Transportin2-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transportin2-like protein

Species:

Leishmania braziliensis

UniProt:

A4HPD4_LEIBR

TriTrypDb:

LbrM.35.2890 , LBRM2903_350036900

Length:

938

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005634	nucleus	5	4
GO:0005643	nuclear pore	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HPD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPD4

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	12
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0006913	nucleocytoplasmic transport	5	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0033365	protein localization to organelle	5	12
GO:0034504	protein localization to nucleus	6	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051169	nuclear transport	4	12
GO:0051170	import into nucleus	6	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0072594	establishment of protein localization to organelle	4	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005515	protein binding	2	5
GO:0019899	enzyme binding	3	5
GO:0031267	small GTPase binding	5	5
GO:0051020	GTPase binding	4	5
GO:0005048	signal sequence binding	4	1
GO:0008139	nuclear localization sequence binding	5	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1
GO:0061608	nuclear import signal receptor activity	3	1
GO:0140104	molecular carrier activity	1	1
GO:0140142	nucleocytoplasmic carrier activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	181	187	PF00089	0.378
CLV_NRD_NRD_1	198	200	PF00675	0.350
CLV_NRD_NRD_1	908	910	PF00675	0.377
CLV_PCSK_FUR_1	605	609	PF00082	0.260
CLV_PCSK_KEX2_1	525	527	PF00082	0.315
CLV_PCSK_KEX2_1	607	609	PF00082	0.256
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.315
CLV_PCSK_PC1ET2_1	607	609	PF00082	0.256
CLV_PCSK_SKI1_1	200	204	PF00082	0.390
CLV_PCSK_SKI1_1	353	357	PF00082	0.442
CLV_PCSK_SKI1_1	631	635	PF00082	0.311
CLV_PCSK_SKI1_1	670	674	PF00082	0.461
CLV_PCSK_SKI1_1	723	727	PF00082	0.291
CLV_PCSK_SKI1_1	85	89	PF00082	0.451
CLV_PCSK_SKI1_1	928	932	PF00082	0.403
CLV_PCSK_SKI1_1	98	102	PF00082	0.336
DEG_APCC_DBOX_1	702	710	PF00400	0.242
DEG_APCC_DBOX_1	97	105	PF00400	0.368
DEG_Nend_Nbox_1	1	3	PF02207	0.577
DEG_SPOP_SBC_1	568	572	PF00917	0.386
DOC_CDC14_PxL_1	345	353	PF14671	0.410
DOC_CDC14_PxL_1	552	560	PF14671	0.402
DOC_CKS1_1	1	6	PF01111	0.548
DOC_MAPK_gen_1	111	121	PF00069	0.338
DOC_MAPK_gen_1	199	207	PF00069	0.446
DOC_MAPK_gen_1	372	381	PF00069	0.543
DOC_MAPK_gen_1	442	451	PF00069	0.344
DOC_MAPK_gen_1	723	732	PF00069	0.339
DOC_MAPK_MEF2A_6	114	123	PF00069	0.330
DOC_MAPK_MEF2A_6	622	629	PF00069	0.447
