Glycerophosphocholine phosphodiesterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

related to multifunctional cyclin-dependent kinase pho85-like protein

Species:

Leishmania braziliensis

UniProt:

A4HPC4_LEIBR

TriTrypDb:

LbrM.35.2790 , LBRM2903_350035500

Length:

1017

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HPC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPC4

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006650	glycerophospholipid metabolic process	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009395	phospholipid catabolic process	5	7
GO:0009987	cellular process	1	7
GO:0016042	lipid catabolic process	4	7
GO:0016310	phosphorylation	5	5
GO:0019637	organophosphate metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044242	cellular lipid catabolic process	4	7
GO:0044248	cellular catabolic process	3	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0046434	organophosphate catabolic process	4	7
GO:0046475	glycerophospholipid catabolic process	6	7
GO:0046486	glycerolipid metabolic process	4	7
GO:0046503	glycerolipid catabolic process	5	7
GO:0071704	organic substance metabolic process	2	7
GO:1901575	organic substance catabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008081	phosphoric diester hydrolase activity	5	7
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0047389	glycerophosphocholine phosphodiesterase activity	6	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	333	337	PF00656	0.718
CLV_C14_Caspase3-7	390	394	PF00656	0.535
CLV_C14_Caspase3-7	429	433	PF00656	0.542
CLV_NRD_NRD_1	240	242	PF00675	0.503
CLV_NRD_NRD_1	329	331	PF00675	0.571
CLV_NRD_NRD_1	427	429	PF00675	0.678
CLV_NRD_NRD_1	607	609	PF00675	0.227
CLV_NRD_NRD_1	629	631	PF00675	0.369
CLV_PCSK_KEX2_1	240	242	PF00082	0.503
CLV_PCSK_KEX2_1	286	288	PF00082	0.524
CLV_PCSK_KEX2_1	328	330	PF00082	0.586
CLV_PCSK_KEX2_1	371	373	PF00082	0.591
CLV_PCSK_KEX2_1	380	382	PF00082	0.577
CLV_PCSK_KEX2_1	427	429	PF00082	0.678
CLV_PCSK_KEX2_1	607	609	PF00082	0.227
CLV_PCSK_KEX2_1	661	663	PF00082	0.315
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.517
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.558
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.527
CLV_PCSK_PC1ET2_1	661	663	PF00082	0.304
CLV_PCSK_SKI1_1	173	177	PF00082	0.549
CLV_PCSK_SKI1_1	455	459	PF00082	0.482
CLV_PCSK_SKI1_1	707	711	PF00082	0.304
CLV_PCSK_SKI1_1	727	731	PF00082	0.227
CLV_PCSK_SKI1_1	766	770	PF00082	0.304
CLV_PCSK_SKI1_1	812	816	PF00082	0.304
