Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPB8_LEIBR

TriTrypDb:

LbrM.35.2730 , LBRM2903_350034400

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPB8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	20	26	PF00089	0.419
CLV_NRD_NRD_1	117	119	PF00675	0.529
CLV_NRD_NRD_1	144	146	PF00675	0.566
CLV_NRD_NRD_1	256	258	PF00675	0.649
CLV_NRD_NRD_1	342	344	PF00675	0.679
CLV_PCSK_KEX2_1	144	146	PF00082	0.566
CLV_PCSK_KEX2_1	171	173	PF00082	0.604
CLV_PCSK_KEX2_1	256	258	PF00082	0.649
CLV_PCSK_KEX2_1	341	343	PF00082	0.714
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.604
CLV_PCSK_PC7_1	140	146	PF00082	0.568
CLV_PCSK_SKI1_1	144	148	PF00082	0.689
CLV_PCSK_SKI1_1	202	206	PF00082	0.607
CLV_PCSK_SKI1_1	250	254	PF00082	0.619
CLV_PCSK_SKI1_1	256	260	PF00082	0.587
CLV_PCSK_SKI1_1	296	300	PF00082	0.709
CLV_PCSK_SKI1_1	342	346	PF00082	0.727
CLV_PCSK_SKI1_1	61	65	PF00082	0.689
DEG_APCC_DBOX_1	201	209	PF00400	0.610
DOC_CYCLIN_RxL_1	199	209	PF00134	0.609
DOC_CYCLIN_RxL_1	339	348	PF00134	0.717
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.805
DOC_CYCLIN_yCln2_LP_2	59	65	PF00134	0.598
DOC_MAPK_DCC_7	188	198	PF00069	0.769
DOC_MAPK_gen_1	88	97	PF00069	0.522
DOC_MAPK_MEF2A_6	91	99	PF00069	0.511
DOC_PP2B_LxvP_1	187	190	PF13499	0.821
DOC_PP2B_LxvP_1	79	82	PF13499	0.555
DOC_PP4_FxxP_1	28	31	PF00568	0.675
DOC_PP4_FxxP_1	325	328	PF00568	0.627
DOC_USP7_MATH_1	129	133	PF00917	0.699
DOC_USP7_MATH_1	182	186	PF00917	0.727
DOC_USP7_MATH_1	235	239	PF00917	0.565
DOC_USP7_MATH_1	66	70	PF00917	0.561
DOC_WW_Pin1_4	135	140	PF00397	0.567
DOC_WW_Pin1_4	165	170	PF00397	0.838
DOC_WW_Pin1_4	177	182	PF00397	0.695
DOC_WW_Pin1_4	237	242	PF00397	0.701
DOC_WW_Pin1_4	289	294	PF00397	0.705
LIG_14-3-3_CanoR_1	172	178	PF00244	0.693
LIG_14-3-3_CanoR_1	88	94	PF00244	0.470
LIG_BRCT_BRCA1_1	24	28	PF00533	0.419
LIG_CtBP_PxDLS_1	315	319	PF00389	0.542
LIG_FHA_1	66	72	PF00498	0.503
LIG_FHA_1	90	96	PF00498	0.513
LIG_FHA_2	27	33	PF00498	0.518
LIG_FHA_2	3	9	PF00498	0.713
LIG_FHA_2	55	61	PF00498	0.592
LIG_LIR_Apic_2	25	31	PF02991	0.472
LIG_LIR_Apic_2	322	328	PF02991	0.637
LIG_LIR_Gen_1	16	24	PF02991	0.555
LIG_LIR_Gen_1	327	337	PF02991	0.609
LIG_LIR_Gen_1	37	45	PF02991	0.592
LIG_LIR_Gen_1	75	86	PF02991	0.543
LIG_LIR_Nem_3	16	20	PF02991	0.509
LIG_LIR_Nem_3	327	333	PF02991	0.714
LIG_LIR_Nem_3	37	42	PF02991	0.595
LIG_LIR_Nem_3	49	53	PF02991	0.484
LIG_LIR_Nem_3	75	81	PF02991	0.489
LIG_LIR_Nem_3	90	96	PF02991	0.513
LIG_LIR_Nem_3	98	102	PF02991	0.508
LIG_NRP_CendR_1	349	350	PF00754	0.763
LIG_Pex14_2	24	28	PF04695	0.620
LIG_Pex14_2	39	43	PF04695	0.521
LIG_SH2_CRK	17	21	PF00017	0.654
LIG_SH2_NCK_1	310	314	PF00017	0.482
LIG_SH2_STAP1	17	21	PF00017	0.584
LIG_SH2_STAP1	310	314	PF00017	0.482
LIG_SH2_STAT3	102	105	PF00017	0.541
LIG_SH2_STAT3	266	269	PF00017	0.747
LIG_SH2_STAT5	266	269	PF00017	0.727
LIG_SH2_STAT5	50	53	PF00017	0.545
LIG_SH2_STAT5	78	81	PF00017	0.538
LIG_SH3_3	175	181	PF00018	0.671
LIG_SH3_3	187	193	PF00018	0.628
LIG_SH3_3	291	297	PF00018	0.501
LIG_SH3_3	59	65	PF00018	0.598
LIG_SUMO_SIM_par_1	194	199	PF11976	0.636
LIG_SUMO_SIM_par_1	68	76	PF11976	0.636
LIG_TRAF2_1	314	317	PF00917	0.754
LIG_WRC_WIRS_1	96	101	PF05994	0.466
MOD_CDC14_SPxK_1	168	171	PF00782	0.591
MOD_CDK_SPK_2	135	140	PF00069	0.598
MOD_CDK_SPxK_1	165	171	PF00069	0.589
MOD_CDK_SPxxK_3	165	172	PF00069	0.592
MOD_CDK_SPxxK_3	289	296	PF00069	0.702
MOD_CK1_1	138	144	PF00069	0.642
MOD_CK1_1	155	161	PF00069	0.644
MOD_CK1_1	214	220	PF00069	0.727
MOD_CK2_1	129	135	PF00069	0.767
MOD_CK2_1	2	8	PF00069	0.620
MOD_CK2_1	242	248	PF00069	0.614
MOD_CK2_1	26	32	PF00069	0.478
MOD_CK2_1	43	49	PF00069	0.533
MOD_CK2_1	77	83	PF00069	0.557
MOD_GlcNHglycan	140	143	PF01048	0.808
MOD_GlcNHglycan	217	220	PF01048	0.733
MOD_GlcNHglycan	221	224	PF01048	0.743
MOD_GlcNHglycan	228	231	PF01048	0.703
MOD_GlcNHglycan	237	240	PF01048	0.665
MOD_GlcNHglycan	273	276	PF01048	0.669
MOD_GlcNHglycan	277	280	PF01048	0.637
MOD_GlcNHglycan	311	314	PF01048	0.633
MOD_GlcNHglycan	75	78	PF01048	0.525
MOD_GSK3_1	131	138	PF00069	0.646
MOD_GSK3_1	150	157	PF00069	0.642
MOD_GSK3_1	173	180	PF00069	0.790
MOD_GSK3_1	211	218	PF00069	0.708
MOD_GSK3_1	22	29	PF00069	0.434
MOD_GSK3_1	226	233	PF00069	0.724
MOD_GSK3_1	271	278	PF00069	0.651
MOD_GSK3_1	73	80	PF00069	0.633
MOD_NEK2_1	101	106	PF00069	0.507
MOD_NEK2_1	152	157	PF00069	0.574
MOD_NEK2_1	43	48	PF00069	0.478
MOD_NEK2_1	72	77	PF00069	0.517
MOD_NEK2_1	95	100	PF00069	0.463
MOD_NEK2_2	320	325	PF00069	0.619
MOD_PIKK_1	101	107	PF00454	0.553
MOD_PKA_1	144	150	PF00069	0.572
MOD_PKA_1	256	262	PF00069	0.731
MOD_PKA_2	144	150	PF00069	0.716
MOD_PKA_2	2	8	PF00069	0.620
MOD_PKA_2	22	28	PF00069	0.342
MOD_PKA_2	256	262	PF00069	0.731
MOD_PKA_2	32	38	PF00069	0.600
MOD_PKA_2	87	93	PF00069	0.395
MOD_Plk_1	119	125	PF00069	0.562
MOD_Plk_1	43	49	PF00069	0.541
MOD_Plk_2-3	32	38	PF00069	0.560
MOD_Plk_4	320	326	PF00069	0.648
MOD_Plk_4	95	101	PF00069	0.447
MOD_ProDKin_1	135	141	PF00069	0.568
MOD_ProDKin_1	165	171	PF00069	0.840
MOD_ProDKin_1	177	183	PF00069	0.695
MOD_ProDKin_1	237	243	PF00069	0.701
MOD_ProDKin_1	289	295	PF00069	0.702
MOD_SUMO_rev_2	245	252	PF00179	0.745
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.707
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.720
TRG_ENDOCYTIC_2	17	20	PF00928	0.514
TRG_ENDOCYTIC_2	21	24	PF00928	0.504
TRG_ENDOCYTIC_2	78	81	PF00928	0.611
TRG_ER_diArg_1	255	257	PF00400	0.738
TRG_ER_diArg_1	331	334	PF00400	0.594
TRG_ER_diArg_1	341	343	PF00400	0.613
TRG_NES_CRM1_1	19	32	PF08389	0.672
TRG_Pf-PMV_PEXEL_1	343	348	PF00026	0.726

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y4	Leptomonas seymouri	49%	100%
A0A3S7XB07	Leishmania donovani	81%	100%
A4ICF8	Leishmania infantum	81%	100%
E9AT29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q1G9	Leishmania major	80%	100%