DOC_PP4_FxxP_1	428	431	PF00568	0.383
DOC_USP7_MATH_1	100	104	PF00917	0.434
DOC_USP7_MATH_1	113	117	PF00917	0.332
DOC_USP7_MATH_1	125	129	PF00917	0.293
DOC_USP7_MATH_1	233	237	PF00917	0.465
DOC_USP7_MATH_1	802	806	PF00917	0.357
DOC_USP7_MATH_1	900	904	PF00917	0.370
DOC_USP7_MATH_2	869	875	PF00917	0.274
DOC_USP7_UBL2_3	521	525	PF12436	0.257
DOC_WW_Pin1_4	221	226	PF00397	0.382
DOC_WW_Pin1_4	274	279	PF00397	0.377
DOC_WW_Pin1_4	502	507	PF00397	0.423
LIG_14-3-3_CanoR_1	111	121	PF00244	0.402
LIG_14-3-3_CanoR_1	184	190	PF00244	0.319
LIG_14-3-3_CanoR_1	261	266	PF00244	0.390
LIG_14-3-3_CanoR_1	297	303	PF00244	0.351
LIG_14-3-3_CanoR_1	406	413	PF00244	0.342
LIG_14-3-3_CanoR_1	496	502	PF00244	0.413
LIG_14-3-3_CanoR_1	519	529	PF00244	0.354
LIG_14-3-3_CanoR_1	591	597	PF00244	0.571
LIG_14-3-3_CanoR_1	608	612	PF00244	0.357
LIG_14-3-3_CanoR_1	655	661	PF00244	0.482
LIG_14-3-3_CanoR_1	670	679	PF00244	0.472
LIG_14-3-3_CanoR_1	703	707	PF00244	0.488
LIG_14-3-3_CanoR_1	909	913	PF00244	0.264
LIG_Actin_WH2_2	505	523	PF00022	0.251
LIG_Actin_WH2_2	690	705	PF00022	0.389
LIG_Actin_WH2_2	784	799	PF00022	0.421
LIG_APCC_ABBAyCdc20_2	804	810	PF00400	0.535
LIG_BRCT_BRCA1_1	46	50	PF00533	0.318
LIG_BRCT_BRCA1_1	804	808	PF00533	0.438
LIG_BRCT_BRCA1_1	873	877	PF00533	0.532
LIG_BRCT_BRCA1_1	902	906	PF00533	0.442
LIG_deltaCOP1_diTrp_1	699	707	PF00928	0.395
LIG_eIF4E_1	161	167	PF01652	0.295
LIG_eIF4E_1	210	216	PF01652	0.445
LIG_FHA_1	240	246	PF00498	0.308
LIG_FHA_1	260	266	PF00498	0.172
LIG_FHA_1	318	324	PF00498	0.400
LIG_FHA_1	385	391	PF00498	0.747
LIG_FHA_1	546	552	PF00498	0.430
LIG_FHA_1	569	575	PF00498	0.389
LIG_FHA_1	680	686	PF00498	0.354
LIG_FHA_1	688	694	PF00498	0.321
LIG_FHA_1	720	726	PF00498	0.487
LIG_FHA_1	756	762	PF00498	0.404
LIG_FHA_1	791	797	PF00498	0.488
LIG_FHA_1	856	862	PF00498	0.334
LIG_FHA_2	1	7	PF00498	0.420
LIG_FHA_2	125	131	PF00498	0.393
LIG_FHA_2	317	323	PF00498	0.418
LIG_FHA_2	657	663	PF00498	0.236
LIG_LIR_Apic_2	704	710	PF02991	0.468
LIG_LIR_Gen_1	252	260	PF02991	0.451
LIG_LIR_Gen_1	268	278	PF02991	0.335
LIG_LIR_Gen_1	422	432	PF02991	0.383
LIG_LIR_Gen_1	471	480	PF02991	0.525
LIG_LIR_Gen_1	613	621	PF02991	0.375
LIG_LIR_Gen_1	658	667	PF02991	0.339
LIG_LIR_Gen_1	677	688	PF02991	0.317
LIG_LIR_Gen_1	914	924	PF02991	0.540
LIG_LIR_Nem_3	252	258	PF02991	0.444
LIG_LIR_Nem_3	268	273	PF02991	0.238
LIG_LIR_Nem_3	422	428	PF02991	0.354
LIG_LIR_Nem_3	471	476	PF02991	0.518
LIG_LIR_Nem_3	658	663	PF02991	0.357
LIG_LIR_Nem_3	67	72	PF02991	0.328
LIG_LIR_Nem_3	677	683	PF02991	0.203
LIG_LIR_Nem_3	871	876	PF02991	0.425
LIG_LIR_Nem_3	914	919	PF02991	0.475
LIG_LIR_Nem_3	933	937	PF02991	0.417