CLV_PCSK_SKI1_1	856	860	PF00082	0.304
CLV_PCSK_SKI1_1	949	953	PF00082	0.304
CLV_Separin_Metazoa	325	329	PF03568	0.614
CLV_Separin_Metazoa	574	578	PF03568	0.464
CLV_Separin_Metazoa	809	813	PF03568	0.227
DEG_APCC_DBOX_1	569	577	PF00400	0.397
DEG_SPOP_SBC_1	338	342	PF00917	0.565
DEG_SPOP_SBC_1	401	405	PF00917	0.662
DOC_CDC14_PxL_1	232	240	PF14671	0.594
DOC_CDC14_PxL_1	983	991	PF14671	0.443
DOC_CKS1_1	67	72	PF01111	0.447
DOC_MAPK_gen_1	607	614	PF00069	0.227
DOC_MAPK_gen_1	630	637	PF00069	0.369
DOC_MAPK_gen_1	840	848	PF00069	0.304
DOC_PP1_RVXF_1	810	816	PF00149	0.304
DOC_PP1_RVXF_1	820	827	PF00149	0.304
DOC_PP2B_LxvP_1	119	122	PF13499	0.452
DOC_PP2B_LxvP_1	364	367	PF13499	0.561
DOC_PP4_FxxP_1	362	365	PF00568	0.477
DOC_USP7_MATH_1	139	143	PF00917	0.618
DOC_USP7_MATH_1	270	274	PF00917	0.664
DOC_USP7_MATH_1	314	318	PF00917	0.597
DOC_USP7_MATH_1	367	371	PF00917	0.494
DOC_USP7_MATH_1	384	388	PF00917	0.573
DOC_USP7_MATH_1	401	405	PF00917	0.594
DOC_USP7_MATH_1	46	50	PF00917	0.482
DOC_USP7_MATH_1	464	468	PF00917	0.395
DOC_USP7_MATH_1	879	883	PF00917	0.304
DOC_WW_Pin1_4	164	169	PF00397	0.501
DOC_WW_Pin1_4	266	271	PF00397	0.529
DOC_WW_Pin1_4	289	294	PF00397	0.661
DOC_WW_Pin1_4	396	401	PF00397	0.631
DOC_WW_Pin1_4	410	415	PF00397	0.520
DOC_WW_Pin1_4	602	607	PF00397	0.354
DOC_WW_Pin1_4	66	71	PF00397	0.519
DOC_WW_Pin1_4	769	774	PF00397	0.304
DOC_WW_Pin1_4	887	892	PF00397	0.369
LIG_14-3-3_CanoR_1	100	109	PF00244	0.513
LIG_14-3-3_CanoR_1	157	161	PF00244	0.591
LIG_14-3-3_CanoR_1	240	244	PF00244	0.516
LIG_14-3-3_CanoR_1	318	327	PF00244	0.450
LIG_14-3-3_CanoR_1	602	606	PF00244	0.374
LIG_14-3-3_CanoR_1	88	93	PF00244	0.489
LIG_Actin_WH2_2	118	136	PF00022	0.422
LIG_APCC_ABBA_1	274	279	PF00400	0.660
LIG_APCC_ABBAyCdc20_2	172	178	PF00400	0.471
LIG_BRCT_BRCA1_1	297	301	PF00533	0.472
LIG_BRCT_BRCA1_1	437	441	PF00533	0.632
LIG_BRCT_BRCA1_1	774	778	PF00533	0.304
LIG_BRCT_BRCA1_1	791	795	PF00533	0.345
LIG_BRCT_BRCA1_1	797	801	PF00533	0.321
LIG_Clathr_ClatBox_1	125	129	PF01394	0.483
LIG_CtBP_PxDLS_1	773	777	PF00389	0.222
LIG_eIF4E_1	784	790	PF01652	0.447
LIG_FHA_1	215	221	PF00498	0.615
LIG_FHA_1	333	339	PF00498	0.536
LIG_FHA_1	403	409	PF00498	0.686
LIG_FHA_1	480	486	PF00498	0.375
LIG_FHA_1	496	502	PF00498	0.531
LIG_FHA_1	528	534	PF00498	0.427
LIG_FHA_1	559	565	PF00498	0.303
LIG_FHA_1	67	73	PF00498	0.452
LIG_FHA_1	704	710	PF00498	0.388
LIG_FHA_2	100	106	PF00498	0.534
LIG_FHA_2	165	171	PF00498	0.536
LIG_FHA_2	953	959	PF00498	0.489
LIG_LIR_Apic_2	155	161	PF02991	0.589
