COP9 signalosome complex subunit 3

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPB2_LEIBR

TriTrypDb:

LbrM.35.2670 , LBRM2903_350033800

Length:

703

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPB2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.433
CLV_C14_Caspase3-7	87	91	PF00656	0.475
CLV_NRD_NRD_1	349	351	PF00675	0.689
CLV_NRD_NRD_1	383	385	PF00675	0.629
CLV_NRD_NRD_1	418	420	PF00675	0.735
CLV_NRD_NRD_1	486	488	PF00675	0.571
CLV_PCSK_KEX2_1	383	385	PF00082	0.629
CLV_PCSK_KEX2_1	417	419	PF00082	0.734
CLV_PCSK_KEX2_1	486	488	PF00082	0.571
CLV_PCSK_KEX2_1	53	55	PF00082	0.415
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.415
CLV_PCSK_PC7_1	379	385	PF00082	0.639
CLV_PCSK_SKI1_1	369	373	PF00082	0.622
CLV_PCSK_SKI1_1	524	528	PF00082	0.565
CLV_PCSK_SKI1_1	579	583	PF00082	0.490
CLV_PCSK_SKI1_1	643	647	PF00082	0.365
CLV_PCSK_SKI1_1	84	88	PF00082	0.497
CLV_Separin_Metazoa	414	418	PF03568	0.519
DEG_APCC_DBOX_1	523	531	PF00400	0.527
DEG_APCC_DBOX_1	578	586	PF00400	0.487
DOC_MAPK_gen_1	134	143	PF00069	0.488
DOC_MAPK_MEF2A_6	137	145	PF00069	0.495
DOC_MAPK_MEF2A_6	475	484	PF00069	0.598
DOC_MAPK_MEF2A_6	579	587	PF00069	0.582
DOC_PP2B_LxvP_1	79	82	PF13499	0.632
DOC_PP4_FxxP_1	443	446	PF00568	0.594
DOC_USP7_MATH_1	102	106	PF00917	0.650
DOC_USP7_MATH_1	205	209	PF00917	0.594
DOC_USP7_MATH_1	314	318	PF00917	0.674
DOC_USP7_MATH_1	561	565	PF00917	0.712
DOC_USP7_MATH_1	672	676	PF00917	0.492
DOC_WW_Pin1_4	223	228	PF00397	0.570
DOC_WW_Pin1_4	402	407	PF00397	0.651
DOC_WW_Pin1_4	452	457	PF00397	0.698
DOC_WW_Pin1_4	556	561	PF00397	0.814
DOC_WW_Pin1_4	88	93	PF00397	0.741
LIG_14-3-3_CanoR_1	111	117	PF00244	0.521
LIG_14-3-3_CanoR_1	22	26	PF00244	0.622
LIG_14-3-3_CanoR_1	220	226	PF00244	0.552
LIG_14-3-3_CanoR_1	319	323	PF00244	0.600
LIG_14-3-3_CanoR_1	470	477	PF00244	0.514
LIG_14-3-3_CanoR_1	515	519	PF00244	0.583
LIG_14-3-3_CanoR_1	84	93	PF00244	0.516
LIG_Actin_WH2_2	123	139	PF00022	0.490
LIG_BRCT_BRCA1_1	128	132	PF00533	0.306
LIG_BRCT_BRCA1_2	128	134	PF00533	0.310
LIG_eIF4E_1	241	247	PF01652	0.336
LIG_eIF4E_1	580	586	PF01652	0.327
LIG_FHA_1	341	347	PF00498	0.565
LIG_FHA_1	452	458	PF00498	0.594
LIG_FHA_1	476	482	PF00498	0.393
LIG_FHA_1	504	510	PF00498	0.513
LIG_FHA_1	58	64	PF00498	0.577
LIG_FHA_1	590	596	PF00498	0.490
LIG_FHA_1	637	643	PF00498	0.524
LIG_FHA_1	672	678	PF00498	0.718
LIG_FHA_2	10	16	PF00498	0.452
LIG_FHA_2	182	188	PF00498	0.423
LIG_FHA_2	85	91	PF00498	0.507
LIG_LIR_Apic_2	641	647	PF02991	0.607
LIG_LIR_Gen_1	129	140	PF02991	0.325
LIG_LIR_Gen_1	256	267	PF02991	0.517
LIG_LIR_Gen_1	323	334	PF02991	0.603
