Methyltransf_11 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HPD1_LEIBR

TriTrypDb:

LbrM.35.2860 , LBRM2903_350036200

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPD1

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	12
GO:0002098	tRNA wobble uridine modification	8	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006399	tRNA metabolic process	7	12
GO:0006400	tRNA modification	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008033	tRNA processing	8	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008173	RNA methyltransferase activity	4	12
GO:0008175	tRNA methyltransferase activity	5	12
GO:0016300	tRNA (uracil) methyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0000049	tRNA binding	5	1
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.542
CLV_NRD_NRD_1	171	173	PF00675	0.448
CLV_NRD_NRD_1	232	234	PF00675	0.342
CLV_NRD_NRD_1	323	325	PF00675	0.537
CLV_PCSK_FUR_1	169	173	PF00082	0.435
CLV_PCSK_FUR_1	229	233	PF00082	0.451
CLV_PCSK_KEX2_1	168	170	PF00082	0.440
CLV_PCSK_KEX2_1	171	173	PF00082	0.431
CLV_PCSK_KEX2_1	231	233	PF00082	0.339
CLV_PCSK_KEX2_1	264	266	PF00082	0.517
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.430
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.499
CLV_PCSK_PC7_1	260	266	PF00082	0.602
CLV_PCSK_SKI1_1	99	103	PF00082	0.595
CLV_Separin_Metazoa	150	154	PF03568	0.425
DEG_APCC_KENBOX_2	329	333	PF00400	0.342
DEG_SCF_FBW7_1	109	115	PF00400	0.457
DEG_SCF_FBW7_2	185	191	PF00400	0.199
DOC_ANK_TNKS_1	178	185	PF00023	0.199
DOC_CKS1_1	109	114	PF01111	0.461
DOC_CKS1_1	185	190	PF01111	0.404
DOC_MAPK_gen_1	15	23	PF00069	0.494
DOC_MAPK_gen_1	229	236	PF00069	0.391
DOC_MAPK_gen_1	241	251	PF00069	0.268
DOC_MAPK_MEF2A_6	15	23	PF00069	0.494
DOC_PP1_RVXF_1	97	103	PF00149	0.341
DOC_PP4_FxxP_1	33	36	PF00568	0.603
DOC_USP7_MATH_1	126	130	PF00917	0.645
DOC_USP7_MATH_1	131	135	PF00917	0.656
DOC_USP7_MATH_1	68	72	PF00917	0.543
DOC_WW_Pin1_4	100	105	PF00397	0.399
DOC_WW_Pin1_4	108	113	PF00397	0.423
DOC_WW_Pin1_4	184	189	PF00397	0.404
DOC_WW_Pin1_4	32	37	PF00397	0.470
LIG_14-3-3_CanoR_1	153	160	PF00244	0.453
LIG_14-3-3_CanoR_1	324	328	PF00244	0.424
LIG_Actin_WH2_2	138	155	PF00022	0.339
LIG_BIR_II_1	1	5	PF00653	0.763
LIG_BIR_III_2	26	30	PF00653	0.454
LIG_FHA_1	195	201	PF00498	0.304
LIG_FHA_1	261	267	PF00498	0.594
LIG_FHA_1	314	320	PF00498	0.563
LIG_FHA_2	70	76	PF00498	0.465
LIG_HCF-1_HBM_1	44	47	PF13415	0.280
LIG_LIR_Gen_1	331	337	PF02991	0.326
LIG_PDZ_Class_3	335	340	PF00595	0.483
LIG_SH2_CRK	52	56	PF00017	0.391
LIG_SH2_NCK_1	284	288	PF00017	0.356
LIG_SH2_NCK_1	52	56	PF00017	0.338
LIG_SH2_STAP1	147	151	PF00017	0.372
LIG_SH2_STAP1	43	47	PF00017	0.343
LIG_SH2_STAP1	52	56	PF00017	0.336
LIG_SH2_STAT5	141	144	PF00017	0.339
LIG_SH2_STAT5	253	256	PF00017	0.399
LIG_SH2_STAT5	47	50	PF00017	0.403
LIG_SH2_STAT5	93	96	PF00017	0.391
LIG_SH3_3	125	131	PF00018	0.629
LIG_SH3_3	182	188	PF00018	0.451
LIG_SH3_3	189	195	PF00018	0.253
LIG_SH3_3	28	34	PF00018	0.614
LIG_SUMO_SIM_anti_2	219	224	PF11976	0.304
LIG_WRC_WIRS_1	70	75	PF05994	0.256
MOD_CK1_1	108	114	PF00069	0.647
MOD_CK1_1	35	41	PF00069	0.433
MOD_CK2_1	69	75	PF00069	0.263
MOD_GlcNHglycan	1	4	PF01048	0.740
MOD_GlcNHglycan	279	283	PF01048	0.581
MOD_GlcNHglycan	285	288	PF01048	0.504
MOD_GlcNHglycan	52	55	PF01048	0.439
MOD_GlcNHglycan	94	97	PF01048	0.486
MOD_GSK3_1	108	115	PF00069	0.642
MOD_GSK3_1	309	316	PF00069	0.511
MOD_N-GLC_2	332	334	PF02516	0.322
MOD_NEK2_1	105	110	PF00069	0.578
MOD_NEK2_1	132	137	PF00069	0.547
MOD_NEK2_1	151	156	PF00069	0.377
MOD_NEK2_1	59	64	PF00069	0.430
MOD_PIKK_1	152	158	PF00454	0.425
MOD_PKA_2	152	158	PF00069	0.453
MOD_PKA_2	323	329	PF00069	0.391
MOD_Plk_2-3	309	315	PF00069	0.563
MOD_Plk_4	323	329	PF00069	0.369
MOD_Plk_4	69	75	PF00069	0.353
MOD_ProDKin_1	100	106	PF00069	0.406
MOD_ProDKin_1	108	114	PF00069	0.417
MOD_ProDKin_1	184	190	PF00069	0.404
MOD_ProDKin_1	32	38	PF00069	0.472
MOD_SUMO_rev_2	190	195	PF00179	0.199
TRG_DiLeu_BaEn_1	238	243	PF01217	0.309
TRG_DiLeu_LyEn_5	238	243	PF01217	0.199
TRG_ENDOCYTIC_2	294	297	PF00928	0.324
TRG_ENDOCYTIC_2	52	55	PF00928	0.378
TRG_ER_diArg_1	169	172	PF00400	0.466
TRG_ER_diArg_1	231	233	PF00400	0.339
TRG_NLS_MonoExtC_3	14	20	PF00514	0.722
TRG_NLS_MonoExtN_4	12	19	PF00514	0.711
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I4	Leptomonas seymouri	59%	100%
A0A0S4J705	Bodo saltans	36%	100%
A0A1X0NKG3	Trypanosomatidae	42%	100%
A0A3S7XB23	Leishmania donovani	80%	100%
A0A422ND22	Trypanosoma rangeli	42%	100%
A4ICH1	Leishmania infantum	79%	100%
C4V9L5	Nosema ceranae (strain BRL01)	30%	100%
D0A3J1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AT42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
P49957	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q10224	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q4Q1F6	Leishmania major	82%	100%
V5DGL8	Trypanosoma cruzi	46%	100%