Nuclear pore protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP96

Species:

Leishmania braziliensis

UniProt:

A4HPB7_LEIBR

TriTrypDb:

LbrM.35.2720 , LBRM2903_350034300

Length:

900

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	12
GO:0016020	membrane	2	12
GO:0032991	protein-containing complex	1	12
GO:0110165	cellular anatomical entity	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0044612	nuclear pore linkers	3	1

Expansion

Sequence features

A4HPB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPB7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0015931	nucleobase-containing compound transport	5	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0050657	nucleic acid transport	6	12
GO:0050658	RNA transport	4	12
GO:0051028	mRNA transport	5	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051236	establishment of RNA localization	3	12
GO:0051641	cellular localization	2	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0006405	RNA export from nucleus	5	1
GO:0006406	mRNA export from nucleus	6	1
GO:0006606	protein import into nucleus	5	1
GO:0006886	intracellular protein transport	4	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0016973	poly(A)+ mRNA export from nucleus	7	1
GO:0033365	protein localization to organelle	5	1
GO:0034504	protein localization to nucleus	6	1
GO:0046907	intracellular transport	3	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051170	import into nucleus	6	1
GO:0051649	establishment of localization in cell	3	1
GO:0072594	establishment of protein localization to organelle	4	1

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	12
GO:0017056	structural constituent of nuclear pore	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	407	411	PF00656	0.461
CLV_C14_Caspase3-7	555	559	PF00656	0.348
CLV_C14_Caspase3-7	851	855	PF00656	0.223
CLV_MEL_PAP_1	386	392	PF00089	0.475
CLV_NRD_NRD_1	11	13	PF00675	0.770
CLV_NRD_NRD_1	176	178	PF00675	0.607
CLV_NRD_NRD_1	318	320	PF00675	0.449
CLV_NRD_NRD_1	333	335	PF00675	0.341
CLV_NRD_NRD_1	337	339	PF00675	0.315
CLV_NRD_NRD_1	603	605	PF00675	0.415
CLV_NRD_NRD_1	712	714	PF00675	0.451
CLV_NRD_NRD_1	73	75	PF00675	0.567
CLV_PCSK_KEX2_1	11	13	PF00082	0.783
CLV_PCSK_KEX2_1	176	178	PF00082	0.596
CLV_PCSK_KEX2_1	318	320	PF00082	0.449
CLV_PCSK_KEX2_1	333	335	PF00082	0.413
CLV_PCSK_KEX2_1	603	605	PF00082	0.363
CLV_PCSK_KEX2_1	712	714	PF00082	0.475
CLV_PCSK_KEX2_1	861	863	PF00082	0.402
CLV_PCSK_PC1ET2_1	861	863	PF00082	0.455
CLV_PCSK_SKI1_1	119	123	PF00082	0.435
CLV_PCSK_SKI1_1	468	472	PF00082	0.449
CLV_PCSK_SKI1_1	512	516	PF00082	0.360
CLV_PCSK_SKI1_1	547	551	PF00082	0.393
DEG_APCC_DBOX_1	298	306	PF00400	0.495
DEG_APCC_DBOX_1	337	345	PF00400	0.328
DEG_APCC_DBOX_1	39	47	PF00400	0.701
DEG_APCC_DBOX_1	511	519	PF00400	0.363
DEG_Nend_Nbox_1	1	3	PF02207	0.700
DOC_CYCLIN_yCln2_LP_2	580	586	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	795	801	PF00134	0.449
DOC_MAPK_gen_1	318	325	PF00069	0.223