LIG_NRBOX	583	589	PF00104	0.498
LIG_NRBOX	596	602	PF00104	0.303
LIG_NRBOX	732	738	PF00104	0.328
LIG_PCNA_yPIPBox_3	142	155	PF02747	0.303
LIG_Pex14_2	203	207	PF04695	0.357
LIG_Pex14_2	873	877	PF04695	0.383
LIG_PTB_Apo_2	36	43	PF02174	0.390
LIG_REV1ctd_RIR_1	833	841	PF16727	0.242
LIG_SH2_CRK	30	34	PF00017	0.471
LIG_SH2_CRK	354	358	PF00017	0.376
LIG_SH2_CRK	69	73	PF00017	0.304
LIG_SH2_GRB2like	284	287	PF00017	0.514
LIG_SH2_GRB2like	689	692	PF00017	0.371
LIG_SH2_STAP1	284	288	PF00017	0.382
LIG_SH2_STAP1	616	620	PF00017	0.390
LIG_SH2_STAP1	689	693	PF00017	0.368
LIG_SH2_STAT3	161	164	PF00017	0.290
LIG_SH2_STAT3	784	787	PF00017	0.480
LIG_SH2_STAT3	885	888	PF00017	0.393
LIG_SH2_STAT3	935	938	PF00017	0.528
LIG_SH2_STAT5	161	164	PF00017	0.322
LIG_SH2_STAT5	165	168	PF00017	0.362
LIG_SH2_STAT5	2	5	PF00017	0.533
LIG_SH2_STAT5	269	272	PF00017	0.322
LIG_SH2_STAT5	284	287	PF00017	0.324
LIG_SH2_STAT5	30	33	PF00017	0.514
LIG_SH2_STAT5	616	619	PF00017	0.342
LIG_SH2_STAT5	620	623	PF00017	0.384
LIG_SH2_STAT5	689	692	PF00017	0.400
LIG_SH2_STAT5	814	817	PF00017	0.482
LIG_SH3_3	550	556	PF00018	0.500
LIG_SH3_3	863	869	PF00018	0.389
LIG_SH3_3	889	895	PF00018	0.427
LIG_Sin3_3	348	355	PF02671	0.365
LIG_SUMO_SIM_anti_2	570	579	PF11976	0.485
LIG_SUMO_SIM_par_1	256	262	PF11976	0.394
LIG_SUMO_SIM_par_1	318	325	PF11976	0.425
LIG_SUMO_SIM_par_1	411	418	PF11976	0.376
LIG_SUMO_SIM_par_1	447	453	PF11976	0.395
LIG_SUMO_SIM_par_1	485	491	PF11976	0.312
LIG_TRAF2_1	358	361	PF00917	0.393
LIG_TRFH_1	345	349	PF08558	0.359
LIG_TYR_ITIM	352	357	PF00017	0.369
LIG_TYR_ITIM	537	542	PF00017	0.368
LIG_UBA3_1	512	521	PF00899	0.238
LIG_WRC_WIRS_1	416	421	PF05994	0.335
LIG_WRC_WIRS_1	901	906	PF05994	0.467
LIG_WRC_WIRS_1	931	936	PF05994	0.398
MOD_CK1_1	231	237	PF00069	0.461
MOD_CK1_1	239	245	PF00069	0.437
MOD_CK1_1	299	305	PF00069	0.610
MOD_CK1_1	338	344	PF00069	0.366
MOD_CK1_1	417	423	PF00069	0.375
MOD_CK1_1	495	501	PF00069	0.421
MOD_CK1_1	505	511	PF00069	0.459
MOD_CK1_1	567	573	PF00069	0.421
MOD_CK1_1	658	664	PF00069	0.264
MOD_CK1_1	692	698	PF00069	0.366
MOD_CK1_1	759	765	PF00069	0.463
MOD_CK1_1	855	861	PF00069	0.327
MOD_CK2_1	124	130	PF00069	0.395
MOD_CK2_1	240	246	PF00069	0.352
MOD_CK2_1	274	280	PF00069	0.503
MOD_CK2_1	355	361	PF00069	0.354
MOD_CK2_1	434	440	PF00069	0.578
MOD_CK2_1	465	471	PF00069	0.307
MOD_CK2_1	485	491	PF00069	0.269
MOD_CK2_1	554	560	PF00069	0.276
MOD_CK2_1	589	595	PF00069	0.564
MOD_CK2_1	607	613	PF00069	0.344
MOD_CK2_1	759	765	PF00069	0.550
MOD_CK2_1	915	921	PF00069	0.406
MOD_GlcNHglycan	115	118	PF01048	0.541
MOD_GlcNHglycan	134	137	PF01048	0.270
