Putative membrane-bound acid phosphatase 2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

membrane-bound acid phosphatase 2, putative

Species:

Leishmania braziliensis

UniProt:

A4HPC5_LEIBR

TriTrypDb:

LbrM.35.2800 , LBRM2903_350035600

Length:

578

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 65

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 43, no: 4
NetGPI	no	yes: 0, no: 47

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	36
GO:0110165	cellular anatomical entity	1	36

Expansion

Sequence features

A4HPC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPC5

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016311	dephosphorylation	5	5
GO:0044237	cellular metabolic process	2	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0003993	acid phosphatase activity	6	4
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016791	phosphatase activity	5	9
GO:0042578	phosphoric ester hydrolase activity	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	544	546	PF00675	0.413
CLV_PCSK_KEX2_1	177	179	PF00082	0.545
CLV_PCSK_KEX2_1	397	399	PF00082	0.539
CLV_PCSK_KEX2_1	544	546	PF00082	0.403
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.475
CLV_PCSK_PC1ET2_1	397	399	PF00082	0.529
CLV_PCSK_SKI1_1	137	141	PF00082	0.529
CLV_PCSK_SKI1_1	177	181	PF00082	0.590
CLV_PCSK_SKI1_1	196	200	PF00082	0.479
CLV_PCSK_SKI1_1	222	226	PF00082	0.531
CLV_PCSK_SKI1_1	251	255	PF00082	0.528
CLV_PCSK_SKI1_1	398	402	PF00082	0.594
CLV_PCSK_SKI1_1	501	505	PF00082	0.704
DEG_APCC_DBOX_1	5	13	PF00400	0.517
DEG_APCC_KENBOX_2	386	390	PF00400	0.199
DOC_CDC14_PxL_1	237	245	PF14671	0.433
DOC_CKS1_1	431	436	PF01111	0.319
DOC_CYCLIN_RxL_1	217	226	PF00134	0.372
DOC_MAPK_gen_1	249	258	PF00069	0.313
DOC_PP1_RVXF_1	396	403	PF00149	0.395
DOC_PP4_FxxP_1	108	111	PF00568	0.345
DOC_PP4_MxPP_1	326	329	PF00568	0.378
DOC_USP7_MATH_1	21	25	PF00917	0.624
DOC_USP7_MATH_1	367	371	PF00917	0.260
DOC_USP7_MATH_1	515	519	PF00917	0.339
DOC_USP7_UBL2_3	397	401	PF12436	0.230
DOC_WW_Pin1_4	102	107	PF00397	0.388
DOC_WW_Pin1_4	319	324	PF00397	0.331
DOC_WW_Pin1_4	356	361	PF00397	0.324
DOC_WW_Pin1_4	430	435	PF00397	0.395
DOC_WW_Pin1_4	69	74	PF00397	0.415
LIG_14-3-3_CanoR_1	121	129	PF00244	0.332
LIG_14-3-3_CanoR_1	554	563	PF00244	0.690
LIG_14-3-3_CanoR_1	95	100	PF00244	0.385
LIG_APCC_ABBA_1	390	395	PF00400	0.318
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_BIR_III_4	378	382	PF00653	0.419
LIG_BRCT_BRCA1_1	104	108	PF00533	0.401
LIG_deltaCOP1_diTrp_1	365	372	PF00928	0.290
LIG_EH1_1	523	531	PF00400	0.377
LIG_FHA_1	121	127	PF00498	0.338
LIG_FHA_1	186	192	PF00498	0.320
LIG_FHA_1	252	258	PF00498	0.341
LIG_FHA_1	296	302	PF00498	0.322
LIG_FHA_1	533	539	PF00498	0.463
LIG_FHA_1	569	575	PF00498	0.690
LIG_FHA_1	63	69	PF00498	0.420
LIG_FHA_2	150	156	PF00498	0.378
LIG_FHA_2	214	220	PF00498	0.370
LIG_FHA_2	221	227	PF00498	0.358
LIG_FHA_2	285	291	PF00498	0.429
LIG_FHA_2	315	321	PF00498	0.366
LIG_FHA_2	360	366	PF00498	0.262
LIG_FHA_2	484	490	PF00498	0.538
LIG_FHA_2	502	508	PF00498	0.389