DOC_MAPK_gen_1	347	356	PF00069	0.425
DOC_MAPK_gen_1	709	717	PF00069	0.347
DOC_MAPK_HePTP_8	455	467	PF00069	0.223
DOC_MAPK_MEF2A_6	127	135	PF00069	0.675
DOC_MAPK_MEF2A_6	163	170	PF00069	0.645
DOC_MAPK_MEF2A_6	447	455	PF00069	0.344
DOC_MAPK_MEF2A_6	458	467	PF00069	0.344
DOC_MAPK_MEF2A_6	592	601	PF00069	0.449
DOC_MAPK_MEF2A_6	686	694	PF00069	0.363
DOC_MAPK_NFAT4_5	163	171	PF00069	0.644
DOC_PP2B_LxvP_1	580	583	PF13499	0.449
DOC_PP2B_LxvP_1	726	729	PF13499	0.449
DOC_PP2B_LxvP_1	795	798	PF13499	0.449
DOC_PP4_FxxP_1	799	802	PF00568	0.449
DOC_USP7_MATH_1	220	224	PF00917	0.745
DOC_USP7_MATH_1	232	236	PF00917	0.760
DOC_USP7_MATH_1	246	250	PF00917	0.570
DOC_USP7_MATH_1	503	507	PF00917	0.393
DOC_USP7_MATH_1	729	733	PF00917	0.475
DOC_USP7_MATH_1	848	852	PF00917	0.417
DOC_USP7_MATH_1	881	885	PF00917	0.475
DOC_USP7_UBL2_3	75	79	PF12436	0.463
DOC_WW_Pin1_4	499	504	PF00397	0.475
DOC_WW_Pin1_4	6	11	PF00397	0.709
DOC_WW_Pin1_4	716	721	PF00397	0.449
LIG_14-3-3_CanoR_1	338	342	PF00244	0.443
LIG_14-3-3_CanoR_1	40	44	PF00244	0.610
LIG_14-3-3_CanoR_1	423	427	PF00244	0.243
LIG_14-3-3_CanoR_1	488	495	PF00244	0.329
LIG_14-3-3_CanoR_1	531	536	PF00244	0.344
LIG_14-3-3_CanoR_1	575	584	PF00244	0.447
LIG_14-3-3_CanoR_1	592	597	PF00244	0.290
LIG_14-3-3_CanoR_1	604	610	PF00244	0.377
LIG_14-3-3_CanoR_1	645	649	PF00244	0.428
LIG_14-3-3_CanoR_1	731	735	PF00244	0.482
LIG_14-3-3_CanoR_1	834	844	PF00244	0.480
LIG_14-3-3_CanoR_1	868	873	PF00244	0.407
LIG_14-3-3_CanoR_1	882	886	PF00244	0.276
LIG_Actin_WH2_2	474	490	PF00022	0.427
LIG_BIR_III_2	139	143	PF00653	0.481
LIG_BIR_III_4	401	405	PF00653	0.475
LIG_Clathr_ClatBox_1	598	602	PF01394	0.369
LIG_CSL_BTD_1	193	196	PF09270	0.647
LIG_EH1_1	534	542	PF00400	0.449
LIG_eIF4E_1	446	452	PF01652	0.363
LIG_eIF4E_1	593	599	PF01652	0.344
LIG_FHA_1	105	111	PF00498	0.663
LIG_FHA_1	177	183	PF00498	0.622
LIG_FHA_1	286	292	PF00498	0.421
LIG_FHA_1	3	9	PF00498	0.778
LIG_FHA_1	34	40	PF00498	0.714
LIG_FHA_1	398	404	PF00498	0.367
LIG_FHA_1	476	482	PF00498	0.348
LIG_FHA_1	658	664	PF00498	0.404
LIG_FHA_1	686	692	PF00498	0.475
LIG_FHA_1	806	812	PF00498	0.484
LIG_FHA_2	439	445	PF00498	0.344
LIG_FHA_2	553	559	PF00498	0.345
LIG_FHA_2	869	875	PF00498	0.475
LIG_Integrin_isoDGR_2	297	299	PF01839	0.388
LIG_LIR_Gen_1	203	212	PF02991	0.594
LIG_LIR_Gen_1	303	313	PF02991	0.495
LIG_LIR_Gen_1	483	492	PF02991	0.328
LIG_LIR_Gen_1	591	601	PF02991	0.423
LIG_LIR_Gen_1	613	624	PF02991	0.435
LIG_LIR_Gen_1	765	772	PF02991	0.343
LIG_LIR_Gen_1	792	802	PF02991	0.425
LIG_LIR_Nem_3	147	152	PF02991	0.698
LIG_LIR_Nem_3	203	208	PF02991	0.551
LIG_LIR_Nem_3	285	290	PF02991	0.441
LIG_LIR_Nem_3	303	309	PF02991	0.514
LIG_LIR_Nem_3	483	489	PF02991	0.317
LIG_LIR_Nem_3	591	596	PF02991	0.423
LIG_LIR_Nem_3	613	619	PF02991	0.377
LIG_LIR_Nem_3	765	769	PF02991	0.343
LIG_LIR_Nem_3	792	797	PF02991	0.425
LIG_LIR_Nem_3	884	890	PF02991	0.580
LIG_LYPXL_yS_3	887	890	PF13949	0.556
LIG_NRBOX	340	346	PF00104	0.413
LIG_NRBOX	450	456	PF00104	0.328
LIG_NRBOX	466	472	PF00104	0.223