LIG_LIR_Gen_1	461	466	PF02991	0.670
LIG_LIR_Gen_1	577	587	PF02991	0.340
LIG_LIR_Gen_1	62	72	PF02991	0.326
LIG_LIR_Nem_3	129	135	PF02991	0.312
LIG_LIR_Nem_3	235	240	PF02991	0.481
LIG_LIR_Nem_3	24	28	PF02991	0.638
LIG_LIR_Nem_3	256	262	PF02991	0.450
LIG_LIR_Nem_3	323	329	PF02991	0.616
LIG_LIR_Nem_3	461	465	PF02991	0.678
LIG_LIR_Nem_3	577	583	PF02991	0.351
LIG_LIR_Nem_3	617	621	PF02991	0.613
LIG_LIR_Nem_3	62	67	PF02991	0.326
LIG_MAD2	419	427	PF02301	0.522
LIG_MLH1_MIPbox_1	128	132	PF16413	0.306
LIG_NRBOX	581	587	PF00104	0.573
LIG_PCNA_yPIPBox_3	124	137	PF02747	0.324
LIG_RPA_C_Fungi	481	493	PF08784	0.345
LIG_SH2_CRK	259	263	PF00017	0.509
LIG_SH2_CRK	326	330	PF00017	0.527
LIG_SH2_CRK	580	584	PF00017	0.336
LIG_SH2_NCK_1	241	245	PF00017	0.350
LIG_SH2_NCK_1	259	263	PF00017	0.607
LIG_SH2_NCK_1	534	538	PF00017	0.501
LIG_SH2_NCK_1	580	584	PF00017	0.336
LIG_SH2_SRC	241	244	PF00017	0.339
LIG_SH2_SRC	534	537	PF00017	0.605
LIG_SH2_STAP1	241	245	PF00017	0.400
LIG_SH2_STAP1	254	258	PF00017	0.545
LIG_SH2_STAP1	477	481	PF00017	0.586
LIG_SH2_STAT5	131	134	PF00017	0.499
LIG_SH2_STAT5	237	240	PF00017	0.440
LIG_SH2_STAT5	352	355	PF00017	0.777
LIG_SH2_STAT5	477	480	PF00017	0.367
LIG_SH2_STAT5	667	670	PF00017	0.674
LIG_SH2_STAT5	68	71	PF00017	0.443
LIG_SH3_3	300	306	PF00018	0.592
LIG_SH3_3	438	444	PF00018	0.592
LIG_SH3_3	657	663	PF00018	0.586
LIG_SH3_3	89	95	PF00018	0.622
LIG_SUMO_SIM_anti_2	510	515	PF11976	0.581
LIG_SUMO_SIM_par_1	370	375	PF11976	0.452
LIG_SUMO_SIM_par_1	452	461	PF11976	0.690
LIG_SUMO_SIM_par_1	59	65	PF11976	0.551
LIG_TRAF2_1	564	567	PF00917	0.713
LIG_TRAF2_1	620	623	PF00917	0.604
LIG_TRFH_1	259	263	PF08558	0.523
LIG_UBA3_1	28	32	PF00899	0.638
LIG_WRC_WIRS_1	459	464	PF05994	0.678
MOD_CDC14_SPxK_1	91	94	PF00782	0.768
MOD_CDK_SPK_2	402	407	PF00069	0.651
MOD_CDK_SPxK_1	88	94	PF00069	0.744
MOD_CK1_1	162	168	PF00069	0.637
MOD_CK1_1	186	192	PF00069	0.513
MOD_CK1_1	208	214	PF00069	0.620
MOD_CK1_1	24	30	PF00069	0.443
MOD_CK1_1	270	276	PF00069	0.702
MOD_CK1_1	317	323	PF00069	0.601
MOD_CK1_1	428	434	PF00069	0.720
MOD_CK1_1	458	464	PF00069	0.678
MOD_CK1_1	636	642	PF00069	0.571
MOD_CK2_1	1	7	PF00069	0.480
MOD_CK2_1	102	108	PF00069	0.593
MOD_CK2_1	112	118	PF00069	0.416
MOD_CK2_1	170	176	PF00069	0.349
MOD_CK2_1	372	378	PF00069	0.588
MOD_CK2_1	561	567	PF00069	0.724
MOD_GlcNHglycan	161	164	PF01048	0.612
MOD_GlcNHglycan	207	210	PF01048	0.438
MOD_GlcNHglycan	255	258	PF01048	0.490
MOD_GlcNHglycan	309	312	PF01048	0.766
MOD_GlcNHglycan	33	36	PF01048	0.364
MOD_GlcNHglycan	374	377	PF01048	0.571
MOD_GlcNHglycan	434	437	PF01048	0.555
MOD_GlcNHglycan	472	475	PF01048	0.642
MOD_GlcNHglycan	54	57	PF01048	0.395
MOD_GlcNHglycan	556	559	PF01048	0.576
MOD_GlcNHglycan	629	632	PF01048	0.569
MOD_GlcNHglycan	648	651	PF01048	0.440
MOD_GSK3_1	126	133	PF00069	0.423
MOD_GSK3_1	179	186	PF00069	0.446
MOD_GSK3_1	223	230	PF00069	0.532
MOD_GSK3_1	314	321	PF00069	0.671
MOD_GSK3_1	346	353	PF00069	0.612
MOD_GSK3_1	42	49	PF00069	0.363
MOD_GSK3_1	428	435	PF00069	0.622
MOD_GSK3_1	451	458	PF00069	0.690
MOD_GSK3_1	503	510	PF00069	0.603
MOD_GSK3_1	627	634	PF00069	0.662
MOD_GSK3_1	84	91	PF00069	0.608
MOD_N-GLC_1	561	566	PF02516	0.631
MOD_N-GLC_2	588	590	PF02516	0.327
MOD_NEK2_1	130	135	PF00069	0.468
MOD_NEK2_1	136	141	PF00069	0.489
MOD_NEK2_1	185	190	PF00069	0.468
MOD_NEK2_1	21	26	PF00069	0.648
MOD_NEK2_1	31	36	PF00069	0.568
MOD_NEK2_1	372	377	PF00069	0.440
MOD_NEK2_1	451	456	PF00069	0.594
MOD_NEK2_1	46	51	PF00069	0.289
MOD_NEK2_1	595	600	PF00069	0.541
MOD_NEK2_1	635	640	PF00069	0.648
MOD_NEK2_2	614	619	PF00069	0.416
MOD_PIKK_1	208	214	PF00454	0.541
MOD_PIKK_1	46	52	PF00454	0.340
MOD_PKA_1	350	356	PF00069	0.669
MOD_PKA_2	136	142	PF00069	0.593
MOD_PKA_2	205	211	PF00069	0.503
MOD_PKA_2	21	27	PF00069	0.615
MOD_PKA_2	270	276	PF00069	0.608
MOD_PKA_2	318	324	PF00069	0.544
MOD_PKA_2	514	520	PF00069	0.583
MOD_PKA_2	697	703	PF00069	0.517
MOD_PKA_2	93	99	PF00069	0.665
MOD_Plk_1	507	513	PF00069	0.555
MOD_Plk_1	672	678	PF00069	0.594
MOD_Plk_2-3	187	193	PF00069	0.471
MOD_Plk_4	1	7	PF00069	0.384
MOD_Plk_4	126	132	PF00069	0.462
MOD_Plk_4	24	30	PF00069	0.647
MOD_Plk_4	42	48	PF00069	0.306
MOD_Plk_4	425	431	PF00069	0.750
MOD_Plk_4	458	464	PF00069	0.426
MOD_Plk_4	514	520	PF00069	0.501
MOD_Plk_4	59	65	PF00069	0.544
MOD_Plk_4	614	620	PF00069	0.557
MOD_Plk_4	672	678	PF00069	0.616
MOD_ProDKin_1	223	229	PF00069	0.573
MOD_ProDKin_1	402	408	PF00069	0.655
MOD_ProDKin_1	452	458	PF00069	0.696
MOD_ProDKin_1	556	562	PF00069	0.818
MOD_ProDKin_1	88	94	PF00069	0.744
MOD_SUMO_rev_2	563	571	PF00179	0.622
TRG_DiLeu_BaEn_1	243	248	PF01217	0.557
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.484
TRG_ENDOCYTIC_2	259	262	PF00928	0.501
TRG_ENDOCYTIC_2	326	329	PF00928	0.603
TRG_ENDOCYTIC_2	477	480	PF00928	0.488
TRG_ENDOCYTIC_2	534	537	PF00928	0.570
TRG_ENDOCYTIC_2	580	583	PF00928	0.331
TRG_ER_diArg_1	383	385	PF00400	0.377
TRG_ER_diArg_1	416	419	PF00400	0.716
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBJ6	Leptomonas seymouri	36%	100%
A0A3Q8INV1	Leishmania donovani	75%	100%
A4ICF2	Leishmania infantum	75%	100%
E9AT23	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%
Q4Q1H5	Leishmania major	75%	100%