LeishMANIAdb
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Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
Gene product:
dihydrolipoamide acetyltransferase precursor, putative
Species:
Leishmania braziliensis
UniProt:
A4HPD2_LEIBR
TriTrypDb:
LbrM.35.2870 , LBRM2903_350036600 *
Length:
462

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 8
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0032991 protein-containing complex 1 11
GO:0045254 pyruvate dehydrogenase complex 4 11
GO:1902494 catalytic complex 2 11
GO:1990204 oxidoreductase complex 3 11
GO:0005739 mitochondrion 5 1
GO:0005967 mitochondrial pyruvate dehydrogenase complex 3 1
GO:0020023 kinetoplast 2 1
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0098798 mitochondrial protein-containing complex 2 1
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A4HPD2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPD2

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 11
GO:0006084 acetyl-CoA metabolic process 5 11
GO:0006085 acetyl-CoA biosynthetic process 6 11
GO:0006086 acetyl-CoA biosynthetic process from pyruvate 7 11
GO:0006090 pyruvate metabolic process 7 11
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006163 purine nucleotide metabolic process 5 11
GO:0006164 purine nucleotide biosynthetic process 6 11
GO:0006637 acyl-CoA metabolic process 4 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006753 nucleoside phosphate metabolic process 4 11
GO:0006790 sulfur compound metabolic process 3 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009058 biosynthetic process 2 11
GO:0009117 nucleotide metabolic process 5 11
GO:0009150 purine ribonucleotide metabolic process 6 11
GO:0009152 purine ribonucleotide biosynthetic process 7 11
GO:0009165 nucleotide biosynthetic process 6 11
GO:0009259 ribonucleotide metabolic process 5 11
GO:0009260 ribonucleotide biosynthetic process 6 11
GO:0009987 cellular process 1 11
GO:0018130 heterocycle biosynthetic process 4 11
GO:0019438 aromatic compound biosynthetic process 4 11
GO:0019637 organophosphate metabolic process 3 11
GO:0019693 ribose phosphate metabolic process 4 11
GO:0019752 carboxylic acid metabolic process 5 11
GO:0032787 monocarboxylic acid metabolic process 6 11
GO:0033865 nucleoside bisphosphate metabolic process 5 11
GO:0033866 nucleoside bisphosphate biosynthetic process 6 11
GO:0033875 ribonucleoside bisphosphate metabolic process 6 11
GO:0034030 ribonucleoside bisphosphate biosynthetic process 7 11
GO:0034032 purine nucleoside bisphosphate metabolic process 5 11
GO:0034033 purine nucleoside bisphosphate biosynthetic process 6 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0034654 nucleobase-containing compound biosynthetic process 4 11
GO:0035383 thioester metabolic process 3 11
GO:0035384 thioester biosynthetic process 4 11
GO:0043436 oxoacid metabolic process 4 11
GO:0043603 amide metabolic process 3 11
GO:0043604 amide biosynthetic process 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044249 cellular biosynthetic process 3 11
GO:0044271 cellular nitrogen compound biosynthetic process 4 11
GO:0044272 sulfur compound biosynthetic process 4 11
GO:0044281 small molecule metabolic process 2 11
GO:0046390 ribose phosphate biosynthetic process 5 11
GO:0046483 heterocycle metabolic process 3 11
GO:0055086 nucleobase-containing small molecule metabolic process 3 11
GO:0071616 acyl-CoA biosynthetic process 5 11
GO:0071704 organic substance metabolic process 2 11
GO:0072521 purine-containing compound metabolic process 4 11
GO:0072522 purine-containing compound biosynthetic process 5 11
