Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPC2_LEIBR

TriTrypDb:

LbrM.35.2770 , LBRM2903_350035300

Length:

905

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPC2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.502
CLV_C14_Caspase3-7	377	381	PF00656	0.727
CLV_C14_Caspase3-7	39	43	PF00656	0.485
CLV_C14_Caspase3-7	711	715	PF00656	0.616
CLV_NRD_NRD_1	521	523	PF00675	0.411
CLV_NRD_NRD_1	625	627	PF00675	0.544
CLV_PCSK_KEX2_1	521	523	PF00082	0.411
CLV_PCSK_KEX2_1	625	627	PF00082	0.518
CLV_PCSK_SKI1_1	208	212	PF00082	0.491
CLV_PCSK_SKI1_1	98	102	PF00082	0.552
DEG_APCC_DBOX_1	207	215	PF00400	0.458
DEG_APCC_DBOX_1	895	903	PF00400	0.372
DEG_SPOP_SBC_1	145	149	PF00917	0.782
DEG_SPOP_SBC_1	150	154	PF00917	0.691
DEG_SPOP_SBC_1	77	81	PF00917	0.613
DOC_CKS1_1	421	426	PF01111	0.600
DOC_CYCLIN_yCln2_LP_2	110	116	PF00134	0.530
DOC_MAPK_DCC_7	447	457	PF00069	0.460
DOC_MAPK_gen_1	744	752	PF00069	0.441
DOC_MAPK_gen_1	866	874	PF00069	0.543
DOC_MAPK_gen_1	894	901	PF00069	0.450
DOC_MAPK_MEF2A_6	227	236	PF00069	0.465
DOC_MAPK_MEF2A_6	462	469	PF00069	0.505
DOC_PP1_RVXF_1	206	213	PF00149	0.515
DOC_PP2B_LxvP_1	110	113	PF13499	0.543
DOC_PP2B_LxvP_1	332	335	PF13499	0.538
DOC_PP4_FxxP_1	463	466	PF00568	0.534
DOC_PP4_FxxP_1	509	512	PF00568	0.513
DOC_SPAK_OSR1_1	442	446	PF12202	0.504
DOC_USP7_MATH_1	140	144	PF00917	0.714
DOC_USP7_MATH_1	145	149	PF00917	0.758
DOC_USP7_MATH_1	21	25	PF00917	0.573
DOC_USP7_MATH_1	249	253	PF00917	0.534
DOC_USP7_MATH_1	268	272	PF00917	0.465
DOC_USP7_MATH_1	274	278	PF00917	0.646
DOC_USP7_MATH_1	320	324	PF00917	0.463
DOC_USP7_MATH_1	572	576	PF00917	0.739
DOC_USP7_MATH_1	77	81	PF00917	0.552
DOC_USP7_MATH_1	795	799	PF00917	0.639
DOC_USP7_MATH_1	839	843	PF00917	0.723
DOC_USP7_MATH_1	870	874	PF00917	0.475
DOC_WW_Pin1_4	136	141	PF00397	0.692
DOC_WW_Pin1_4	151	156	PF00397	0.528
DOC_WW_Pin1_4	191	196	PF00397	0.595
DOC_WW_Pin1_4	239	244	PF00397	0.582
DOC_WW_Pin1_4	264	269	PF00397	0.538
DOC_WW_Pin1_4	270	275	PF00397	0.665
DOC_WW_Pin1_4	333	338	PF00397	0.413
DOC_WW_Pin1_4	420	425	PF00397	0.599
DOC_WW_Pin1_4	437	442	PF00397	0.476
DOC_WW_Pin1_4	531	536	PF00397	0.715
DOC_WW_Pin1_4	73	78	PF00397	0.548
DOC_WW_Pin1_4	771	776	PF00397	0.567
LIG_14-3-3_CanoR_1	106	111	PF00244	0.548
LIG_14-3-3_CanoR_1	133	140	PF00244	0.676
LIG_14-3-3_CanoR_1	146	151	PF00244	0.736
LIG_14-3-3_CanoR_1	170	175	PF00244	0.546
LIG_14-3-3_CanoR_1	241	247	PF00244	0.588
LIG_14-3-3_CanoR_1	315	320	PF00244	0.409
LIG_14-3-3_CanoR_1	552	558	PF00244	0.568
LIG_14-3-3_CanoR_1	561	568	PF00244	0.625
LIG_14-3-3_CanoR_1	641	651	PF00244	0.563
LIG_14-3-3_CanoR_1	684	690	PF00244	0.542
LIG_14-3-3_CanoR_1	869	875	PF00244	0.495
LIG_14-3-3_CanoR_1	894	902	PF00244	0.412
LIG_14-3-3_CanoR_1	98	103	PF00244	0.562
LIG_Actin_WH2_2	300	317	PF00022	0.317
LIG_AP2alpha_2	102	104	PF02296	0.483
LIG_BIR_II_1	1	5	PF00653	0.709
LIG_BIR_III_2	714	718	PF00653	0.459
LIG_BIR_III_4	840	844	PF00653	0.531
LIG_BRCT_BRCA1_1	134	138	PF00533	0.490
LIG_BRCT_BRCA1_1	431	435	PF00533	0.455
LIG_BRCT_BRCA1_1	439	443	PF00533	0.522
LIG_BRCT_BRCA1_1	48	52	PF00533	0.533
LIG_BRCT_BRCA1_1	756	760	PF00533	0.551
LIG_deltaCOP1_diTrp_1	163	169	PF00928	0.494
LIG_FAT_LD_1	387	395	PF03623	0.383
LIG_FHA_1	281	287	PF00498	0.517
LIG_FHA_1	416	422	PF00498	0.628
LIG_FHA_1	506	512	PF00498	0.538
LIG_FHA_1	582	588	PF00498	0.493
LIG_FHA_1	590	596	PF00498	0.417
LIG_FHA_1	657	663	PF00498	0.517
LIG_FHA_1	733	739	PF00498	0.497
LIG_FHA_1	775	781	PF00498	0.591
LIG_FHA_1	883	889	PF00498	0.370
LIG_FHA_2	151	157	PF00498	0.493
LIG_FHA_2	34	40	PF00498	0.506
LIG_FHA_2	405	411	PF00498	0.567
LIG_FHA_2	594	600	PF00498	0.533
LIG_FHA_2	642	648	PF00498	0.575
LIG_FHA_2	749	755	PF00498	0.445
LIG_LIR_Apic_2	508	512	PF02991	0.518
LIG_LIR_Apic_2	702	707	PF02991	0.488
LIG_LIR_Apic_2	770	775	PF02991	0.558
LIG_LIR_Gen_1	101	112	PF02991	0.421
LIG_LIR_Gen_1	383	392	PF02991	0.477
LIG_LIR_Gen_1	410	416	PF02991	0.551
LIG_LIR_Gen_1	49	59	PF02991	0.520
LIG_LIR_Gen_1	592	600	PF02991	0.543
LIG_LIR_Gen_1	757	768	PF02991	0.490
LIG_LIR_Nem_3	101	107	PF02991	0.431
LIG_LIR_Nem_3	383	387	PF02991	0.445
LIG_LIR_Nem_3	410	415	PF02991	0.543
LIG_LIR_Nem_3	49	55	PF02991	0.438
LIG_LIR_Nem_3	592	597	PF02991	0.530
LIG_LIR_Nem_3	614	619	PF02991	0.510
LIG_LIR_Nem_3	757	763	PF02991	0.467
LIG_LIR_Nem_3	766	771	PF02991	0.396
LIG_NRBOX	206	212	PF00104	0.511
LIG_PCNA_PIPBox_1	391	400	PF02747	0.470
LIG_PCNA_yPIPBox_3	178	191	PF02747	0.529
LIG_PCNA_yPIPBox_3	670	684	PF02747	0.527
LIG_Pex14_1	722	726	PF04695	0.510
LIG_Pex14_2	212	216	PF04695	0.503
LIG_PTB_Apo_2	210	217	PF02174	0.525
LIG_RPA_C_Fungi	864	876	PF08784	0.561
LIG_SH2_CRK	704	708	PF00017	0.580
LIG_SH2_CRK	772	776	PF00017	0.501
LIG_SH2_NCK_1	704	708	PF00017	0.609
LIG_SH2_SRC	400	403	PF00017	0.467
LIG_SH2_STAP1	808	812	PF00017	0.488
LIG_SH2_STAT3	31	34	PF00017	0.539
LIG_SH2_STAT3	327	330	PF00017	0.512
LIG_SH2_STAT3	342	345	PF00017	0.514
LIG_SH2_STAT5	164	167	PF00017	0.507
LIG_SH2_STAT5	31	34	PF00017	0.526
LIG_SH2_STAT5	327	330	PF00017	0.512
LIG_SH2_STAT5	342	345	PF00017	0.514
LIG_SH2_STAT5	400	403	PF00017	0.502
LIG_SH2_STAT5	505	508	PF00017	0.490
LIG_SH2_STAT5	593	596	PF00017	0.407
LIG_SH2_STAT5	772	775	PF00017	0.391
LIG_SH2_STAT5	860	863	PF00017	0.619
LIG_SH3_2	222	227	PF14604	0.454
LIG_SH3_3	155	161	PF00018	0.643
LIG_SH3_3	211	217	PF00018	0.411
LIG_SH3_3	219	225	PF00018	0.400
LIG_SH3_3	262	268	PF00018	0.558
LIG_SH3_3	331	337	PF00018	0.387
LIG_SH3_3	35	41	PF00018	0.599
LIG_SH3_3	529	535	PF00018	0.469
LIG_SH3_3	547	553	PF00018	0.280
LIG_SH3_3	594	600	PF00018	0.562
LIG_SH3_3	97	103	PF00018	0.452
LIG_SUMO_SIM_anti_2	122	127	PF11976	0.545
LIG_SUMO_SIM_anti_2	429	435	PF11976	0.493
LIG_SUMO_SIM_anti_2	897	903	PF11976	0.462
LIG_SUMO_SIM_par_1	289	295	PF11976	0.404
LIG_SUMO_SIM_par_1	465	470	PF11976	0.501
LIG_SUMO_SIM_par_1	777	784	PF11976	0.559
LIG_TRAF2_1	279	282	PF00917	0.519
LIG_TRAF2_1	690	693	PF00917	0.601
LIG_TRFH_1	412	416	PF08558	0.422
LIG_WRC_WIRS_1	250	255	PF05994	0.433
LIG_WRC_WIRS_1	506	511	PF05994	0.550
MOD_CDC14_SPxK_1	267	270	PF00782	0.438
MOD_CDK_SPK_2	141	146	PF00069	0.747
MOD_CDK_SPK_2	437	442	PF00069	0.540
MOD_CDK_SPK_2	771	776	PF00069	0.326
MOD_CDK_SPxK_1	264	270	PF00069	0.652
MOD_CK1_1	132	138	PF00069	0.684
MOD_CK1_1	141	147	PF00069	0.752
MOD_CK1_1	148	154	PF00069	0.758
MOD_CK1_1	242	248	PF00069	0.585
MOD_CK1_1	273	279	PF00069	0.627
MOD_CK1_1	364	370	PF00069	0.758
MOD_CK1_1	534	540	PF00069	0.750
MOD_CK1_1	76	82	PF00069	0.648
MOD_CK1_1	774	780	PF00069	0.483
MOD_CK1_1	793	799	PF00069	0.595
MOD_CK2_1	150	156	PF00069	0.717
MOD_CK2_1	641	647	PF00069	0.577
MOD_CK2_1	748	754	PF00069	0.603
MOD_CK2_1	839	845	PF00069	0.687
MOD_CMANNOS	166	169	PF00535	0.532
MOD_DYRK1A_RPxSP_1	191	195	PF00069	0.623
MOD_DYRK1A_RPxSP_1	270	274	PF00069	0.677
MOD_DYRK1A_RPxSP_1	333	337	PF00069	0.463
MOD_GlcNHglycan	134	137	PF01048	0.701
MOD_GlcNHglycan	158	161	PF01048	0.593
MOD_GlcNHglycan	191	194	PF01048	0.631
MOD_GlcNHglycan	228	231	PF01048	0.462
MOD_GlcNHglycan	25	28	PF01048	0.402
MOD_GlcNHglycan	368	371	PF01048	0.566
MOD_GlcNHglycan	469	472	PF01048	0.511
MOD_GlcNHglycan	48	51	PF01048	0.391
MOD_GlcNHglycan	539	542	PF01048	0.621
MOD_GlcNHglycan	574	577	PF01048	0.701
MOD_GlcNHglycan	65	68	PF01048	0.737
MOD_GlcNHglycan	840	844	PF01048	0.703
MOD_GSK3_1	132	139	PF00069	0.688
MOD_GSK3_1	140	147	PF00069	0.742
MOD_GSK3_1	150	157	PF00069	0.714
MOD_GSK3_1	187	194	PF00069	0.539
MOD_GSK3_1	264	271	PF00069	0.662
MOD_GSK3_1	362	369	PF00069	0.710
MOD_GSK3_1	533	540	PF00069	0.662
MOD_GSK3_1	566	573	PF00069	0.709
MOD_GSK3_1	589	596	PF00069	0.542
MOD_GSK3_1	72	79	PF00069	0.605
MOD_GSK3_1	744	751	PF00069	0.633
MOD_GSK3_1	770	777	PF00069	0.448
MOD_GSK3_1	831	838	PF00069	0.660
MOD_GSK3_1	98	105	PF00069	0.557
MOD_N-GLC_1	141	146	PF02516	0.664
MOD_NEK2_1	263	268	PF00069	0.523
MOD_NEK2_1	280	285	PF00069	0.460
MOD_NEK2_1	314	319	PF00069	0.515
MOD_NEK2_1	427	432	PF00069	0.464
MOD_NEK2_1	435	440	PF00069	0.429
MOD_NEK2_1	788	793	PF00069	0.570
MOD_NEK2_2	320	325	PF00069	0.485
MOD_NEK2_2	516	521	PF00069	0.509
MOD_PIKK_1	14	20	PF00454	0.593
MOD_PIKK_1	561	567	PF00454	0.595
MOD_PK_1	146	152	PF00069	0.743
MOD_PK_1	746	752	PF00069	0.659
MOD_PKA_2	132	138	PF00069	0.685
MOD_PKA_2	145	151	PF00069	0.732
MOD_PKA_2	226	232	PF00069	0.497
MOD_PKA_2	314	320	PF00069	0.538
MOD_PKA_2	793	799	PF00069	0.415
MOD_PKA_2	826	832	PF00069	0.594
MOD_PKA_2	835	841	PF00069	0.668
MOD_Plk_1	280	286	PF00069	0.570
MOD_Plk_1	763	769	PF00069	0.509
MOD_Plk_1	897	903	PF00069	0.327
MOD_Plk_2-3	748	754	PF00069	0.415
MOD_Plk_4	170	176	PF00069	0.447
MOD_Plk_4	33	39	PF00069	0.510
MOD_Plk_4	386	392	PF00069	0.409
MOD_Plk_4	429	435	PF00069	0.410
MOD_Plk_4	505	511	PF00069	0.462
MOD_Plk_4	589	595	PF00069	0.444
MOD_Plk_4	611	617	PF00069	0.509
MOD_Plk_4	694	700	PF00069	0.518
MOD_Plk_4	754	760	PF00069	0.542
MOD_Plk_4	870	876	PF00069	0.461
MOD_Plk_4	897	903	PF00069	0.538
MOD_Plk_4	9	15	PF00069	0.699
MOD_ProDKin_1	136	142	PF00069	0.695
MOD_ProDKin_1	151	157	PF00069	0.514
MOD_ProDKin_1	191	197	PF00069	0.589
MOD_ProDKin_1	239	245	PF00069	0.582
MOD_ProDKin_1	264	270	PF00069	0.547
MOD_ProDKin_1	333	339	PF00069	0.405
MOD_ProDKin_1	420	426	PF00069	0.590
MOD_ProDKin_1	437	443	PF00069	0.481
MOD_ProDKin_1	531	537	PF00069	0.720
MOD_ProDKin_1	73	79	PF00069	0.545
MOD_ProDKin_1	771	777	PF00069	0.564
TRG_DiLeu_BaEn_1	228	233	PF01217	0.509
TRG_DiLeu_BaEn_1	669	674	PF01217	0.414
TRG_DiLeu_BaEn_1	784	789	PF01217	0.517
TRG_DiLeu_BaEn_4	281	287	PF01217	0.336
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.379
TRG_DiLeu_BaLyEn_6	308	313	PF01217	0.489
TRG_DiLeu_BaLyEn_6	451	456	PF01217	0.396
TRG_ENDOCYTIC_2	554	557	PF00928	0.544
TRG_ENDOCYTIC_2	768	771	PF00928	0.429
TRG_ER_diArg_1	520	522	PF00400	0.409
TRG_NES_CRM1_1	670	682	PF08389	0.279
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	521	526	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5G2	Leptomonas seymouri	47%	91%
A0A0S4JVI2	Bodo saltans	21%	100%
A0A1X0P8G4	Trypanosomatidae	24%	100%
A0A3Q8IHB1	Leishmania donovani	78%	97%
A0A422NCC8	Trypanosoma rangeli	26%	100%
A4ICG2	Leishmania infantum	78%	97%
D0A3D8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AT33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	98%
Q4Q1G5	Leishmania major	77%	100%
V5BCJ8	Trypanosoma cruzi	25%	100%