LIG_GBD_Chelix_1	9	17	PF00786	0.559
LIG_LIR_Apic_2	105	111	PF02991	0.350
LIG_LIR_Apic_2	428	434	PF02991	0.418
LIG_LIR_Gen_1	144	154	PF02991	0.404
LIG_LIR_Gen_1	165	173	PF02991	0.367
LIG_LIR_Gen_1	244	253	PF02991	0.331
LIG_LIR_Nem_3	144	150	PF02991	0.349
LIG_LIR_Nem_3	165	171	PF02991	0.317
LIG_LIR_Nem_3	194	198	PF02991	0.398
LIG_LIR_Nem_3	238	243	PF02991	0.364
LIG_LIR_Nem_3	244	250	PF02991	0.345
LIG_LIR_Nem_3	395	399	PF02991	0.293
LIG_LIR_Nem_3	78	82	PF02991	0.411
LIG_LYPXL_yS_3	240	243	PF13949	0.430
LIG_PDZ_Class_3	573	578	PF00595	0.790
LIG_Pex14_1	168	172	PF04695	0.353
LIG_Pex14_1	546	550	PF04695	0.496
LIG_Pex14_2	135	139	PF04695	0.387
LIG_Pex14_2	364	368	PF04695	0.415
LIG_SH2_CRK	147	151	PF00017	0.413
LIG_SH2_CRK	431	435	PF00017	0.451
LIG_SH2_GRB2like	173	176	PF00017	0.395
LIG_SH2_PTP2	348	351	PF00017	0.384
LIG_SH2_SRC	206	209	PF00017	0.242
LIG_SH2_SRC	260	263	PF00017	0.374
LIG_SH2_STAP1	260	264	PF00017	0.316
LIG_SH2_STAT3	413	416	PF00017	0.231
LIG_SH2_STAT5	348	351	PF00017	0.328
LIG_SH2_STAT5	411	414	PF00017	0.289
LIG_SH2_STAT5	459	462	PF00017	0.354
LIG_SH2_STAT5	76	79	PF00017	0.337
LIG_SH3_3	100	106	PF00018	0.414
LIG_SH3_3	180	186	PF00018	0.352
LIG_SH3_3	434	440	PF00018	0.415
LIG_Sin3_3	14	21	PF02671	0.569
LIG_TRAF2_2	356	361	PF00917	0.376
LIG_UBA3_1	224	232	PF00899	0.401
MOD_CDK_SPxxK_3	356	363	PF00069	0.367
MOD_CK1_1	120	126	PF00069	0.369
MOD_CK1_1	252	258	PF00069	0.267
MOD_CK1_1	359	365	PF00069	0.387
MOD_CK1_1	471	477	PF00069	0.418
MOD_CK1_1	478	484	PF00069	0.502
MOD_CK1_1	555	561	PF00069	0.670
MOD_CK1_1	98	104	PF00069	0.421
MOD_CK2_1	149	155	PF00069	0.401
MOD_CK2_1	209	215	PF00069	0.439
MOD_CK2_1	284	290	PF00069	0.394
MOD_CK2_1	483	489	PF00069	0.535
MOD_GlcNHglycan	130	133	PF01048	0.510
MOD_GlcNHglycan	155	158	PF01048	0.488
MOD_GlcNHglycan	304	307	PF01048	0.539
MOD_GlcNHglycan	34	37	PF01048	0.616
MOD_GlcNHglycan	447	450	PF01048	0.561
MOD_GlcNHglycan	481	484	PF01048	0.662
MOD_GlcNHglycan	511	514	PF01048	0.718
MOD_GlcNHglycan	554	557	PF01048	0.392
MOD_GSK3_1	149	156	PF00069	0.351
MOD_GSK3_1	209	216	PF00069	0.363
MOD_GSK3_1	302	309	PF00069	0.313
MOD_GSK3_1	471	478	PF00069	0.404
MOD_GSK3_1	479	486	PF00069	0.475
MOD_GSK3_1	501	508	PF00069	0.578
MOD_GSK3_1	63	70	PF00069	0.386
MOD_GSK3_1	91	98	PF00069	0.365
MOD_N-GLC_1	264	269	PF02516	0.561
MOD_N-GLC_1	32	37	PF02516	0.601
MOD_N-GLC_1	340	345	PF02516	0.507
MOD_N-GLC_1	478	483	PF02516	0.704
MOD_N-GLC_1	63	68	PF02516	0.579
MOD_N-GLC_2	389	391	PF02516	0.525
MOD_NEK2_1	160	165	PF00069	0.353
MOD_NEK2_1	171	176	PF00069	0.376
MOD_NEK2_1	293	298	PF00069	0.398
MOD_NEK2_1	302	307	PF00069	0.356
MOD_NEK2_1	339	344	PF00069	0.326
MOD_NEK2_1	445	450	PF00069	0.371
MOD_NEK2_1	457	462	PF00069	0.354
MOD_NEK2_1	505	510	PF00069	0.575
MOD_NEK2_1	540	545	PF00069	0.571
MOD_NEK2_1	91	96	PF00069	0.333
MOD_NEK2_2	21	26	PF00069	0.329
MOD_NEK2_2	220	225	PF00069	0.366
MOD_OFUCOSY	468	475	PF10250	0.616
MOD_PIKK_1	162	168	PF00454	0.361
MOD_PIKK_1	235	241	PF00454	0.344
MOD_PK_1	249	255	PF00069	0.181
MOD_PKA_2	120	126	PF00069	0.340
MOD_PKA_2	487	493	PF00069	0.560
