LeishMANIAdb
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Membrane-bound acid phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Membrane-bound acid phosphatase
Gene product:
membrane-bound acid phosphatase precursor
Species:
Leishmania braziliensis
UniProt:
A4HPC1_LEIBR
TriTrypDb:
LbrM.35.2760 , LBRM2903_350034700
Length:
516

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 1
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 65
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 34, no: 4
NetGPI no yes: 0, no: 38
Cellular components
Term Name Level Count
GO:0016020 membrane 2 27
GO:0110165 cellular anatomical entity 1 27

Expansion

Sequence features

A4HPC1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPC1

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 5
GO:0006796 phosphate-containing compound metabolic process 4 5
GO:0008152 metabolic process 1 5
GO:0009987 cellular process 1 5
GO:0016311 dephosphorylation 5 5
GO:0044237 cellular metabolic process 2 5
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0003993 acid phosphatase activity 6 1
GO:0016787 hydrolase activity 2 6
GO:0016788 hydrolase activity, acting on ester bonds 3 6
GO:0016791 phosphatase activity 5 6
GO:0042578 phosphoric ester hydrolase activity 4 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 311 315 PF00656 0.262
CLV_C14_Caspase3-7 330 334 PF00656 0.408
CLV_NRD_NRD_1 169 171 PF00675 0.504
CLV_NRD_NRD_1 2 4 PF00675 0.719
CLV_NRD_NRD_1 436 438 PF00675 0.540
CLV_NRD_NRD_1 501 503 PF00675 0.456
CLV_PCSK_KEX2_1 169 171 PF00082 0.470
CLV_PCSK_KEX2_1 2 4 PF00082 0.752
CLV_PCSK_KEX2_1 501 503 PF00082 0.449
CLV_PCSK_SKI1_1 11 15 PF00082 0.703
CLV_PCSK_SKI1_1 126 130 PF00082 0.519
CLV_PCSK_SKI1_1 275 279 PF00082 0.428
CLV_PCSK_SKI1_1 501 505 PF00082 0.417
CLV_Separin_Metazoa 498 502 PF03568 0.384
DEG_Nend_UBRbox_1 1 4 PF02207 0.633
DEG_SPOP_SBC_1 335 339 PF00917 0.197
DOC_CYCLIN_RxL_1 123 131 PF00134 0.294
DOC_MAPK_gen_1 205 212 PF00069 0.415
DOC_MAPK_gen_1 504 514 PF00069 0.688
DOC_MAPK_HePTP_8 81 93 PF00069 0.197
DOC_MAPK_MEF2A_6 11 20 PF00069 0.646
DOC_MAPK_MEF2A_6 507 516 PF00069 0.568
DOC_MAPK_MEF2A_6 84 93 PF00069 0.197
DOC_PP4_MxPP_1 316 319 PF00568 0.360
DOC_USP7_MATH_1 218 222 PF00917 0.316
DOC_USP7_MATH_1 23 27 PF00917 0.655
DOC_USP7_MATH_1 335 339 PF00917 0.389
DOC_USP7_MATH_1 463 467 PF00917 0.497
DOC_USP7_UBL2_3 275 279 PF12436 0.245
DOC_WW_Pin1_4 351 356 PF00397 0.332
DOC_WW_Pin1_4 398 403 PF00397 0.351
