Cyclin-e binding protein 1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclin-e binding protein 1-like protein

Species:

Leishmania braziliensis

UniProt:

A4HPC6_LEIBR

TriTrypDb:

LbrM.35.2810 , LBRM2903_350035700

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPC6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.719
CLV_C14_Caspase3-7	184	188	PF00656	0.639
CLV_C14_Caspase3-7	26	30	PF00656	0.518
CLV_C14_Caspase3-7	592	596	PF00656	0.728
CLV_NRD_NRD_1	162	164	PF00675	0.618
CLV_NRD_NRD_1	233	235	PF00675	0.484
CLV_NRD_NRD_1	365	367	PF00675	0.613
CLV_PCSK_KEX2_1	162	164	PF00082	0.516
CLV_PCSK_KEX2_1	233	235	PF00082	0.551
CLV_PCSK_KEX2_1	333	335	PF00082	0.541
CLV_PCSK_KEX2_1	365	367	PF00082	0.613
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.524
CLV_PCSK_SKI1_1	278	282	PF00082	0.519
CLV_PCSK_SKI1_1	32	36	PF00082	0.653
CLV_PCSK_SKI1_1	402	406	PF00082	0.567
CLV_PCSK_SKI1_1	489	493	PF00082	0.663
CLV_PCSK_SKI1_1	614	618	PF00082	0.697
DEG_COP1_1	595	605	PF00400	0.535
DEG_Nend_Nbox_1	1	3	PF02207	0.640
DEG_SPOP_SBC_1	566	570	PF00917	0.534
DOC_CDC14_PxL_1	286	294	PF14671	0.315
DOC_CYCLIN_yCln2_LP_2	686	692	PF00134	0.546
DOC_MAPK_DCC_7	197	207	PF00069	0.714
DOC_MAPK_gen_1	333	343	PF00069	0.389
DOC_MAPK_HePTP_8	700	712	PF00069	0.517
DOC_MAPK_MEF2A_6	66	74	PF00069	0.571
DOC_MAPK_MEF2A_6	703	712	PF00069	0.511
DOC_PP1_SILK_1	614	619	PF00149	0.530
DOC_PP2B_LxvP_1	158	161	PF13499	0.546
DOC_PP2B_LxvP_1	376	379	PF13499	0.690
DOC_PP2B_LxvP_1	390	393	PF13499	0.718
DOC_PP2B_LxvP_1	554	557	PF13499	0.693
DOC_PP4_FxxP_1	524	527	PF00568	0.539
DOC_USP7_MATH_1	103	107	PF00917	0.496
DOC_USP7_MATH_1	379	383	PF00917	0.655
DOC_USP7_MATH_1	527	531	PF00917	0.619
DOC_USP7_MATH_1	542	546	PF00917	0.791
DOC_USP7_MATH_1	692	696	PF00917	0.758
DOC_USP7_MATH_1	711	715	PF00917	0.499
DOC_USP7_MATH_1	86	90	PF00917	0.603
DOC_USP7_UBL2_3	610	614	PF12436	0.680
DOC_WW_Pin1_4	212	217	PF00397	0.723
DOC_WW_Pin1_4	37	42	PF00397	0.642
DOC_WW_Pin1_4	460	465	PF00397	0.432
DOC_WW_Pin1_4	573	578	PF00397	0.747
DOC_WW_Pin1_4	655	660	PF00397	0.703
DOC_WW_Pin1_4	677	682	PF00397	0.773
LIG_14-3-3_CanoR_1	337	342	PF00244	0.573
LIG_14-3-3_CanoR_1	597	603	PF00244	0.705
LIG_14-3-3_CanoR_1	618	624	PF00244	0.685
LIG_14-3-3_CanoR_1	703	711	PF00244	0.583
LIG_APCC_ABBA_1	31	36	PF00400	0.640
LIG_APCC_ABBA_1	513	518	PF00400	0.522
LIG_BIR_III_4	170	174	PF00653	0.488
LIG_CtBP_PxDLS_1	206	210	PF00389	0.494
LIG_eIF4E_1	627	633	PF01652	0.666
LIG_FHA_1	251	257	PF00498	0.376
LIG_FHA_1	330	336	PF00498	0.560
LIG_FHA_1	464	470	PF00498	0.673
LIG_FHA_1	476	482	PF00498	0.525
LIG_FHA_1	505	511	PF00498	0.543
LIG_FHA_1	607	613	PF00498	0.531
LIG_FHA_1	627	633	PF00498	0.647
LIG_FHA_1	648	654	PF00498	0.693
LIG_FHA_1	695	701	PF00498	0.796