GO:0090407 organophosphate biosynthetic process 4 11
GO:1901135 carbohydrate derivative metabolic process 3 11
GO:1901137 carbohydrate derivative biosynthetic process 4 11
GO:1901293 nucleoside phosphate biosynthetic process 5 11
GO:1901360 organic cyclic compound metabolic process 3 11
GO:1901362 organic cyclic compound biosynthetic process 4 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:1901566 organonitrogen compound biosynthetic process 4 11
GO:1901576 organic substance biosynthetic process 3 11
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0016740 transferase activity 2 11
GO:0016746 acyltransferase activity 3 11
GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity 3 2
GO:0016407 acetyltransferase activity 5 2
GO:0016417 S-acyltransferase activity 5 2
GO:0016418 S-acetyltransferase activity 6 2
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 2
GO:0140096 catalytic activity, acting on a protein 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 155 157 PF00675 0.261
CLV_PCSK_KEX2_1 242 244 PF00082 0.256
CLV_PCSK_PC1ET2_1 242 244 PF00082 0.274
CLV_PCSK_SKI1_1 17 21 PF00082 0.367
CLV_PCSK_SKI1_1 348 352 PF00082 0.348
CLV_PCSK_SKI1_1 78 82 PF00082 0.320
CLV_Separin_Metazoa 407 411 PF03568 0.175
DEG_Nend_Nbox_1 1 3 PF02207 0.487
DOC_CKS1_1 209 214 PF01111 0.566
DOC_CKS1_1 324 329 PF01111 0.285
DOC_CKS1_1 330 335 PF01111 0.308
DOC_CYCLIN_yClb3_PxF_3 222 228 PF00134 0.534
DOC_MAPK_DCC_7 17 26 PF00069 0.374
DOC_MAPK_MEF2A_6 313 322 PF00069 0.256
DOC_USP7_MATH_1 187 191 PF00917 0.475
DOC_USP7_MATH_1 398 402 PF00917 0.300
DOC_USP7_MATH_1 63 67 PF00917 0.276
DOC_USP7_UBL2_3 351 355 PF12436 0.256
DOC_WW_Pin1_4 149 154 PF00397 0.422
DOC_WW_Pin1_4 19 24 PF00397 0.329
DOC_WW_Pin1_4 205 210 PF00397 0.558
DOC_WW_Pin1_4 218 223 PF00397 0.545
DOC_WW_Pin1_4 27 32 PF00397 0.256
DOC_WW_Pin1_4 323 328 PF00397 0.278
DOC_WW_Pin1_4 329 334 PF00397 0.286
LIG_14-3-3_CanoR_1 178 184 PF00244 0.513
LIG_14-3-3_CanoR_1 295 300 PF00244 0.339
LIG_14-3-3_CanoR_1 313 319 PF00244 0.226
LIG_14-3-3_CanoR_1 78 84 PF00244 0.259
LIG_FHA_1 190 196 PF00498 0.488
LIG_FHA_1 315 321 PF00498 0.274
LIG_FHA_1 326 332 PF00498 0.269
LIG_FHA_1 369 375 PF00498 0.273
LIG_FHA_1 384 390 PF00498 0.356
LIG_FHA_1 418 424 PF00498 0.387
LIG_FHA_1 90 96 PF00498 0.314
LIG_FHA_2 178 184 PF00498 0.475
LIG_FHA_2 282 288 PF00498 0.274
LIG_LIR_Gen_1 53 63 PF02991 0.257
LIG_LIR_Gen_1 73 83 PF02991 0.323
LIG_LIR_Nem_3 53 58 PF02991 0.257
LIG_LIR_Nem_3 73 79 PF02991 0.323
LIG_MYND_1 27 31 PF01753 0.256
LIG_PDZ_Class_2 457 462 PF00595 0.256
LIG_Pex14_1 307 311 PF04695 0.300
LIG_Pex14_1 446 450 PF04695 0.256
LIG_Pex14_2 429 433 PF04695 0.256
LIG_PTAP_UEV_1 118 123 PF05743 0.476
LIG_REV1ctd_RIR_1 73 82 PF16727 0.387
LIG_SH2_GRB2like 67 70 PF00017 0.274
LIG_SH2_NCK_1 315 319 PF00017 0.333
LIG_SH2_NCK_1 67 71 PF00017 0.274
LIG_SH2_SRC 67 70 PF00017 0.274
LIG_SH2_STAP1 154 158 PF00017 0.513
LIG_SH2_STAT5 256 259 PF00017 0.256
LIG_SH2_STAT5 288 291 PF00017 0.256
LIG_SH3_2 209 214 PF14604 0.462
LIG_SH3_3 116 122 PF00018 0.714
LIG_SH3_3 206 212 PF00018 0.581
LIG_SH3_3 220 226 PF00018 0.551
LIG_SH3_3 321 327 PF00018 0.259
LIG_SH3_3 42 48 PF00018 0.280
LIG_SUMO_SIM_par_1 126 132 PF11976 0.482
LIG_SUMO_SIM_par_1 316 321 PF11976 0.274
LIG_SUMO_SIM_par_1 342 347 PF11976 0.342
LIG_SUMO_SIM_par_1 395 401 PF11976 0.258
LIG_SxIP_EBH_1 17 30 PF03271 0.274
LIG_SxIP_EBH_1 224 237 PF03271 0.356
LIG_TRAF2_1 70 73 PF00917 0.321
LIG_UBA3_1 266 271 PF00899 0.300
LIG_UBA3_1 395 403 PF00899 0.269
MOD_CDK_SPxK_1 208 214 PF00069 0.463
MOD_CDK_SPxxK_3 149 156 PF00069 0.447