LIG_NRBOX	545	551	PF00104	0.417
LIG_PDZ_Class_2	895	900	PF00595	0.467
LIG_Pex14_1	194	198	PF04695	0.609
LIG_Pex14_1	283	287	PF04695	0.373
LIG_Pex14_1	381	385	PF04695	0.344
LIG_Pex14_2	190	194	PF04695	0.643
LIG_RPA_C_Fungi	69	81	PF08784	0.713
LIG_SH2_CRK	593	597	PF00017	0.344
LIG_SH2_NCK_1	278	282	PF00017	0.549
LIG_SH2_NCK_1	393	397	PF00017	0.363
LIG_SH2_NCK_1	94	98	PF00017	0.717
LIG_SH2_PTP2	198	201	PF00017	0.662
LIG_SH2_SRC	278	281	PF00017	0.546
LIG_SH2_SRC	436	439	PF00017	0.449
LIG_SH2_SRC	814	817	PF00017	0.449
LIG_SH2_SRC	94	97	PF00017	0.721
LIG_SH2_STAP1	205	209	PF00017	0.552
LIG_SH2_STAP1	779	783	PF00017	0.427
LIG_SH2_STAT5	198	201	PF00017	0.602
LIG_SH2_STAT5	290	293	PF00017	0.549
LIG_SH2_STAT5	328	331	PF00017	0.363
LIG_SH2_STAT5	593	596	PF00017	0.363
LIG_SH2_STAT5	618	621	PF00017	0.328
LIG_SH2_STAT5	814	817	PF00017	0.449
LIG_SH2_STAT5	818	821	PF00017	0.449
LIG_SH3_3	795	801	PF00018	0.344
LIG_SH3_3	882	888	PF00018	0.449
LIG_SUMO_SIM_anti_2	249	256	PF11976	0.555
LIG_SUMO_SIM_anti_2	300	306	PF11976	0.413
LIG_SUMO_SIM_anti_2	321	327	PF11976	0.438
LIG_SUMO_SIM_anti_2	595	600	PF11976	0.345
LIG_SUMO_SIM_par_1	520	525	PF11976	0.390
LIG_SUMO_SIM_par_1	595	600	PF11976	0.290
LIG_TYR_ITIM	885	890	PF00017	0.572
LIG_WRC_WIRS_1	532	537	PF05994	0.449
LIG_WRC_WIRS_1	766	771	PF05994	0.475
LIG_WRC_WIRS_1	791	796	PF05994	0.298
MOD_CDK_SPK_2	6	11	PF00069	0.535
MOD_CDK_SPxK_1	6	12	PF00069	0.712
MOD_CK1_1	235	241	PF00069	0.626
MOD_CK1_1	244	250	PF00069	0.668
MOD_CK1_1	3	9	PF00069	0.746
MOD_CK1_1	42	48	PF00069	0.648
MOD_CK1_1	506	512	PF00069	0.449
MOD_CK1_1	622	628	PF00069	0.449
MOD_CK1_1	679	685	PF00069	0.449
MOD_CK1_1	730	736	PF00069	0.367
MOD_CK2_1	575	581	PF00069	0.393
MOD_CK2_1	86	92	PF00069	0.725
MOD_CK2_1	868	874	PF00069	0.475
MOD_GlcNHglycan	14	17	PF01048	0.705
MOD_GlcNHglycan	145	149	PF01048	0.649
MOD_GlcNHglycan	21	26	PF01048	0.660
MOD_GlcNHglycan	222	225	PF01048	0.660
MOD_GlcNHglycan	226	229	PF01048	0.675
MOD_GlcNHglycan	234	237	PF01048	0.706
MOD_GlcNHglycan	243	246	PF01048	0.530
MOD_GlcNHglycan	255	258	PF01048	0.527
MOD_GlcNHglycan	362	365	PF01048	0.475
MOD_GlcNHglycan	496	500	PF01048	0.480
MOD_GlcNHglycan	577	580	PF01048	0.425
MOD_GlcNHglycan	621	624	PF01048	0.449
MOD_GlcNHglycan	678	681	PF01048	0.440
MOD_GlcNHglycan	829	832	PF01048	0.445
MOD_GlcNHglycan	837	840	PF01048	0.452
MOD_GlcNHglycan	854	857	PF01048	0.145
MOD_GSK3_1	2	9	PF00069	0.658
MOD_GSK3_1	220	227	PF00069	0.673
MOD_GSK3_1	228	235	PF00069	0.663
MOD_GSK3_1	255	262	PF00069	0.566
MOD_GSK3_1	285	292	PF00069	0.456
MOD_GSK3_1	29	36	PF00069	0.616
MOD_GSK3_1	324	331	PF00069	0.413
MOD_GSK3_1	371	378	PF00069	0.425
MOD_GSK3_1	495	502	PF00069	0.441
MOD_GSK3_1	588	595	PF00069	0.423
MOD_GSK3_1	657	664	PF00069	0.431
MOD_GSK3_1	729	736	PF00069	0.353
MOD_GSK3_1	82	89	PF00069	0.568
MOD_GSK3_1	848	855	PF00069	0.302
MOD_LATS_1	175	181	PF00433	0.672
MOD_N-GLC_1	360	365	PF02516	0.475
MOD_N-GLC_1	785	790	PF02516	0.406
MOD_N-GLC_1	849	854	PF02516	0.359