LIG_LIR_Gen_1	227	237	PF02991	0.513
LIG_LIR_Gen_1	357	367	PF02991	0.484
LIG_LIR_Gen_1	549	559	PF02991	0.409
LIG_LIR_Gen_1	581	591	PF02991	0.422
LIG_LIR_Gen_1	636	641	PF02991	0.369
LIG_LIR_Gen_1	673	681	PF02991	0.292
LIG_LIR_Gen_1	842	849	PF02991	0.459
LIG_LIR_Gen_1	961	970	PF02991	0.369
LIG_LIR_Nem_3	227	232	PF02991	0.511
LIG_LIR_Nem_3	242	246	PF02991	0.656
LIG_LIR_Nem_3	357	362	PF02991	0.477
LIG_LIR_Nem_3	38	44	PF02991	0.515
LIG_LIR_Nem_3	549	554	PF02991	0.435
LIG_LIR_Nem_3	581	587	PF02991	0.429
LIG_LIR_Nem_3	673	677	PF02991	0.434
LIG_LIR_Nem_3	842	847	PF02991	0.459
LIG_LIR_Nem_3	860	864	PF02991	0.304
LIG_LIR_Nem_3	934	938	PF02991	0.305
LIG_LIR_Nem_3	961	967	PF02991	0.344
LIG_PCNA_yPIPBox_3	88	96	PF02747	0.436
LIG_Pex14_1	551	555	PF04695	0.429
LIG_REV1ctd_RIR_1	17	26	PF16727	0.557
LIG_SH2_CRK	158	162	PF00017	0.574
LIG_SH2_CRK	233	237	PF00017	0.579
LIG_SH2_CRK	674	678	PF00017	0.418
LIG_SH2_CRK	686	690	PF00017	0.229
LIG_SH2_GRB2like	302	305	PF00017	0.446
LIG_SH2_NCK_1	158	162	PF00017	0.574
LIG_SH2_NCK_1	233	237	PF00017	0.579
LIG_SH2_NCK_1	395	399	PF00017	0.559
LIG_SH2_SRC	865	868	PF00017	0.482
LIG_SH2_STAP1	844	848	PF00017	0.304
LIG_SH2_STAT3	784	787	PF00017	0.304
LIG_SH2_STAT3	95	98	PF00017	0.460
LIG_SH2_STAT5	503	506	PF00017	0.471
LIG_SH2_STAT5	536	539	PF00017	0.503
LIG_SH2_STAT5	555	558	PF00017	0.264
LIG_SH2_STAT5	600	603	PF00017	0.222
LIG_SH2_STAT5	674	677	PF00017	0.418
LIG_SH2_STAT5	686	689	PF00017	0.350
LIG_SH2_STAT5	76	79	PF00017	0.615
LIG_SH2_STAT5	865	868	PF00017	0.482
LIG_SH2_STAT5	95	98	PF00017	0.525
LIG_SH2_STAT5	962	965	PF00017	0.313
LIG_SH2_STAT5	967	970	PF00017	0.294
LIG_SH3_1	233	239	PF00018	0.589
LIG_SH3_2	168	173	PF14604	0.429
LIG_SH3_2	236	241	PF14604	0.613
LIG_SH3_3	165	171	PF00018	0.391
LIG_SH3_3	233	239	PF00018	0.538
LIG_SH3_3	264	270	PF00018	0.604
LIG_SH3_3	303	309	PF00018	0.487
LIG_SH3_3	453	459	PF00018	0.503
LIG_SH3_3	496	502	PF00018	0.465
LIG_SH3_3	528	534	PF00018	0.445
LIG_SH3_3	779	785	PF00018	0.304
LIG_SH3_3	892	898	PF00018	0.323
LIG_SH3_3	926	932	PF00018	0.369
LIG_SH3_3	981	987	PF00018	0.387
LIG_SUMO_SIM_par_1	124	130	PF11976	0.492
LIG_SUMO_SIM_par_1	295	300	PF11976	0.424
LIG_SUMO_SIM_par_1	57	62	PF11976	0.476
LIG_SUMO_SIM_par_1	646	652	PF11976	0.394
LIG_TRAF2_1	1003	1006	PF00917	0.514
LIG_TRAF2_1	102	105	PF00917	0.475
LIG_TRAF2_1	258	261	PF00917	0.535
LIG_TRAF2_2	306	311	PF00917	0.563
LIG_TYR_ITIM	684	689	PF00017	0.369
LIG_UBA3_1	654	661	PF00899	0.317
LIG_WRC_WIRS_1	621	626	PF05994	0.369