MOD_CDK_SPxxK_3 329 336 PF00069 0.256
MOD_CK1_1 208 214 PF00069 0.699
MOD_CK2_1 79 85 PF00069 0.391
MOD_GlcNHglycan 144 147 PF01048 0.601
MOD_GlcNHglycan 166 169 PF01048 0.316
MOD_GlcNHglycan 189 192 PF01048 0.543
MOD_GlcNHglycan 400 403 PF01048 0.298
MOD_GSK3_1 231 238 PF00069 0.352
MOD_GSK3_1 314 321 PF00069 0.287
MOD_GSK3_1 325 332 PF00069 0.256
MOD_GSK3_1 368 375 PF00069 0.273
MOD_N-GLC_1 162 167 PF02516 0.242
MOD_N-GLC_1 226 231 PF02516 0.262
MOD_N-GLC_1 303 308 PF02516 0.278
MOD_N-GLC_1 68 73 PF02516 0.274
MOD_NEK2_1 244 249 PF00069 0.329
MOD_NEK2_1 377 382 PF00069 0.288
MOD_NEK2_1 417 422 PF00069 0.361
MOD_NEK2_2 232 237 PF00069 0.335
MOD_PKA_2 177 183 PF00069 0.475
MOD_Plk_1 162 168 PF00069 0.442
MOD_Plk_1 303 309 PF00069 0.271
MOD_Plk_1 318 324 PF00069 0.256
MOD_Plk_1 84 90 PF00069 0.302
MOD_Plk_2-3 68 74 PF00069 0.274
MOD_Plk_4 295 301 PF00069 0.331
MOD_Plk_4 422 428 PF00069 0.175
MOD_Plk_4 456 462 PF00069 0.256
MOD_Plk_4 84 90 PF00069 0.359
MOD_ProDKin_1 149 155 PF00069 0.422
MOD_ProDKin_1 19 25 PF00069 0.331
MOD_ProDKin_1 205 211 PF00069 0.559
MOD_ProDKin_1 218 224 PF00069 0.537
MOD_ProDKin_1 27 33 PF00069 0.256
MOD_ProDKin_1 323 329 PF00069 0.278
MOD_SUMO_rev_2 101 110 PF00179 0.359
MOD_SUMO_rev_2 345 353 PF00179 0.256
TRG_ENDOCYTIC_2 255 258 PF00928 0.260
TRG_ENDOCYTIC_2 315 318 PF00928 0.279
TRG_Pf-PMV_PEXEL_1 341 345 PF00026 0.295

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHV8 Leptomonas seymouri 80% 100%
A0A0N1PBB0 Leptomonas seymouri 27% 81%
A0A0S4JC61 Bodo saltans 59% 98%
A0A0S4JS90 Bodo saltans 28% 100%
A0A1X0NKN9 Trypanosomatidae 65% 98%
A0A1X0P2L7 Trypanosomatidae 23% 92%
A0A3Q8IGX8 Leishmania donovani 32% 100%
A0A3Q8IJE7 Leishmania donovani 84% 100%
A0A3S5H5G3 Leishmania donovani 25% 97%
A0A3S5ISA9 Trypanosoma rangeli 24% 100%
A4H464 Leishmania braziliensis 26% 100%
A4I3X3 Leishmania infantum 32% 100%
A4ICH2 Leishmania infantum 84% 100%
C9ZPW7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
D0A3J2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 63% 100%
E9AG63 Leishmania infantum 26% 97%
E9AKC2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 97%
E9AT43 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 99%
E9B063 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
G0S4X6 Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) 42% 100%
O00330 Homo sapiens 37% 92%
O06159 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 26% 100%
O31550 Bacillus subtilis (strain 168) 31% 100%
O59816 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 40% 96%
O66119 Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) 35% 100%
O94681 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 100%
P06959 Escherichia coli (strain K12) 31% 73%
P08461 Rattus norvegicus 43% 73%
P09062 Pseudomonas putida 27% 100%
P0AFG6 Escherichia coli (strain K12) 30% 100%
P0AFG7 Escherichia coli O157:H7 30% 100%
P10515 Homo sapiens 41% 71%
P10802 Azotobacter vinelandii 29% 72%
P11181 Bos taurus 25% 96%
P11182 Homo sapiens 25% 96%
P11961 Geobacillus stearothermophilus 30% 100%
P12695 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 36% 96%
P16263 Bacillus subtilis (strain 168) 30% 100%
P20285 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 40% 100%
P20708 Azotobacter vinelandii 27% 100%
P21883 Bacillus subtilis (strain 168) 31% 100%
P22439 Bos taurus 37% 92%
P35489 Acholeplasma laidlawii 28% 85%
P36413 Dictyostelium discoideum 38% 73%
P37942 Bacillus subtilis (strain 168) 34% 100%
P45118 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 31% 81%
P45302 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 29% 100%