MOD_PKB_1	93	101	PF00069	0.434
MOD_Plk_1	235	241	PF00069	0.387
MOD_Plk_1	307	313	PF00069	0.320
MOD_Plk_1	32	38	PF00069	0.372
MOD_Plk_2-3	415	421	PF00069	0.238
MOD_Plk_4	142	148	PF00069	0.382
MOD_Plk_4	21	27	PF00069	0.374
MOD_Plk_4	252	258	PF00069	0.372
MOD_Plk_4	425	431	PF00069	0.313
MOD_Plk_4	433	439	PF00069	0.336
MOD_Plk_4	8	14	PF00069	0.428
MOD_Plk_4	98	104	PF00069	0.386
MOD_ProDKin_1	102	108	PF00069	0.382
MOD_ProDKin_1	319	325	PF00069	0.325
MOD_ProDKin_1	356	362	PF00069	0.326
MOD_ProDKin_1	430	436	PF00069	0.396
MOD_ProDKin_1	69	75	PF00069	0.409
MOD_SUMO_rev_2	359	364	PF00179	0.251
TRG_DiLeu_BaLyEn_6	175	180	PF01217	0.203
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.333
TRG_ENDOCYTIC_2	147	150	PF00928	0.372
TRG_ENDOCYTIC_2	240	243	PF00928	0.390
TRG_ENDOCYTIC_2	299	302	PF00928	0.392
TRG_ENDOCYTIC_2	348	351	PF00928	0.367
TRG_ENDOCYTIC_2	411	414	PF00928	0.325
TRG_ENDOCYTIC_2	548	551	PF00928	0.672
TRG_ER_diArg_1	544	546	PF00400	0.571
TRG_ER_diArg_1	92	95	PF00400	0.359
TRG_NES_CRM1_1	324	337	PF08389	0.393
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	572	576	PF00026	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y5	Leptomonas seymouri	61%	100%
A0A0N1I756	Leptomonas seymouri	40%	100%
A0A0N1PEH4	Leptomonas seymouri	38%	100%
A0A0S4IV77	Bodo saltans	34%	100%
A0A0S4JEA9	Bodo saltans	27%	100%
A0A0S4JJK3	Bodo saltans	27%	100%
A0A0S4JW09	Bodo saltans	31%	100%
A0A1X0NNY4	Trypanosomatidae	34%	100%
A0A1X0NQL4	Trypanosomatidae	30%	100%
A0A1X0NY34	Trypanosomatidae	24%	100%
A0A1X0P7V5	Trypanosomatidae	46%	100%
A0A3Q8IR23	Leishmania donovani	80%	100%
A0A3R7KGH3	Trypanosoma rangeli	23%	100%
A0A3R7KSH4	Trypanosoma rangeli	24%	100%
A0A3R7MEN7	Trypanosoma rangeli	43%	100%
A0A3R7MHJ7	Trypanosoma rangeli	31%	100%
A0A3S5H827	Leishmania donovani	38%	100%
A0A3S7WXU0	Leishmania donovani	50%	100%
A0A3S7X1W4	Leishmania donovani	42%	100%
A4HCZ0	Leishmania braziliensis	50%	100%
A4HGW8	Leishmania braziliensis	45%	100%
A4HPC1	Leishmania braziliensis	40%	100%
A4HQG6	Leishmania braziliensis	37%	100%
A4HQG9	Leishmania braziliensis	37%	100%
A4I0H5	Leishmania infantum	50%	100%
A4I3Z8	Leishmania infantum	42%	100%
A4ICA5	Leishmania infantum	39%	87%
A4ICG3	Leishmania infantum	38%	100%
A4ICG5	Leishmania infantum	81%	100%
D0A3E0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0A947	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A948	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A9J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AT34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AT36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E9AWD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9B088	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
Q4Q0A9	Leishmania major	29%	98%
Q4Q1G2	Leishmania major	80%	99%
Q4Q1G4	Leishmania major	39%	100%
Q4Q7Z7	Leishmania major	45%	100%
Q4QB35	Leishmania major	50%	100%
V5BCI2	Trypanosoma cruzi	25%	100%
V5BIM1	Trypanosoma cruzi	25%	100%
V5BK91	Trypanosoma cruzi	41%	100%
V5BL75	Trypanosoma cruzi	30%	100%