MOD_GlcNHglycan	176	180	PF01048	0.295
MOD_GlcNHglycan	291	294	PF01048	0.491
MOD_GlcNHglycan	337	340	PF01048	0.509
MOD_GlcNHglycan	357	360	PF01048	0.235
MOD_GlcNHglycan	407	410	PF01048	0.332
MOD_GlcNHglycan	46	49	PF01048	0.360
MOD_GlcNHglycan	461	465	PF01048	0.307
MOD_GlcNHglycan	532	535	PF01048	0.330
MOD_GlcNHglycan	560	563	PF01048	0.326
MOD_GlcNHglycan	597	600	PF01048	0.335
MOD_GlcNHglycan	711	714	PF01048	0.481
MOD_GlcNHglycan	741	744	PF01048	0.414
MOD_GlcNHglycan	788	791	PF01048	0.583
MOD_GlcNHglycan	810	813	PF01048	0.450
MOD_GlcNHglycan	815	818	PF01048	0.299
MOD_GlcNHglycan	873	876	PF01048	0.481
MOD_GlcNHglycan	878	881	PF01048	0.418
MOD_GSK3_1	121	128	PF00069	0.335
MOD_GSK3_1	231	238	PF00069	0.366
MOD_GSK3_1	361	368	PF00069	0.503
MOD_GSK3_1	373	380	PF00069	0.545
MOD_GSK3_1	384	391	PF00069	0.608
MOD_GSK3_1	401	408	PF00069	0.432
MOD_GSK3_1	414	421	PF00069	0.365
MOD_GSK3_1	497	504	PF00069	0.405
MOD_GSK3_1	515	522	PF00069	0.212
MOD_GSK3_1	554	561	PF00069	0.381
MOD_GSK3_1	564	571	PF00069	0.434
MOD_GSK3_1	603	610	PF00069	0.338
MOD_GSK3_1	642	649	PF00069	0.426
MOD_GSK3_1	666	673	PF00069	0.433
MOD_GSK3_1	687	694	PF00069	0.355
MOD_GSK3_1	715	722	PF00069	0.344
MOD_GSK3_1	755	762	PF00069	0.433
MOD_GSK3_1	786	793	PF00069	0.547
MOD_GSK3_1	848	855	PF00069	0.398
MOD_GSK3_1	871	878	PF00069	0.451
MOD_GSK3_1	911	918	PF00069	0.334
MOD_N-GLC_1	502	507	PF02516	0.423
MOD_N-GLC_1	572	577	PF02516	0.340
MOD_N-GLC_1	655	660	PF02516	0.456
MOD_N-GLC_1	670	675	PF02516	0.445
MOD_N-GLC_1	79	84	PF02516	0.307
MOD_N-GLC_2	456	458	PF02516	0.374
MOD_NEK2_1	183	188	PF00069	0.468
MOD_NEK2_1	245	250	PF00069	0.301
MOD_NEK2_1	316	321	PF00069	0.374
MOD_NEK2_1	335	340	PF00069	0.250
MOD_NEK2_1	343	348	PF00069	0.423
MOD_NEK2_1	405	410	PF00069	0.320
MOD_NEK2_1	450	455	PF00069	0.336
MOD_NEK2_1	497	502	PF00069	0.285
MOD_NEK2_1	515	520	PF00069	0.368
MOD_NEK2_1	558	563	PF00069	0.369
MOD_NEK2_1	612	617	PF00069	0.337
MOD_NEK2_1	702	707	PF00069	0.523
MOD_NEK2_1	717	722	PF00069	0.336
MOD_NEK2_1	749	754	PF00069	0.427
MOD_NEK2_1	808	813	PF00069	0.453
MOD_NEK2_1	915	920	PF00069	0.351
MOD_NEK2_1	930	935	PF00069	0.347
MOD_NEK2_2	401	406	PF00069	0.440
MOD_NEK2_2	564	569	PF00069	0.321
MOD_NEK2_2	642	647	PF00069	0.466
MOD_NEK2_2	73	78	PF00069	0.292
MOD_PIKK_1	183	189	PF00454	0.461
MOD_PIKK_1	231	237	PF00454	0.483
MOD_PIKK_1	271	277	PF00454	0.442
MOD_PIKK_1	28	34	PF00454	0.330
MOD_PIKK_1	296	302	PF00454	0.611
MOD_PIKK_1	338	344	PF00454	0.302
MOD_PIKK_1	64	70	PF00454	0.248
MOD_PIKK_1	839	845	PF00454	0.493
MOD_PKA_1	607	613	PF00069	0.262
MOD_PKA_2	113	119	PF00069	0.452
MOD_PKA_2	183	189	PF00069	0.388