LIG_WRC_WIRS_1	826	831	PF05994	0.307
LIG_WRC_WIRS_1	861	866	PF05994	0.304
MOD_CDC14_SPxK_1	605	608	PF00782	0.227
MOD_CDK_SPK_2	602	607	PF00069	0.227
MOD_CDK_SPxK_1	602	608	PF00069	0.227
MOD_CK1_1	159	165	PF00069	0.479
MOD_CK1_1	317	323	PF00069	0.592
MOD_CK1_1	34	40	PF00069	0.632
MOD_CK1_1	387	393	PF00069	0.561
MOD_CK1_1	396	402	PF00069	0.598
MOD_CK1_1	403	409	PF00069	0.659
MOD_CK1_1	413	419	PF00069	0.555
MOD_CK1_1	426	432	PF00069	0.572
MOD_CK1_1	525	531	PF00069	0.430
MOD_CK1_1	578	584	PF00069	0.421
MOD_CK1_1	617	623	PF00069	0.337
MOD_CK1_1	732	738	PF00069	0.482
MOD_CK1_1	744	750	PF00069	0.369
MOD_CK2_1	1000	1006	PF00069	0.526
MOD_CK2_1	111	117	PF00069	0.533
MOD_CK2_1	164	170	PF00069	0.523
MOD_CK2_1	196	202	PF00069	0.479
MOD_CK2_1	221	227	PF00069	0.549
MOD_CK2_1	32	38	PF00069	0.468
MOD_CK2_1	418	424	PF00069	0.607
MOD_CK2_1	761	767	PF00069	0.369
MOD_CK2_1	87	93	PF00069	0.600
MOD_CK2_1	99	105	PF00069	0.412
MOD_Cter_Amidation	284	287	PF01082	0.516
MOD_DYRK1A_RPxSP_1	266	270	PF00069	0.524
MOD_DYRK1A_RPxSP_1	602	606	PF00069	0.227
MOD_GlcNHglycan	251	254	PF01048	0.594
MOD_GlcNHglycan	26	29	PF01048	0.646
MOD_GlcNHglycan	283	286	PF01048	0.611
MOD_GlcNHglycan	34	37	PF01048	0.621
MOD_GlcNHglycan	386	389	PF01048	0.584
MOD_GlcNHglycan	415	418	PF01048	0.648
MOD_GlcNHglycan	428	431	PF01048	0.561
MOD_GlcNHglycan	437	440	PF01048	0.552
MOD_GlcNHglycan	465	469	PF01048	0.474
MOD_GlcNHglycan	519	522	PF01048	0.433
MOD_GlcNHglycan	527	530	PF01048	0.417
MOD_GlcNHglycan	907	910	PF01048	0.477
MOD_GSK3_1	156	163	PF00069	0.710
MOD_GSK3_1	266	273	PF00069	0.739
MOD_GSK3_1	314	321	PF00069	0.706
MOD_GSK3_1	396	403	PF00069	0.663
MOD_GSK3_1	406	413	PF00069	0.574
MOD_GSK3_1	418	425	PF00069	0.625
MOD_GSK3_1	513	520	PF00069	0.412
MOD_GSK3_1	523	530	PF00069	0.436
MOD_GSK3_1	596	603	PF00069	0.346
MOD_GSK3_1	731	738	PF00069	0.389
MOD_GSK3_1	740	747	PF00069	0.320
MOD_GSK3_1	927	934	PF00069	0.342
MOD_N-GLC_1	270	275	PF02516	0.546
MOD_N-GLC_1	393	398	PF02516	0.565
MOD_N-GLC_1	684	689	PF02516	0.369
MOD_N-GLC_1	740	745	PF02516	0.227
MOD_N-GLC_2	5	7	PF02516	0.462
MOD_N-GLC_2	832	834	PF02516	0.304
MOD_NEK2_1	133	138	PF00069	0.468
MOD_NEK2_1	297	302	PF00069	0.429
MOD_NEK2_1	31	36	PF00069	0.542
MOD_NEK2_1	463	468	PF00069	0.471
MOD_NEK2_1	522	527	PF00069	0.501
MOD_NEK2_1	585	590	PF00069	0.382
MOD_NEK2_1	596	601	PF00069	0.389
MOD_NEK2_1	684	689	PF00069	0.333
MOD_NEK2_1	729	734	PF00069	0.369
MOD_NEK2_1	789	794	PF00069	0.404
MOD_NEK2_1	839	844	PF00069	0.304
MOD_NEK2_2	450	455	PF00069	0.553
