471
MOD_CDK_SPK_2	863	868	PF00069	0.467
MOD_CDK_SPxxK_3	180	187	PF00069	0.737
MOD_CK1_1	1005	1011	PF00069	0.689
MOD_CK1_1	20	26	PF00069	0.610
MOD_CK1_1	238	244	PF00069	0.643
MOD_CK1_1	259	265	PF00069	0.498
MOD_CK1_1	4	10	PF00069	0.560
MOD_CK1_1	409	415	PF00069	0.387
MOD_CK1_1	690	696	PF00069	0.615
MOD_CK1_1	863	869	PF00069	0.710
MOD_CK1_1	934	940	PF00069	0.567
MOD_CK2_1	113	119	PF00069	0.578
MOD_CK2_1	159	165	PF00069	0.659
MOD_CK2_1	213	219	PF00069	0.379
MOD_CK2_1	262	268	PF00069	0.408
MOD_CK2_1	302	308	PF00069	0.643
MOD_CK2_1	353	359	PF00069	0.532
MOD_CK2_1	393	399	PF00069	0.515
MOD_CK2_1	470	476	PF00069	0.415
MOD_CK2_1	509	515	PF00069	0.514
MOD_CK2_1	603	609	PF00069	0.716
MOD_CK2_1	612	618	PF00069	0.585
MOD_CK2_1	787	793	PF00069	0.535
MOD_CK2_1	829	835	PF00069	0.687
MOD_CK2_1	83	89	PF00069	0.550
MOD_CK2_1	884	890	PF00069	0.482
MOD_GlcNHglycan	1007	1010	PF01048	0.794
MOD_GlcNHglycan	258	261	PF01048	0.674
MOD_GlcNHglycan	3	6	PF01048	0.672
MOD_GlcNHglycan	314	317	PF01048	0.814
MOD_GlcNHglycan	326	329	PF01048	0.584
MOD_GlcNHglycan	334	337	PF01048	0.612
MOD_GlcNHglycan	338	341	PF01048	0.529
MOD_GlcNHglycan	376	379	PF01048	0.537
MOD_GlcNHglycan	408	411	PF01048	0.512
MOD_GlcNHglycan	524	527	PF01048	0.560
MOD_GlcNHglycan	582	585	PF01048	0.632
MOD_GlcNHglycan	592	595	PF01048	0.431
MOD_GlcNHglycan	671	674	PF01048	0.640
MOD_GlcNHglycan	740	743	PF01048	0.697
MOD_GlcNHglycan	763	766	PF01048	0.715
MOD_GlcNHglycan	850	853	PF01048	0.598
MOD_GlcNHglycan	938	941	PF01048	0.630
MOD_GSK3_1	17	24	PF00069	0.674
MOD_GSK3_1	237	244	PF00069	0.644
MOD_GSK3_1	262	269	PF00069	0.581
MOD_GSK3_1	319	326	PF00069	0.730
MOD_GSK3_1	332	339	PF00069	0.554
MOD_GSK3_1	4	11	PF00069	0.535
MOD_GSK3_1	562	569	PF00069	0.443
MOD_GSK3_1	687	694	PF00069	0.635
MOD_GSK3_1	696	703	PF00069	0.713
MOD_GSK3_1	880	887	PF00069	0.490
MOD_GSK3_1	966	973	PF00069	0.653
MOD_GSK3_1	975	982	PF00069	0.668
MOD_GSK3_1	998	1005	PF00069	0.746
MOD_N-GLC_1	522	527	PF02516	0.626
MOD_NEK2_1	1	6	PF00069	0.765
MOD_NEK2_1	151	156	PF00069	0.572
MOD_NEK2_1	213	218	PF00069	0.517
MOD_NEK2_1	228	233	PF00069	0.496
MOD_NEK2_1	237	242	PF00069	0.680
MOD_NEK2_1	266	271	PF00069	0.562
MOD_NEK2_1	374	379	PF00069	0.477
MOD_NEK2_1	538	543	PF00069	0.411
MOD_NEK2_1	568	573	PF00069	0.612
MOD_NEK2_1	602	607	PF00069	0.557
MOD_NEK2_1	669	674	PF00069	0.641
MOD_NEK2_1	696	701	PF00069	0.580
MOD_NEK2_1	80	85	PF00069	0.415
MOD_NEK2_1	821	826	PF00069	0.621
MOD_NEK2_1	884	889	PF00069	0.564
MOD_NEK2_1	910	915	PF00069	0.632
MOD_NEK2_2	776	781	PF00069	0.663
MOD_NEK2_2	975	980	PF00069	0.796
MOD_PIKK_1	547	553	PF00454	0.649
MOD_PIKK_1	730	736	PF00454	0.733
MOD_PIKK_1	826	832	PF00454	0.411
MOD_PKA_1	235	241	PF00069	0.437
