RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPB4_LEIBR

TriTrypDb:

LbrM.35.2690 , LBRM2903_350034000

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPB4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.750
CLV_NRD_NRD_1	139	141	PF00675	0.553
CLV_NRD_NRD_1	211	213	PF00675	0.645
CLV_NRD_NRD_1	255	257	PF00675	0.591
CLV_NRD_NRD_1	47	49	PF00675	0.437
CLV_NRD_NRD_1	92	94	PF00675	0.519
CLV_PCSK_FUR_1	92	96	PF00082	0.576
CLV_PCSK_KEX2_1	139	141	PF00082	0.584
CLV_PCSK_KEX2_1	18	20	PF00082	0.447
CLV_PCSK_KEX2_1	211	213	PF00082	0.601
CLV_PCSK_KEX2_1	225	227	PF00082	0.483
CLV_PCSK_KEX2_1	47	49	PF00082	0.437
CLV_PCSK_KEX2_1	5	7	PF00082	0.430
CLV_PCSK_KEX2_1	92	94	PF00082	0.517
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.599
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.447
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.586
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.430
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.599
CLV_PCSK_SKI1_1	170	174	PF00082	0.673
CLV_PCSK_SKI1_1	221	225	PF00082	0.594
CLV_PCSK_SKI1_1	58	62	PF00082	0.535
CLV_Separin_Metazoa	23	27	PF03568	0.592
DEG_APCC_DBOX_1	5	13	PF00400	0.436
DEG_Nend_UBRbox_2	1	3	PF02207	0.513
DOC_USP7_MATH_1	150	154	PF00917	0.538
DOC_USP7_MATH_1	230	234	PF00917	0.806
DOC_USP7_MATH_1	32	36	PF00917	0.574
DOC_USP7_UBL2_3	221	225	PF12436	0.614
DOC_USP7_UBL2_3	253	257	PF12436	0.594
DOC_USP7_UBL2_3	269	273	PF12436	0.605
DOC_WW_Pin1_4	28	33	PF00397	0.563
LIG_14-3-3_CanoR_1	174	180	PF00244	0.519
LIG_14-3-3_CanoR_1	211	220	PF00244	0.705
LIG_14-3-3_CanoR_1	71	79	PF00244	0.550
LIG_Actin_WH2_2	56	73	PF00022	0.552
LIG_deltaCOP1_diTrp_1	107	117	PF00928	0.494
LIG_FHA_2	15	21	PF00498	0.430
LIG_FHA_2	250	256	PF00498	0.609
LIG_LIR_Apic_2	73	79	PF02991	0.542
LIG_LIR_Gen_1	46	57	PF02991	0.570
LIG_LIR_Nem_3	46	52	PF02991	0.572
LIG_PROFILIN_1	242	248	PF00235	0.754
LIG_SH2_CRK	142	146	PF00017	0.498
LIG_SH2_NCK_1	142	146	PF00017	0.479
LIG_SH2_NCK_1	76	80	PF00017	0.547
LIG_SH2_SRC	165	168	PF00017	0.739
LIG_SH2_SRC	76	79	PF00017	0.548
LIG_SH2_SRC	88	91	PF00017	0.644
LIG_SH2_STAP1	142	146	PF00017	0.479
LIG_SH2_STAP1	84	88	PF00017	0.567
LIG_SH3_2	248	253	PF14604	0.614
LIG_SH3_3	236	242	PF00018	0.669
LIG_SH3_3	243	249	PF00018	0.599
LIG_TRAF2_1	252	255	PF00917	0.590
MOD_CK2_1	14	20	PF00069	0.458
MOD_CK2_1	249	255	PF00069	0.626
MOD_GlcNHglycan	179	182	PF01048	0.721
MOD_GlcNHglycan	258	261	PF01048	0.559
MOD_GSK3_1	191	198	PF00069	0.708
MOD_GSK3_1	228	235	PF00069	0.739
MOD_GSK3_1	28	35	PF00069	0.570
MOD_LATS_1	168	174	PF00433	0.509
MOD_N-GLC_1	186	191	PF02516	0.524
MOD_N-GLC_1	26	31	PF02516	0.487
MOD_N-GLC_1	71	76	PF02516	0.547
MOD_NEK2_1	118	123	PF00069	0.520
MOD_NEK2_1	135	140	PF00069	0.500
MOD_NEK2_1	70	75	PF00069	0.535
MOD_NEK2_1	82	87	PF00069	0.595
MOD_PIKK_1	172	178	PF00454	0.500
MOD_PIKK_1	186	192	PF00454	0.483
MOD_PKA_1	211	217	PF00069	0.539
MOD_PKA_1	256	262	PF00069	0.566
MOD_PKA_2	210	216	PF00069	0.657
MOD_PKA_2	228	234	PF00069	0.652
MOD_PKA_2	70	76	PF00069	0.552
MOD_Plk_1	195	201	PF00069	0.528
MOD_Plk_1	71	77	PF00069	0.481
MOD_Plk_2-3	196	202	PF00069	0.530
MOD_Plk_4	71	77	PF00069	0.534
MOD_ProDKin_1	28	34	PF00069	0.569
MOD_SUMO_rev_2	250	259	PF00179	0.582
TRG_DiLeu_BaEn_1	20	25	PF01217	0.542
TRG_DiLeu_BaEn_4	101	107	PF01217	0.568
TRG_ENDOCYTIC_2	142	145	PF00928	0.463
TRG_ENDOCYTIC_2	49	52	PF00928	0.395
TRG_ER_diArg_1	114	117	PF00400	0.585
TRG_ER_diArg_1	210	212	PF00400	0.781
TRG_ER_diArg_1	25	28	PF00400	0.455
TRG_ER_diArg_1	47	49	PF00400	0.459
TRG_ER_diArg_1	92	95	PF00400	0.521
TRG_ER_diLys_1	269	274	PF00400	0.647
TRG_NLS_Bipartite_1	211	228	PF00514	0.540
TRG_NLS_MonoExtC_3	223	228	PF00514	0.591
TRG_NLS_MonoExtN_4	221	228	PF00514	0.594
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXA6	Leptomonas seymouri	80%	98%
A0A0S4JT72	Bodo saltans	41%	100%
A0A1X0P8H3	Trypanosomatidae	42%	96%
A0A3Q8IJE0	Leishmania donovani	78%	100%
A0A422NCV8	Trypanosoma rangeli	44%	99%
A4ICF4	Leishmania infantum	78%	100%
D0A3C3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AT25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q1H3	Leishmania major	77%	94%
V5D8K3	Trypanosoma cruzi	45%	100%