DOC_WW_Pin1_4 43 48 PF00397 0.294
DOC_WW_Pin1_4 464 469 PF00397 0.479
LIG_14-3-3_CanoR_1 110 118 PF00244 0.312
LIG_14-3-3_CanoR_1 180 184 PF00244 0.341
LIG_14-3-3_CanoR_1 2 10 PF00244 0.497
LIG_14-3-3_CanoR_1 392 402 PF00244 0.331
LIG_14-3-3_CanoR_1 427 436 PF00244 0.346
LIG_14-3-3_CanoR_1 460 469 PF00244 0.512
LIG_14-3-3_CanoR_1 472 478 PF00244 0.353
LIG_14-3-3_CanoR_1 82 92 PF00244 0.377
LIG_Actin_WH2_2 266 284 PF00022 0.283
LIG_APCC_ABBA_1 384 389 PF00400 0.369
LIG_BRCT_BRCA1_1 194 198 PF00533 0.365
LIG_BRCT_BRCA1_1 304 308 PF00533 0.334
LIG_BRCT_BRCA1_1 338 342 PF00533 0.356
LIG_Clathr_ClatBox_1 413 417 PF01394 0.290
LIG_FHA_1 110 116 PF00498 0.337
LIG_FHA_1 220 226 PF00498 0.364
LIG_FHA_1 240 246 PF00498 0.346
LIG_FHA_1 30 36 PF00498 0.270
LIG_FHA_1 320 326 PF00498 0.331
LIG_FHA_1 358 364 PF00498 0.383
LIG_FHA_1 403 409 PF00498 0.399
LIG_FHA_1 489 495 PF00498 0.422
LIG_LIR_Apic_2 405 410 PF02991 0.352
LIG_LIR_Gen_1 182 191 PF02991 0.361
LIG_LIR_Gen_1 340 351 PF02991 0.370
LIG_LIR_Gen_1 377 386 PF02991 0.321
LIG_LIR_Gen_1 389 398 PF02991 0.302
LIG_LIR_Nem_3 134 139 PF02991 0.307
LIG_LIR_Nem_3 182 186 PF02991 0.353
LIG_LIR_Nem_3 227 231 PF02991 0.317
LIG_LIR_Nem_3 265 269 PF02991 0.421
LIG_LIR_Nem_3 340 346 PF02991 0.358
LIG_LIR_Nem_3 377 381 PF02991 0.344
LIG_LIR_Nem_3 389 393 PF02991 0.329
LIG_LIR_Nem_3 454 459 PF02991 0.287
LIG_LIR_Nem_3 75 80 PF02991 0.429
LIG_LYPXL_S_1 135 139 PF13949 0.524
LIG_LYPXL_yS_3 136 139 PF13949 0.306
LIG_PCNA_yPIPBox_3 116 129 PF02747 0.240
LIG_PDZ_Class_2 511 516 PF00595 0.599
LIG_Pex14_2 320 324 PF04695 0.326
LIG_Pex14_2 61 65 PF04695 0.269
LIG_SH2_CRK 378 382 PF00017 0.327
LIG_SH2_CRK 459 463 PF00017 0.368
LIG_SH2_PTP2 343 346 PF00017 0.381
LIG_SH2_SRC 407 410 PF00017 0.346
LIG_SH2_SRC 450 453 PF00017 0.417
LIG_SH2_STAP1 194 198 PF00017 0.266
LIG_SH2_STAP1 31 35 PF00017 0.258
LIG_SH2_STAT3 164 167 PF00017 0.365
LIG_SH2_STAT3 436 439 PF00017 0.299
LIG_SH2_STAT3 68 71 PF00017 0.368
LIG_SH2_STAT3 96 99 PF00017 0.415
LIG_SH2_STAT5 202 205 PF00017 0.348
LIG_SH2_STAT5 31 34 PF00017 0.349
LIG_SH2_STAT5 343 346 PF00017 0.334
LIG_SH2_STAT5 378 381 PF00017 0.331
LIG_SH2_STAT5 407 410 PF00017 0.328
LIG_SH2_STAT5 450 453 PF00017 0.386
LIG_SH2_STAT5 80 83 PF00017 0.323
LIG_SH2_STAT5 85 88 PF00017 0.318
LIG_SH2_STAT5 96 99 PF00017 0.293
LIG_SH3_3 127 133 PF00018 0.247
LIG_SH3_3 169 175 PF00018 0.316
LIG_SH3_3 396 402 PF00018 0.300
LIG_SH3_3 465 471 PF00018 0.531
LIG_SH3_3 89 95 PF00018 0.345
