Putative DEAD/DEAH box helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent DEAD/H RNA helicase, putative

Species:

Leishmania braziliensis

UniProt:

A4HPB9_LEIBR

TriTrypDb:

LbrM.35.2740 , LBRM2903_350034500

Length:

717

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	3
GO:0010494	cytoplasmic stress granule	5	1
GO:0034399	nuclear periphery	2	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0097165	nuclear stress granule	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0005739	mitochondrion	5	2
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

A4HPB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPB9

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	1
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1902775	mitochondrial large ribosomal subunit assembly	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016556	mRNA modification	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	22
GO:0003676	nucleic acid binding	3	22
GO:0003824	catalytic activity	1	22
GO:0004386	helicase activity	2	22
GO:0005488	binding	1	22
GO:0005524	ATP binding	5	22
GO:0017076	purine nucleotide binding	4	22
GO:0030554	adenyl nucleotide binding	5	22
GO:0032553	ribonucleotide binding	3	22
GO:0032555	purine ribonucleotide binding	4	22
GO:0032559	adenyl ribonucleotide binding	5	22
GO:0035639	purine ribonucleoside triphosphate binding	4	22
GO:0036094	small molecule binding	2	22
GO:0043167	ion binding	2	22
GO:0043168	anion binding	3	22
GO:0097159	organic cyclic compound binding	2	22
GO:0097367	carbohydrate derivative binding	2	22
GO:0140640	catalytic activity, acting on a nucleic acid	2	22
GO:0140657	ATP-dependent activity	1	22
GO:1901265	nucleoside phosphate binding	3	22
GO:1901363	heterocyclic compound binding	2	22
GO:0003724	RNA helicase activity	3	5
GO:0003743	translation initiation factor activity	4	4
GO:0008135	translation factor activity, RNA binding	3	4
GO:0008186	ATP-dependent activity, acting on RNA	2	5
GO:0016787	hydrolase activity	2	10
GO:0045182	translation regulator activity	1	4
GO:0090079	translation regulator activity, nucleic acid binding	2	4
GO:0140098	catalytic activity, acting on RNA	3	5
GO:0003723	RNA binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	86	90	PF00656	0.798
CLV_NRD_NRD_1	156	158	PF00675	0.448
CLV_NRD_NRD_1	230	232	PF00675	0.335
CLV_NRD_NRD_1	284	286	PF00675	0.287
CLV_NRD_NRD_1	339	341	PF00675	0.288
CLV_NRD_NRD_1	372	374	PF00675	0.307
CLV_NRD_NRD_1	683	685	PF00675	0.589
CLV_NRD_NRD_1	700	702	PF00675	0.649
CLV_NRD_NRD_1	98	100	PF00675	0.714
CLV_PCSK_KEX2_1	230	232	PF00082	0.295
CLV_PCSK_KEX2_1	284	286	PF00082	0.287
CLV_PCSK_KEX2_1	372	374	PF00082	0.219
CLV_PCSK_KEX2_1	700	702	PF00082	0.650
CLV_PCSK_KEX2_1	97	99	PF00082	0.779
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.742
CLV_PCSK_PC7_1	280	286	PF00082	0.328
