Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPC3_LEIBR

TriTrypDb:

LbrM.35.2780 , LBRM2903_350035400

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPC3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	174	176	PF00675	0.689
CLV_NRD_NRD_1	218	220	PF00675	0.673
CLV_NRD_NRD_1	258	260	PF00675	0.640
CLV_NRD_NRD_1	311	313	PF00675	0.605
CLV_NRD_NRD_1	348	350	PF00675	0.676
CLV_NRD_NRD_1	42	44	PF00675	0.613
CLV_NRD_NRD_1	79	81	PF00675	0.698
CLV_PCSK_KEX2_1	174	176	PF00082	0.689
CLV_PCSK_KEX2_1	20	22	PF00082	0.481
CLV_PCSK_KEX2_1	258	260	PF00082	0.640
CLV_PCSK_KEX2_1	311	313	PF00082	0.605
CLV_PCSK_KEX2_1	348	350	PF00082	0.676
CLV_PCSK_KEX2_1	42	44	PF00082	0.613
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.481
CLV_PCSK_SKI1_1	129	133	PF00082	0.580
CLV_PCSK_SKI1_1	177	181	PF00082	0.690
CLV_PCSK_SKI1_1	20	24	PF00082	0.686
CLV_PCSK_SKI1_1	312	316	PF00082	0.739
DEG_APCC_DBOX_1	111	119	PF00400	0.443
DEG_APCC_DBOX_1	300	308	PF00400	0.732
DOC_CKS1_1	270	275	PF01111	0.713
DOC_CKS1_1	34	39	PF01111	0.487
DOC_MAPK_gen_1	126	134	PF00069	0.695
DOC_MAPK_gen_1	40	49	PF00069	0.638
DOC_MAPK_MEF2A_6	40	49	PF00069	0.707
DOC_PP1_RVXF_1	257	264	PF00149	0.707
DOC_PP4_FxxP_1	146	149	PF00568	0.707
DOC_PP4_FxxP_1	270	273	PF00568	0.460
DOC_USP7_MATH_1	205	209	PF00917	0.684
DOC_USP7_MATH_1	283	287	PF00917	0.680
DOC_WW_Pin1_4	269	274	PF00397	0.642
DOC_WW_Pin1_4	279	284	PF00397	0.551
DOC_WW_Pin1_4	33	38	PF00397	0.620
LIG_14-3-3_CanoR_1	112	116	PF00244	0.563
LIG_14-3-3_CanoR_1	154	158	PF00244	0.575
LIG_14-3-3_CanoR_1	177	182	PF00244	0.455
LIG_14-3-3_CanoR_1	21	25	PF00244	0.480
LIG_14-3-3_CanoR_1	232	237	PF00244	0.654
LIG_14-3-3_CanoR_1	284	288	PF00244	0.707
LIG_14-3-3_CanoR_1	80	86	PF00244	0.747
LIG_BIR_II_1	1	5	PF00653	0.770
LIG_FHA_1	201	207	PF00498	0.659
LIG_FHA_1	332	338	PF00498	0.745
LIG_FHA_1	34	40	PF00498	0.637
LIG_FHA_2	178	184	PF00498	0.570
LIG_FHA_2	21	27	PF00498	0.691
LIG_FHA_2	225	231	PF00498	0.681
LIG_FHA_2	321	327	PF00498	0.671
LIG_IRF3_LxIS_1	128	135	PF10401	0.466
LIG_LIR_Apic_2	144	149	PF02991	0.704
LIG_LIR_Gen_1	355	365	PF02991	0.594
LIG_LIR_Gen_1	366	373	PF02991	0.600
LIG_LIR_Gen_1	70	79	PF02991	0.692
LIG_LIR_Nem_3	230	234	PF02991	0.577
LIG_LIR_Nem_3	246	252	PF02991	0.561
LIG_LIR_Nem_3	355	360	PF02991	0.571
LIG_LIR_Nem_3	366	370	PF02991	0.593
LIG_LIR_Nem_3	50	55	PF02991	0.623
LIG_LIR_Nem_3	70	74	PF02991	0.402
LIG_LYPXL_yS_3	52	55	PF13949	0.683
LIG_PDZ_Class_3	368	373	PF00595	0.753
LIG_SH2_CRK	231	235	PF00017	0.570
LIG_SH2_PTP2	357	360	PF00017	0.591
LIG_SH2_SRC	247	250	PF00017	0.682
LIG_SH2_SRC	367	370	PF00017	0.618
LIG_SH2_STAP1	247	251	PF00017	0.643
LIG_SH2_STAT5	161	164	PF00017	0.586
LIG_SH2_STAT5	201	204	PF00017	0.670
LIG_SH2_STAT5	357	360	PF00017	0.591
LIG_SH3_3	251	257	PF00018	0.459
LIG_SH3_3	31	37	PF00018	0.505
LIG_SH3_3	334	340	PF00018	0.742
LIG_SH3_3	355	361	PF00018	0.643