LIG_SUMO_SIM_anti_2 32 37 PF11976 0.260
LIG_SUMO_SIM_anti_2 491 496 PF11976 0.436
LIG_SUMO_SIM_anti_2 509 515 PF11976 0.565
LIG_SUMO_SIM_par_1 327 333 PF11976 0.363
LIG_TRAF2_1 165 168 PF00917 0.365
MOD_CDK_SPK_2 467 472 PF00069 0.373
MOD_CK1_1 109 115 PF00069 0.353
MOD_CK1_1 179 185 PF00069 0.264
MOD_CK1_1 357 363 PF00069 0.390
MOD_CK1_1 464 470 PF00069 0.503
MOD_CK1_1 98 104 PF00069 0.346
MOD_CK2_1 361 367 PF00069 0.395
MOD_GlcNHglycan 119 122 PF01048 0.506
MOD_GlcNHglycan 152 155 PF01048 0.467
MOD_GlcNHglycan 20 23 PF01048 0.662
MOD_GlcNHglycan 25 28 PF01048 0.614
MOD_GlcNHglycan 294 297 PF01048 0.535
MOD_GlcNHglycan 304 307 PF01048 0.513
MOD_GlcNHglycan 395 398 PF01048 0.605
MOD_GlcNHglycan 429 432 PF01048 0.592
MOD_GlcNHglycan 463 466 PF01048 0.635
MOD_GlcNHglycan 474 477 PF01048 0.728
MOD_GSK3_1 292 299 PF00069 0.322
MOD_GSK3_1 357 364 PF00069 0.416
MOD_GSK3_1 393 400 PF00069 0.291
MOD_GSK3_1 463 470 PF00069 0.493
MOD_GSK3_1 98 105 PF00069 0.259
MOD_N-GLC_1 102 107 PF02516 0.528
MOD_N-GLC_1 200 205 PF02516 0.572
MOD_N-GLC_1 252 257 PF02516 0.511
MOD_N-GLC_1 357 362 PF02516 0.565
MOD_N-GLC_1 425 430 PF02516 0.566
MOD_N-GLC_1 51 56 PF02516 0.568
MOD_N-GLC_2 171 173 PF02516 0.423
MOD_N-GLC_2 383 385 PF02516 0.556
MOD_NEK2_1 104 109 PF00069 0.323
MOD_NEK2_1 149 154 PF00069 0.370
MOD_NEK2_1 308 313 PF00069 0.276
MOD_NEK2_1 361 366 PF00069 0.408
MOD_NEK2_1 374 379 PF00069 0.474
MOD_NEK2_1 393 398 PF00069 0.278
MOD_NEK2_1 451 456 PF00069 0.394
MOD_NEK2_2 138 143 PF00069 0.415
MOD_NEK2_2 200 205 PF00069 0.362
MOD_NEK2_2 402 407 PF00069 0.347
MOD_PIKK_1 192 198 PF00454 0.232
MOD_PIKK_1 95 101 PF00454 0.415
MOD_PKA_1 2 8 PF00069 0.528
MOD_PKA_2 109 115 PF00069 0.313
MOD_PKA_2 179 185 PF00069 0.267
MOD_PKA_2 2 8 PF00069 0.501
MOD_PKA_2 471 477 PF00069 0.364
MOD_PKA_2 83 89 PF00069 0.374
MOD_Plk_1 102 108 PF00069 0.301
MOD_Plk_1 200 206 PF00069 0.363
MOD_Plk_1 297 303 PF00069 0.316
MOD_Plk_1 309 315 PF00069 0.300
MOD_Plk_1 357 363 PF00069 0.355
MOD_Plk_1 425 431 PF00069 0.401
MOD_Plk_1 51 57 PF00069 0.355
MOD_Plk_2-3 327 333 PF00069 0.232
MOD_Plk_4 262 268 PF00069 0.364
MOD_Plk_4 4 10 PF00069 0.549
MOD_Plk_4 479 485 PF00069 0.283
MOD_Plk_4 490 496 PF00069 0.311
MOD_Plk_4 51 57 PF00069 0.378
MOD_ProDKin_1 351 357 PF00069 0.333
MOD_ProDKin_1 398 404 PF00069 0.349
MOD_ProDKin_1 43 49 PF00069 0.295
MOD_ProDKin_1 464 470 PF00069 0.481
TRG_DiLeu_BaLyEn_6 226 231 PF01217 0.303
TRG_DiLeu_BaLyEn_6 342 347 PF01217 0.392
TRG_ENDOCYTIC_2 136 139 PF00928 0.335
