Chromatin assembly factor 1 subunit b-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chromatin assembly factor 1 subunit b-like protein

Species:

Leishmania braziliensis

UniProt:

A4HPB6_LEIBR

TriTrypDb:

LbrM.35.2710 , LBRM2903_350034200

Length:

657

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0000417	HIR complex	2	1
GO:0005654	nucleoplasm	2	1
GO:0005840	ribosome	5	6
GO:0032991	protein-containing complex	1	6
GO:0043228	non-membrane-bounded organelle	3	6
GO:0043232	intracellular non-membrane-bounded organelle	4	6
GO:1990904	ribonucleoprotein complex	2	6

Expansion

Sequence features

A4HPB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPB6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006325	chromatin organization	4	12
GO:0006351	DNA-templated transcription	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0016070	RNA metabolic process	5	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0032774	RNA biosynthetic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090304	nucleic acid metabolic process	4	11
GO:0097659	nucleic acid-templated transcription	6	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0006335	DNA replication-dependent chromatin assembly	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.517
CLV_C14_Caspase3-7	631	635	PF00656	0.505
CLV_C14_Caspase3-7	68	72	PF00656	0.488
CLV_NRD_NRD_1	263	265	PF00675	0.469
CLV_NRD_NRD_1	270	272	PF00675	0.388
CLV_NRD_NRD_1	287	289	PF00675	0.302
CLV_NRD_NRD_1	429	431	PF00675	0.497
CLV_NRD_NRD_1	478	480	PF00675	0.532
CLV_NRD_NRD_1	598	600	PF00675	0.782
CLV_NRD_NRD_1	622	624	PF00675	0.620
CLV_PCSK_FUR_1	476	480	PF00082	0.580
CLV_PCSK_KEX2_1	263	265	PF00082	0.464
CLV_PCSK_KEX2_1	287	289	PF00082	0.318
CLV_PCSK_KEX2_1	429	431	PF00082	0.497
CLV_PCSK_KEX2_1	478	480	PF00082	0.538
CLV_PCSK_KEX2_1	598	600	PF00082	0.712
CLV_PCSK_PC7_1	425	431	PF00082	0.493
CLV_PCSK_SKI1_1	175	179	PF00082	0.331
CLV_PCSK_SKI1_1	194	198	PF00082	0.155
CLV_PCSK_SKI1_1	405	409	PF00082	0.332
CLV_PCSK_SKI1_1	488	492	PF00082	0.355
CLV_PCSK_SKI1_1	519	523	PF00082	0.438
CLV_PCSK_SKI1_1	64	68	PF00082	0.237
DEG_SPOP_SBC_1	443	447	PF00917	0.529
DEG_SPOP_SBC_1	614	618	PF00917	0.671
DOC_MAPK_gen_1	104	112	PF00069	0.475
DOC_MAPK_gen_1	20	29	PF00069	0.430
DOC_MAPK_MEF2A_6	575	583	PF00069	0.560
DOC_PP1_RVXF_1	227	234	PF00149	0.324
DOC_PP1_RVXF_1	285	292	PF00149	0.413
DOC_PP1_RVXF_1	403	410	PF00149	0.321
DOC_PP2B_LxvP_1	298	301	PF13499	0.405
DOC_PP2B_LxvP_1	408	411	PF13499	0.361
DOC_PP4_FxxP_1	413	416	PF00568	0.481
DOC_USP7_MATH_1	140	144	PF00917	0.599
DOC_USP7_MATH_1	161	165	PF00917	0.445
DOC_USP7_MATH_1	352	356	PF00917	0.771
DOC_USP7_MATH_1	565	569	PF00917	0.605
DOC_USP7_MATH_1	615	619	PF00917	0.715