CLV_PCSK_SKI1_1	161	165	PF00082	0.534
CLV_PCSK_SKI1_1	178	182	PF00082	0.211
CLV_PCSK_SKI1_1	395	399	PF00082	0.233
CLV_PCSK_SKI1_1	403	407	PF00082	0.221
CLV_PCSK_SKI1_1	410	414	PF00082	0.237
CLV_PCSK_SKI1_1	428	432	PF00082	0.576
CLV_PCSK_SKI1_1	435	439	PF00082	0.396
CLV_PCSK_SKI1_1	639	643	PF00082	0.358
DEG_APCC_DBOX_1	339	347	PF00400	0.485
DEG_APCC_DBOX_1	434	442	PF00400	0.398
DEG_APCC_DBOX_1	492	500	PF00400	0.527
DEG_SPOP_SBC_1	214	218	PF00917	0.381
DOC_CYCLIN_RxL_1	407	416	PF00134	0.439
DOC_CYCLIN_RxL_1	425	433	PF00134	0.572
DOC_CYCLIN_yCln2_LP_2	122	128	PF00134	0.523
DOC_CYCLIN_yCln2_LP_2	15	21	PF00134	0.507
DOC_CYCLIN_yCln2_LP_2	654	657	PF00134	0.409
DOC_MAPK_gen_1	280	289	PF00069	0.467
DOC_MAPK_JIP1_4	407	413	PF00069	0.444
DOC_PP1_RVXF_1	495	502	PF00149	0.434
DOC_PP1_RVXF_1	509	515	PF00149	0.293
DOC_PP1_RVXF_1	524	531	PF00149	0.515
DOC_PP1_RVXF_1	586	593	PF00149	0.433
DOC_PP2B_LxvP_1	122	125	PF13499	0.542
DOC_PP2B_LxvP_1	654	657	PF13499	0.409
DOC_PP4_FxxP_1	265	268	PF00568	0.503
DOC_PP4_FxxP_1	632	635	PF00568	0.331
DOC_PP4_FxxP_1	676	679	PF00568	0.518
DOC_USP7_MATH_1	266	270	PF00917	0.523
DOC_USP7_MATH_1	278	282	PF00917	0.498
DOC_USP7_MATH_1	445	449	PF00917	0.620
DOC_USP7_MATH_1	450	454	PF00917	0.659
DOC_USP7_MATH_1	456	460	PF00917	0.704
DOC_USP7_MATH_1	546	550	PF00917	0.381
DOC_USP7_MATH_1	663	667	PF00917	0.445
DOC_USP7_MATH_1	688	692	PF00917	0.679
DOC_USP7_MATH_1	80	84	PF00917	0.491
DOC_WW_Pin1_4	140	145	PF00397	0.510
DOC_WW_Pin1_4	161	166	PF00397	0.456
DOC_WW_Pin1_4	353	358	PF00397	0.484
DOC_WW_Pin1_4	461	466	PF00397	0.746
DOC_WW_Pin1_4	689	694	PF00397	0.683
DOC_WW_Pin1_4	81	86	PF00397	0.506
LIG_14-3-3_CanoR_1	372	378	PF00244	0.501
LIG_14-3-3_CanoR_1	573	581	PF00244	0.522
LIG_14-3-3_CanoR_1	626	631	PF00244	0.311
LIG_Actin_WH2_2	66	84	PF00022	0.515
LIG_AP2alpha_1	667	671	PF02296	0.531
LIG_APCC_ABBA_1	246	251	PF00400	0.528
LIG_BIR_III_4	120	124	PF00653	0.542
LIG_BIR_III_4	50	54	PF00653	0.626
LIG_BRCT_BRCA1_1	432	436	PF00533	0.372
LIG_EH1_1	324	332	PF00400	0.431
LIG_eIF4E_1	194	200	PF01652	0.528
LIG_FHA_1	195	201	PF00498	0.411
LIG_FHA_1	425	431	PF00498	0.465
LIG_FHA_1	484	490	PF00498	0.484
LIG_FHA_1	516	522	PF00498	0.463
LIG_FHA_1	576	582	PF00498	0.471
LIG_FHA_1	690	696	PF00498	0.692
LIG_FHA_2	441	447	PF00498	0.520
LIG_FHA_2	561	567	PF00498	0.381
LIG_Integrin_RGD_1	619	621	PF01839	0.181
LIG_IRF3_LxIS_1	248	255	PF10401	0.389
LIG_LIR_Apic_2	263	268	PF02991	0.503
LIG_LIR_Apic_2	629	635	PF02991	0.321
LIG_LIR_Apic_2	674	679	PF02991	0.499
LIG_LIR_Gen_1	135	144	PF02991	0.551
LIG_LIR_Gen_1	433	441	PF02991	0.412
LIG_LIR_Gen_1	629	638	PF02991	0.347
LIG_LIR_Gen_1	666	675	PF02991	0.591
LIG_LIR_Gen_1	9	20	PF02991	0.490
LIG_LIR_Nem_3	111	117	PF02991	0.441
LIG_LIR_Nem_3	135	139	PF02991	0.498
LIG_LIR_Nem_3	176	180	PF02991	0.525
LIG_LIR_Nem_3	35	40	PF02991	0.739
LIG_LIR_Nem_3	433	439	PF02991	0.401
LIG_LIR_Nem_3	591	595	PF02991	0.433
LIG_LIR_Nem_3	629	633	PF02991	0.486
LIG_LIR_Nem_3	666	670	PF02991	0.587
LIG_LIR_Nem_3	699	705	PF02991	0.546
LIG_LIR_Nem_3	9	15	PF02991	0.499
LIG_NRBOX	198	204	PF00104	0.485
LIG_OCRL_FandH_1	317	329	PF00620	0.431
LIG_PCNA_PIPBox_1	707	716	PF02747	0.549
LIG_PCNA_yPIPBox_3	148	161	PF02747	0.319
LIG_Pex14_2	667	671	PF04695	0.531
LIG_PTB_Apo_2	670	677	PF02174	0.547
LIG_SH2_CRK	114	118	PF00017	0.481
LIG_SH2_CRK	160	164	PF00017	0.569
LIG_SH2_CRK	196	200	PF00017	0.489
LIG_SH2_CRK	422	426	PF00017	0.328
LIG_SH2_CRK	601	605	PF00017	0.482
LIG_SH2_NCK_1	601	605	PF00017	0.482
LIG_SH2_STAP1	196	200	PF00017	0.528
LIG_SH2_STAP1	628	632	PF00017	0.242
LIG_SH2_STAT3	647	650	PF00017	0.458
LIG_SH2_STAT3	662	665	PF00017	0.360
LIG_SH2_STAT5	194	197	PF00017	0.470
LIG_SH2_STAT5	249	252	PF00017	0.444
LIG_SH2_STAT5	342	345	PF00017	0.549
LIG_SH2_STAT5	539	542	PF00017	0.474
LIG_SH2_STAT5	597	600	PF00017	0.474
LIG_SH2_STAT5	628	631	PF00017	0.325
LIG_SH2_STAT5	647	650	PF00017	0.554
LIG_SH3_1	41	47	PF00018	0.519
LIG_SH3_2	679	684	PF14604	0.579
LIG_SH3_3	123	129	PF00018	0.382
LIG_SH3_3	15	21	PF00018	0.557
LIG_SH3_3	23	29	PF00018	0.539
LIG_SH3_3	293	299	PF00018	0.474
LIG_SH3_3	300	306	PF00018	0.499
LIG_SH3_3	351	357	PF00018	0.549
LIG_SH3_3	402	408	PF00018	0.549
LIG_SH3_3	41	47	PF00018	0.519
LIG_SH3_3	462	468	PF00018	0.702
LIG_SH3_3	676	682	PF00018	0.535
LIG_SH3_3	74	80	PF00018	0.683
LIG_SH3_3	99	105	PF00018	0.587
LIG_SUMO_SIM_par_1	115	120	PF11976	0.364
LIG_SUMO_SIM_par_1	437	443	PF11976	0.381
LIG_TRAF2_1	335	338	PF00917	0.445
LIG_TYR_ITIM	175	180	PF00017	0.528
LIG_TYR_ITIM	420	425	PF00017	0.422
LIG_UBA3_1	199	205	PF00899	0.528
LIG_UBA3_1	360	368	PF00899	0.444
LIG_UBA3_1	397	403	PF00899	0.424
LIG_WRC_WIRS_1	233	238	PF05994	0.431
MOD_CK1_1	224	230	PF00069	0.464
MOD_CK1_1	356	362	PF00069	0.431
MOD_CK1_1	45	51	PF00069	0.827
MOD_CK1_1	458	464	PF00069	0.626
MOD_CK1_1	558	564	PF00069	0.435
MOD_CK1_1	58	64	PF00069	0.668
MOD_CK1_1	83	89	PF00069	0.513
MOD_CK2_1	103	109	PF00069	0.485
MOD_CK2_1	250	256	PF00069	0.507
MOD_CK2_1	266	272	PF00069	0.453
MOD_CK2_1	292	298	PF00069	0.441
MOD_CK2_1	331	337	PF00069	0.448
MOD_CK2_1	440	446	PF00069	0.579
MOD_CK2_1	560	566	PF00069	0.431
MOD_GlcNHglycan	222	226	PF01048	0.302
MOD_GlcNHglycan	334	337	PF01048	0.277
MOD_GlcNHglycan	44	47	PF01048	0.724
MOD_GlcNHglycan	481	484	PF01048	0.580
MOD_GSK3_1	105	112	PF00069	0.550
MOD_GSK3_1	142	149	PF00069	0.506
MOD_GSK3_1	209	216	PF00069	0.481
MOD_GSK3_1	268	275	PF00069	0.477
MOD_GSK3_1	305	312	PF00069	0.491
MOD_GSK3_1	42	49	PF00069	0.792
MOD_GSK3_1	450	457	PF00069	0.677
MOD_GSK3_1	479	486	PF00069	0.598
MOD_GSK3_1	55	62	PF00069	0.698
MOD_GSK3_1	551	558	PF00069	0.437
MOD_GSK3_1	571	578	PF00069	0.487
MOD_GSK3_1	580	587	PF00069	0.490
MOD_N-GLC_1	551	556	PF02516	0.328
MOD_N-GLC_1	671	676	PF02516	0.515