TRG_ENDOCYTIC_2 343 346 PF00928 0.366
TRG_ENDOCYTIC_2 378 381 PF00928 0.276
TRG_ER_diArg_1 1 3 PF00400 0.685
TRG_ER_diArg_1 158 161 PF00400 0.330
TRG_ER_diArg_1 204 207 PF00400 0.365
TRG_ER_diArg_1 500 502 PF00400 0.628
TRG_NES_CRM1_1 314 327 PF08389 0.316
TRG_NLS_MonoExtC_3 503 509 PF00514 0.566
TRG_NLS_MonoExtN_4 501 508 PF00514 0.572
TRG_Pf-PMV_PEXEL_1 427 432 PF00026 0.630

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5Y5 Leptomonas seymouri 37% 90%
A0A0N1I756 Leptomonas seymouri 62% 100%
A0A0N1PEH4 Leptomonas seymouri 39% 100%
A0A0S4IRF5 Bodo saltans 24% 77%
A0A0S4IUV8 Bodo saltans 24% 100%
A0A0S4IV77 Bodo saltans 35% 99%
A0A0S4JEA9 Bodo saltans 26% 100%
A0A0S4JJK3 Bodo saltans 31% 100%
A0A0S4JW09 Bodo saltans 28% 100%
A0A1X0NNY4 Trypanosomatidae 34% 93%
A0A1X0NQL4 Trypanosomatidae 28% 94%
A0A1X0NY34 Trypanosomatidae 27% 100%
A0A1X0P7V5 Trypanosomatidae 38% 99%
A0A3Q8IR23 Leishmania donovani 40% 90%
A0A3R7KSH4 Trypanosoma rangeli 25% 100%
A0A3R7MEN7 Trypanosoma rangeli 40% 100%
A0A3R7MHJ7 Trypanosoma rangeli 27% 100%
A0A3S5H827 Leishmania donovani 70% 100%
A0A3S7WXU0 Leishmania donovani 39% 97%
A0A3S7X1W4 Leishmania donovani 35% 94%
A4HCZ0 Leishmania braziliensis 39% 100%
A4HGW8 Leishmania braziliensis 37% 100%
A4HPC5 Leishmania braziliensis 40% 89%
A4HQG6 Leishmania braziliensis 37% 100%
A4HQG9 Leishmania braziliensis 37% 99%
A4I0H5 Leishmania infantum 39% 97%
A4I3Z8 Leishmania infantum 35% 94%
A4ICA5 Leishmania infantum 36% 77%
A4ICG3 Leishmania infantum 70% 100%
A4ICG5 Leishmania infantum 40% 90%
B1H1P9 Xenopus laevis 28% 100%
D0A3E0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 98%
D0A947 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 23% 100%
D0A948 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 23% 100%
D0A9J5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 98%
E9AT34 Leishmania mexicana (strain MHOM/GT/2001/U1103) 68% 100%
E9AT36 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 90%
E9AWD7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 97%
E9B088 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 94%
P11117 Homo sapiens 25% 100%
Q0P5F0 Bos taurus 25% 100%
Q4Q0A9 Leishmania major 32% 96%
Q4Q1G2 Leishmania major 37% 100%
Q4Q1G4 Leishmania major 71% 100%
Q4Q7Z7 Leishmania major 35% 100%
Q4QB35 Leishmania major 39% 100%
V5BCI2 Trypanosoma cruzi 26% 100%
V5BK91 Trypanosoma cruzi 37% 100%
V5BL75 Trypanosoma cruzi 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS