Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPB5_LEIBR

TriTrypDb:

LbrM.35.2700 , LBRM2903_350034100

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPB5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.542
CLV_C14_Caspase3-7	187	191	PF00656	0.575
CLV_NRD_NRD_1	171	173	PF00675	0.563
CLV_NRD_NRD_1	390	392	PF00675	0.617
CLV_PCSK_KEX2_1	390	392	PF00082	0.617
CLV_PCSK_KEX2_1	404	406	PF00082	0.429
CLV_PCSK_PC1ET2_1	404	406	PF00082	0.660
CLV_PCSK_SKI1_1	209	213	PF00082	0.524
CLV_PCSK_SKI1_1	251	255	PF00082	0.501
DEG_SCF_FBW7_1	62	68	PF00400	0.841
DEG_SPOP_SBC_1	151	155	PF00917	0.821
DEG_SPOP_SBC_1	182	186	PF00917	0.577
DEG_SPOP_SBC_1	83	87	PF00917	0.653
DOC_CKS1_1	129	134	PF01111	0.626
DOC_CKS1_1	28	33	PF01111	0.852
DOC_CKS1_1	438	443	PF01111	0.525
DOC_CKS1_1	59	64	PF01111	0.843
DOC_CYCLIN_yClb5_NLxxxL_5	263	272	PF00134	0.602
DOC_MAPK_gen_1	172	180	PF00069	0.578
DOC_MAPK_MEF2A_6	432	439	PF00069	0.603
DOC_MAPK_NFAT4_5	432	440	PF00069	0.607
DOC_PP1_RVXF_1	207	214	PF00149	0.527
DOC_SPAK_OSR1_1	385	389	PF12202	0.621
DOC_USP7_MATH_1	182	186	PF00917	0.577
DOC_USP7_MATH_1	323	327	PF00917	0.624
DOC_USP7_MATH_1	466	470	PF00917	0.728
DOC_USP7_MATH_1	487	491	PF00917	0.735
DOC_USP7_UBL2_3	22	26	PF12436	0.594
DOC_WW_Pin1_4	128	133	PF00397	0.621
DOC_WW_Pin1_4	24	29	PF00397	0.702
DOC_WW_Pin1_4	437	442	PF00397	0.458
DOC_WW_Pin1_4	445	450	PF00397	0.613
DOC_WW_Pin1_4	55	60	PF00397	0.848
DOC_WW_Pin1_4	61	66	PF00397	0.743
LIG_14-3-3_CanoR_1	172	180	PF00244	0.578
LIG_14-3-3_CanoR_1	251	261	PF00244	0.524
LIG_14-3-3_CanoR_1	385	389	PF00244	0.621
LIG_14-3-3_CanoR_1	390	396	PF00244	0.511
LIG_14-3-3_CanoR_1	73	78	PF00244	0.722
LIG_BIR_III_4	160	164	PF00653	0.798
LIG_BRCT_BRCA1_1	382	386	PF00533	0.605
LIG_BRCT_BRCA1_1	424	428	PF00533	0.402
LIG_CaM_IQ_9	377	393	PF13499	0.610
LIG_EH1_1	283	291	PF00400	0.434
LIG_FHA_1	175	181	PF00498	0.838
LIG_FHA_1	193	199	PF00498	0.543
LIG_FHA_1	28	34	PF00498	0.602
LIG_FHA_1	290	296	PF00498	0.582
LIG_FHA_1	408	414	PF00498	0.610
LIG_FHA_1	438	444	PF00498	0.538
LIG_FHA_1	473	479	PF00498	0.563
LIG_FHA_1	62	68	PF00498	0.749
LIG_FHA_2	271	277	PF00498	0.356
LIG_FHA_2	304	310	PF00498	0.503
LIG_FHA_2	45	51	PF00498	0.597
LIG_FHA_2	452	458	PF00498	0.675
LIG_FHA_2	83	89	PF00498	0.744
LIG_IRF3_LxIS_1	347	352	PF10401	0.579
LIG_LIR_Gen_1	231	240	PF02991	0.629
LIG_LIR_LC3C_4	457	461	PF02991	0.628
LIG_LIR_Nem_3	103	109	PF02991	0.673
LIG_LIR_Nem_3	231	236	PF02991	0.636
LIG_LIR_Nem_3	256	262	PF02991	0.607
LIG_LIR_Nem_3	278	284	PF02991	0.605
LIG_SH2_CRK	233	237	PF00017	0.384
LIG_SH2_GRB2like	281	284	PF00017	0.330
LIG_SH2_STAP1	299	303	PF00017	0.367
LIG_SH2_STAT3	299	302	PF00017	0.609
LIG_SH2_STAT5	233	236	PF00017	0.634
LIG_SH2_STAT5	299	302	PF00017	0.609
LIG_SH3_2	136	141	PF14604	0.749
LIG_SH3_3	106	112	PF00018	0.745
LIG_SH3_3	133	139	PF00018	0.753
LIG_SH3_3	208	214	PF00018	0.756
LIG_SH3_3	25	31	PF00018	0.844
LIG_SH3_3	255	261	PF00018	0.611
LIG_SH3_3	413	419	PF00018	0.632
LIG_SH3_3	435	441	PF00018	0.594
LIG_SH3_3	458	464	PF00018	0.461
LIG_SH3_3	56	62	PF00018	0.843
LIG_SUMO_SIM_anti_2	457	462	PF11976	0.621
LIG_SUMO_SIM_par_1	260	265	PF11976	0.612
LIG_SUMO_SIM_par_1	409	415	PF11976	0.612
LIG_SUMO_SIM_par_1	457	462	PF11976	0.621
LIG_TRAF2_1	336	339	PF00917	0.515
LIG_TRAF2_1	37	40	PF00917	0.609
LIG_UBA3_1	165	173	PF00899	0.552
LIG_WW_3	204	208	PF00397	0.542
MOD_CDK_SPxK_1	128	134	PF00069	0.623
MOD_CK1_1	153	159	PF00069	0.719
MOD_CK1_1	168	174	PF00069	0.574
MOD_CK1_1	183	189	PF00069	0.681
MOD_CK1_1	192	198	PF00069	0.602
MOD_CK1_1	225	231	PF00069	0.637
MOD_CK1_1	27	33	PF00069	0.848
MOD_CK1_1	352	358	PF00069	0.694
MOD_CK1_1	448	454	PF00069	0.590
MOD_CK1_1	468	474	PF00069	0.633
MOD_CK1_1	58	64	PF00069	0.776
MOD_CK1_1	87	93	PF00069	0.742
MOD_CK2_1	270	276	PF00069	0.390
MOD_CK2_1	328	334	PF00069	0.803
MOD_CK2_1	82	88	PF00069	0.652
MOD_GlcNHglycan	103	106	PF01048	0.772
MOD_GlcNHglycan	214	217	PF01048	0.660
MOD_GlcNHglycan	321	324	PF01048	0.651
MOD_GlcNHglycan	352	355	PF01048	0.638
MOD_GlcNHglycan	397	400	PF01048	0.535
MOD_GSK3_1	142	149	PF00069	0.810
MOD_GSK3_1	150	157	PF00069	0.664
MOD_GSK3_1	180	187	PF00069	0.733
MOD_GSK3_1	225	232	PF00069	0.640
MOD_GSK3_1	297	304	PF00069	0.454
MOD_GSK3_1	310	317	PF00069	0.767
MOD_GSK3_1	319	326	PF00069	0.677
MOD_GSK3_1	352	359	PF00069	0.701
MOD_GSK3_1	380	387	PF00069	0.603
MOD_GSK3_1	391	398	PF00069	0.341
MOD_GSK3_1	422	429	PF00069	0.399
MOD_GSK3_1	465	472	PF00069	0.714
MOD_GSK3_1	61	68	PF00069	0.749
MOD_GSK3_1	73	80	PF00069	0.607
MOD_GSK3_1	82	89	PF00069	0.732
MOD_GSK3_1	91	98	PF00069	0.814
MOD_LATS_1	389	395	PF00433	0.602
MOD_N-GLC_1	142	147	PF02516	0.600
MOD_N-GLC_1	174	179	PF02516	0.578
MOD_N-GLC_1	180	185	PF02516	0.561
MOD_N-GLC_1	373	378	PF02516	0.470
MOD_N-GLC_1	480	485	PF02516	0.832
MOD_NEK2_1	180	185	PF00069	0.647
MOD_NEK2_1	229	234	PF00069	0.639
MOD_NEK2_1	262	267	PF00069	0.609
MOD_NEK2_1	301	306	PF00069	0.521
MOD_NEK2_1	307	312	PF00069	0.551
MOD_NEK2_1	349	354	PF00069	0.447
MOD_NEK2_1	356	361	PF00069	0.568
MOD_NEK2_1	368	373	PF00069	0.524
MOD_NEK2_1	380	385	PF00069	0.408
MOD_NEK2_1	395	400	PF00069	0.295
MOD_NEK2_1	459	464	PF00069	0.608
MOD_NEK2_1	470	475	PF00069	0.629
MOD_NEK2_2	174	179	PF00069	0.578
MOD_NEK2_2	384	389	PF00069	0.613
MOD_NEK2_2	399	404	PF00069	0.426
MOD_PIKK_1	13	19	PF00454	0.826
MOD_PIKK_1	422	428	PF00454	0.396
MOD_PIKK_1	448	454	PF00454	0.675
MOD_PIKK_1	480	486	PF00454	0.579
MOD_PK_1	134	140	PF00069	0.710
MOD_PK_1	73	79	PF00069	0.588
MOD_PKA_2	192	198	PF00069	0.586
MOD_PKA_2	310	316	PF00069	0.816
MOD_PKA_2	384	390	PF00069	0.617
MOD_Plk_1	142	148	PF00069	0.598
MOD_Plk_1	174	180	PF00069	0.580
MOD_Plk_1	333	339	PF00069	0.776
MOD_Plk_1	373	379	PF00069	0.631
MOD_Plk_2-3	333	339	PF00069	0.776
MOD_Plk_4	2	8	PF00069	0.649
MOD_Plk_4	222	228	PF00069	0.657
MOD_Plk_4	235	241	PF00069	0.406
MOD_ProDKin_1	128	134	PF00069	0.623
MOD_ProDKin_1	24	30	PF00069	0.702
MOD_ProDKin_1	437	443	PF00069	0.464
MOD_ProDKin_1	445	451	PF00069	0.600
MOD_ProDKin_1	55	61	PF00069	0.845
MOD_SUMO_rev_2	23	28	PF00179	0.830
TRG_DiLeu_BaEn_1	455	460	PF01217	0.661
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.593
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.453
TRG_ENDOCYTIC_2	106	109	PF00928	0.595
TRG_ENDOCYTIC_2	233	236	PF00928	0.634
TRG_ENDOCYTIC_2	281	284	PF00928	0.583
TRG_ER_diArg_1	206	209	PF00400	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAX1	Leishmania donovani	74%	100%
A4ICF5	Leishmania infantum	74%	100%
E9AT26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q1H2	Leishmania major	74%	100%