MOD_N-GLC_1	689	694	PF02516	0.552
MOD_NEK2_1	273	278	PF00069	0.440
MOD_NEK2_1	292	297	PF00069	0.494
MOD_NEK2_1	413	418	PF00069	0.475
MOD_NEK2_1	424	429	PF00069	0.417
MOD_NEK2_1	455	460	PF00069	0.543
MOD_NEK2_1	481	486	PF00069	0.527
MOD_NEK2_1	515	520	PF00069	0.474
MOD_NEK2_1	530	535	PF00069	0.457
MOD_NEK2_1	571	576	PF00069	0.537
MOD_NEK2_1	671	676	PF00069	0.480
MOD_NEK2_2	628	633	PF00069	0.314
MOD_PIKK_1	103	109	PF00454	0.695
MOD_PIKK_1	146	152	PF00454	0.372
MOD_PIKK_1	305	311	PF00454	0.437
MOD_PIKK_1	440	446	PF00454	0.392
MOD_PIKK_1	546	552	PF00454	0.431
MOD_PIKK_1	63	69	PF00454	0.719
MOD_PIKK_1	83	89	PF00454	0.540
MOD_PK_1	98	104	PF00069	0.563
MOD_PKA_1	98	104	PF00069	0.563
MOD_PKA_2	209	215	PF00069	0.381
MOD_PKA_2	331	337	PF00069	0.472
MOD_PKA_2	696	702	PF00069	0.652
MOD_PKA_2	98	104	PF00069	0.589
MOD_PKB_1	624	632	PF00069	0.289
MOD_Plk_1	221	227	PF00069	0.509
MOD_Plk_1	250	256	PF00069	0.507
MOD_Plk_1	273	279	PF00069	0.426
MOD_Plk_1	551	557	PF00069	0.490
MOD_Plk_1	671	677	PF00069	0.521
MOD_Plk_4	142	148	PF00069	0.515
MOD_Plk_4	232	238	PF00069	0.431
MOD_Plk_4	356	362	PF00069	0.439
MOD_Plk_4	373	379	PF00069	0.511
MOD_Plk_4	628	634	PF00069	0.360
MOD_Plk_4	663	669	PF00069	0.479
MOD_Plk_4	671	677	PF00069	0.475
MOD_ProDKin_1	140	146	PF00069	0.514
MOD_ProDKin_1	161	167	PF00069	0.338
MOD_ProDKin_1	353	359	PF00069	0.484
MOD_ProDKin_1	461	467	PF00069	0.747
MOD_ProDKin_1	689	695	PF00069	0.684
MOD_ProDKin_1	81	87	PF00069	0.508
TRG_DiLeu_BaEn_1	176	181	PF01217	0.441
TRG_DiLeu_BaEn_1	298	303	PF01217	0.433
TRG_DiLeu_BaLyEn_6	407	412	PF01217	0.436
TRG_ENDOCYTIC_2	114	117	PF00928	0.438
TRG_ENDOCYTIC_2	160	163	PF00928	0.531
TRG_ENDOCYTIC_2	177	180	PF00928	0.585
TRG_ENDOCYTIC_2	196	199	PF00928	0.528
TRG_ENDOCYTIC_2	249	252	PF00928	0.444
TRG_ENDOCYTIC_2	422	425	PF00928	0.390
TRG_ENDOCYTIC_2	630	633	PF00928	0.368
TRG_ER_diArg_1	371	373	PF00400	0.462
TRG_ER_diArg_1	623	626	PF00400	0.394
TRG_ER_diArg_1	700	702	PF00400	0.645
TRG_Pf-PMV_PEXEL_1	319	324	PF00026	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I458	Leptomonas seymouri	73%	100%
A0A0N1I5R1	Leptomonas seymouri	20%	90%
A0A0S4IX79	Bodo saltans	23%	98%
A0A0S4JPF4	Bodo saltans	38%	100%
A0A1X0P7J3	Trypanosomatidae	56%	100%
A0A3Q8ID91	Leishmania donovani	26%	100%
A0A3Q8IF94	Leishmania donovani	24%	100%
A0A3Q8IG57	Leishmania donovani	86%	92%
A4HGR1	Leishmania braziliensis	26%	100%
A4I3T6	Leishmania infantum	26%	100%
A4I7K4	Leishmania infantum	24%	100%
A4ICF9	Leishmania infantum	88%	100%
D0A3C9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AT30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B028	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B2G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q1G8	Leishmania major	87%	100%
Q4Q5P5	Leishmania major	24%	100%
Q4Q858	Leishmania major	26%	100%
V5D8J9	Trypanosoma cruzi	56%	100%