DOC_USP7_UBL2_3	626	630	PF12436	0.502
DOC_WW_Pin1_4	114	119	PF00397	0.356
DOC_WW_Pin1_4	157	162	PF00397	0.483
DOC_WW_Pin1_4	289	294	PF00397	0.357
DOC_WW_Pin1_4	560	565	PF00397	0.617
LIG_14-3-3_CanoR_1	104	110	PF00244	0.430
LIG_14-3-3_CanoR_1	238	244	PF00244	0.368
LIG_14-3-3_CanoR_1	399	408	PF00244	0.398
LIG_14-3-3_CanoR_1	509	516	PF00244	0.382
LIG_14-3-3_CanoR_1	519	526	PF00244	0.342
LIG_AP2alpha_2	234	236	PF02296	0.341
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_deltaCOP1_diTrp_1	234	243	PF00928	0.338
LIG_deltaCOP1_diTrp_1	28	33	PF00928	0.529
LIG_FHA_1	176	182	PF00498	0.539
LIG_FHA_1	212	218	PF00498	0.367
LIG_FHA_1	235	241	PF00498	0.461
LIG_FHA_1	24	30	PF00498	0.391
LIG_FHA_1	314	320	PF00498	0.650
LIG_FHA_1	417	423	PF00498	0.616
LIG_FHA_1	48	54	PF00498	0.470
LIG_FHA_1	533	539	PF00498	0.328
LIG_FHA_1	589	595	PF00498	0.563
LIG_FHA_1	614	620	PF00498	0.655
LIG_FHA_2	364	370	PF00498	0.691
LIG_FHA_2	52	58	PF00498	0.507
LIG_FHA_2	601	607	PF00498	0.577
LIG_FHA_2	629	635	PF00498	0.718
LIG_FHA_2	66	72	PF00498	0.448
LIG_Integrin_RGD_1	604	606	PF01839	0.524
LIG_LIR_Gen_1	234	243	PF02991	0.478
LIG_LIR_Gen_1	511	521	PF02991	0.379
LIG_LIR_Gen_1	539	547	PF02991	0.332
LIG_LIR_Nem_3	107	112	PF02991	0.393
LIG_LIR_Nem_3	169	174	PF02991	0.388
LIG_LIR_Nem_3	234	239	PF02991	0.376
LIG_LIR_Nem_3	285	289	PF02991	0.349
LIG_LIR_Nem_3	511	516	PF02991	0.378
LIG_LIR_Nem_3	539	544	PF02991	0.320
LIG_NRBOX	568	574	PF00104	0.586
LIG_PDZ_Class_1	652	657	PF00595	0.640
LIG_Pex14_1	409	413	PF04695	0.383
LIG_Pex14_2	239	243	PF04695	0.440
LIG_SH2_CRK	286	290	PF00017	0.407
LIG_SH2_CRK	302	306	PF00017	0.514
LIG_SH2_CRK	359	363	PF00017	0.498
LIG_SH2_PTP2	541	544	PF00017	0.331
LIG_SH2_STAP1	185	189	PF00017	0.480
LIG_SH2_STAP1	384	388	PF00017	0.305
LIG_SH2_STAP1	534	538	PF00017	0.432
LIG_SH2_STAT5	15	18	PF00017	0.442
LIG_SH2_STAT5	195	198	PF00017	0.448
LIG_SH2_STAT5	277	280	PF00017	0.469
LIG_SH2_STAT5	382	385	PF00017	0.342
LIG_SH2_STAT5	502	505	PF00017	0.381
LIG_SH2_STAT5	534	537	PF00017	0.318
LIG_SH2_STAT5	541	544	PF00017	0.319
LIG_SUMO_SIM_anti_2	26	31	PF11976	0.398
LIG_SUMO_SIM_anti_2	616	623	PF11976	0.714
LIG_TYR_ITIM	284	289	PF00017	0.489
LIG_TYR_ITIM	300	305	PF00017	0.298
LIG_UBA3_1	319	328	PF00899	0.630
LIG_WRC_WIRS_1	240	245	PF05994	0.338
LIG_WRC_WIRS_1	557	562	PF05994	0.423
MOD_CDK_SPxxK_3	560	567	PF00069	0.610
MOD_CK1_1	152	158	PF00069	0.726
MOD_CK1_1	160	166	PF00069	0.404
MOD_CK1_1	190	196	PF00069	0.448
MOD_CK1_1	445	451	PF00069	0.557
MOD_CK1_1	47	53	PF00069	0.488
MOD_CK1_1	508	514	PF00069	0.410
MOD_CK1_1	559	565	PF00069	0.511
MOD_CK1_1	586	592	PF00069	0.538
MOD_CMANNOS	233	236	PF00535	0.330
MOD_GlcNHglycan	1	4	PF01048	0.442
MOD_GlcNHglycan	124	127	PF01048	0.302
MOD_GlcNHglycan	142	145	PF01048	0.485