LIG_TRAF2_1	300	303	PF00917	0.617
MOD_CDK_SPK_2	279	284	PF00069	0.610
MOD_CDK_SPxxK_3	33	40	PF00069	0.494
MOD_CK1_1	235	241	PF00069	0.615
MOD_CK1_1	250	256	PF00069	0.602
MOD_CK1_1	282	288	PF00069	0.728
MOD_CK2_1	147	153	PF00069	0.691
MOD_CK2_1	183	189	PF00069	0.558
MOD_CK2_1	20	26	PF00069	0.696
MOD_CK2_1	224	230	PF00069	0.572
MOD_CK2_1	272	278	PF00069	0.718
MOD_CK2_1	283	289	PF00069	0.608
MOD_CK2_1	296	302	PF00069	0.663
MOD_CK2_1	320	326	PF00069	0.657
MOD_CK2_1	91	97	PF00069	0.750
MOD_GlcNHglycan	249	252	PF01048	0.599
MOD_GlcNHglycan	289	293	PF01048	0.533
MOD_GlcNHglycan	298	301	PF01048	0.703
MOD_GlcNHglycan	317	320	PF01048	0.448
MOD_GlcNHglycan	344	347	PF01048	0.714
MOD_GSK3_1	165	172	PF00069	0.574
MOD_GSK3_1	200	207	PF00069	0.586
MOD_GSK3_1	243	250	PF00069	0.568
MOD_GSK3_1	279	286	PF00069	0.599
MOD_GSK3_1	325	332	PF00069	0.681
MOD_GSK3_1	84	91	PF00069	0.662
MOD_N-GLC_1	353	358	PF02516	0.742
MOD_N-GLC_1	88	93	PF02516	0.677
MOD_NEK2_1	103	108	PF00069	0.623
MOD_NEK2_1	132	137	PF00069	0.607
MOD_NEK2_1	169	174	PF00069	0.708
MOD_NEK2_1	243	248	PF00069	0.550
MOD_NEK2_1	263	268	PF00069	0.382
MOD_NEK2_1	277	282	PF00069	0.517
MOD_NEK2_1	288	293	PF00069	0.625
MOD_PIKK_1	224	230	PF00454	0.719
MOD_PKA_1	20	26	PF00069	0.476
MOD_PKA_2	111	117	PF00069	0.661
MOD_PKA_2	153	159	PF00069	0.574
MOD_PKA_2	20	26	PF00069	0.617
MOD_PKA_2	283	289	PF00069	0.591
MOD_PKA_2	315	321	PF00069	0.590
MOD_PKA_2	329	335	PF00069	0.657
MOD_PKB_1	175	183	PF00069	0.456
MOD_Plk_1	152	158	PF00069	0.611
MOD_Plk_1	191	197	PF00069	0.653
MOD_Plk_1	263	269	PF00069	0.713
MOD_Plk_1	277	283	PF00069	0.512
MOD_Plk_1	312	318	PF00069	0.579
MOD_Plk_1	353	359	PF00069	0.733
MOD_Plk_1	69	75	PF00069	0.680
MOD_Plk_2-3	165	171	PF00069	0.708
MOD_Plk_2-3	183	189	PF00069	0.649
MOD_Plk_2-3	70	76	PF00069	0.695
MOD_Plk_4	111	117	PF00069	0.658
MOD_Plk_4	213	219	PF00069	0.674
MOD_Plk_4	272	278	PF00069	0.672
MOD_Plk_4	283	289	PF00069	0.635
MOD_Plk_4	353	359	PF00069	0.743
MOD_ProDKin_1	269	275	PF00069	0.640
MOD_ProDKin_1	279	285	PF00069	0.549
MOD_ProDKin_1	33	39	PF00069	0.622
TRG_DiLeu_BaEn_4	302	308	PF01217	0.584
TRG_ENDOCYTIC_2	201	204	PF00928	0.599
TRG_ENDOCYTIC_2	231	234	PF00928	0.570
TRG_ENDOCYTIC_2	357	360	PF00928	0.564
TRG_ENDOCYTIC_2	367	370	PF00928	0.604
TRG_ENDOCYTIC_2	52	55	PF00928	0.683
TRG_ER_diArg_1	173	175	PF00400	0.606
TRG_ER_diArg_1	257	259	PF00400	0.634
TRG_ER_diArg_1	310	312	PF00400	0.602
TRG_ER_diArg_1	347	349	PF00400	0.686
TRG_ER_diArg_1	42	44	PF00400	0.613
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYX6	Leptomonas seymouri	60%	97%
A0A1X0P7K9	Trypanosomatidae	38%	100%
A0A3Q8IKB1	Leishmania donovani	81%	100%
A0A3R7K7R7	Trypanosoma rangeli	41%	100%
A4ICG1	Leishmania infantum	80%	100%
D0A3D6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AT32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q1G6	Leishmania major	81%	100%
V5BH32	Trypanosoma cruzi	37%	100%