MOD_NEK2_1	1	6	PF00069	0.717
MOD_NEK2_1	104	109	PF00069	0.555
MOD_NEK2_1	305	310	PF00069	0.393
MOD_NEK2_1	362	367	PF00069	0.365
MOD_NEK2_1	487	492	PF00069	0.384
MOD_NEK2_1	550	555	PF00069	0.416
MOD_NEK2_1	560	565	PF00069	0.375
MOD_NEK2_1	610	615	PF00069	0.361
MOD_NEK2_1	619	624	PF00069	0.309
MOD_NEK2_1	70	75	PF00069	0.675
MOD_NEK2_1	827	832	PF00069	0.393
MOD_NEK2_2	404	409	PF00069	0.475
MOD_NEK2_2	503	508	PF00069	0.449
MOD_PIKK_1	104	110	PF00454	0.584
MOD_PIKK_1	522	528	PF00454	0.449
MOD_PIKK_1	737	743	PF00454	0.433
MOD_PK_1	177	183	PF00069	0.699
MOD_PK_1	592	598	PF00069	0.449
MOD_PKA_1	176	182	PF00069	0.639
MOD_PKA_1	318	324	PF00069	0.475
MOD_PKA_2	176	182	PF00069	0.617
MOD_PKA_2	224	230	PF00069	0.682
MOD_PKA_2	318	324	PF00069	0.449
MOD_PKA_2	337	343	PF00069	0.445
MOD_PKA_2	39	45	PF00069	0.620
MOD_PKA_2	422	428	PF00069	0.243
MOD_PKA_2	475	481	PF00069	0.385
MOD_PKA_2	487	493	PF00069	0.358
MOD_PKA_2	605	611	PF00069	0.472
MOD_PKA_2	644	650	PF00069	0.362
MOD_PKA_2	730	736	PF00069	0.451
MOD_PKA_2	848	854	PF00069	0.417
MOD_PKA_2	881	887	PF00069	0.385
MOD_Plk_1	21	27	PF00069	0.795
MOD_Plk_1	292	298	PF00069	0.584
MOD_Plk_1	300	306	PF00069	0.432
MOD_Plk_1	550	556	PF00069	0.343
MOD_Plk_4	177	183	PF00069	0.631
MOD_Plk_4	185	191	PF00069	0.557
MOD_Plk_4	246	252	PF00069	0.613
MOD_Plk_4	300	306	PF00069	0.510
MOD_Plk_4	324	330	PF00069	0.379
MOD_Plk_4	531	537	PF00069	0.315
MOD_Plk_4	592	598	PF00069	0.362
MOD_Plk_4	605	611	PF00069	0.326
MOD_Plk_4	650	656	PF00069	0.474
MOD_Plk_4	730	736	PF00069	0.449
MOD_Plk_4	790	796	PF00069	0.332
MOD_Plk_4	868	874	PF00069	0.393
MOD_ProDKin_1	499	505	PF00069	0.475
MOD_ProDKin_1	6	12	PF00069	0.712
MOD_ProDKin_1	716	722	PF00069	0.449
MOD_SUMO_rev_2	331	341	PF00179	0.329
MOD_SUMO_rev_2	854	863	PF00179	0.451
TRG_DiLeu_BaEn_2	144	150	PF01217	0.618
TRG_DiLeu_BaEn_4	357	363	PF01217	0.223
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.647
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.449
TRG_DiLeu_BaLyEn_6	544	549	PF01217	0.328
TRG_DiLeu_BaLyEn_6	637	642	PF01217	0.449
TRG_DiLeu_BaLyEn_6	861	866	PF01217	0.449
TRG_ENDOCYTIC_2	198	201	PF00928	0.635
TRG_ENDOCYTIC_2	205	208	PF00928	0.658
TRG_ENDOCYTIC_2	593	596	PF00928	0.344
TRG_ENDOCYTIC_2	766	769	PF00928	0.449
TRG_ENDOCYTIC_2	887	890	PF00928	0.556
TRG_ER_diArg_1	10	12	PF00400	0.771
TRG_ER_diArg_1	333	335	PF00400	0.413
TRG_ER_diArg_1	603	606	PF00400	0.413
TRG_ER_diArg_1	711	713	PF00400	0.475
TRG_ER_diArg_1	862	865	PF00400	0.421
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	347	352	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6C7	Leptomonas seymouri	73%	100%
A0A0S4JS37	Bodo saltans	31%	100%
A0A1X0P8L0	Trypanosomatidae	36%	100%
A0A3Q8IW16	Leishmania donovani	89%	100%
A0A422NCE5	Trypanosoma rangeli	37%	100%
A4ICF7	Leishmania infantum	89%	100%
D0A3C7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AT28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q1H0	Leishmania major	90%	100%
V5BCK1	Trypanosoma cruzi	36%	100%