P52993 Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) 30% 100%
P53395 Mus musculus 26% 96%
P65634 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 29% 84%
P65635 Staphylococcus aureus (strain Mu50 / ATCC 700699) 32% 100%
P65636 Staphylococcus aureus (strain N315) 32% 100%
P9WIS6 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 29% 84%
P9WIS7 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 29% 84%
Q0WQF7 Arabidopsis thaliana 37% 73%
Q19749 Caenorhabditis elegans 41% 91%
Q1RHI5 Rickettsia bellii (strain RML369-C) 30% 100%
Q1RJT3 Rickettsia bellii (strain RML369-C) 39% 100%
Q23571 Caenorhabditis elegans 26% 100%
Q2FH26 Staphylococcus aureus (strain USA300) 28% 100%
Q2FYM2 Staphylococcus aureus (strain NCTC 8325 / PS 47) 28% 100%
Q2YY06 Staphylococcus aureus (strain bovine RF122 / ET3-1) 28% 100%
Q49110 Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154) 29% 100%
Q49XM4 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) 29% 100%
Q4L6C3 Staphylococcus haemolyticus (strain JCSC1435) 27% 100%
Q4Q1F5 Leishmania major 87% 100%
Q4Q822 Leishmania major 32% 100%
Q4QJI5 Leishmania major 26% 100%
Q4UKI7 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) 29% 100%
Q4ULG1 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) 35% 100%
Q59098 Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) 31% 84%
Q59638 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 31% 84%
Q59821 Staphylococcus aureus 31% 100%
Q5HG07 Staphylococcus aureus (strain COL) 28% 100%
Q5HGY9 Staphylococcus aureus (strain COL) 32% 100%
Q5HPC7 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) 28% 100%
Q5HQ74 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) 30% 100%
Q5M729 Arabidopsis thaliana 41% 86%
Q68WK6 Rickettsia typhi (strain ATCC VR-144 / Wilmington) 34% 100%
Q68XI8 Rickettsia typhi (strain ATCC VR-144 / Wilmington) 28% 100%
Q6FYD4 Bartonella quintana (strain Toulouse) 28% 100%
Q6G9E9 Staphylococcus aureus (strain MSSA476) 28% 100%
Q6GAB9 Staphylococcus aureus (strain MSSA476) 32% 100%
Q6GGZ6 Staphylococcus aureus (strain MRSA252) 28% 100%
Q6GHZ0 Staphylococcus aureus (strain MRSA252) 32% 100%
Q7A5N4 Staphylococcus aureus (strain N315) 28% 100%
Q89AJ6 Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) 23% 100%
Q89AQ9 Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) 23% 100%
Q8BKZ9 Mus musculus 37% 92%
Q8BMF4 Mus musculus 44% 72%
Q8CSL9 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 28% 100%
Q8CT13 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 30% 100%
Q8GCY1 Bartonella vinsonii subsp. berkhoffii 28% 100%
Q8K9T8 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) 28% 100%
Q8NNJ2 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) 31% 68%
Q8NWR7 Staphylococcus aureus (strain MW2) 28% 100%
Q8NX76 Staphylococcus aureus (strain MW2) 32% 100%
Q8RWN9 Arabidopsis thaliana 42% 86%
Q92HK7 Rickettsia conorii (strain ATCC VR-613 / Malish 7) 36% 100%
Q92J43 Rickettsia conorii (strain ATCC VR-613 / Malish 7) 30% 100%
Q99U75 Staphylococcus aureus (strain Mu50 / ATCC 700699) 28% 100%
Q9C8P0 Arabidopsis thaliana 31% 99%
Q9I1M0 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 27% 100%
Q9I3D2 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 30% 100%
Q9M7Z1 Arabidopsis thaliana 25% 96%
Q9R9N3 Rhizobium meliloti (strain 1021) 39% 100%
Q9SQI8 Arabidopsis thaliana 33% 96%
Q9ZD20 Rickettsia prowazekii (strain Madrid E) 33% 100%
Q9ZDY4 Rickettsia prowazekii (strain Madrid E) 28% 100%
V5BFP9 Trypanosoma cruzi 63% 98%
V5BJF4 Trypanosoma cruzi 24% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS