Putative acid phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acid phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HPB3_LEIBR

TriTrypDb:

LbrM.35.2680 , LBRM2903_350033900

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 4
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPB3

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0003993	acid phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.304
CLV_NRD_NRD_1	192	194	PF00675	0.359
CLV_NRD_NRD_1	90	92	PF00675	0.359
CLV_PCSK_KEX2_1	192	194	PF00082	0.344
CLV_PCSK_KEX2_1	92	94	PF00082	0.269
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.394
CLV_PCSK_SKI1_1	204	208	PF00082	0.485
CLV_PCSK_SKI1_1	255	259	PF00082	0.515
CLV_PCSK_SKI1_1	297	301	PF00082	0.443
CLV_PCSK_SKI1_1	332	336	PF00082	0.331
CLV_PCSK_SKI1_1	366	370	PF00082	0.378
CLV_PCSK_SKI1_1	59	63	PF00082	0.473
DEG_APCC_DBOX_1	296	304	PF00400	0.401
DEG_APCC_DBOX_1	331	339	PF00400	0.291
DEG_Nend_UBRbox_4	1	3	PF02207	0.402
DEG_ODPH_VHL_1	261	274	PF01847	0.218
DOC_CKS1_1	386	391	PF01111	0.320
DOC_MAPK_gen_1	258	267	PF00069	0.414
DOC_MAPK_MEF2A_6	270	278	PF00069	0.346
DOC_USP7_MATH_1	213	217	PF00917	0.304
DOC_USP7_MATH_1	5	9	PF00917	0.528
DOC_WW_Pin1_4	308	313	PF00397	0.569
DOC_WW_Pin1_4	385	390	PF00397	0.298
DOC_WW_Pin1_4	430	435	PF00397	0.400
LIG_14-3-3_CanoR_1	142	150	PF00244	0.309
LIG_14-3-3_CanoR_1	217	222	PF00244	0.493
LIG_14-3-3_CanoR_1	270	275	PF00244	0.290
LIG_14-3-3_CanoR_1	383	387	PF00244	0.376
LIG_Actin_WH2_2	239	257	PF00022	0.492
LIG_AP2alpha_1	155	159	PF02296	0.274
LIG_APCC_ABBA_1	172	177	PF00400	0.342
LIG_APCC_ABBA_1	367	372	PF00400	0.430
LIG_APCC_ABBAyCdc20_2	366	372	PF00400	0.266
LIG_CSL_BTD_1	386	389	PF09270	0.344
LIG_DLG_GKlike_1	270	277	PF00625	0.298
LIG_FHA_1	2	8	PF00498	0.673
LIG_FHA_1	213	219	PF00498	0.411
LIG_FHA_1	358	364	PF00498	0.301
LIG_FHA_1	393	399	PF00498	0.478
LIG_FHA_1	438	444	PF00498	0.633
LIG_FHA_1	61	67	PF00498	0.357
LIG_FHA_2	117	123	PF00498	0.170
LIG_FHA_2	239	245	PF00498	0.315
LIG_FHA_2	319	325	PF00498	0.398
LIG_FHA_2	416	422	PF00498	0.345
LIG_FHA_2	431	437	PF00498	0.383
LIG_FHA_2	46	52	PF00498	0.596
LIG_LIR_Gen_1	379	389	PF02991	0.403
LIG_LIR_Gen_1	423	434	PF02991	0.365
LIG_LIR_LC3C_4	63	67	PF02991	0.439
LIG_LIR_Nem_3	109	115	PF02991	0.339
LIG_LIR_Nem_3	118	123	PF02991	0.300
LIG_LIR_Nem_3	203	209	PF02991	0.521
LIG_LIR_Nem_3	385	390	PF02991	0.311
LIG_LIR_Nem_3	423	429	PF02991	0.326
LIG_MYND_1	349	353	PF01753	0.265
LIG_PCNA_PIPBox_1	275	284	PF02747	0.345
LIG_PCNA_yPIPBox_3	270	282	PF02747	0.351
LIG_Pex14_2	155	159	PF04695	0.285
LIG_Pex14_2	171	175	PF04695	0.345
LIG_Pex14_2	248	252	PF04695	0.322
LIG_SH2_CRK	236	240	PF00017	0.373
LIG_SH2_CRK	346	350	PF00017	0.312
LIG_SH2_CRK	390	394	PF00017	0.408
LIG_SH2_NCK_1	336	340	PF00017	0.288
LIG_SH2_NCK_1	346	350	PF00017	0.387
LIG_SH2_SRC	164	167	PF00017	0.453
LIG_SH2_SRC	236	239	PF00017	0.445
LIG_SH2_STAT3	432	435	PF00017	0.553
LIG_SH2_STAT5	134	137	PF00017	0.399
LIG_SH2_STAT5	164	167	PF00017	0.520
LIG_SH2_STAT5	183	186	PF00017	0.409
LIG_SH2_STAT5	229	232	PF00017	0.490
LIG_SH2_STAT5	238	241	PF00017	0.243
LIG_SH2_STAT5	328	331	PF00017	0.311
LIG_SH2_STAT5	381	384	PF00017	0.304
LIG_SH2_STAT5	394	397	PF00017	0.457
LIG_SH2_STAT5	432	435	PF00017	0.391
LIG_SH3_1	346	352	PF00018	0.301
LIG_SH3_3	135	141	PF00018	0.251
LIG_SH3_3	163	169	PF00018	0.367
LIG_SH3_3	346	352	PF00018	0.274
LIG_SH3_3	73	79	PF00018	0.316
LIG_SUMO_SIM_anti_2	63	69	PF11976	0.353
LIG_TRAF2_1	321	324	PF00917	0.383
LIG_TRAF2_1	433	436	PF00917	0.516
LIG_TRAF2_2	312	317	PF00917	0.625
LIG_TYR_ITSM	386	393	PF00017	0.377
MOD_CK1_1	42	48	PF00069	0.617
MOD_CK2_1	318	324	PF00069	0.431
MOD_CK2_1	415	421	PF00069	0.337
MOD_CK2_1	430	436	PF00069	0.365
MOD_CK2_1	45	51	PF00069	0.584
MOD_GlcNHglycan	13	16	PF01048	0.703
MOD_GlcNHglycan	145	148	PF01048	0.251
MOD_GlcNHglycan	19	23	PF01048	0.691
MOD_GSK3_1	1	8	PF00069	0.473
MOD_GSK3_1	173	180	PF00069	0.417
MOD_GSK3_1	213	220	PF00069	0.253
MOD_GSK3_1	295	302	PF00069	0.438
MOD_GSK3_1	318	325	PF00069	0.368
MOD_GSK3_1	372	379	PF00069	0.604
MOD_N-GLC_1	128	133	PF02516	0.182
MOD_N-GLC_1	195	200	PF02516	0.394
MOD_N-GLC_1	270	275	PF02516	0.298
MOD_N-GLC_1	36	41	PF02516	0.576
MOD_N-GLC_1	376	381	PF02516	0.567
MOD_NEK2_1	1	6	PF00069	0.445
MOD_NEK2_1	116	121	PF00069	0.224
MOD_NEK2_1	128	133	PF00069	0.160
MOD_NEK2_1	265	270	PF00069	0.478
MOD_NEK2_1	303	308	PF00069	0.435
MOD_NEK2_1	318	323	PF00069	0.386
MOD_NEK2_1	344	349	PF00069	0.322
MOD_NEK2_1	60	65	PF00069	0.318
MOD_NEK2_2	5	10	PF00069	0.422
MOD_PKA_2	116	122	PF00069	0.365
MOD_PKA_2	382	388	PF00069	0.375
MOD_Plk_1	128	134	PF00069	0.182
MOD_Plk_1	270	276	PF00069	0.297
MOD_Plk_1	323	329	PF00069	0.330
MOD_Plk_1	376	382	PF00069	0.522
MOD_Plk_1	39	45	PF00069	0.574
MOD_Plk_4	217	223	PF00069	0.520
MOD_Plk_4	286	292	PF00069	0.430
MOD_Plk_4	323	329	PF00069	0.363
MOD_Plk_4	358	364	PF00069	0.324
MOD_Plk_4	377	383	PF00069	0.519
MOD_Plk_4	5	11	PF00069	0.475
MOD_ProDKin_1	308	314	PF00069	0.570
MOD_ProDKin_1	385	391	PF00069	0.316
MOD_ProDKin_1	430	436	PF00069	0.411
MOD_SUMO_rev_2	405	412	PF00179	0.379
MOD_SUMO_rev_2	51	61	PF00179	0.546
TRG_ENDOCYTIC_2	120	123	PF00928	0.266
TRG_ENDOCYTIC_2	236	239	PF00928	0.320
TRG_ENDOCYTIC_2	381	384	PF00928	0.319
TRG_ENDOCYTIC_2	390	393	PF00928	0.381
TRG_ER_diArg_1	191	193	PF00400	0.373
TRG_ER_diArg_1	91	94	PF00400	0.340
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKN6	Leptomonas seymouri	73%	96%
A0A0S4JT27	Bodo saltans	54%	100%
A0A1X0P7L7	Trypanosomatidae	57%	92%
A0A3S7XAY1	Leishmania donovani	81%	100%
A0A422NCB6	Trypanosoma rangeli	58%	97%
A4ICF3	Leishmania infantum	82%	100%
D0A3C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AT24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q1H4	Leishmania major	81%	100%
Q4R5N9	Macaca fascicularis	23%	100%
V5BCK5	Trypanosoma cruzi	58%	98%