MOD_GlcNHglycan	154	157	PF01048	0.604
MOD_GlcNHglycan	189	192	PF01048	0.280
MOD_GlcNHglycan	197	200	PF01048	0.339
MOD_GlcNHglycan	434	437	PF01048	0.690
MOD_GlcNHglycan	606	610	PF01048	0.664
MOD_GSK3_1	110	117	PF00069	0.450
MOD_GSK3_1	157	164	PF00069	0.534
MOD_GSK3_1	175	182	PF00069	0.539
MOD_GSK3_1	218	225	PF00069	0.543
MOD_GSK3_1	278	285	PF00069	0.458
MOD_GSK3_1	428	435	PF00069	0.761
MOD_GSK3_1	439	446	PF00069	0.549
MOD_GSK3_1	454	461	PF00069	0.546
MOD_GSK3_1	47	54	PF00069	0.615
MOD_GSK3_1	500	507	PF00069	0.501
MOD_GSK3_1	524	531	PF00069	0.427
MOD_GSK3_1	556	563	PF00069	0.474
MOD_GSK3_1	579	586	PF00069	0.560
MOD_GSK3_1	600	607	PF00069	0.636
MOD_LATS_1	517	523	PF00433	0.401
MOD_N-GLC_1	47	52	PF02516	0.347
MOD_NEK2_1	105	110	PF00069	0.503
MOD_NEK2_1	122	127	PF00069	0.216
MOD_NEK2_1	210	215	PF00069	0.410
MOD_NEK2_1	239	244	PF00069	0.378
MOD_NEK2_1	250	255	PF00069	0.309
MOD_NEK2_1	547	552	PF00069	0.495
MOD_NEK2_1	65	70	PF00069	0.458
MOD_PIKK_1	464	470	PF00454	0.557
MOD_PKA_1	598	604	PF00069	0.710
MOD_PKA_1	625	631	PF00069	0.594
MOD_PKA_2	105	111	PF00069	0.479
MOD_PKA_2	428	434	PF00069	0.499
MOD_PKA_2	508	514	PF00069	0.396
MOD_PKA_2	586	592	PF00069	0.634
MOD_PKA_2	598	604	PF00069	0.687
MOD_Plk_1	341	347	PF00069	0.561
MOD_Plk_1	528	534	PF00069	0.438
MOD_Plk_1	6	12	PF00069	0.443
MOD_Plk_4	105	111	PF00069	0.461
MOD_Plk_4	201	207	PF00069	0.437
MOD_Plk_4	245	251	PF00069	0.399
MOD_ProDKin_1	114	120	PF00069	0.357
MOD_ProDKin_1	157	163	PF00069	0.476
MOD_ProDKin_1	289	295	PF00069	0.355
MOD_ProDKin_1	560	566	PF00069	0.610
MOD_SUMO_rev_2	125	132	PF00179	0.355
MOD_SUMO_rev_2	164	173	PF00179	0.567
TRG_DiLeu_BaEn_1	38	43	PF01217	0.576
TRG_DiLeu_BaEn_4	38	44	PF01217	0.494
TRG_DiLeu_BaLyEn_6	461	466	PF01217	0.434
TRG_ENDOCYTIC_2	174	177	PF00928	0.448
TRG_ENDOCYTIC_2	286	289	PF00928	0.408
TRG_ENDOCYTIC_2	302	305	PF00928	0.499
TRG_ENDOCYTIC_2	541	544	PF00928	0.331
TRG_ER_diArg_1	22	25	PF00400	0.406
TRG_ER_diArg_1	263	265	PF00400	0.498
TRG_ER_diArg_1	286	288	PF00400	0.320
TRG_ER_diArg_1	476	479	PF00400	0.615
TRG_NES_CRM1_1	372	387	PF08389	0.342
TRG_NLS_MonoCore_2	622	627	PF00514	0.571
TRG_NLS_MonoExtC_3	622	627	PF00514	0.571
TRG_NLS_MonoExtN_4	623	628	PF00514	0.577
TRG_Pf-PMV_PEXEL_1	519	523	PF00026	0.367
TRG_PTS2	1	33	PF00400	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBV3	Leptomonas seymouri	63%	96%
A0A0S4JTR4	Bodo saltans	31%	100%
A0A1X0P8Z1	Trypanosomatidae	46%	100%
A0A3S7XAX4	Leishmania donovani	78%	100%
A0A422NCI3	Trypanosoma rangeli	49%	100%
A4ICF6	Leishmania infantum	78%	100%
D0A3C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AT27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	97%
Q4Q1H1	Leishmania major	81%	100%
V5BH36	Trypanosoma cruzi	47%	100%