LIG_FHA_1	703	709	PF00498	0.701
LIG_FHA_2	446	452	PF00498	0.528
LIG_FHA_2	567	573	PF00498	0.693
LIG_LIR_Apic_2	521	527	PF02991	0.536
LIG_LIR_Gen_1	307	316	PF02991	0.376
LIG_LIR_Gen_1	423	434	PF02991	0.513
LIG_LIR_Gen_1	446	455	PF02991	0.520
LIG_LIR_Gen_1	59	65	PF02991	0.307
LIG_LIR_Gen_1	714	719	PF02991	0.683
LIG_LIR_Nem_3	123	129	PF02991	0.417
LIG_LIR_Nem_3	231	235	PF02991	0.744
LIG_LIR_Nem_3	285	289	PF02991	0.420
LIG_LIR_Nem_3	307	311	PF02991	0.376
LIG_LIR_Nem_3	384	390	PF02991	0.646
LIG_LIR_Nem_3	423	429	PF02991	0.526
LIG_LIR_Nem_3	446	450	PF02991	0.487
LIG_LIR_Nem_3	59	64	PF02991	0.375
LIG_LIR_Nem_3	668	674	PF02991	0.602
LIG_LIR_Nem_3	714	718	PF02991	0.682
LIG_NRBOX	631	637	PF00104	0.468
LIG_SH2_CRK	126	130	PF00017	0.354
LIG_SH2_CRK	373	377	PF00017	0.740
LIG_SH2_CRK	442	446	PF00017	0.622
LIG_SH2_CRK	61	65	PF00017	0.489
LIG_SH2_GRB2like	122	125	PF00017	0.376
LIG_SH2_PTP2	715	718	PF00017	0.755
LIG_SH2_STAP1	122	126	PF00017	0.430
LIG_SH2_STAP1	61	65	PF00017	0.489
LIG_SH2_STAT3	499	502	PF00017	0.626
LIG_SH2_STAT5	110	113	PF00017	0.430
LIG_SH2_STAT5	442	445	PF00017	0.563
LIG_SH2_STAT5	499	502	PF00017	0.626
LIG_SH2_STAT5	715	718	PF00017	0.755
LIG_SH3_3	150	156	PF00018	0.580
LIG_SH3_3	232	238	PF00018	0.668
LIG_SH3_3	38	44	PF00018	0.469
LIG_SH3_3	497	503	PF00018	0.646
LIG_SH3_3	574	580	PF00018	0.595
LIG_SH3_3	705	711	PF00018	0.508
LIG_SUMO_SIM_anti_2	67	75	PF11976	0.515
LIG_SUMO_SIM_par_1	205	211	PF11976	0.495
LIG_SUMO_SIM_par_1	252	257	PF11976	0.376
LIG_SUMO_SIM_par_1	67	75	PF11976	0.504
LIG_TRAF2_1	545	548	PF00917	0.539
MOD_CDK_SPxxK_3	460	467	PF00069	0.451
MOD_CK1_1	133	139	PF00069	0.608
MOD_CK1_1	189	195	PF00069	0.654
MOD_CK1_1	208	214	PF00069	0.666
MOD_CK1_1	382	388	PF00069	0.609
MOD_CK1_1	460	466	PF00069	0.504
MOD_CK1_1	530	536	PF00069	0.668
MOD_CK1_1	56	62	PF00069	0.457
MOD_CK1_1	596	602	PF00069	0.735
MOD_CK1_1	691	697	PF00069	0.731
MOD_CK2_1	445	451	PF00069	0.536
MOD_CK2_1	542	548	PF00069	0.673
MOD_CK2_1	566	572	PF00069	0.599
MOD_CK2_1	86	92	PF00069	0.550
MOD_Cter_Amidation	363	366	PF01082	0.558
MOD_GlcNHglycan	113	116	PF01048	0.430
MOD_GlcNHglycan	158	161	PF01048	0.618
MOD_GlcNHglycan	174	177	PF01048	0.669
MOD_GlcNHglycan	223	226	PF01048	0.686
MOD_GlcNHglycan	258	261	PF01048	0.478
MOD_GlcNHglycan	350	354	PF01048	0.632
MOD_GlcNHglycan	61	64	PF01048	0.441
MOD_GlcNHglycan	624	627	PF01048	0.757
MOD_GlcNHglycan	655	658	PF01048	0.701
MOD_GlcNHglycan	671	674	PF01048	0.713
MOD_GlcNHglycan	690	693	PF01048	0.611
MOD_GlcNHglycan	694	697	PF01048	0.709
MOD_GlcNHglycan	83	86	PF01048	0.656
MOD_GlcNHglycan	92	95	PF01048	0.537
MOD_GSK3_1	130	137	PF00069	0.557
MOD_GSK3_1	208	215	PF00069	0.678
MOD_GSK3_1	216	223	PF00069	0.613
MOD_GSK3_1	250	257	PF00069	0.376
MOD_GSK3_1	355	362	PF00069	0.686