MOD_PIKK_1	10	16	PF00454	0.600
MOD_PIKK_1	100	106	PF00454	0.627
MOD_PIKK_1	156	162	PF00454	0.580
MOD_PIKK_1	304	310	PF00454	0.539
MOD_PIKK_1	474	480	PF00454	0.447
MOD_PIKK_1	732	738	PF00454	0.354
MOD_PK_1	88	94	PF00069	0.429
MOD_PKA_2	133	139	PF00069	0.473
MOD_PKA_2	156	162	PF00069	0.580
MOD_PKA_2	239	245	PF00069	0.516
MOD_PKA_2	317	323	PF00069	0.464
MOD_PKA_2	331	337	PF00069	0.479
MOD_PKA_2	426	432	PF00069	0.769
MOD_PKA_2	435	441	PF00069	0.696
MOD_PKA_2	601	607	PF00069	0.227
MOD_PKA_2	87	93	PF00069	0.501
MOD_PKA_2	99	105	PF00069	0.510
MOD_PKB_1	330	338	PF00069	0.504
MOD_Plk_1	139	145	PF00069	0.556
MOD_Plk_1	495	501	PF00069	0.392
MOD_Plk_1	617	623	PF00069	0.348
MOD_Plk_1	672	678	PF00069	0.227
MOD_Plk_1	684	690	PF00069	0.369
MOD_Plk_1	740	746	PF00069	0.250
MOD_Plk_1	748	754	PF00069	0.312
MOD_Plk_2-3	111	117	PF00069	0.455
MOD_Plk_4	146	152	PF00069	0.511
MOD_Plk_4	297	303	PF00069	0.435
MOD_Plk_4	505	511	PF00069	0.488
MOD_Plk_4	513	519	PF00069	0.404
MOD_Plk_4	527	533	PF00069	0.419
MOD_Plk_4	546	552	PF00069	0.327
MOD_Plk_4	586	592	PF00069	0.355
MOD_Plk_4	713	719	PF00069	0.400
MOD_Plk_4	748	754	PF00069	0.425
MOD_Plk_4	884	890	PF00069	0.304
MOD_Plk_4	958	964	PF00069	0.447
MOD_ProDKin_1	164	170	PF00069	0.509
MOD_ProDKin_1	266	272	PF00069	0.527
MOD_ProDKin_1	289	295	PF00069	0.648
MOD_ProDKin_1	396	402	PF00069	0.631
MOD_ProDKin_1	410	416	PF00069	0.519
MOD_ProDKin_1	602	608	PF00069	0.354
MOD_ProDKin_1	66	72	PF00069	0.525
MOD_ProDKin_1	769	775	PF00069	0.304
MOD_ProDKin_1	887	893	PF00069	0.369
MOD_SUMO_for_1	660	663	PF00179	0.369
MOD_SUMO_rev_2	775	785	PF00179	0.304
MOD_SUMO_rev_2	845	855	PF00179	0.304
MOD_SUMO_rev_2	996	1003	PF00179	0.532
TRG_DiLeu_BaEn_2	226	232	PF01217	0.469
TRG_DiLeu_BaEn_2	801	807	PF01217	0.304
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.462
TRG_DiLeu_BaLyEn_6	650	655	PF01217	0.369
TRG_ENDOCYTIC_2	674	677	PF00928	0.418
TRG_ENDOCYTIC_2	686	689	PF00928	0.229
TRG_ENDOCYTIC_2	844	847	PF00928	0.304
TRG_ENDOCYTIC_2	861	864	PF00928	0.304
TRG_ENDOCYTIC_2	962	965	PF00928	0.468
TRG_ER_diArg_1	239	241	PF00400	0.490
TRG_ER_diArg_1	327	330	PF00400	0.572
TRG_ER_diArg_1	606	608	PF00400	0.227
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	690	695	PF00026	0.304
TRG_Pf-PMV_PEXEL_1	856	860	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL19	Leptomonas seymouri	53%	99%
A0A3S7XAZ7	Leishmania donovani	80%	100%
A4ICG4	Leishmania infantum	80%	100%
E9AT35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q1G3	Leishmania major	80%	100%