MOD_PKA_2	282	288	PF00069	0.393
MOD_PKA_2	296	302	PF00069	0.379
MOD_PKA_2	373	379	PF00069	0.593
MOD_PKA_2	405	411	PF00069	0.350
MOD_PKA_2	495	501	PF00069	0.462
MOD_PKA_2	590	596	PF00069	0.562
MOD_PKA_2	607	613	PF00069	0.383
MOD_PKA_2	702	708	PF00069	0.475
MOD_PKA_2	908	914	PF00069	0.437
MOD_PKB_1	372	380	PF00069	0.509
MOD_Plk_1	210	216	PF00069	0.274
MOD_Plk_1	374	380	PF00069	0.543
MOD_Plk_1	421	427	PF00069	0.419
MOD_Plk_1	460	466	PF00069	0.312
MOD_Plk_1	490	496	PF00069	0.284
MOD_Plk_1	572	578	PF00069	0.336
MOD_Plk_1	612	618	PF00069	0.334
MOD_Plk_1	655	661	PF00069	0.381
MOD_Plk_1	79	85	PF00069	0.512
MOD_Plk_1	848	854	PF00069	0.444
MOD_Plk_1	855	861	PF00069	0.343
MOD_Plk_2-3	211	217	PF00069	0.461
MOD_Plk_2-3	361	367	PF00069	0.437
MOD_Plk_2-3	632	638	PF00069	0.308
MOD_Plk_4	211	217	PF00069	0.461
MOD_Plk_4	240	246	PF00069	0.319
MOD_Plk_4	261	267	PF00069	0.404
MOD_Plk_4	361	367	PF00069	0.477
MOD_Plk_4	465	471	PF00069	0.363
MOD_Plk_4	497	503	PF00069	0.384
MOD_Plk_4	546	552	PF00069	0.417
MOD_Plk_4	554	560	PF00069	0.351
MOD_Plk_4	564	570	PF00069	0.355
MOD_Plk_4	572	578	PF00069	0.385
MOD_Plk_4	607	613	PF00069	0.349
MOD_Plk_4	679	685	PF00069	0.371
MOD_Plk_4	702	708	PF00069	0.395
MOD_Plk_4	749	755	PF00069	0.403
MOD_Plk_4	821	827	PF00069	0.434
MOD_Plk_4	900	906	PF00069	0.404
MOD_Plk_4	911	917	PF00069	0.357
MOD_Plk_4	930	936	PF00069	0.450
MOD_ProDKin_1	221	227	PF00069	0.371
MOD_ProDKin_1	274	280	PF00069	0.372
MOD_ProDKin_1	502	508	PF00069	0.416
MOD_SUMO_rev_2	147	157	PF00179	0.356
MOD_SUMO_rev_2	661	669	PF00179	0.247
MOD_SUMO_rev_2	720	728	PF00179	0.482
TRG_DiLeu_BaEn_1	211	216	PF01217	0.455
TRG_DiLeu_BaEn_1	624	629	PF01217	0.526
TRG_DiLeu_BaEn_2	250	256	PF01217	0.403
TRG_DiLeu_BaEn_3	360	366	PF01217	0.376
TRG_DiLeu_BaLyEn_6	511	516	PF01217	0.462
TRG_DiLeu_BaLyEn_6	772	777	PF01217	0.405
TRG_ENDOCYTIC_2	269	272	PF00928	0.525
TRG_ENDOCYTIC_2	30	33	PF00928	0.421
TRG_ENDOCYTIC_2	354	357	PF00928	0.396
TRG_ENDOCYTIC_2	425	428	PF00928	0.460
TRG_ENDOCYTIC_2	539	542	PF00928	0.468
TRG_ENDOCYTIC_2	616	619	PF00928	0.360
TRG_ENDOCYTIC_2	69	72	PF00928	0.307
TRG_ER_diArg_1	371	374	PF00400	0.480
TRG_NES_CRM1_1	921	936	PF08389	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBU0	Leptomonas seymouri	65%	100%
A0A0S4JDM2	Bodo saltans	32%	100%
A0A1X0NKI1	Trypanosomatidae	44%	100%
A0A3Q8IR35	Leishmania donovani	88%	100%
A0A3R7N6Q2	Trypanosoma rangeli	43%	100%
A4ICH9	Leishmania infantum	87%	100%
D0A3J8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AT50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q1E8	Leishmania major	87%	100%
V5BFP7	Trypanosoma cruzi	44%	100%