MOD_PKA_2	149	155	PF00069	0.548
MOD_PKA_2	214	220	PF00069	0.564
MOD_PKA_2	235	241	PF00069	0.573
MOD_PKA_2	312	318	PF00069	0.704
MOD_PKA_2	324	330	PF00069	0.702
MOD_PKA_2	387	393	PF00069	0.684
MOD_PKA_2	471	477	PF00069	0.424
MOD_PKA_2	48	54	PF00069	0.590
MOD_PKA_2	761	767	PF00069	0.762
MOD_PKA_2	80	86	PF00069	0.411
MOD_PKA_2	998	1004	PF00069	0.783
MOD_PKB_1	1000	1008	PF00069	0.679
MOD_Plk_1	266	272	PF00069	0.575
MOD_Plk_1	499	505	PF00069	0.461
MOD_Plk_1	552	558	PF00069	0.474
MOD_Plk_1	676	682	PF00069	0.606
MOD_Plk_1	910	916	PF00069	0.730
MOD_Plk_2-3	399	405	PF00069	0.525
MOD_Plk_2-3	893	899	PF00069	0.719
MOD_Plk_4	1002	1008	PF00069	0.680
MOD_Plk_4	266	272	PF00069	0.383
MOD_Plk_4	353	359	PF00069	0.579
MOD_Plk_4	399	405	PF00069	0.459
MOD_Plk_4	499	505	PF00069	0.499
MOD_Plk_4	538	544	PF00069	0.395
MOD_Plk_4	692	698	PF00069	0.716
MOD_Plk_4	700	706	PF00069	0.707
MOD_Plk_4	712	718	PF00069	0.531
MOD_Plk_4	768	774	PF00069	0.646
MOD_Plk_4	821	827	PF00069	0.551
MOD_Plk_4	829	835	PF00069	0.617
MOD_ProDKin_1	14	20	PF00069	0.644
MOD_ProDKin_1	180	186	PF00069	0.738
MOD_ProDKin_1	199	205	PF00069	0.282
MOD_ProDKin_1	351	357	PF00069	0.536
MOD_ProDKin_1	554	560	PF00069	0.412
MOD_ProDKin_1	66	72	PF00069	0.543
MOD_ProDKin_1	687	693	PF00069	0.557
MOD_ProDKin_1	787	793	PF00069	0.507
MOD_ProDKin_1	83	89	PF00069	0.385
MOD_ProDKin_1	863	869	PF00069	0.710
MOD_ProDKin_1	931	937	PF00069	0.662
MOD_SUMO_for_1	940	943	PF00179	0.684
MOD_SUMO_rev_2	569	574	PF00179	0.422
TRG_DiLeu_BaEn_1	165	170	PF01217	0.370
TRG_DiLeu_BaEn_4	398	404	PF01217	0.501
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.588
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.303
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.499
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.497
TRG_DiLeu_BaLyEn_6	556	561	PF01217	0.399
TRG_DiLeu_BaLyEn_6	807	812	PF01217	0.597
TRG_DiLeu_BaLyEn_6	876	881	PF01217	0.661
TRG_ENDOCYTIC_2	460	463	PF00928	0.418
TRG_ENDOCYTIC_2	482	485	PF00928	0.324
TRG_ENDOCYTIC_2	576	579	PF00928	0.679
TRG_ENDOCYTIC_2	705	708	PF00928	0.747
TRG_ENDOCYTIC_2	823	826	PF00928	0.437
TRG_ER_diArg_1	1013	1016	PF00400	0.683
TRG_ER_diArg_1	295	298	PF00400	0.522
TRG_ER_diArg_1	469	472	PF00400	0.524
TRG_ER_diArg_1	999	1002	PF00400	0.671
TRG_NES_CRM1_1	140	153	PF08389	0.441
TRG_NES_CRM1_1	391	405	PF08389	0.362
TRG_Pf-PMV_PEXEL_1	425	429	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	781	785	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I662	Leptomonas seymouri	48%	93%
A0A3S7XB33	Leishmania donovani	82%	100%
A4ICI1	Leishmania infantum	82%	100%
E9AT52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q1E6	Leishmania major	82%	100%