MOD_GSK3_1	379	386	PF00069	0.643
MOD_GSK3_1	445	452	PF00069	0.440
MOD_GSK3_1	469	476	PF00069	0.738
MOD_GSK3_1	543	550	PF00069	0.693
MOD_GSK3_1	589	596	PF00069	0.744
MOD_GSK3_1	622	629	PF00069	0.732
MOD_GSK3_1	665	672	PF00069	0.665
MOD_GSK3_1	673	680	PF00069	0.575
MOD_GSK3_1	688	695	PF00069	0.722
MOD_GSK3_1	86	93	PF00069	0.618
MOD_N-GLC_1	469	474	PF02516	0.629
MOD_N-GLC_1	573	578	PF02516	0.618
MOD_N-GLC_1	669	674	PF02516	0.529
MOD_N-GLC_2	179	181	PF02516	0.546
MOD_N-GLC_2	322	324	PF02516	0.376
MOD_N-GLC_2	562	564	PF02516	0.768
MOD_NEK2_1	172	177	PF00069	0.567
MOD_NEK2_1	23	28	PF00069	0.553
MOD_NEK2_1	254	259	PF00069	0.376
MOD_NEK2_1	35	40	PF00069	0.634
MOD_NEK2_1	449	454	PF00069	0.357
MOD_NEK2_1	598	603	PF00069	0.694
MOD_NEK2_1	653	658	PF00069	0.694
MOD_NEK2_1	72	77	PF00069	0.482
MOD_NEK2_2	372	377	PF00069	0.683
MOD_NEK2_2	432	437	PF00069	0.436
MOD_NEK2_2	527	532	PF00069	0.531
MOD_PIKK_1	254	260	PF00454	0.465
MOD_PK_1	337	343	PF00069	0.390
MOD_PKA_2	179	185	PF00069	0.682
MOD_PKA_2	336	342	PF00069	0.572
MOD_PKA_2	596	602	PF00069	0.778
MOD_PKA_2	606	612	PF00069	0.614
MOD_PKA_2	617	623	PF00069	0.559
MOD_PKA_2	702	708	PF00069	0.578
MOD_Plk_1	122	128	PF00069	0.421
MOD_Plk_1	13	19	PF00069	0.435
MOD_Plk_1	186	192	PF00069	0.591
MOD_Plk_1	383	389	PF00069	0.646
MOD_Plk_4	130	136	PF00069	0.472
MOD_Plk_4	189	195	PF00069	0.502
MOD_Plk_4	250	256	PF00069	0.357
MOD_Plk_4	304	310	PF00069	0.420
MOD_Plk_4	383	389	PF00069	0.646
MOD_Plk_4	56	62	PF00069	0.426
MOD_Plk_4	619	625	PF00069	0.768
MOD_Plk_4	627	633	PF00069	0.606
MOD_Plk_4	648	654	PF00069	0.747
MOD_Plk_4	695	701	PF00069	0.723
MOD_Plk_4	711	717	PF00069	0.684
MOD_Plk_4	86	92	PF00069	0.510
MOD_ProDKin_1	212	218	PF00069	0.722
MOD_ProDKin_1	37	43	PF00069	0.638
MOD_ProDKin_1	460	466	PF00069	0.442
MOD_ProDKin_1	573	579	PF00069	0.746
MOD_ProDKin_1	655	661	PF00069	0.705
MOD_ProDKin_1	677	683	PF00069	0.770
MOD_SUMO_rev_2	182	188	PF00179	0.532
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.308
TRG_DiLeu_BaLyEn_6	339	344	PF01217	0.415
TRG_DiLeu_BaLyEn_6	487	492	PF01217	0.659
TRG_ENDOCYTIC_2	126	129	PF00928	0.354
TRG_ENDOCYTIC_2	373	376	PF00928	0.664
TRG_ENDOCYTIC_2	387	390	PF00928	0.555
TRG_ENDOCYTIC_2	426	429	PF00928	0.698
TRG_ENDOCYTIC_2	442	445	PF00928	0.550
TRG_ENDOCYTIC_2	61	64	PF00928	0.440
TRG_ENDOCYTIC_2	715	718	PF00928	0.683
TRG_ER_diArg_1	161	163	PF00400	0.626
TRG_ER_diArg_1	232	234	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	402	407	PF00026	0.669

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB4	Leptomonas seymouri	43%	100%
A0A3S7XAY5	Leishmania donovani	71%	100%
A4ICG6	Leishmania infantum	71%	100%
E9AT37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q1G1	Leishmania major	72%	100%
V5BPT3	Trypanosoma cruzi	34%	100%