Centrosomal protein POC5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPD7_LEIBR

TriTrypDb:

LbrM.35.2920 , LBRM2903_350037200

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0005814	centriole	5	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1

Expansion

Sequence features

A4HPD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPD7

Function

Biological processes
Term	Name	Level	Count
GO:0007049	cell cycle	2	9
GO:0009987	cellular process	1	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.436
CLV_NRD_NRD_1	120	122	PF00675	0.470
CLV_NRD_NRD_1	149	151	PF00675	0.365
CLV_NRD_NRD_1	286	288	PF00675	0.421
CLV_NRD_NRD_1	327	329	PF00675	0.559
CLV_NRD_NRD_1	41	43	PF00675	0.477
CLV_NRD_NRD_1	57	59	PF00675	0.334
CLV_NRD_NRD_1	63	65	PF00675	0.476
CLV_PCSK_FUR_1	117	121	PF00082	0.517
CLV_PCSK_KEX2_1	110	112	PF00082	0.424
CLV_PCSK_KEX2_1	119	121	PF00082	0.404
CLV_PCSK_KEX2_1	149	151	PF00082	0.419
CLV_PCSK_KEX2_1	161	163	PF00082	0.459
CLV_PCSK_KEX2_1	286	288	PF00082	0.421
CLV_PCSK_KEX2_1	327	329	PF00082	0.559
CLV_PCSK_KEX2_1	40	42	PF00082	0.489
CLV_PCSK_KEX2_1	63	65	PF00082	0.454
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.512
CLV_PCSK_SKI1_1	103	107	PF00082	0.493
CLV_PCSK_SKI1_1	195	199	PF00082	0.437
DEG_APCC_DBOX_1	98	106	PF00400	0.357
DOC_CYCLIN_RxL_1	99	108	PF00134	0.314
DOC_MAPK_DCC_7	238	247	PF00069	0.496
DOC_MAPK_gen_1	117	124	PF00069	0.474
DOC_PP4_FxxP_1	272	275	PF00568	0.529
DOC_USP7_MATH_1	293	297	PF00917	0.679
DOC_USP7_MATH_1	300	304	PF00917	0.601
DOC_USP7_UBL2_3	157	161	PF12436	0.493
DOC_WW_Pin1_4	289	294	PF00397	0.534
LIG_14-3-3_CanoR_1	238	243	PF00244	0.666
LIG_14-3-3_CanoR_1	291	300	PF00244	0.673
LIG_14-3-3_CanoR_1	328	337	PF00244	0.540
LIG_BIR_III_4	267	271	PF00653	0.529
LIG_BRCT_BRCA1_1	302	306	PF00533	0.644
LIG_eIF4E_1	139	145	PF01652	0.380
LIG_LIR_Nem_3	140	145	PF02991	0.315
LIG_SH2_STAT3	176	179	PF00017	0.474
LIG_SH2_STAT5	139	142	PF00017	0.306
LIG_SH2_STAT5	281	284	PF00017	0.538
LIG_SH2_STAT5	38	41	PF00017	0.447
LIG_SH3_2	322	327	PF14604	0.622
LIG_SH3_3	319	325	PF00018	0.609
LIG_SUMO_SIM_anti_2	53	58	PF11976	0.385
LIG_TRAF2_1	50	53	PF00917	0.422
LIG_TRAF2_1	73	76	PF00917	0.499
MOD_CK1_1	188	194	PF00069	0.340
MOD_CK1_1	232	238	PF00069	0.708
MOD_CK1_1	250	256	PF00069	0.622
MOD_CK1_1	292	298	PF00069	0.572
MOD_CK1_1	317	323	PF00069	0.728
MOD_CK1_1	330	336	PF00069	0.615
MOD_GlcNHglycan	295	298	PF01048	0.763
MOD_GlcNHglycan	300	303	PF01048	0.655
MOD_GlcNHglycan	31	34	PF01048	0.325
MOD_GlcNHglycan	319	322	PF01048	0.475
MOD_GSK3_1	234	241	PF00069	0.560
MOD_GSK3_1	246	253	PF00069	0.610
MOD_GSK3_1	289	296	PF00069	0.578
MOD_LATS_1	79	85	PF00433	0.355
MOD_NEK2_1	105	110	PF00069	0.570
MOD_NEK2_1	247	252	PF00069	0.670
MOD_NEK2_1	329	334	PF00069	0.729
MOD_PIKK_1	137	143	PF00454	0.307
MOD_PIKK_1	81	87	PF00454	0.441
MOD_PK_1	238	244	PF00069	0.663
MOD_PKA_1	327	333	PF00069	0.470
MOD_PKA_2	188	194	PF00069	0.363
MOD_PKA_2	232	238	PF00069	0.600
MOD_PKA_2	327	333	PF00069	0.530
MOD_Plk_1	247	253	PF00069	0.660
MOD_ProDKin_1	289	295	PF00069	0.539
MOD_SUMO_for_1	4	7	PF00179	0.595
MOD_SUMO_for_1	50	53	PF00179	0.476
TRG_ER_diArg_1	109	111	PF00400	0.502
TRG_ER_diArg_1	119	121	PF00400	0.480
TRG_ER_diArg_1	326	328	PF00400	0.567
TRG_ER_diArg_1	39	42	PF00400	0.522
TRG_ER_diArg_1	63	65	PF00400	0.423
TRG_Pf-PMV_PEXEL_1	120	125	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	178	183	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2V9	Leptomonas seymouri	50%	99%
A0A1X0NKY4	Trypanosomatidae	29%	82%
A0A3Q8IKC6	Leishmania donovani	81%	100%
A4ICH6	Leishmania infantum	81%	100%
E9AT47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q1F1	Leishmania major	80%	100%
V5BK99	Trypanosoma cruzi	26%	90%